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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for POU2AF1 |
 Gene summary |
| Gene information | Gene symbol | POU2AF1 | Gene ID | 5450 |
| Gene name | POU class 2 associating factor 1 | |
| Synonyms | BOB1|OBF-1|OBF1|OCAB | |
| Cytomap | 11q23.1 | |
| Type of gene | protein-coding | |
| Description | POU domain class 2-associating factor 1B-cell-specific coactivator OBF-1BOB-1OCA-BOCT-binding factor 1 | |
| Modification date | 20180519 | |
| UniProtAcc | Q16633 | |
| Context | PubMed: POU2AF1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for POU2AF1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for POU2AF1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for POU2AF1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_77325 | 11 | 111228250:111228435:111228519:111228562:111229512:111229643 | 111228519:111228562 | ENSG00000110777.7 | ENST00000525584.1,ENST00000531398.1,ENST00000393067.3 |
| exon_skip_77330 | 11 | 111229541:111229643:111248498:111248577:111249886:111250000 | 111248498:111248577 | ENSG00000110777.7 | ENST00000530793.1 |
| exon_skip_77334 | 11 | 111256978:111257017:111267575:111267768:111268304:111268431 | 111267575:111267768 | ENSG00000110777.7 | ENST00000515029.2 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for POU2AF1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_77325 | 11 | 111228250:111228435:111228519:111228562:111229512:111229643 | 111228519:111228562 | ENSG00000110777.7 | ENST00000393067.3,ENST00000525584.1,ENST00000531398.1 |
| exon_skip_77330 | 11 | 111229541:111229643:111248498:111248577:111249886:111250000 | 111248498:111248577 | ENSG00000110777.7 | ENST00000530793.1 |
| exon_skip_77334 | 11 | 111256978:111257017:111267575:111267768:111268304:111268431 | 111267575:111267768 | ENSG00000110777.7 | ENST00000515029.2 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for POU2AF1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000393067 | 111228519 | 111228562 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000393067 | 111228519 | 111228562 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for POU2AF1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for POU2AF1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for POU2AF1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for POU2AF1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for POU2AF1 |
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RelatedDrugs for POU2AF1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for POU2AF1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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