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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for CYTL1 |
 Gene summary |
| Gene information | Gene symbol | CYTL1 | Gene ID | 54360 |
| Gene name | cytokine like 1 | |
| Synonyms | C17|C4orf4 | |
| Cytomap | 4p16.2 | |
| Type of gene | protein-coding | |
| Description | cytokine-like protein 1cytokine-like protein C17 | |
| Modification date | 20180329 | |
| UniProtAcc | Q9NRR1 | |
| Context | PubMed: CYTL1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for CYTL1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for CYTL1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for CYTL1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_428272 | 4 | 5016870:5016961:5018562:5018691:5018861:5018906 | 5018562:5018691 | ENSG00000170891.6 | ENST00000307746.4 |
| exon_skip_428275 | 4 | 5016870:5016961:5018861:5018906:5021019:5021164 | 5018861:5018906 | ENSG00000170891.6 | ENST00000509419.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for CYTL1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_428272 | 4 | 5016870:5016961:5018562:5018691:5018861:5018906 | 5018562:5018691 | ENSG00000170891.6 | ENST00000307746.4 |
| exon_skip_428275 | 4 | 5016870:5016961:5018861:5018906:5021019:5021164 | 5018861:5018906 | ENSG00000170891.6 | ENST00000509419.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for CYTL1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000307746 | 5018562 | 5018691 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000307746 | 5018562 | 5018691 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CYTL1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000307746 | 1020 | 136 | 5018562 | 5018691 | 226 | 354 | 66 | 109 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000307746 | 1020 | 136 | 5018562 | 5018691 | 226 | 354 | 66 | 109 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9NRR1 | 66 | 109 | 23 | 136 | Chain | ID=PRO_0000020838;Note=Cytokine-like protein 1 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9NRR1 | 66 | 109 | 23 | 136 | Chain | ID=PRO_0000020838;Note=Cytokine-like protein 1 |
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SNVs in the skipped exons for CYTL1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| THYM | TCGA-X7-A8D6-01 | exon_skip_428272 | 5018563 | 5018691 | 5018686 | 5018686 | Nonsense_Mutation | G | T | p.Y68X |
| UCS | TCGA-ND-A4WC-01 | exon_skip_428275 | 5018862 | 5018906 | 5018861 | 5018861 | Splice_Site | C | T | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| PACADD119_PANCREAS | 5018563 | 5018691 | 5018578 | 5018578 | Missense_Mutation | G | T | p.N104K |
| JHUEM2_ENDOMETRIUM | 5018862 | 5018906 | 5018890 | 5018890 | Missense_Mutation | T | C | p.Y57C |
| TMK1_STOMACH | 5018563 | 5018691 | 5018690 | 5018690 | Splice_Site | T | C | p.N67S |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CYTL1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CYTL1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CYTL1 |
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RelatedDrugs for CYTL1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CYTL1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| CYTL1 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
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