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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for PLAUR |
 Gene summary |
| Gene information | Gene symbol | PLAUR | Gene ID | 5329 |
| Gene name | plasminogen activator, urokinase receptor | |
| Synonyms | CD87|U-PAR|UPAR|URKR | |
| Cytomap | 19q13.31 | |
| Type of gene | protein-coding | |
| Description | urokinase plasminogen activator surface receptormonocyte activation antigen Mo3u-plasminogen activator receptor form 2urokinase-type plasminogen activator (uPA) receptor | |
| Modification date | 20180523 | |
| UniProtAcc | Q03405 | |
| Context | PubMed: PLAUR [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| PLAUR | GO:0043388 | positive regulation of DNA binding | 22984561 |
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Exon skipping events across known transcript of Ensembl for PLAUR from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for PLAUR |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for PLAUR |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_319270 | 19 | 44150246:44150700:44156376:44156523:44159590:44159725 | 44156376:44156523 | ENSG00000011422.7 | ENST00000339082.3 |
| exon_skip_319279 | 19 | 44152731:44153295:44156376:44156523:44159590:44159725 | 44156376:44156523 | ENSG00000011422.7 | ENST00000340093.3 |
| exon_skip_319280 | 19 | 44152731:44153295:44156376:44156523:44160630:44160725 | 44156376:44156523 | ENSG00000011422.7 | ENST00000221264.4 |
| exon_skip_319284 | 19 | 44152731:44153295:44159590:44159725:44160630:44160725 | 44159590:44159725 | ENSG00000011422.7 | ENST00000601723.1 |
| exon_skip_319289 | 19 | 44156415:44156523:44159590:44159725:44160630:44160725 | 44159590:44159725 | ENSG00000011422.7 | ENST00000595038.1,ENST00000339082.3,ENST00000593447.1,ENST00000593714.1,ENST00000340093.3,ENST00000599892.1 |
| exon_skip_319292 | 19 | 44156415:44156523:44160630:44160792:44169467:44169611 | 44160630:44160792 | ENSG00000011422.7 | ENST00000221264.4 |
| exon_skip_319293 | 19 | 44159664:44159725:44160630:44160792:44169467:44169611 | 44160630:44160792 | ENSG00000011422.7 | ENST00000339082.3,ENST00000340093.3,ENST00000599892.1,ENST00000602141.1,ENST00000601723.1 |
| exon_skip_319297 | 19 | 44160717:44160792:44169467:44169611:44171732:44171843 | 44169467:44169611 | ENSG00000011422.7 | ENST00000339082.3,ENST00000221264.4,ENST00000593939.1,ENST00000340093.3,ENST00000599892.1,ENST00000602141.1,ENST00000601723.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for PLAUR |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_319270 | 19 | 44150246:44150700:44156376:44156523:44159590:44159725 | 44156376:44156523 | ENSG00000011422.7 | ENST00000339082.3 |
| exon_skip_319279 | 19 | 44152731:44153295:44156376:44156523:44159590:44159725 | 44156376:44156523 | ENSG00000011422.7 | ENST00000340093.3 |
| exon_skip_319280 | 19 | 44152731:44153295:44156376:44156523:44160630:44160725 | 44156376:44156523 | ENSG00000011422.7 | ENST00000221264.4 |
| exon_skip_319284 | 19 | 44152731:44153295:44159590:44159725:44160630:44160725 | 44159590:44159725 | ENSG00000011422.7 | ENST00000601723.1 |
| exon_skip_319289 | 19 | 44156415:44156523:44159590:44159725:44160630:44160725 | 44159590:44159725 | ENSG00000011422.7 | ENST00000339082.3,ENST00000593447.1,ENST00000340093.3,ENST00000595038.1,ENST00000593714.1,ENST00000599892.1 |
| exon_skip_319292 | 19 | 44156415:44156523:44160630:44160792:44169467:44169611 | 44160630:44160792 | ENSG00000011422.7 | ENST00000221264.4 |
| exon_skip_319293 | 19 | 44159664:44159725:44160630:44160792:44169467:44169611 | 44160630:44160792 | ENSG00000011422.7 | ENST00000339082.3,ENST00000601723.1,ENST00000340093.3,ENST00000599892.1,ENST00000602141.1 |
| exon_skip_319297 | 19 | 44160717:44160792:44169467:44169611:44171732:44171843 | 44169467:44169611 | ENSG00000011422.7 | ENST00000339082.3,ENST00000601723.1,ENST00000340093.3,ENST00000221264.4,ENST00000599892.1,ENST00000602141.1,ENST00000593939.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for PLAUR |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000340093 | 44156376 | 44156523 | In-frame |
| ENST00000340093 | 44159590 | 44159725 | In-frame |
| ENST00000340093 | 44160630 | 44160792 | In-frame |
| ENST00000340093 | 44169467 | 44169611 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000340093 | 44156376 | 44156523 | In-frame |
| ENST00000340093 | 44159590 | 44159725 | In-frame |
| ENST00000340093 | 44160630 | 44160792 | In-frame |
| ENST00000340093 | 44169467 | 44169611 | In-frame |
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Infer the effects of exon skipping event on protein functional features for PLAUR |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000340093 | 1565 | 335 | 44169467 | 44169611 | 397 | 540 | 55 | 103 |
| ENST00000340093 | 1565 | 335 | 44160630 | 44160792 | 541 | 702 | 103 | 157 |
| ENST00000340093 | 1565 | 335 | 44159590 | 44159725 | 703 | 837 | 157 | 202 |
| ENST00000340093 | 1565 | 335 | 44156376 | 44156523 | 838 | 984 | 202 | 251 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000340093 | 1565 | 335 | 44169467 | 44169611 | 397 | 540 | 55 | 103 |
| ENST00000340093 | 1565 | 335 | 44160630 | 44160792 | 541 | 702 | 103 | 157 |
| ENST00000340093 | 1565 | 335 | 44159590 | 44159725 | 703 | 837 | 157 | 202 |
| ENST00000340093 | 1565 | 335 | 44156376 | 44156523 | 838 | 984 | 202 | 251 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for PLAUR |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_319280 exon_skip_319270 exon_skip_319279 | 44156377 | 44156523 | 44156402 | 44156402 | Frame_Shift_Del | T | - | p.Q198fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_319280 exon_skip_319270 exon_skip_319279 | 44156377 | 44156523 | 44156433 | 44156433 | Frame_Shift_Del | A | - | p.F188fs |
| BLCA | TCGA-GC-A3RB-01 | exon_skip_319297 | 44169468 | 44169611 | 44169569 | 44169569 | Nonsense_Mutation | G | T | p.S70* |
| LUSC | TCGA-33-6737-01 | exon_skip_319297 | 44169468 | 44169611 | 44169569 | 44169569 | Nonsense_Mutation | G | C | p.S70* |
| LUSC | TCGA-46-3769-01 | exon_skip_319289 exon_skip_319284 | 44159591 | 44159725 | 44159726 | 44159726 | Splice_Site | C | T | p.G158_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| NCIH1694_LUNG | 44156377 | 44156523 | 44156386 | 44156386 | Missense_Mutation | C | G | p.G249R |
| UW228_CENTRAL_NERVOUS_SYSTEM | 44156377 | 44156523 | 44156401 | 44156401 | Missense_Mutation | A | G | p.C244R |
| SNU886_LIVER | 44160631 | 44160792 | 44160657 | 44160657 | Missense_Mutation | G | A | p.T149I |
| EPLC272H_LUNG | 44160631 | 44160792 | 44160784 | 44160784 | Missense_Mutation | C | T | p.V107I |
| HEC108_ENDOMETRIUM | 44169468 | 44169611 | 44169510 | 44169510 | Missense_Mutation | C | T | p.E90K |
| KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 44169468 | 44169611 | 44169575 | 44169575 | Missense_Mutation | G | C | p.T68S |
| NCIH889_LUNG | 44160631 | 44160792 | 44160679 | 44160679 | Nonsense_Mutation | C | A | p.E142* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PLAUR |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PLAUR |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PLAUR |
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RelatedDrugs for PLAUR |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Q03405 | DB00009 | Alteplase | Urokinase plasminogen activator surface receptor | biotech | approved | |
| Q03405 | DB00029 | Anistreplase | Urokinase plasminogen activator surface receptor | biotech | approved | |
| Q03405 | DB00031 | Tenecteplase | Urokinase plasminogen activator surface receptor | biotech | approved | |
| Q03405 | DB00015 | Reteplase | Urokinase plasminogen activator surface receptor | biotech | approved|investigational | |
| Q03405 | DB00013 | Urokinase | Urokinase plasminogen activator surface receptor | biotech | approved|investigational|withdrawn |
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RelatedDiseases for PLAUR |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| PLAUR | C0004352 | Autistic Disorder | 2 | CTD_human |
| PLAUR | C0021368 | Inflammation | 1 | CTD_human |
| PLAUR | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| PLAUR | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| PLAUR | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| PLAUR | C3495559 | Juvenile arthritis | 1 | CTD_human |
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