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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for PLAT |
 Gene summary |
| Gene information | Gene symbol | PLAT | Gene ID | 5327 |
| Gene name | plasminogen activator, tissue type | |
| Synonyms | T-PA|TPA | |
| Cytomap | 8p11.21 | |
| Type of gene | protein-coding | |
| Description | tissue-type plasminogen activatoralteplaseplasminogen/activator kringlereteplaset-plasminogen activator | |
| Modification date | 20180523 | |
| UniProtAcc | P00750 | |
| Context | PubMed: PLAT [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| PLAT | GO:0031639 | plasminogen activation | 12694198|17849409|24196407 |
| PLAT | GO:0045861 | negative regulation of proteolysis | 1695900 |
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Exon skipping events across known transcript of Ensembl for PLAT from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for PLAT |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for PLAT |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_489467 | 8 | 42040236:42040408:42042598:42042676:42045423:42045534 | 42042598:42042676 | ENSG00000104368.13 | ENST00000519510.1 |
| exon_skip_489468 | 8 | 42040236:42040408:42042598:42042690:42044915:42045090 | 42042598:42042690 | ENSG00000104368.13 | ENST00000220809.4,ENST00000429089.2,ENST00000352041.3,ENST00000270189.6 |
| exon_skip_489471 | 8 | 42040236:42040408:42045423:42045534:42046451:42046579 | 42045423:42045534 | ENSG00000104368.13 | ENST00000524009.1 |
| exon_skip_489475 | 8 | 42040236:42040408:42046451:42046589:42048889:42048932 | 42046451:42046589 | ENSG00000104368.13 | ENST00000429710.2 |
| exon_skip_489477 | 8 | 42042598:42042690:42044915:42045090:42045423:42045450 | 42044915:42045090 | ENSG00000104368.13 | ENST00000220809.4,ENST00000429089.2,ENST00000352041.3,ENST00000270189.6 |
| exon_skip_489479 | 8 | 42045423:42045534:42046451:42046589:42048889:42048932 | 42046451:42046589 | ENSG00000104368.13 | ENST00000220809.4,ENST00000524009.1,ENST00000520523.1,ENST00000521694.1,ENST00000429089.2,ENST00000270189.6,ENST00000519510.1 |
| exon_skip_489482 | 8 | 42045423:42045534:42048889:42048932:42050631:42050729 | 42048889:42048932 | ENSG00000104368.13 | ENST00000352041.3 |
| exon_skip_489483 | 8 | 42046451:42046589:42048889:42048932:42050631:42050729 | 42048889:42048932 | ENSG00000104368.13 | ENST00000220809.4,ENST00000524009.1,ENST00000520523.1,ENST00000521694.1,ENST00000429089.2,ENST00000429710.2,ENST00000270189.6,ENST00000519510.1 |
| exon_skip_489484 | 8 | 42048889:42048932:42050631:42050729:42065011:42065083 | 42050631:42050729 | ENSG00000104368.13 | ENST00000220809.4,ENST00000524009.1,ENST00000352041.3,ENST00000429710.2,ENST00000519510.1 |
| exon_skip_489486 | 8 | 42050631:42050729:42064164:42064216:42065011:42065083 | 42064164:42064216 | ENSG00000104368.13 | ENST00000429089.2 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for PLAT |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_489467 | 8 | 42040236:42040408:42042598:42042676:42045423:42045534 | 42042598:42042676 | ENSG00000104368.13 | ENST00000519510.1 |
| exon_skip_489468 | 8 | 42040236:42040408:42042598:42042690:42044915:42045090 | 42042598:42042690 | ENSG00000104368.13 | ENST00000270189.6,ENST00000429089.2,ENST00000220809.4,ENST00000352041.3 |
| exon_skip_489471 | 8 | 42040236:42040408:42045423:42045534:42046451:42046579 | 42045423:42045534 | ENSG00000104368.13 | ENST00000524009.1 |
| exon_skip_489475 | 8 | 42040236:42040408:42046451:42046589:42048889:42048932 | 42046451:42046589 | ENSG00000104368.13 | ENST00000429710.2 |
| exon_skip_489477 | 8 | 42042598:42042690:42044915:42045090:42045423:42045450 | 42044915:42045090 | ENSG00000104368.13 | ENST00000270189.6,ENST00000429089.2,ENST00000220809.4,ENST00000352041.3 |
| exon_skip_489479 | 8 | 42045423:42045534:42046451:42046589:42048889:42048932 | 42046451:42046589 | ENSG00000104368.13 | ENST00000270189.6,ENST00000429089.2,ENST00000220809.4,ENST00000519510.1,ENST00000524009.1,ENST00000520523.1,ENST00000521694.1 |
| exon_skip_489482 | 8 | 42045423:42045534:42048889:42048932:42050631:42050729 | 42048889:42048932 | ENSG00000104368.13 | ENST00000352041.3 |
| exon_skip_489483 | 8 | 42046451:42046589:42048889:42048932:42050631:42050729 | 42048889:42048932 | ENSG00000104368.13 | ENST00000270189.6,ENST00000429089.2,ENST00000220809.4,ENST00000519510.1,ENST00000429710.2,ENST00000524009.1,ENST00000520523.1,ENST00000521694.1 |
| exon_skip_489484 | 8 | 42048889:42048932:42050631:42050729:42065011:42065083 | 42050631:42050729 | ENSG00000104368.13 | ENST00000220809.4,ENST00000352041.3,ENST00000519510.1,ENST00000429710.2,ENST00000524009.1 |
| exon_skip_489486 | 8 | 42050631:42050729:42064164:42064216:42065011:42065083 | 42064164:42064216 | ENSG00000104368.13 | ENST00000429089.2 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for PLAT |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000220809 | 42050631 | 42050729 | 3UTR-3CDS |
| ENST00000429089 | 42064164 | 42064216 | 3UTR-3UTR |
| ENST00000220809 | 42042598 | 42042690 | Frame-shift |
| ENST00000429089 | 42042598 | 42042690 | Frame-shift |
| ENST00000220809 | 42044915 | 42045090 | Frame-shift |
| ENST00000429089 | 42044915 | 42045090 | Frame-shift |
| ENST00000220809 | 42048889 | 42048932 | Frame-shift |
| ENST00000429089 | 42048889 | 42048932 | Frame-shift |
| ENST00000220809 | 42046451 | 42046589 | In-frame |
| ENST00000429089 | 42046451 | 42046589 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000220809 | 42050631 | 42050729 | 3UTR-3CDS |
| ENST00000429089 | 42064164 | 42064216 | 3UTR-3UTR |
| ENST00000220809 | 42042598 | 42042690 | Frame-shift |
| ENST00000429089 | 42042598 | 42042690 | Frame-shift |
| ENST00000220809 | 42044915 | 42045090 | Frame-shift |
| ENST00000429089 | 42044915 | 42045090 | Frame-shift |
| ENST00000220809 | 42048889 | 42048932 | Frame-shift |
| ENST00000429089 | 42048889 | 42048932 | Frame-shift |
| ENST00000220809 | 42046451 | 42046589 | In-frame |
| ENST00000429089 | 42046451 | 42046589 | In-frame |
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Infer the effects of exon skipping event on protein functional features for PLAT |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000220809 | 2723 | 562 | 42046451 | 42046589 | 373 | 510 | 38 | 84 |
| ENST00000429089 | 2616 | 562 | 42046451 | 42046589 | 266 | 403 | 38 | 84 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000220809 | 2723 | 562 | 42046451 | 42046589 | 373 | 510 | 38 | 84 |
| ENST00000429089 | 2616 | 562 | 42046451 | 42046589 | 266 | 403 | 38 | 84 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for PLAT |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_489471 | 42045424 | 42045534 | 42045471 | 42045471 | Frame_Shift_Del | A | - | p.F106fs |
| BLCA | TCGA-G2-AA3F-01 | exon_skip_489467 | 42042599 | 42042676 | 42042656 | 42042657 | Frame_Shift_Ins | - | GTAG | p.V192fs |
| BLCA | TCGA-G2-AA3F-01 | exon_skip_489468 | 42042599 | 42042690 | 42042656 | 42042657 | Frame_Shift_Ins | - | GTAG | p.V192fs |
| LUAD | TCGA-55-A4DG-01 | exon_skip_489475 exon_skip_489479 | 42046452 | 42046589 | 42046466 | 42046466 | Nonsense_Mutation | G | C | p.S80* |
| UCEC | TCGA-AP-A0LM-01 | exon_skip_489482 exon_skip_489483 | 42048890 | 42048932 | 42048920 | 42048920 | Nonsense_Mutation | G | A | p.R29* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| KYSE70_OESOPHAGUS | 42042599 | 42042676 | 42042614 | 42042614 | Missense_Mutation | G | A | p.P206S |
| KYSE70_OESOPHAGUS | 42042599 | 42042690 | 42042614 | 42042614 | Missense_Mutation | G | A | p.P206S |
| HT115_LARGE_INTESTINE | 42042599 | 42042676 | 42042616 | 42042616 | Missense_Mutation | G | A | p.T205I |
| HT115_LARGE_INTESTINE | 42042599 | 42042690 | 42042616 | 42042616 | Missense_Mutation | G | A | p.T205I |
| NCIH446_LUNG | 42044916 | 42045090 | 42044919 | 42044919 | Missense_Mutation | C | A | p.C179F |
| HEC265_ENDOMETRIUM | 42044916 | 42045090 | 42044938 | 42044938 | Missense_Mutation | G | T | p.L173M |
| HEC1A_ENDOMETRIUM | 42044916 | 42045090 | 42045026 | 42045026 | Missense_Mutation | C | A | p.E143D |
| SNU1040_LARGE_INTESTINE | 42044916 | 42045090 | 42045030 | 42045030 | Missense_Mutation | G | A | p.A142V |
| SW780_URINARY_TRACT | 42045424 | 42045534 | 42045483 | 42045483 | Missense_Mutation | T | G | p.Y102S |
| SMSCTR_SOFT_TISSUE | 42045424 | 42045534 | 42045508 | 42045508 | Missense_Mutation | C | T | p.G94R |
| PLCPRF5_LIVER | 42046452 | 42046589 | 42046480 | 42046480 | Missense_Mutation | C | A | p.R75S |
| KCL22_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 42046452 | 42046589 | 42046520 | 42046520 | Missense_Mutation | C | T | p.R62K |
| SNU81_LARGE_INTESTINE | 42046452 | 42046589 | 42046532 | 42046532 | Missense_Mutation | C | T | p.R58H |
| HEC59_ENDOMETRIUM | 42046452 | 42046589 | 42046583 | 42046583 | Missense_Mutation | C | T | p.C41Y |
| SUM149PT_BREAST | 42048890 | 42048932 | 42048919 | 42048919 | Missense_Mutation | C | T | p.R29Q |
| WSUNHL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 42050632 | 42050729 | 42050646 | 42050646 | Missense_Mutation | C | T | p.V20I |
| CAMA1_BREAST | 42042599 | 42042676 | 42042673 | 42042673 | Nonsense_Mutation | G | C | p.S186* |
| CAMA1_BREAST | 42042599 | 42042690 | 42042673 | 42042673 | Nonsense_Mutation | G | C | p.S186* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PLAT |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PLAT |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PLAT |
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RelatedDrugs for PLAT |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P00750 | DB06404 | Human C1-esterase inhibitor | Tissue-type plasminogen activator | biotech | approved | |
| P00750 | DB00513 | Aminocaproic Acid | Tissue-type plasminogen activator | small molecule | approved|investigational | |
| P00750 | DB01088 | Iloprost | Tissue-type plasminogen activator | small molecule | approved|investigational | |
| P00750 | DB09213 | Dexibuprofen | Tissue-type plasminogen activator | small molecule | approved|investigational | |
| P00750 | DB09228 | Conestat alfa | Tissue-type plasminogen activator | biotech | approved|investigational | |
| P00750 | DB00013 | Urokinase | Tissue-type plasminogen activator | biotech | approved|investigational|withdrawn |
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RelatedDiseases for PLAT |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| PLAT | C0038454 | Cerebrovascular accident | 59 | CTD_human |
| PLAT | C0027051 | Myocardial Infarction | 35 | CTD_human |
| PLAT | C0007786 | Brain Ischemia | 25 | CTD_human |
| PLAT | C2937358 | Cerebral Hemorrhage | 21 | CTD_human |
| PLAT | C0151699 | Intracranial Hemorrhages | 14 | CTD_human |
| PLAT | C0034065 | Pulmonary Embolism | 9 | CTD_human |
| PLAT | C0019080 | Hemorrhage | 8 | CTD_human |
| PLAT | C0007785 | Cerebral Infarction | 6 | CTD_human |
| PLAT | C0040053 | Thrombosis | 4 | CTD_human |
| PLAT | C0740392 | Infarction, Middle Cerebral Artery | 4 | CTD_human |
| PLAT | C0002994 | Angioedema | 3 | CTD_human |
| PLAT | C0010072 | Coronary Thrombosis | 3 | CTD_human |
| PLAT | C0042487 | Venous Thrombosis | 3 | CTD_human |
| PLAT | C0007781 | Intracranial Embolism and Thrombosis | 2 | CTD_human |
| PLAT | C0877172 | Hematoma, Epidural, Spinal | 2 | CTD_human |
| PLAT | C0001125 | Acidosis, Lactic | 1 | CTD_human |
| PLAT | C0001883 | Airway Obstruction | 1 | CTD_human |
| PLAT | C0003537 | Aphasia | 1 | CTD_human |
| PLAT | C0003838 | Arterial Occlusive Diseases | 1 | CTD_human |
| PLAT | C0004153 | Atherosclerosis | 1 | CTD_human |
| PLAT | C0004604 | Back Pain | 1 | CTD_human |
| PLAT | C0004610 | Bacteremia | 1 | CTD_human |
| PLAT | C0007177 | Cardiac Tamponade | 1 | CTD_human |
| PLAT | C0013922 | Embolism | 1 | CTD_human |
| PLAT | C0018801 | Heart failure | 1 | CTD_human |
| PLAT | C0018946 | Hematoma, Subdural | 1 | CTD_human |
| PLAT | C0020538 | Hypertensive disease | 1 | CTD_human |
| PLAT | C0020649 | Hypotension | 1 | CTD_human |
| PLAT | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| PLAT | C0024031 | Low Back Pain | 1 | CTD_human |
| PLAT | C0025309 | Meningoencephalitis | 1 | CTD_human |
| PLAT | C0027746 | Nerve Degeneration | 1 | CTD_human |
| PLAT | C0030552 | Paresis | 1 | CTD_human |
| PLAT | C0031039 | Pericardial effusion | 1 | CTD_human |
| PLAT | C0033975 | Psychotic Disorders | 1 | PSYGENET |
| PLAT | C0035126 | Reperfusion Injury | 1 | CTD_human |
| PLAT | C0035229 | Respiratory Insufficiency | 1 | CTD_human |
| PLAT | C0036341 | Schizophrenia | 1 | PSYGENET |
| PLAT | C0036980 | Shock, Cardiogenic | 1 | CTD_human |
| PLAT | C0037926 | Compression of spinal cord | 1 | CTD_human |
| PLAT | C0040038 | Thromboembolism | 1 | CTD_human |
| PLAT | C0085307 | Embolism and Thrombosis | 1 | CTD_human |
| PLAT | C0149649 | Cholesterol Embolism | 1 | CTD_human |
| PLAT | C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |
| PLAT | C0235032 | Neurotoxicity Syndromes | 1 | CTD_human |
| PLAT | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
| PLAT | C0242184 | Hypoxia | 1 | CTD_human |
| PLAT | C0242698 | Ventricular Dysfunction, Left | 1 | CTD_human |
| PLAT | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
| PLAT | C0740858 | Substance abuse problem | 1 | PSYGENET |
| PLAT | C0751895 | Vasospasm, Intracranial | 1 | CTD_human |
| PLAT | C0751955 | Brain Infarction | 1 | CTD_human |
| PLAT | C0752143 | Intracranial Thrombosis | 1 | CTD_human |
| PLAT | C1861172 | Venous Thromboembolism | 1 | CTD_human |
| PLAT | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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