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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for LUZP4 |
 Gene summary |
| Gene information | Gene symbol | LUZP4 | Gene ID | 51213 |
| Gene name | leucine zipper protein 4 | |
| Synonyms | CT-28|CT-8|CT28|HOM-TES-85 | |
| Cytomap | Xq23 | |
| Type of gene | protein-coding | |
| Description | leucine zipper protein 4HOM-TES-85 tumor antigencancer/testis antigen 28tumor antigen HOM-TES-85 | |
| Modification date | 20180519 | |
| UniProtAcc | Q9P127 | |
| Context | PubMed: LUZP4 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for LUZP4 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for LUZP4 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for LUZP4 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_511994 | X | 114536556:114536688:114537864:114537983:114540769:114542119 | 114537864:114537983 | ENSG00000102021.6 | ENST00000371920.3 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for LUZP4 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_511994 | X | 114536556:114536688:114537864:114537983:114540769:114542119 | 114537864:114537983 | ENSG00000102021.6 | ENST00000371920.3 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for LUZP4 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000371920 | 114537864 | 114537983 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000371920 | 114537864 | 114537983 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for LUZP4 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for LUZP4 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_511994 | 114537865 | 114537983 | 114537909 | 114537909 | Frame_Shift_Del | A | - | p.K91fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_511994 | 114537865 | 114537983 | 114537909 | 114537909 | Frame_Shift_Del | A | - | p.K91fs |
| STAD | TCGA-BR-6452-01 | exon_skip_511994 | 114537865 | 114537983 | 114537909 | 114537909 | Frame_Shift_Del | A | - | p.D89fs |
| UCEC | TCGA-D1-A17M-01 | exon_skip_511994 | 114537865 | 114537983 | 114537909 | 114537909 | Frame_Shift_Del | A | - | p.K90fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_511994 | 114537865 | 114537983 | 114537959 | 114537959 | Frame_Shift_Del | A | - | p.L106fs |
| BLCA | TCGA-ZF-A9R7-01 | exon_skip_511994 | 114537865 | 114537983 | 114537871 | 114537871 | Nonsense_Mutation | C | G | p.S77* |
| STAD | TCGA-CD-8536-01 | exon_skip_511994 | 114537865 | 114537983 | 114537966 | 114537966 | Nonsense_Mutation | C | T | p.Q109* |
| STAD | TCGA-CD-8536-01 | exon_skip_511994 | 114537865 | 114537983 | 114537966 | 114537966 | Nonsense_Mutation | C | T | p.Q109X |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| MDST8_LARGE_INTESTINE | 114537865 | 114537983 | 114537891 | 114537891 | Missense_Mutation | G | A | p.E84K |
| SNU719_STOMACH | 114537865 | 114537983 | 114537901 | 114537901 | Missense_Mutation | A | C | p.N87T |
| JHUEM7_ENDOMETRIUM | 114537865 | 114537983 | 114537915 | 114537915 | Missense_Mutation | C | A | p.P92T |
| HCC2998_LARGE_INTESTINE | 114537865 | 114537983 | 114537973 | 114537973 | Nonsense_Mutation | T | G | p.L111* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for LUZP4 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for LUZP4 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for LUZP4 |
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RelatedDrugs for LUZP4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LUZP4 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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