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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for GAL |
 Gene summary |
| Gene information | Gene symbol | GAL | Gene ID | 51083 |
| Gene name | galanin and GMAP prepropeptide | |
| Synonyms | ETL8|GAL-GMAP|GALN|GLNN|GMAP | |
| Cytomap | 11q13.2 | |
| Type of gene | protein-coding | |
| Description | galanin peptidesgalanin prepropeptidegalanin-message-associated peptidegalanin-related peptidegalanin/GMAP prepropeptide | |
| Modification date | 20180523 | |
| UniProtAcc | P22466 | |
| Context | PubMed: GAL [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| GAL | GO:0010737 | protein kinase A signaling | 17982695 |
| GAL | GO:0019933 | cAMP-mediated signaling | 17982695 |
| GAL | GO:0045944 | positive regulation of transcription by RNA polymerase II | 24517231 |
| GAL | GO:0051464 | positive regulation of cortisol secretion | 17982695 |
| GAL | GO:0051795 | positive regulation of timing of catagen | 22329353 |
| GAL | GO:1902608 | positive regulation of large conductance calcium-activated potassium channel activity | 24602615 |
| GAL | GO:1902891 | negative regulation of root hair elongation | 22329353 |
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Exon skipping events across known transcript of Ensembl for GAL from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for GAL |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for GAL |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_62524 | 11 | 68451942:68452200:68452391:68452472:68453061:68453116 | 68452391:68452472 | ENSG00000069482.6 | ENST00000265643.3 |
| exon_skip_62531 | 11 | 68455481:68455568:68456316:68456394:68458384:68458643 | 68456316:68456394 | ENSG00000069482.6 | ENST00000265643.3 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for GAL |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_62524 | 11 | 68451942:68452200:68452391:68452472:68453061:68453116 | 68452391:68452472 | ENSG00000069482.6 | ENST00000265643.3 |
| exon_skip_62531 | 11 | 68455481:68455568:68456316:68456394:68458384:68458643 | 68456316:68456394 | ENSG00000069482.6 | ENST00000265643.3 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for GAL |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000265643 | 68452391 | 68452472 | In-frame |
| ENST00000265643 | 68456316 | 68456394 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000265643 | 68452391 | 68452472 | In-frame |
| ENST00000265643 | 68456316 | 68456394 | In-frame |
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Infer the effects of exon skipping event on protein functional features for GAL |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000265643 | 835 | 123 | 68452391 | 68452472 | 259 | 339 | 0 | 27 |
| ENST00000265643 | 835 | 123 | 68456316 | 68456394 | 482 | 559 | 74 | 100 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000265643 | 835 | 123 | 68452391 | 68452472 | 259 | 339 | 0 | 27 |
| ENST00000265643 | 835 | 123 | 68456316 | 68456394 | 482 | 559 | 74 | 100 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P22466 | 0 | 27 | 16 | 16 | Natural variant | ID=VAR_049121;Note=A->V;Dbxref=dbSNP:rs34725707 |
| P22466 | 0 | 27 | 20 | 30 | Propeptide | ID=PRO_0000010448 |
| P22466 | 0 | 27 | 1 | 19 | Signal peptide | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P22466 | 74 | 100 | 65 | 123 | Peptide | ID=PRO_0000010450;Note=Galanin message-associated peptide |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P22466 | 0 | 27 | 16 | 16 | Natural variant | ID=VAR_049121;Note=A->V;Dbxref=dbSNP:rs34725707 |
| P22466 | 0 | 27 | 20 | 30 | Propeptide | ID=PRO_0000010448 |
| P22466 | 0 | 27 | 1 | 19 | Signal peptide | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P22466 | 74 | 100 | 65 | 123 | Peptide | ID=PRO_0000010450;Note=Galanin message-associated peptide |
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SNVs in the skipped exons for GAL |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| MN60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 68452392 | 68452472 | 68452407 | 68452407 | Missense_Mutation | G | A | p.A6T |
| HCC1438_LUNG | 68452392 | 68452472 | 68452456 | 68452456 | Missense_Mutation | C | A | p.A22E |
| CHLA57_BONE | 68452392 | 68452472 | 68452472 | 68452472 | Splice_Site | G | A | p.P27P |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for GAL |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for GAL |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for GAL |
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RelatedDrugs for GAL |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GAL |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| GAL | C0011570 | Mental Depression | 5 | PSYGENET |
| GAL | C0011581 | Depressive disorder | 5 | PSYGENET |
| GAL | C0525045 | Mood Disorders | 5 | PSYGENET |
| GAL | C0085762 | Alcohol abuse | 4 | PSYGENET |
| GAL | C0001973 | Alcoholic Intoxication, Chronic | 2 | PSYGENET |
| GAL | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| GAL | C0020429 | Hyperalgesia | 1 | CTD_human |
| GAL | C0020538 | Hypertensive disease | 1 | CTD_human |
| GAL | C0021368 | Inflammation | 1 | CTD_human |
| GAL | C0024809 | Marijuana Abuse | 1 | PSYGENET |
| GAL | C0027796 | Neuralgia | 1 | CTD_human |
| GAL | C0039231 | Tachycardia | 1 | CTD_human |
| GAL | C0338715 | Drug-induced depressive state | 1 | PSYGENET |
| GAL | C4225318 | EPILEPSY, FAMILIAL TEMPORAL LOBE, 8 | 1 | UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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