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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for SPOCK3 |
 Gene summary |
| Gene information | Gene symbol | SPOCK3 | Gene ID | 50859 |
| Gene name | SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3 | |
| Synonyms | HSAJ1454|TES-3|TICN3 | |
| Cytomap | 4q32.3 | |
| Type of gene | protein-coding | |
| Description | testican-3SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 | |
| Modification date | 20180523 | |
| UniProtAcc | Q9BQ16 | |
| Context | PubMed: SPOCK3 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for SPOCK3 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for SPOCK3 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for SPOCK3 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_432877 | 4 | 167658617:167658755:167663147:167663210:167675658:167675880 | 167663147:167663210 | ENSG00000196104.6 | ENST00000535728.1,ENST00000507370.1,ENST00000541354.1,ENST00000421836.2,ENST00000511269.1,ENST00000504953.1,ENST00000511905.1,ENST00000534949.1,ENST00000505187.1,ENST00000502821.1,ENST00000511531.1,ENST00000512681.1,ENST00000510741.1,ENST00000357154.3,ENS |
| exon_skip_432878 | 4 | 167663147:167663210:167675658:167675880:167713320:167713440 | 167675658:167675880 | ENSG00000196104.6 | ENST00000507370.1,ENST00000541354.1,ENST00000421836.2,ENST00000511269.1,ENST00000504953.1,ENST00000511905.1,ENST00000534949.1,ENST00000505187.1,ENST00000502821.1,ENST00000511531.1,ENST00000512681.1,ENST00000357154.3,ENST00000502330.1,ENST00000357545.4,ENS |
| exon_skip_432879 | 4 | 167675792:167675880:167713320:167713440:167810280:167810395 | 167713320:167713440 | ENSG00000196104.6 | ENST00000507370.1,ENST00000541354.1,ENST00000421836.2,ENST00000511269.1,ENST00000504953.1,ENST00000511905.1,ENST00000515143.1,ENST00000534949.1,ENST00000505187.1,ENST00000502821.1,ENST00000511531.1,ENST00000512648.1,ENST00000512681.1,ENST00000357154.3,ENS |
| exon_skip_432880 | 4 | 167810386:167810395:167833770:167833894:167921499:167921614 | 167833770:167833894 | ENSG00000196104.6 | ENST00000535728.1,ENST00000421836.2,ENST00000511269.1,ENST00000504953.1,ENST00000509854.1,ENST00000505187.1,ENST00000502821.1,ENST00000511531.1,ENST00000512648.1,ENST00000510741.1,ENST00000357154.3,ENST00000502330.1,ENST00000357545.4,ENST00000506886.1,ENS |
| exon_skip_432881 | 4 | 167810386:167810395:167833770:167833894:168155135:168155206 | 167833770:167833894 | ENSG00000196104.6 | ENST00000507370.1,ENST00000534949.1 |
| exon_skip_432886 | 4 | 167833844:167833894:167921499:167921614:167983642:167983688 | 167921499:167921614 | ENSG00000196104.6 | ENST00000535728.1,ENST00000421836.2,ENST00000511269.1,ENST00000504953.1,ENST00000509854.1,ENST00000502821.1,ENST00000511531.1,ENST00000512648.1,ENST00000510741.1,ENST00000357154.3,ENST00000502330.1,ENST00000357545.4,ENST00000506886.1,ENST00000507137.1 |
| exon_skip_432887 | 4 | 167833844:167833894:167921499:167921614:168155135:168155206 | 167921499:167921614 | ENSG00000196104.6 | ENST00000505187.1 |
| exon_skip_432888 | 4 | 167833844:167833894:167983642:167983688:168155135:168155206 | 167983642:167983688 | ENSG00000196104.6 | ENST00000541354.1,ENST00000511905.1,ENST00000511226.1 |
| exon_skip_432891 | 4 | 167921512:167921614:167932372:167932453:167983642:167983688 | 167932372:167932453 | ENSG00000196104.6 | ENST00000515316.1 |
| exon_skip_432892 | 4 | 167921512:167921614:167983642:167983688:168155135:168155206 | 167983642:167983688 | ENSG00000196104.6 | ENST00000535728.1,ENST00000511269.1,ENST00000504953.1,ENST00000515143.1,ENST00000509854.1,ENST00000512648.1,ENST00000510741.1,ENST00000357545.4 |
| exon_skip_432893 | 4 | 167983642:167983688:167983792:167983801:168155135:168155324 | 167983792:167983801 | ENSG00000196104.6 | ENST00000512042.1,ENST00000502741.1,ENST00000511531.1,ENST00000502330.1 |
| exon_skip_432894 | 4 | 167983642:167983688:168004388:168004397:168155135:168155324 | 168004388:168004397 | ENSG00000196104.6 | ENST00000507086.1,ENST00000357154.3,ENST00000506697.1,ENST00000506886.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for SPOCK3 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_432877 | 4 | 167658617:167658755:167663147:167663210:167675658:167675880 | 167663147:167663210 | ENSG00000196104.6 | ENST00000357154.3,ENST00000357545.4,ENST00000504953.1,ENST00000511531.1,ENST00000506886.1,ENST00000507137.1,ENST00000510741.1,ENST00000502330.1,ENST00000511905.1,ENST00000541354.1,ENST00000512681.1,ENST00000511269.1,ENST00000507370.1,ENST00000535728.1,ENS |
| exon_skip_432878 | 4 | 167663147:167663210:167675658:167675880:167713320:167713440 | 167675658:167675880 | ENSG00000196104.6 | ENST00000357154.3,ENST00000357545.4,ENST00000504953.1,ENST00000511531.1,ENST00000506886.1,ENST00000507137.1,ENST00000502330.1,ENST00000511905.1,ENST00000541354.1,ENST00000512681.1,ENST00000511269.1,ENST00000507370.1,ENST00000502821.1,ENST00000421836.2,ENS |
| exon_skip_432879 | 4 | 167675792:167675880:167713320:167713440:167810280:167810395 | 167713320:167713440 | ENSG00000196104.6 | ENST00000357154.3,ENST00000357545.4,ENST00000504953.1,ENST00000511531.1,ENST00000506886.1,ENST00000507137.1,ENST00000502330.1,ENST00000511905.1,ENST00000541354.1,ENST00000512681.1,ENST00000511269.1,ENST00000507370.1,ENST00000502821.1,ENST00000421836.2,ENS |
| exon_skip_432880 | 4 | 167810386:167810395:167833770:167833894:167921499:167921614 | 167833770:167833894 | ENSG00000196104.6 | ENST00000357154.3,ENST00000357545.4,ENST00000504953.1,ENST00000511531.1,ENST00000506886.1,ENST00000507137.1,ENST00000510741.1,ENST00000502330.1,ENST00000511269.1,ENST00000535728.1,ENST00000502821.1,ENST00000421836.2,ENST00000505187.1,ENST00000512648.1,ENS |
| exon_skip_432881 | 4 | 167810386:167810395:167833770:167833894:168155135:168155206 | 167833770:167833894 | ENSG00000196104.6 | ENST00000507370.1,ENST00000534949.1 |
| exon_skip_432886 | 4 | 167833844:167833894:167921499:167921614:167983642:167983688 | 167921499:167921614 | ENSG00000196104.6 | ENST00000357154.3,ENST00000357545.4,ENST00000504953.1,ENST00000511531.1,ENST00000506886.1,ENST00000507137.1,ENST00000510741.1,ENST00000502330.1,ENST00000511269.1,ENST00000535728.1,ENST00000502821.1,ENST00000421836.2,ENST00000512648.1,ENST00000509854.1 |
| exon_skip_432887 | 4 | 167833844:167833894:167921499:167921614:168155135:168155206 | 167921499:167921614 | ENSG00000196104.6 | ENST00000505187.1 |
| exon_skip_432888 | 4 | 167833844:167833894:167983642:167983688:168155135:168155206 | 167983642:167983688 | ENSG00000196104.6 | ENST00000511905.1,ENST00000541354.1,ENST00000511226.1 |
| exon_skip_432891 | 4 | 167921512:167921614:167932372:167932453:167983642:167983688 | 167932372:167932453 | ENSG00000196104.6 | ENST00000515316.1 |
| exon_skip_432892 | 4 | 167921512:167921614:167983642:167983688:168155135:168155206 | 167983642:167983688 | ENSG00000196104.6 | ENST00000357545.4,ENST00000504953.1,ENST00000510741.1,ENST00000511269.1,ENST00000535728.1,ENST00000512648.1,ENST00000515143.1,ENST00000509854.1 |
| exon_skip_432893 | 4 | 167983642:167983688:167983792:167983801:168155135:168155324 | 167983792:167983801 | ENSG00000196104.6 | ENST00000511531.1,ENST00000502330.1,ENST00000502741.1,ENST00000512042.1 |
| exon_skip_432894 | 4 | 167983642:167983688:168004388:168004397:168155135:168155324 | 168004388:168004397 | ENSG00000196104.6 | ENST00000357154.3,ENST00000506886.1,ENST00000507086.1,ENST00000506697.1 |
| exon_skip_432895 | 4 | 167983642:167983688:168040944:168041025:168155135:168155324 | 168040944:168041025 | ENSG00000196104.6 | ENST00000502821.1,ENST00000421836.2 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for SPOCK3 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000357545 | 167833770 | 167833894 | Frame-shift |
| ENST00000504953 | 167833770 | 167833894 | Frame-shift |
| ENST00000511269 | 167833770 | 167833894 | Frame-shift |
| ENST00000357545 | 167921499 | 167921614 | Frame-shift |
| ENST00000504953 | 167921499 | 167921614 | Frame-shift |
| ENST00000511269 | 167921499 | 167921614 | Frame-shift |
| ENST00000357545 | 167983642 | 167983688 | Frame-shift |
| ENST00000504953 | 167983642 | 167983688 | Frame-shift |
| ENST00000511269 | 167983642 | 167983688 | Frame-shift |
| ENST00000357545 | 167663147 | 167663210 | In-frame |
| ENST00000504953 | 167663147 | 167663210 | In-frame |
| ENST00000511269 | 167663147 | 167663210 | In-frame |
| ENST00000357545 | 167675658 | 167675880 | In-frame |
| ENST00000504953 | 167675658 | 167675880 | In-frame |
| ENST00000511269 | 167675658 | 167675880 | In-frame |
| ENST00000357545 | 167713320 | 167713440 | In-frame |
| ENST00000504953 | 167713320 | 167713440 | In-frame |
| ENST00000511269 | 167713320 | 167713440 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000357545 | 167833770 | 167833894 | Frame-shift |
| ENST00000504953 | 167833770 | 167833894 | Frame-shift |
| ENST00000511269 | 167833770 | 167833894 | Frame-shift |
| ENST00000357545 | 167921499 | 167921614 | Frame-shift |
| ENST00000504953 | 167921499 | 167921614 | Frame-shift |
| ENST00000511269 | 167921499 | 167921614 | Frame-shift |
| ENST00000357545 | 167983642 | 167983688 | Frame-shift |
| ENST00000504953 | 167983642 | 167983688 | Frame-shift |
| ENST00000511269 | 167983642 | 167983688 | Frame-shift |
| ENST00000357545 | 167663147 | 167663210 | In-frame |
| ENST00000504953 | 167663147 | 167663210 | In-frame |
| ENST00000511269 | 167663147 | 167663210 | In-frame |
| ENST00000357545 | 167675658 | 167675880 | In-frame |
| ENST00000504953 | 167675658 | 167675880 | In-frame |
| ENST00000511269 | 167675658 | 167675880 | In-frame |
| ENST00000357545 | 167713320 | 167713440 | In-frame |
| ENST00000504953 | 167713320 | 167713440 | In-frame |
| ENST00000511269 | 167713320 | 167713440 | In-frame |
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Infer the effects of exon skipping event on protein functional features for SPOCK3 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000357545 | 2953 | 436 | 167713320 | 167713440 | 690 | 809 | 196 | 236 |
| ENST00000504953 | 2917 | 436 | 167713320 | 167713440 | 654 | 773 | 196 | 236 |
| ENST00000511269 | 1785 | 436 | 167713320 | 167713440 | 683 | 802 | 196 | 236 |
| ENST00000357545 | 2953 | 436 | 167675658 | 167675880 | 810 | 1031 | 236 | 310 |
| ENST00000504953 | 2917 | 436 | 167675658 | 167675880 | 774 | 995 | 236 | 310 |
| ENST00000511269 | 1785 | 436 | 167675658 | 167675880 | 803 | 1024 | 236 | 310 |
| ENST00000357545 | 2953 | 436 | 167663147 | 167663210 | 1032 | 1094 | 310 | 331 |
| ENST00000504953 | 2917 | 436 | 167663147 | 167663210 | 996 | 1058 | 310 | 331 |
| ENST00000511269 | 1785 | 436 | 167663147 | 167663210 | 1025 | 1087 | 310 | 331 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000357545 | 2953 | 436 | 167713320 | 167713440 | 690 | 809 | 196 | 236 |
| ENST00000504953 | 2917 | 436 | 167713320 | 167713440 | 654 | 773 | 196 | 236 |
| ENST00000511269 | 1785 | 436 | 167713320 | 167713440 | 683 | 802 | 196 | 236 |
| ENST00000357545 | 2953 | 436 | 167675658 | 167675880 | 810 | 1031 | 236 | 310 |
| ENST00000504953 | 2917 | 436 | 167675658 | 167675880 | 774 | 995 | 236 | 310 |
| ENST00000511269 | 1785 | 436 | 167675658 | 167675880 | 803 | 1024 | 236 | 310 |
| ENST00000357545 | 2953 | 436 | 167663147 | 167663210 | 1032 | 1094 | 310 | 331 |
| ENST00000504953 | 2917 | 436 | 167663147 | 167663210 | 996 | 1058 | 310 | 331 |
| ENST00000511269 | 1785 | 436 | 167663147 | 167663210 | 1025 | 1087 | 310 | 331 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for SPOCK3 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_432878 | 167675659 | 167675880 | 167675753 | 167675753 | Frame_Shift_Del | T | - | p.E282fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_432879 | 167713321 | 167713440 | 167713372 | 167713372 | Frame_Shift_Del | T | - | p.S223fs |
| LUAD | TCGA-73-4666-01 | exon_skip_432877 | 167663148 | 167663210 | 167663162 | 167663163 | Frame_Shift_Ins | - | C | p.K330fs |
| SKCM | TCGA-BF-AAP0-06 | exon_skip_432878 | 167675659 | 167675880 | 167675685 | 167675685 | Nonsense_Mutation | C | T | p.W305* |
| READ | TCGA-EI-6917-01 | exon_skip_432878 | 167675659 | 167675880 | 167675755 | 167675755 | Nonsense_Mutation | C | A | p.E239X |
| SKCM | TCGA-D3-A8GB-06 | exon_skip_432878 | 167675659 | 167675880 | 167675834 | 167675834 | Nonsense_Mutation | C | T | p.W255* |
| SKCM | TCGA-D3-A8GL-06 | exon_skip_432878 | 167675659 | 167675880 | 167675835 | 167675835 | Nonsense_Mutation | C | T | p.W255* |
| HNSC | TCGA-CV-6940-01 | exon_skip_432878 | 167675659 | 167675880 | 167675844 | 167675844 | Nonsense_Mutation | G | C | p.S252* |
| BLCA | TCGA-BT-A2LB-01 | 167921500 | 167921614 | 167921549 | 167921549 | Nonsense_Mutation | G | A | p.Q104* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| NCIH1648_LUNG | 167713321 | 167713440 | 167713368 | 167713368 | Frame_Shift_Del | C | - | p.G224fs |
| NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 167663148 | 167663210 | 167663172 | 167663172 | Missense_Mutation | G | A | p.R327W |
| NCIH513_PLEURA | 167675659 | 167675880 | 167675689 | 167675689 | Missense_Mutation | C | T | p.E304K |
| EGI1_BILIARY_TRACT | 167675659 | 167675880 | 167675694 | 167675694 | Missense_Mutation | T | G | p.N302T |
| NCIH650_LUNG | 167675659 | 167675880 | 167675745 | 167675745 | Missense_Mutation | G | T | p.T285N |
| NCIH841_LUNG | 167675659 | 167675880 | 167675808 | 167675808 | Missense_Mutation | T | C | p.Y264C |
| TCYIK_CERVIX | 167675659 | 167675880 | 167675871 | 167675871 | Missense_Mutation | G | T | p.T243N |
| MM370_SKIN | 167675659 | 167675880 | 167675875 | 167675875 | Missense_Mutation | C | T | p.D242N |
| COLO783_SKIN | 167675659 | 167675880 | 167675875 | 167675875 | Missense_Mutation | C | T | p.D242N |
| SKMES1_LUNG | 167713321 | 167713440 | 167713356 | 167713356 | Missense_Mutation | T | A | p.K228M |
| A172_CENTRAL_NERVOUS_SYSTEM | 167713321 | 167713440 | 167713358 | 167713358 | Missense_Mutation | G | C | p.N227K |
| EN_ENDOMETRIUM | 167713321 | 167713440 | 167713431 | 167713431 | Missense_Mutation | T | A | p.D203V |
| NCIH2066_LUNG | 167833771 | 167833894 | 167833773 | 167833773 | Missense_Mutation | G | T | p.Q161K |
| NCIH661_LUNG | 167833771 | 167833894 | 167833808 | 167833808 | Missense_Mutation | G | T | p.P149H |
| IGR1_SKIN | 167833771 | 167833894 | 167833891 | 167833891 | Missense_Mutation | C | T | p.M121I |
| SW900_LUNG | 167921500 | 167921614 | 167921512 | 167921512 | Missense_Mutation | C | A | p.R116M |
| IGROV1_OVARY | 167921500 | 167921614 | 167921534 | 167921534 | Missense_Mutation | C | T | p.A109T |
| NCIH1975_LUNG | 167921500 | 167921614 | 167921552 | 167921552 | Missense_Mutation | C | T | p.A103T |
| SNU81_LARGE_INTESTINE | 167921500 | 167921614 | 167921561 | 167921561 | Missense_Mutation | C | T | p.V100I |
| NCIH2066_LUNG | 167921500 | 167921614 | 167921573 | 167921573 | Missense_Mutation | T | C | p.S96G |
| RH18_SOFT_TISSUE | 167921500 | 167921614 | 167921580 | 167921580 | Missense_Mutation | C | T | p.M93I |
| MZ7MEL_SKIN | 167921500 | 167921614 | 167921597 | 167921597 | Missense_Mutation | C | T | p.D88N |
| SNGM_ENDOMETRIUM | 167983643 | 167983688 | 167983676 | 167983676 | Missense_Mutation | G | A | p.R71C |
| RT4_URINARY_TRACT | 167983643 | 167983688 | 167983668 | 167983668 | Nonsense_Mutation | C | T | p.W73* |
| NCIH1930_LUNG | 167983643 | 167983688 | 167983644 | 167983644 | Splice_Site | C | A | p.Q81H |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SPOCK3 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SPOCK3 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SPOCK3 |
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RelatedDrugs for SPOCK3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SPOCK3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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