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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for TRAT1 |
 Gene summary |
| Gene information | Gene symbol | TRAT1 | Gene ID | 50852 |
| Gene name | T cell receptor associated transmembrane adaptor 1 | |
| Synonyms | HSPC062|TCRIM|TRIM|pp29/30 | |
| Cytomap | 3q13.13 | |
| Type of gene | protein-coding | |
| Description | T-cell receptor-associated transmembrane adapter 1T cell receptor interacting molecule | |
| Modification date | 20180519 | |
| UniProtAcc | Q6PIZ9 | |
| Context | PubMed: TRAT1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TRAT1 | GO:0001920 | negative regulation of receptor recycling | 11390434 |
| TRAT1 | GO:0050850 | positive regulation of calcium-mediated signaling | 11390434 |
| TRAT1 | GO:0050862 | positive regulation of T cell receptor signaling pathway | 11390434 |
| TRAT1 | GO:0051051 | negative regulation of transport | 11390434 |
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Exon skipping events across known transcript of Ensembl for TRAT1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for TRAT1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for TRAT1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_376512 | 3 | 108541618:108541781:108549516:108549627:108557780:108557814 | 108549516:108549627 | ENSG00000163519.9 | ENST00000493604.1,ENST00000478830.1 |
| exon_skip_376513 | 3 | 108549516:108549627:108557780:108557814:108565914:108566185 | 108557780:108557814 | ENSG00000163519.9 | ENST00000493604.1,ENST00000295756.6 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for TRAT1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_376512 | 3 | 108541618:108541781:108549516:108549627:108557780:108557814 | 108549516:108549627 | ENSG00000163519.9 | ENST00000493604.1,ENST00000478830.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for TRAT1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000295756 | 108557780 | 108557814 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for TRAT1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for TRAT1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_376512 | 108549517 | 108549627 | 108549534 | 108549534 | Frame_Shift_Del | T | - | p.F10fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_376512 | 108549517 | 108549627 | 108549534 | 108549534 | Frame_Shift_Del | T | - | p.F10fs |
| BRCA | TCGA-BH-A0BC-01 | exon_skip_376512 | 108549517 | 108549627 | 108549621 | 108549621 | Nonsense_Mutation | C | T | p.R38* |
| CHOL | TCGA-ZH-A8Y4-01 | exon_skip_376512 | 108549517 | 108549627 | 108549621 | 108549621 | Nonsense_Mutation | C | T | p.R38* |
| CHOL | TCGA-ZH-A8Y4-01 | exon_skip_376512 | 108549517 | 108549627 | 108549621 | 108549621 | Nonsense_Mutation | C | T | p.R38X |
| GBM | TCGA-28-2514-01 | exon_skip_376512 | 108549517 | 108549627 | 108549621 | 108549621 | Nonsense_Mutation | C | T | p.R38* |
| LGG | TCGA-QH-A6XC-01 | exon_skip_376512 | 108549517 | 108549627 | 108549621 | 108549621 | Nonsense_Mutation | C | T | p.R38* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| M1203273_SKIN | 108549517 | 108549627 | 108549612 | 108549612 | Missense_Mutation | G | A | p.E35K |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TRAT1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TRAT1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TRAT1 |
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RelatedDrugs for TRAT1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRAT1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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