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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for PRDX1 |
 Gene summary |
| Gene information | Gene symbol | PRDX1 | Gene ID | 5052 |
| Gene name | peroxiredoxin 1 | |
| Synonyms | MSP23|NKEF-A|NKEFA|PAG|PAGA|PAGB|PRX1|PRXI|TDPX2 | |
| Cytomap | 1p34.1 | |
| Type of gene | protein-coding | |
| Description | peroxiredoxin-1natural killer cell-enhancing factor Anatural killer-enhancing factor Aproliferation-associated gene Aproliferation-associated gene proteinthioredoxin peroxidase 2thioredoxin-dependent peroxide reductase 2 | |
| Modification date | 20180523 | |
| UniProtAcc | Q06830 | |
| Context | PubMed: PRDX1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| PRDX1 | GO:0030101 | natural killer cell activation | 8462106 |
| PRDX1 | GO:0042744 | hydrogen peroxide catabolic process | 11986303|18606987 |
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Exon skipping events across known transcript of Ensembl for PRDX1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for PRDX1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for PRDX1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_26195 | 1 | 45977004:45977086:45980178:45980309:45980544:45980567 | 45980178:45980309 | ENSG00000117450.9 | ENST00000262746.1,ENST00000372079.1,ENST00000319248.8 |
| exon_skip_26200 | 1 | 45980544:45980667:45981325:45981479:45984609:45984719 | 45981325:45981479 | ENSG00000117450.9 | ENST00000262746.1,ENST00000319248.8,ENST00000424390.1,ENST00000447184.1 |
| exon_skip_26206 | 1 | 45981325:45981479:45984609:45984726:45987500:45987526 | 45984609:45984726 | ENSG00000117450.9 | ENST00000319248.8 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for PRDX1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_26195 | 1 | 45977004:45977086:45980178:45980309:45980544:45980567 | 45980178:45980309 | ENSG00000117450.9 | ENST00000262746.1,ENST00000319248.8,ENST00000372079.1 |
| exon_skip_26200 | 1 | 45980544:45980667:45981325:45981479:45984609:45984719 | 45981325:45981479 | ENSG00000117450.9 | ENST00000262746.1,ENST00000319248.8,ENST00000447184.1,ENST00000424390.1 |
| exon_skip_26206 | 1 | 45981325:45981479:45984609:45984726:45987500:45987526 | 45984609:45984726 | ENSG00000117450.9 | ENST00000319248.8 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for PRDX1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000319248 | 45984609 | 45984726 | 3UTR-3CDS |
| ENST00000262746 | 45980178 | 45980309 | Frame-shift |
| ENST00000319248 | 45980178 | 45980309 | Frame-shift |
| ENST00000262746 | 45981325 | 45981479 | Frame-shift |
| ENST00000319248 | 45981325 | 45981479 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000319248 | 45984609 | 45984726 | 3UTR-3CDS |
| ENST00000262746 | 45980178 | 45980309 | Frame-shift |
| ENST00000319248 | 45980178 | 45980309 | Frame-shift |
| ENST00000262746 | 45981325 | 45981479 | Frame-shift |
| ENST00000319248 | 45981325 | 45981479 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for PRDX1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for PRDX1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
PRDX1_CHOL_exon_skip_26206_psi_boxplot.png |
PRDX1_LIHC_exon_skip_26206_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_26195 | 45980179 | 45980309 | 45980300 | 45980300 | Frame_Shift_Del | A | - | p.F131fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_26206 | 45984610 | 45984726 | 45984677 | 45984677 | Frame_Shift_Del | G | - | p.P13fs |
| CHOL | TCGA-W5-AA39-01 | exon_skip_26206 | 45984610 | 45984726 | 45984678 | 45984687 | Frame_Shift_Del | GGGGCAGGGT | - | p.10_13del |
| CHOL | TCGA-W5-AA39-01 | exon_skip_26206 | 45984610 | 45984726 | 45984678 | 45984687 | Frame_Shift_Del | GGGGCAGGGT | - | p.HPAP10fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_26206 | 45984610 | 45984726 | 45984702 | 45984702 | Frame_Shift_Del | T | - | p.N5fs |
| SKCM | TCGA-EB-A431-01 | exon_skip_26195 | 45980179 | 45980309 | 45980212 | 45980212 | Nonsense_Mutation | G | A | p.Q161* |
| SKCM | TCGA-EB-A431-01 | exon_skip_26195 | 45980179 | 45980309 | 45980212 | 45980212 | Nonsense_Mutation | G | A | p.Q161X |
| READ | TCGA-AG-A002-01 | exon_skip_26200 | 45981326 | 45981479 | 45981393 | 45981393 | Nonsense_Mutation | C | A | p.E65X |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-W5-AA39-01 |
| Cancer type: CHOL | |
| ESID: exon_skip_26206 | |
| Skipped exon start: 45984610 | |
| Skipped exon end: 45984726 | |
| Mutation start: 45984678 | |
| Mutation end: 45984687 | |
| Mutation type: Frame_Shift_Del | |
| Reference seq: GGGGCAGGGT | |
| Mutation seq: - | |
| AAchange: p.HPAP10fs | |
| Sample: TCGA-W5-AA39-01 |
| Cancer type: CHOL | |
| ESID: exon_skip_26206 | |
| Skipped exon start: 45984610 | |
| Skipped exon end: 45984726 | |
| Mutation start: 45984678 | |
| Mutation end: 45984687 | |
| Mutation type: Frame_Shift_Del | |
| Reference seq: GGGGCAGGGT | |
| Mutation seq: - | |
| AAchange: p.10_13del | |
exon_skip_148507_CHOL_TCGA-W5-AA39-01.png | |
exon_skip_26206_CHOL_TCGA-W5-AA39-01.png | |
exon_skip_300665_CHOL_TCGA-W5-AA39-01.png | |
exon_skip_94118_CHOL_TCGA-W5-AA39-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| WSUNHL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 45980179 | 45980309 | 45980190 | 45980190 | Missense_Mutation | T | C | p.K168R |
| HEC6_ENDOMETRIUM | 45980179 | 45980309 | 45980208 | 45980208 | Missense_Mutation | G | A | p.A162V |
| LIM1215_LARGE_INTESTINE | 45980179 | 45980309 | 45980217 | 45980217 | Missense_Mutation | A | G | p.L159P |
| NCIH2106_LUNG | 45980179 | 45980309 | 45980265 | 45980265 | Missense_Mutation | G | A | p.T143I |
| DND41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 45981326 | 45981479 | 45981446 | 45981446 | Missense_Mutation | T | C | p.D47G |
| T84_LARGE_INTESTINE | 45984610 | 45984726 | 45984616 | 45984616 | Missense_Mutation | A | T | p.Y34N |
| CW2_LARGE_INTESTINE | 45984610 | 45984726 | 45984630 | 45984630 | Missense_Mutation | A | T | p.I29N |
| HMC18_BREAST | 45984610 | 45984726 | 45984657 | 45984657 | Missense_Mutation | A | C | p.V20G |
| SKUT1_SOFT_TISSUE | 45984610 | 45984726 | 45984690 | 45984690 | Missense_Mutation | C | A | p.G9V |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PRDX1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PRDX1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PRDX1 |
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RelatedDrugs for PRDX1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Q06830 | DB01593 | Zinc | Peroxiredoxin-1 | small molecule | approved|investigational | |
| Q06830 | DB14487 | Zinc acetate | Peroxiredoxin-1 | small molecule | approved|investigational | |
| Q06830 | DB14533 | Zinc chloride | Peroxiredoxin-1 | small molecule | approved|investigational |
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RelatedDiseases for PRDX1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| PRDX1 | C0003949 | Asbestosis | 1 | CTD_human |
| PRDX1 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| PRDX1 | C0022548 | Keloid | 1 | CTD_human |
| PRDX1 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| PRDX1 | C0036323 | Schistosomiasis | 1 | CTD_human |
| PRDX1 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
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