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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for P4HB

check button Gene summary
Gene informationGene symbol

P4HB

Gene ID

5034

Gene nameprolyl 4-hydroxylase subunit beta
SynonymsCLCRP1|DSI|ERBA2L|GIT|P4Hbeta|PDI|PDIA1|PHDB|PO4DB|PO4HB|PROHB
Cytomap

17q25.3

Type of geneprotein-coding
Descriptionprotein disulfide-isomerasecellular thyroid hormone-binding proteincollagen prolyl 4-hydroxylase betaglutathione-insulin transhydrogenasep55procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptideprolyl 4-hydroxyla
Modification date20180523
UniProtAcc

P07237

ContextPubMed: P4HB [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
P4HB

GO:0018401

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

7753822


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Exon skipping events across known transcript of Ensembl for P4HB from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for P4HB

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for P4HB

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_2945761779801941:79801968:79803019:79803106:79803436:7980352379803019:79803106ENSG00000185624.10ENST00000439918.2,ENST00000575069.1,ENST00000571617.1,ENST00000571507.1,ENST00000476482.1,ENST00000331483.4,ENST00000415593.1
exon_skip_2945801779803019:79803106:79803436:79803618:79803746:7980386779803436:79803618ENSG00000185624.10ENST00000439918.2,ENST00000575069.1,ENST00000476482.1,ENST00000331483.4,ENST00000415593.1
exon_skip_2945861779803535:79803618:79803746:79803867:79804304:7980438379803746:79803867ENSG00000185624.10ENST00000439918.2,ENST00000575069.1,ENST00000476482.1,ENST00000331483.4,ENST00000415593.1
exon_skip_2945891779804418:79804505:79804822:79804888:79805118:7980520379804822:79804888ENSG00000185624.10ENST00000415593.1
exon_skip_2945901779804418:79804505:79804822:79804948:79805118:7980520379804822:79804948ENSG00000185624.10ENST00000439918.2,ENST00000575069.1,ENST00000570907.1,ENST00000477607.2,ENST00000478034.1,ENST00000576380.1,ENST00000331483.4,ENST00000472244.1
exon_skip_2945921779804907:79804948:79805118:79805223:79813017:7981315579805118:79805223ENSG00000185624.10ENST00000439918.2,ENST00000574007.1,ENST00000575069.1,ENST00000477607.2,ENST00000478034.1,ENST00000573778.2,ENST00000576380.1,ENST00000331483.4,ENST00000472244.1
exon_skip_2945961779805202:79805223:79813017:79813155:79817054:7981726379813017:79813155ENSG00000185624.10ENST00000439918.2
exon_skip_2945971779805202:79805223:79813017:79813155:79817056:7981709179813017:79813155ENSG00000185624.10ENST00000576380.1
exon_skip_2946001779805202:79805223:79817054:79817263:79818202:7981835479817054:79817263ENSG00000185624.10ENST00000576052.1
exon_skip_2946051779813104:79813155:79813328:79813381:79817056:7981709179813328:79813381ENSG00000185624.10ENST00000576541.1
exon_skip_2946071779813104:79813155:79813328:79813462:79817056:7981709179813328:79813462ENSG00000185624.10ENST00000574007.1,ENST00000575069.1,ENST00000467086.1,ENST00000574914.1,ENST00000331483.4

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for P4HB

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_2945761779801941:79801968:79803019:79803106:79803436:7980352379803019:79803106ENSG00000185624.10ENST00000331483.4,ENST00000575069.1,ENST00000415593.1,ENST00000571507.1,ENST00000476482.1,ENST00000439918.2,ENST00000571617.1
exon_skip_2945801779803019:79803106:79803436:79803618:79803746:7980386779803436:79803618ENSG00000185624.10ENST00000331483.4,ENST00000575069.1,ENST00000415593.1,ENST00000476482.1,ENST00000439918.2
exon_skip_2945861779803535:79803618:79803746:79803867:79804304:7980438379803746:79803867ENSG00000185624.10ENST00000331483.4,ENST00000575069.1,ENST00000415593.1,ENST00000476482.1,ENST00000439918.2
exon_skip_2945891779804418:79804505:79804822:79804888:79805118:7980520379804822:79804888ENSG00000185624.10ENST00000415593.1
exon_skip_2945901779804418:79804505:79804822:79804948:79805118:7980520379804822:79804948ENSG00000185624.10ENST00000331483.4,ENST00000575069.1,ENST00000439918.2,ENST00000478034.1,ENST00000576380.1,ENST00000477607.2,ENST00000472244.1,ENST00000570907.1
exon_skip_2945921779804907:79804948:79805118:79805223:79813017:7981315579805118:79805223ENSG00000185624.10ENST00000331483.4,ENST00000575069.1,ENST00000439918.2,ENST00000478034.1,ENST00000576380.1,ENST00000477607.2,ENST00000472244.1,ENST00000574007.1,ENST00000573778.2
exon_skip_2945961779805202:79805223:79813017:79813155:79817054:7981726379813017:79813155ENSG00000185624.10ENST00000439918.2
exon_skip_2945971779805202:79805223:79813017:79813155:79817056:7981709179813017:79813155ENSG00000185624.10ENST00000576380.1
exon_skip_2946001779805202:79805223:79817054:79817263:79818202:7981835479817054:79817263ENSG00000185624.10ENST00000576052.1
exon_skip_2946051779813104:79813155:79813328:79813381:79817056:7981709179813328:79813381ENSG00000185624.10ENST00000576541.1
exon_skip_2946071779813104:79813155:79813328:79813462:79817056:7981709179813328:79813462ENSG00000185624.10ENST00000331483.4,ENST00000575069.1,ENST00000574007.1,ENST00000574914.1,ENST00000467086.1

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for P4HB

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003314837980343679803618Frame-shift
ENST000003314837980374679803867Frame-shift
ENST000003314837981332879813462Frame-shift
ENST000003314837980301979803106In-frame
ENST000003314837980482279804948In-frame
ENST000003314837980511879805223In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003314837980343679803618Frame-shift
ENST000003314837980374679803867Frame-shift
ENST000003314837981332879813462Frame-shift
ENST000003314837980301979803106In-frame
ENST000003314837980482279804948In-frame
ENST000003314837980511879805223In-frame

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Infer the effects of exon skipping event on protein functional features for P4HB

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000033148326205087980511879805223848952208243
ENST00000331483262050879804822798049489531078243285
ENST000003314832620508798030197980310615831669453482

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000033148326205087980511879805223848952208243
ENST00000331483262050879804822798049489531078243285
ENST000003314832620508798030197980310615831669453482

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
P07237208243199209Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JU5
P07237208243212215Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JU5
P07237208243237239Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BJ5
P0723720824318508ChainID=PRO_0000034195;Note=Protein disulfide-isomerase
P07237208243222232HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JU5
P07237208243222222Modified residueNote=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09103
P07237208243242244TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BJ5
P07237243285250252Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BJ5
P07237243285255260Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BJ5
P07237243285265267Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BJ5
P0723724328518508ChainID=PRO_0000034195;Note=Protein disulfide-isomerase
P07237243285245249HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BJ5
P07237243285268280HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BJ5
P07237243285271271Modified residueNote=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09103
P07237243285242244TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BJ5
P07237243285281285TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BJ5
P0723745348218508ChainID=PRO_0000034195;Note=Protein disulfide-isomerase
P07237453482349475DomainNote=Thioredoxin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691
P07237453482463470HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UEM
P07237453482460460Sequence conflictNote=E->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
P07237453482481481Sequence conflictNote=D->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
P07237453482461461SiteNote=Lowers pKa of C-terminal Cys of second active site;Ontology_term=ECO:0000250;evidence=ECO:0000250
P07237453482471473TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UEM


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
P07237208243199209Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JU5
P07237208243212215Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JU5
P07237208243237239Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BJ5
P0723720824318508ChainID=PRO_0000034195;Note=Protein disulfide-isomerase
P07237208243222232HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4JU5
P07237208243222222Modified residueNote=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09103
P07237208243242244TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BJ5
P07237243285250252Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BJ5
P07237243285255260Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BJ5
P07237243285265267Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BJ5
P0723724328518508ChainID=PRO_0000034195;Note=Protein disulfide-isomerase
P07237243285245249HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BJ5
P07237243285268280HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BJ5
P07237243285271271Modified residueNote=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09103
P07237243285242244TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BJ5
P07237243285281285TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3BJ5
P0723745348218508ChainID=PRO_0000034195;Note=Protein disulfide-isomerase
P07237453482349475DomainNote=Thioredoxin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691
P07237453482463470HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UEM
P07237453482460460Sequence conflictNote=E->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305
P07237453482481481Sequence conflictNote=D->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
P07237453482461461SiteNote=Lowers pKa of C-terminal Cys of second active site;Ontology_term=ECO:0000250;evidence=ECO:0000250
P07237453482471473TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3UEM


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SNVs in the skipped exons for P4HB

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.
P4HB_COAD_exon_skip_294586_psi_boxplot.png
boxplot
P4HB_LIHC_exon_skip_294586_psi_boxplot.png
boxplot

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LIHCTCGA-DD-A1EG-01exon_skip_294580
79803437798036187980356479803564Frame_Shift_DelC-p.G411fs
LIHCTCGA-DD-A3A0-01exon_skip_294580
79803437798036187980361279803612Frame_Shift_DelG-p.P395fs
COADTCGA-AA-3492-01exon_skip_294586
79803747798038677980376479803764Frame_Shift_DelT-p.N387fs
COADTCGA-F4-6856-01exon_skip_294586
79803747798038677980376479803764Frame_Shift_DelT-p.N387fs
LIHCTCGA-DD-A3A0-01exon_skip_294586
79803747798038677980376479803764Frame_Shift_DelT-p.N387fs
LIHCTCGA-G3-A3CJ-01exon_skip_294586
79803747798038677980376479803764Frame_Shift_DelT-p.N387fs
UCECTCGA-BS-A0TJ-01exon_skip_294586
79803747798038677980376479803764Frame_Shift_DelT-p.N387fs
UCECTCGA-D1-A17U-01exon_skip_294586
79803747798038677980376479803764Frame_Shift_DelT-p.N387fs
LIHCTCGA-DD-A3A0-01exon_skip_294592
79805119798052237980522179805221Frame_Shift_DelA-p.F209fs
LIHCTCGA-DD-A39Y-01exon_skip_294600
79817055798172637981722779817227Frame_Shift_DelG-p.P61fs
COADTCGA-A6-6781-01exon_skip_294576
79803020798031067980301979803019Splice_SiteCT.
LUADTCGA-05-4432-01exon_skip_294600
79817055798172637981726479817264Splice_SiteCAp.Y49_splice

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description
P4HB_79803535_79803618_79803746_79803867_79804304_79804383_TCGA-BS-A0TJ-01Sample: TCGA-BS-A0TJ-01
Cancer type: UCEC
ESID: exon_skip_294586
Skipped exon start: 79803747
Skipped exon end: 79803867
Mutation start: 79803764
Mutation end: 79803764
Mutation type: Frame_Shift_Del
Reference seq: T
Mutation seq: -
AAchange: p.N387fs
exon_skip_156153_UCEC_TCGA-BS-A0TJ-01.png
boxplot
exon_skip_294586_UCEC_TCGA-BS-A0TJ-01.png
boxplot
P4HB_79803535_79803618_79803746_79803867_79804304_79804383_TCGA-D1-A17U-01Sample: TCGA-D1-A17U-01
Cancer type: UCEC
ESID: exon_skip_294586
Skipped exon start: 79803747
Skipped exon end: 79803867
Mutation start: 79803764
Mutation end: 79803764
Mutation type: Frame_Shift_Del
Reference seq: T
Mutation seq: -
AAchange: p.N387fs
exon_skip_135111_UCEC_TCGA-D1-A17U-01.png
boxplot
exon_skip_135112_UCEC_TCGA-D1-A17U-01.png
boxplot
exon_skip_135114_UCEC_TCGA-D1-A17U-01.png
boxplot
exon_skip_286384_UCEC_TCGA-D1-A17U-01.png
boxplot
exon_skip_294586_UCEC_TCGA-D1-A17U-01.png
boxplot
exon_skip_365789_UCEC_TCGA-D1-A17U-01.png
boxplot
exon_skip_43714_UCEC_TCGA-D1-A17U-01.png
boxplot

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
CW2_LARGE_INTESTINE79803020798031067980308879803088Frame_Shift_DelC-p.E460fs
SISO_CERVIX79803747798038677980376479803764Frame_Shift_DelT-p.N387fs
SKMEL2_SKIN79803747798038677980376479803764Frame_Shift_DelT-p.N387fs
HEC151_ENDOMETRIUM79803747798038677980376479803764Frame_Shift_DelT-p.N387fs
HEC59_ENDOMETRIUM79803747798038677980376479803764Frame_Shift_DelT-p.N387fs
HEC6_ENDOMETRIUM79803747798038677980376479803764Frame_Shift_DelT-p.N387fs
RKO_LARGE_INTESTINE79803747798038677980376479803764Frame_Shift_DelT-p.N387fs
JHUEM1_ENDOMETRIUM79803747798038677980376479803764Frame_Shift_DelT-p.N387fs
SNU407_LARGE_INTESTINE79803747798038677980376479803764Frame_Shift_DelT-p.N387fs
GRST_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE79803747798038677980376479803764Frame_Shift_DelT-p.N387fs
EN_ENDOMETRIUM79813018798131557981312379813124Frame_Shift_Ins-Ap.L173fs
UMUC16_URINARY_TRACT79803020798031067980302579803025Missense_MutationCGp.D481H
MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE79803020798031067980304179803041Missense_MutationCAp.Q475H
UMUC16_URINARY_TRACT79803020798031067980306579803065Missense_MutationCGp.K467N
DG75_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE79803020798031067980308479803084Missense_MutationCTp.R461H
HPBALL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE79803437798036187980343979803439Missense_MutationTGp.T453P
2313287_STOMACH79803437798036187980343979803439Missense_MutationTCp.T453A
IPC298_SKIN79803437798036187980349479803495Missense_MutationGGAAp.A434V
IPC298_SKIN79803437798036187980349579803495Missense_MutationGAp.A434V
SW1353_BONE79803437798036187980351679803516Missense_MutationGAp.S427L
SNU1040_LARGE_INTESTINE79803437798036187980352979803529Missense_MutationCTp.A423T
PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE79803747798038677980383079803830Missense_MutationTCp.D365G
HC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE79803747798038677980384279803842Missense_MutationGAp.P361L
MHHCALL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE79804823798049487980487679804876Missense_MutationACp.Y268D
MHHCALL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE79804823798048887980487679804876Missense_MutationACp.Y268D
HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE79805119798052237980515079805150Missense_MutationTCp.Q233R
MCC13_SKIN79805119798052237980515579805155Missense_MutationGCp.H231Q
BV173_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE79805119798052237980521779805217Missense_MutationCTp.E211K
ES2_OVARY79813018798131557981303279813032Missense_MutationCAp.V204F
MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE79813018798131557981309579813095Missense_MutationGAp.P183S
NCIH2172_LUNG79813018798131557981310179813101Missense_MutationCTp.D181N
KMRC2_KIDNEY79813329798133817981333479813334Missense_MutationAGp.F161L
KMRC2_KIDNEY79813329798134627981333479813334Missense_MutationAGp.F161L
DND41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE79813329798133817981334879813348Missense_MutationGAp.A156V
DND41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE79813329798134627981334879813348Missense_MutationGAp.A156V
BCP1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE79817055798172637981707479817074Missense_MutationGAp.S112F
A2780_OVARY79817055798172637981708979817089Missense_MutationTCp.N107S
SBC3_LUNG79817055798172637981714679817146Missense_MutationGCp.S88C
KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE79817055798172637981719479817194Missense_MutationGAp.A72V

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for P4HB

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value
exon_skip_2945761779801941:79801968:79803019:79803106:79803436:7980352379803019:79803106ENST00000439918.2,ENST00000575069.1,ENST00000571617.1,ENST00000571507.1,ENST00000476482.1,ENST00000331483.4,ENST00000415593.1BRCArs1130674chr17:79803101A/G5.49e-03
exon_skip_2945921779804907:79804948:79805118:79805223:79813017:7981315579805118:79805223ENST00000439918.2,ENST00000574007.1,ENST00000575069.1,ENST00000477607.2,ENST00000478034.1,ENST00000573778.2,ENST00000576380.1,ENST00000331483.4,ENST00000472244.1LGGrs2070871chr17:79805134A/G2.68e-03

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for P4HB


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for P4HB


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RelatedDrugs for P4HB

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
P07237DB03615RibostamycinProtein disulfide-isomerasesmall moleculeapproved|experimental
P07237DB01593ZincProtein disulfide-isomerasesmall moleculeapproved|investigational
P07237DB14487Zinc acetateProtein disulfide-isomerasesmall moleculeapproved|investigational
P07237DB14533Zinc chlorideProtein disulfide-isomerasesmall moleculeapproved|investigational

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RelatedDiseases for P4HB

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
P4HBC0029456Osteoporosis1CTD_human
P4HBC0033578Prostatic Neoplasms1CTD_human
P4HBC0151744Myocardial Ischemia1CTD_human
P4HBC1846707SPINOCEREBELLAR ATAXIA 171CTD_human
P4HBC1862178Cole Carpenter syndrome1ORPHANET;UNIPROT