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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for OPCML |
 Gene summary |
| Gene information | Gene symbol | OPCML | Gene ID | 4978 |
| Gene name | opioid binding protein/cell adhesion molecule like | |
| Synonyms | IGLON1|OBCAM|OPCM | |
| Cytomap | 11q25 | |
| Type of gene | protein-coding | |
| Description | opioid-binding protein/cell adhesion moleculeIgLON family member 1opioid binding protein/cell adhesion molecule-like preprotein | |
| Modification date | 20180522 | |
| UniProtAcc | Q14982 | |
| Context | PubMed: OPCML [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for OPCML from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for OPCML |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for OPCML |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_78682 | 11 | 132290086:132290187:132305052:132305079:132305979:132306054 | 132305052:132305079 | ENSG00000183715.9 | ENST00000541867.1 |
| exon_skip_78683 | 11 | 132307115:132307253:132398954:132399080:132526981:132527214 | 132398954:132399080 | ENSG00000183715.9 | ENST00000374778.4,ENST00000529038.1,ENST00000524381.1,ENST00000541867.1,ENST00000331898.7 |
| exon_skip_78684 | 11 | 132526981:132527214:132812820:132812905:133402158:133402297 | 132812820:132812905 | ENSG00000183715.9 | ENST00000524381.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for OPCML |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_78682 | 11 | 132290086:132290187:132305052:132305079:132305979:132306054 | 132305052:132305079 | ENSG00000183715.9 | ENST00000541867.1 |
| exon_skip_78683 | 11 | 132307115:132307253:132398954:132399080:132526981:132527214 | 132398954:132399080 | ENSG00000183715.9 | ENST00000331898.7,ENST00000524381.1,ENST00000529038.1,ENST00000374778.4,ENST00000541867.1 |
| exon_skip_78684 | 11 | 132526981:132527214:132812820:132812905:133402158:133402297 | 132812820:132812905 | ENSG00000183715.9 | ENST00000524381.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for OPCML |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000331898 | 132398954 | 132399080 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000331898 | 132398954 | 132399080 | In-frame |
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Infer the effects of exon skipping event on protein functional features for OPCML |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000331898 | 6850 | 345 | 132398954 | 132399080 | 980 | 1105 | 133 | 175 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000331898 | 6850 | 345 | 132398954 | 132399080 | 980 | 1105 | 133 | 175 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q14982 | 133 | 175 | 127 | 141 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UV6 |
| Q14982 | 133 | 175 | 145 | 148 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UV6 |
| Q14982 | 133 | 175 | 153 | 163 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UV6 |
| Q14982 | 133 | 175 | 166 | 171 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UV6 |
| Q14982 | 133 | 175 | 28 | 322 | Chain | ID=PRO_0000015118;Note=Opioid-binding protein/cell adhesion molecule |
| Q14982 | 133 | 175 | 157 | 202 | Disulfide bond | Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114 |
| Q14982 | 133 | 175 | 136 | 219 | Domain | Note=Ig-like C2-type 2 |
| Q14982 | 133 | 175 | 140 | 140 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q14982 | 133 | 175 | 127 | 141 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UV6 |
| Q14982 | 133 | 175 | 145 | 148 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UV6 |
| Q14982 | 133 | 175 | 153 | 163 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UV6 |
| Q14982 | 133 | 175 | 166 | 171 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UV6 |
| Q14982 | 133 | 175 | 28 | 322 | Chain | ID=PRO_0000015118;Note=Opioid-binding protein/cell adhesion molecule |
| Q14982 | 133 | 175 | 157 | 202 | Disulfide bond | Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114 |
| Q14982 | 133 | 175 | 136 | 219 | Domain | Note=Ig-like C2-type 2 |
| Q14982 | 133 | 175 | 140 | 140 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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SNVs in the skipped exons for OPCML |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_78684 | 132812821 | 132812905 | 132812898 | 132812898 | Frame_Shift_Del | G | - | p.P30fs |
| BLCA | TCGA-XF-AAMQ-01 | exon_skip_78683 | 132398955 | 132399080 | 132399053 | 132399053 | Nonsense_Mutation | G | C | p.S143* |
| PAAD | TCGA-IB-7651-01 | exon_skip_78684 | 132812821 | 132812905 | 132812820 | 132812820 | Splice_Site | C | T | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| OC316_OVARY | 132398955 | 132399080 | 132398984 | 132398984 | Missense_Mutation | G | A | p.T166I |
| OC314_OVARY | 132398955 | 132399080 | 132398984 | 132398984 | Missense_Mutation | G | A | p.T166I |
| NCIH1869_LUNG | 132398955 | 132399080 | 132398991 | 132398991 | Missense_Mutation | C | G | p.E164Q |
| CCK81_LARGE_INTESTINE | 132398955 | 132399080 | 132399020 | 132399020 | Missense_Mutation | G | A | p.T154I |
| NCIH2291_LUNG | 132398955 | 132399080 | 132399067 | 132399067 | Missense_Mutation | G | C | p.I138M |
| COLO792_SKIN | 132398955 | 132399080 | 132399075 | 132399075 | Missense_Mutation | G | A | p.P136S |
| C125PM_LARGE_INTESTINE | 132812821 | 132812905 | 132812851 | 132812851 | Missense_Mutation | G | A | p.T46M |
| SCH_STOMACH | 132812821 | 132812905 | 132812859 | 132812859 | Missense_Mutation | G | T | p.D43E |
| HEC251_ENDOMETRIUM | 132812821 | 132812905 | 132812893 | 132812893 | Missense_Mutation | C | T | p.R32H |
| BT474_BREAST | 132398955 | 132399080 | 132399053 | 132399053 | Nonsense_Mutation | G | C | p.S143* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for OPCML |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for OPCML |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for OPCML |
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RelatedDrugs for OPCML |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for OPCML |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| OPCML | C0036341 | Schizophrenia | 1 | PSYGENET |
| OPCML | C1140680 | Malignant neoplasm of ovary | 1 | UNIPROT |
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