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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for NONO |
 Gene summary |
| Gene information | Gene symbol | NONO | Gene ID | 4841 |
| Gene name | non-POU domain containing octamer binding | |
| Synonyms | MRXS34|NMT55|NRB54|P54|P54NRB|PPP1R114 | |
| Cytomap | Xq13.1 | |
| Type of gene | protein-coding | |
| Description | non-POU domain-containing octamer-binding protein54 kDa nuclear RNA- and DNA-binding protein55 kDa nuclear proteinDNA-binding p52/p100 complex, 52 kDa subunitnon-POU domain-containing octamer (ATGCAAAT) binding proteinp54(nrb)protein phosphatase 1, | |
| Modification date | 20180523 | |
| UniProtAcc | Q15233 | |
| Context | PubMed: NONO [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| NONO | GO:0002218 | activation of innate immune response | 28712728 |
| NONO | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway | 15790595 |
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Exon skipping events across known transcript of Ensembl for NONO from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for NONO |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for NONO |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_511110 | X | 70503543:70503571:70504246:70504303:70504833:70504947 | 70504246:70504303 | ENSG00000147140.11 | ENST00000373856.3,ENST00000420903.1 |
| exon_skip_511112 | X | 70503543:70503571:70504246:70504303:70510478:70510641 | 70504246:70504303 | ENSG00000147140.11 | ENST00000276079.8,ENST00000413858.1,ENST00000486613.2 |
| exon_skip_511121 | X | 70503543:70503571:70510478:70510641:70511628:70511671 | 70510478:70510641 | ENSG00000147140.11 | ENST00000373841.1 |
| exon_skip_511126 | X | 70504251:70504303:70504833:70504947:70510478:70510641 | 70504833:70504947 | ENSG00000147140.11 | ENST00000373856.3,ENST00000420903.1 |
| exon_skip_511129 | X | 70511766:70511822:70514076:70514378:70516414:70516510 | 70514076:70514378 | ENSG00000147140.11 | ENST00000276079.8,ENST00000535149.1,ENST00000373856.3,ENST00000373841.1,ENST00000471419.2 |
| exon_skip_511130 | X | 70511766:70511822:70514247:70514378:70516414:70516510 | 70514247:70514378 | ENSG00000147140.11 | ENST00000418921.1 |
| exon_skip_511134 | X | 70518318:70518358:70518556:70518666:70519791:70520119 | 70518556:70518666 | ENSG00000147140.11 | ENST00000276079.8,ENST00000535149.1,ENST00000373856.3,ENST00000373841.1,ENST00000474431.1,ENST00000490044.1,ENST00000473525.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for NONO |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_511110 | X | 70503543:70503571:70504246:70504303:70504833:70504947 | 70504246:70504303 | ENSG00000147140.11 | ENST00000373856.3,ENST00000420903.1 |
| exon_skip_511112 | X | 70503543:70503571:70504246:70504303:70510478:70510641 | 70504246:70504303 | ENSG00000147140.11 | ENST00000276079.8,ENST00000413858.1,ENST00000486613.2 |
| exon_skip_511121 | X | 70503543:70503571:70510478:70510641:70511628:70511671 | 70510478:70510641 | ENSG00000147140.11 | ENST00000373841.1 |
| exon_skip_511126 | X | 70504251:70504303:70504833:70504947:70510478:70510641 | 70504833:70504947 | ENSG00000147140.11 | ENST00000373856.3,ENST00000420903.1 |
| exon_skip_511129 | X | 70511766:70511822:70514076:70514378:70516414:70516510 | 70514076:70514378 | ENSG00000147140.11 | ENST00000535149.1,ENST00000276079.8,ENST00000373856.3,ENST00000373841.1,ENST00000471419.2 |
| exon_skip_511130 | X | 70511766:70511822:70514247:70514378:70516414:70516510 | 70514247:70514378 | ENSG00000147140.11 | ENST00000418921.1 |
| exon_skip_511134 | X | 70518318:70518358:70518556:70518666:70519791:70520119 | 70518556:70518666 | ENSG00000147140.11 | ENST00000535149.1,ENST00000276079.8,ENST00000373856.3,ENST00000373841.1,ENST00000474431.1,ENST00000490044.1,ENST00000473525.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for NONO |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000373841 | 70510478 | 70510641 | 5CDS-5UTR |
| ENST00000276079 | 70504246 | 70504303 | 5UTR-5UTR |
| ENST00000373856 | 70504246 | 70504303 | 5UTR-5UTR |
| ENST00000373856 | 70504833 | 70504947 | 5UTR-5UTR |
| ENST00000276079 | 70514076 | 70514378 | Frame-shift |
| ENST00000373841 | 70514076 | 70514378 | Frame-shift |
| ENST00000373856 | 70514076 | 70514378 | Frame-shift |
| ENST00000276079 | 70518556 | 70518666 | Frame-shift |
| ENST00000373841 | 70518556 | 70518666 | Frame-shift |
| ENST00000373856 | 70518556 | 70518666 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000373841 | 70510478 | 70510641 | 5CDS-5UTR |
| ENST00000276079 | 70504246 | 70504303 | 5UTR-5UTR |
| ENST00000373856 | 70504246 | 70504303 | 5UTR-5UTR |
| ENST00000373856 | 70504833 | 70504947 | 5UTR-5UTR |
| ENST00000276079 | 70514076 | 70514378 | Frame-shift |
| ENST00000373841 | 70514076 | 70514378 | Frame-shift |
| ENST00000373856 | 70514076 | 70514378 | Frame-shift |
| ENST00000276079 | 70518556 | 70518666 | Frame-shift |
| ENST00000373841 | 70518556 | 70518666 | Frame-shift |
| ENST00000373856 | 70518556 | 70518666 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for NONO |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for NONO |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LUAD | TCGA-44-4112-01 | exon_skip_511129 | 70514077 | 70514378 | 70514295 | 70514295 | Frame_Shift_Del | A | - | p.G100fs |
| LUAD | TCGA-44-4112-01 | exon_skip_511129 | 70514077 | 70514378 | 70514295 | 70514295 | Frame_Shift_Del | A | - | p.G189fs |
| LUAD | TCGA-44-4112-01 | exon_skip_511130 | 70514248 | 70514378 | 70514295 | 70514295 | Frame_Shift_Del | A | - | p.G100fs |
| LUAD | TCGA-44-4112-01 | exon_skip_511130 | 70514248 | 70514378 | 70514295 | 70514295 | Frame_Shift_Del | A | - | p.G189fs |
| COAD | TCGA-CK-5912-01 | exon_skip_511121 | 70510479 | 70510641 | 70510601 | 70510602 | Frame_Shift_Ins | - | CCCC | p.P38fs |
| LUAD | TCGA-17-Z015-01 | exon_skip_511121 | 70510479 | 70510641 | 70510515 | 70510515 | Nonsense_Mutation | G | T | p.E10* |
| COAD | TCGA-A6-6141-01 | exon_skip_511129 | 70514077 | 70514378 | 70514185 | 70514185 | Nonsense_Mutation | C | T | p.R64X |
| UCEC | TCGA-B5-A11E-01 | exon_skip_511129 | 70514077 | 70514378 | 70514185 | 70514185 | Nonsense_Mutation | C | T | p.R153* |
| HNSC | TCGA-CR-6481-01 | exon_skip_511129 | 70514077 | 70514378 | 70514197 | 70514197 | Nonsense_Mutation | C | T | p.Q157* |
| HNSC | TCGA-CR-6481-01 | exon_skip_511129 | 70514077 | 70514378 | 70514197 | 70514197 | Nonsense_Mutation | C | T | p.Q68* |
| BLCA | TCGA-G2-A2EF-01 | exon_skip_511129 | 70514077 | 70514378 | 70514379 | 70514379 | Splice_Site | G | A | p.T217_splice |
| BLCA | TCGA-G2-A2EF-01 | exon_skip_511130 | 70514248 | 70514378 | 70514379 | 70514379 | Splice_Site | G | A | p.T217_splice |
| UCEC | TCGA-AP-A059-01 | exon_skip_511129 | 70514077 | 70514378 | 70514379 | 70514379 | Splice_Site | G | A | e3+1 |
| UCEC | TCGA-AP-A059-01 | exon_skip_511130 | 70514248 | 70514378 | 70514379 | 70514379 | Splice_Site | G | A | e3+1 |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HCC461_LUNG | 70510479 | 70510641 | 70510634 | 70510637 | Frame_Shift_Del | CAGC | - | p.SS49fs |
| RCK8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 70518557 | 70518666 | 70518577 | 70518578 | Frame_Shift_Del | AG | - | p.R398fs |
| HKA1_SKIN | 70510479 | 70510641 | 70510492 | 70510492 | Missense_Mutation | A | C | p.Q2P |
| REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 70510479 | 70510641 | 70510562 | 70510562 | Missense_Mutation | G | C | p.Q25H |
| JHUEM3_ENDOMETRIUM | 70510479 | 70510641 | 70510574 | 70510574 | Missense_Mutation | C | G | p.H29Q |
| JHUEM3_ENDOMETRIUM | 70510479 | 70510641 | 70510583 | 70510583 | Missense_Mutation | A | C | p.Q32H |
| JHUEM3_ENDOMETRIUM | 70510479 | 70510641 | 70510586 | 70510586 | Missense_Mutation | G | C | p.Q33H |
| DOV13_OVARY | 70510479 | 70510641 | 70510632 | 70510632 | Missense_Mutation | A | G | p.S49G |
| RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 70514077 | 70514378 | 70514152 | 70514152 | Missense_Mutation | C | T | p.R142C |
| HEC251_ENDOMETRIUM | 70514077 | 70514378 | 70514212 | 70514212 | Missense_Mutation | G | A | p.E162K |
| FARAGE_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 70514077 | 70514378 | 70514212 | 70514212 | Missense_Mutation | G | A | p.E162K |
| SNUC5_LARGE_INTESTINE | 70514248 | 70514378 | 70514285 | 70514285 | Missense_Mutation | G | A | p.R186K |
| SNUC5_LARGE_INTESTINE | 70514077 | 70514378 | 70514285 | 70514285 | Missense_Mutation | G | A | p.R186K |
| OVK18_OVARY | 70514248 | 70514378 | 70514302 | 70514302 | Missense_Mutation | A | G | p.I192V |
| OVK18_OVARY | 70514077 | 70514378 | 70514302 | 70514302 | Missense_Mutation | A | G | p.I192V |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 70514248 | 70514378 | 70514333 | 70514333 | Missense_Mutation | G | C | p.R202P |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 70514077 | 70514378 | 70514333 | 70514333 | Missense_Mutation | G | C | p.R202P |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 70518557 | 70518666 | 70518584 | 70518584 | Missense_Mutation | C | A | p.A400D |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 70518557 | 70518666 | 70518607 | 70518607 | Missense_Mutation | G | C | p.A408P |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 70518557 | 70518666 | 70518607 | 70518607 | Missense_Mutation | G | C | p.A408P |
| NCIH1755_LUNG | 70518557 | 70518666 | 70518623 | 70518623 | Missense_Mutation | C | A | p.P413H |
| SW620_LARGE_INTESTINE | 70518557 | 70518666 | 70518649 | 70518649 | Missense_Mutation | G | T | p.D422Y |
| SNU1040_LARGE_INTESTINE | 70518557 | 70518666 | 70518650 | 70518650 | Missense_Mutation | A | G | p.D422G |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NONO |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for NONO |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for NONO |
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RelatedDrugs for NONO |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NONO |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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