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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for HNRNPM |
 Gene summary |
| Gene information | Gene symbol | HNRNPM | Gene ID | 4670 |
| Gene name | heterogeneous nuclear ribonucleoprotein M | |
| Synonyms | CEAR|HNRNPM4|HNRPM|HNRPM4|HTGR1|NAGR1|hnRNP M | |
| Cytomap | 19p13.2 | |
| Type of gene | protein-coding | |
| Description | heterogeneous nuclear ribonucleoprotein MCEA receptorN-acetylglucosamine receptor 1heterogenous nuclear ribonucleoprotein M4hnRNA-binding protein M4 | |
| Modification date | 20180523 | |
| UniProtAcc | P52272 | |
| Context | PubMed: HNRNPM [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for HNRNPM from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for HNRNPM |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for HNRNPM |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_301821 | 19 | 8509877:8509995:8520288:8520458:8527412:8527465 | 8520288:8520458 | ENSG00000099783.7 | ENST00000594907.1,ENST00000600092.1,ENST00000601645.1,ENST00000325495.4 |
| exon_skip_301823 | 19 | 8520288:8520458:8527412:8527465:8528380:8528384 | 8527412:8527465 | ENSG00000099783.7 | ENST00000594907.1,ENST00000348943.3,ENST00000600092.1,ENST00000601645.1,ENST00000325495.4 |
| exon_skip_301826 | 19 | 8528476:8528570:8530207:8530246:8530363:8530399 | 8530207:8530246 | ENSG00000099783.7 | ENST00000348943.3,ENST00000600092.1,ENST00000596984.1 |
| exon_skip_301827 | 19 | 8530207:8530246:8530363:8530399:8531118:8531227 | 8530363:8530399 | ENSG00000099783.7 | ENST00000348943.3,ENST00000600092.1,ENST00000596984.1 |
| exon_skip_301832 | 19 | 8533699:8533718:8536209:8536311:8538547:8538592 | 8536209:8536311 | ENSG00000099783.7 | ENST00000348943.3,ENST00000597270.1,ENST00000598367.1,ENST00000325495.4 |
| exon_skip_301833 | 19 | 8533699:8533718:8536209:8536311:8539050:8539128 | 8536209:8536311 | ENSG00000099783.7 | ENST00000600092.1,ENST00000600806.1 |
| exon_skip_301841 | 19 | 8536209:8536311:8538547:8538592:8539050:8539128 | 8538547:8538592 | ENSG00000099783.7 | ENST00000348943.3,ENST00000597270.1,ENST00000598367.1,ENST00000325495.4 |
| exon_skip_301844 | 19 | 8536209:8536311:8539050:8539128:8548041:8548095 | 8539050:8539128 | ENSG00000099783.7 | ENST00000600092.1,ENST00000600806.1 |
| exon_skip_301850 | 19 | 8539050:8539128:8548041:8548095:8550486:8550532 | 8548041:8548095 | ENSG00000099783.7 | ENST00000348943.3,ENST00000600092.1,ENST00000600806.1,ENST00000325495.4 |
| exon_skip_301856 | 19 | 8551041:8551289:8551907:8551959:8553574:8553830 | 8551907:8551959 | ENSG00000099783.7 | ENST00000348943.3,ENST00000600806.1,ENST00000325495.4 |
| exon_skip_301857 | 19 | 8551907:8551959:8552892:8552950:8553574:8553830 | 8552892:8552950 | ENSG00000099783.7 | ENST00000596295.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for HNRNPM |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_301821 | 19 | 8509877:8509995:8520288:8520458:8527412:8527465 | 8520288:8520458 | ENSG00000099783.7 | ENST00000325495.4,ENST00000600092.1,ENST00000594907.1,ENST00000601645.1 |
| exon_skip_301823 | 19 | 8520288:8520458:8527412:8527465:8528380:8528384 | 8527412:8527465 | ENSG00000099783.7 | ENST00000348943.3,ENST00000325495.4,ENST00000600092.1,ENST00000594907.1,ENST00000601645.1 |
| exon_skip_301826 | 19 | 8528476:8528570:8530207:8530246:8530363:8530399 | 8530207:8530246 | ENSG00000099783.7 | ENST00000348943.3,ENST00000600092.1,ENST00000596984.1 |
| exon_skip_301827 | 19 | 8530207:8530246:8530363:8530399:8531118:8531227 | 8530363:8530399 | ENSG00000099783.7 | ENST00000348943.3,ENST00000600092.1,ENST00000596984.1 |
| exon_skip_301832 | 19 | 8533699:8533718:8536209:8536311:8538547:8538592 | 8536209:8536311 | ENSG00000099783.7 | ENST00000348943.3,ENST00000325495.4,ENST00000598367.1,ENST00000597270.1 |
| exon_skip_301833 | 19 | 8533699:8533718:8536209:8536311:8539050:8539128 | 8536209:8536311 | ENSG00000099783.7 | ENST00000600092.1,ENST00000600806.1 |
| exon_skip_301841 | 19 | 8536209:8536311:8538547:8538592:8539050:8539128 | 8538547:8538592 | ENSG00000099783.7 | ENST00000348943.3,ENST00000325495.4,ENST00000598367.1,ENST00000597270.1 |
| exon_skip_301844 | 19 | 8536209:8536311:8539050:8539128:8548041:8548095 | 8539050:8539128 | ENSG00000099783.7 | ENST00000600092.1,ENST00000600806.1 |
| exon_skip_301850 | 19 | 8539050:8539128:8548041:8548095:8550486:8550532 | 8548041:8548095 | ENSG00000099783.7 | ENST00000348943.3,ENST00000325495.4,ENST00000600092.1,ENST00000600806.1 |
| exon_skip_301856 | 19 | 8551041:8551289:8551907:8551959:8553574:8553830 | 8551907:8551959 | ENSG00000099783.7 | ENST00000348943.3,ENST00000325495.4,ENST00000600806.1 |
| exon_skip_301857 | 19 | 8551907:8551959:8552892:8552950:8553574:8553830 | 8552892:8552950 | ENSG00000099783.7 | ENST00000596295.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for HNRNPM |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000325495 | 8520288 | 8520458 | Frame-shift |
| ENST00000325495 | 8527412 | 8527465 | Frame-shift |
| ENST00000325495 | 8551907 | 8551959 | Frame-shift |
| ENST00000325495 | 8536209 | 8536311 | In-frame |
| ENST00000325495 | 8538547 | 8538592 | In-frame |
| ENST00000325495 | 8548041 | 8548095 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000325495 | 8520288 | 8520458 | Frame-shift |
| ENST00000325495 | 8527412 | 8527465 | Frame-shift |
| ENST00000325495 | 8551907 | 8551959 | Frame-shift |
| ENST00000325495 | 8536209 | 8536311 | In-frame |
| ENST00000325495 | 8538547 | 8538592 | In-frame |
| ENST00000325495 | 8548041 | 8548095 | In-frame |
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Infer the effects of exon skipping event on protein functional features for HNRNPM |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000325495 | 2511 | 730 | 8536209 | 8536311 | 937 | 1038 | 298 | 332 |
| ENST00000325495 | 2511 | 730 | 8538547 | 8538592 | 1039 | 1083 | 332 | 347 |
| ENST00000325495 | 2511 | 730 | 8548041 | 8548095 | 1162 | 1215 | 373 | 391 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000325495 | 2511 | 730 | 8536209 | 8536311 | 937 | 1038 | 298 | 332 |
| ENST00000325495 | 2511 | 730 | 8538547 | 8538592 | 1039 | 1083 | 332 | 347 |
| ENST00000325495 | 2511 | 730 | 8548041 | 8548095 | 1162 | 1215 | 373 | 391 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P52272 | 298 | 332 | 2 | 730 | Chain | ID=PRO_0000081864;Note=Heterogeneous nuclear ribonucleoprotein M |
| P52272 | 332 | 347 | 2 | 730 | Chain | ID=PRO_0000081864;Note=Heterogeneous nuclear ribonucleoprotein M |
| P52272 | 332 | 347 | 345 | 345 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
| P52272 | 373 | 391 | 2 | 730 | Chain | ID=PRO_0000081864;Note=Heterogeneous nuclear ribonucleoprotein M |
| P52272 | 373 | 391 | 390 | 396 | Compositional bias | Note=Poly-Gly |
| P52272 | 373 | 391 | 381 | 381 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
| P52272 | 373 | 391 | 388 | 388 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733 |
| P52272 | 373 | 391 | 377 | 377 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P52272 | 298 | 332 | 2 | 730 | Chain | ID=PRO_0000081864;Note=Heterogeneous nuclear ribonucleoprotein M |
| P52272 | 332 | 347 | 2 | 730 | Chain | ID=PRO_0000081864;Note=Heterogeneous nuclear ribonucleoprotein M |
| P52272 | 332 | 347 | 345 | 345 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
| P52272 | 373 | 391 | 2 | 730 | Chain | ID=PRO_0000081864;Note=Heterogeneous nuclear ribonucleoprotein M |
| P52272 | 373 | 391 | 390 | 396 | Compositional bias | Note=Poly-Gly |
| P52272 | 373 | 391 | 381 | 381 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
| P52272 | 373 | 391 | 388 | 388 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:25218447,ECO:0000244|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733 |
| P52272 | 373 | 391 | 377 | 377 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
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SNVs in the skipped exons for HNRNPM |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| STAD | TCGA-CG-5728-01 | exon_skip_301821 | 8520289 | 8520458 | 8520329 | 8520329 | Frame_Shift_Del | A | - | p.E51fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_301826 | 8530208 | 8530246 | 8530242 | 8530242 | Frame_Shift_Del | A | - | p.Q158fs |
| BLCA | TCGA-DK-AA6S-01 | exon_skip_301823 | 8527413 | 8527465 | 8527461 | 8527461 | Nonsense_Mutation | C | G | p.S111* |
| ESCA | TCGA-IG-A97H-01 | exon_skip_301832 exon_skip_301833 | 8536210 | 8536311 | 8536251 | 8536251 | Nonsense_Mutation | C | T | p.Q313* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-IG-A97H-01 |
| Cancer type: ESCA | |
| ESID: exon_skip_301833 | |
| Skipped exon start: 8536210 | |
| Skipped exon end: 8536311 | |
| Mutation start: 8536251 | |
| Mutation end: 8536251 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: C | |
| Mutation seq: T | |
| AAchange: p.Q313* | |
exon_skip_301832_ESCA_TCGA-IG-A97H-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 8520289 | 8520458 | 8520292 | 8520294 | In_Frame_Del | AGG | - | p.G40del |
| A4FUK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 8530208 | 8530246 | 8530229 | 8530246 | In_Frame_Del | AGGAGAGCAATGCAAAAG | - | p.RRAMQK154del |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 8520289 | 8520458 | 8520368 | 8520368 | Missense_Mutation | G | T | p.A65S |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 8520289 | 8520458 | 8520368 | 8520368 | Missense_Mutation | G | T | p.A65S |
| P30OHK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 8527413 | 8527465 | 8527422 | 8527422 | Missense_Mutation | T | C | p.V98A |
| ASH3_THYROID | 8527413 | 8527465 | 8527433 | 8527433 | Missense_Mutation | G | A | p.E102K |
| AN3CA_ENDOMETRIUM | 8530364 | 8530399 | 8530373 | 8530373 | Missense_Mutation | C | A | p.L202I |
| JHUEM7_ENDOMETRIUM | 8536210 | 8536311 | 8536266 | 8536266 | Missense_Mutation | A | G | p.N318D |
| HEL9217_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 8536210 | 8536311 | 8536306 | 8536306 | Missense_Mutation | C | A | p.P331H |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 8538548 | 8538592 | 8538588 | 8538588 | Missense_Mutation | G | T | p.M346I |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for HNRNPM |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for HNRNPM |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for HNRNPM |
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RelatedDrugs for HNRNPM |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HNRNPM |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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