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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for MYO9B |
 Gene summary |
| Gene information | Gene symbol | MYO9B | Gene ID | 4650 |
| Gene name | myosin IXB | |
| Synonyms | CELIAC4|MYR5 | |
| Cytomap | 19p13.11 | |
| Type of gene | protein-coding | |
| Description | unconventional myosin-IXbmyosin-IXbunconventional myosin-9b | |
| Modification date | 20180519 | |
| UniProtAcc | Q13459 | |
| Context | PubMed: MYO9B [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| MYO9B | GO:0030048 | actin filament-based movement | 9490638 |
| MYO9B | GO:0032011 | ARF protein signal transduction | 15644318 |
| MYO9B | GO:0035385 | Roundabout signaling pathway | 26529257 |
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Exon skipping events across known transcript of Ensembl for MYO9B from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for MYO9B |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for MYO9B |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_303282 | 19 | 17212991:17213367:17256206:17256301:17263453:17263516 | 17256206:17256301 | ENSG00000099331.9 | ENST00000594824.1,ENST00000397274.2,ENST00000595641.1,ENST00000595618.1 |
| exon_skip_303283 | 19 | 17256206:17256301:17263453:17263516:17264776:17264876 | 17263453:17263516 | ENSG00000099331.9 | ENST00000594824.1,ENST00000397274.2,ENST00000595641.1,ENST00000595618.1 |
| exon_skip_303284 | 19 | 17267718:17267848:17270204:17270294:17273159:17273276 | 17270204:17270294 | ENSG00000099331.9 | ENST00000594824.1,ENST00000397274.2,ENST00000595641.1,ENST00000595618.1 |
| exon_skip_303285 | 19 | 17270204:17270294:17273159:17273276:17273797:17273932 | 17273159:17273276 | ENSG00000099331.9 | ENST00000594824.1,ENST00000397274.2,ENST00000595641.1,ENST00000595618.1 |
| exon_skip_303288 | 19 | 17273159:17273276:17273797:17273932:17278752:17278874 | 17273797:17273932 | ENSG00000099331.9 | ENST00000594824.1,ENST00000397274.2,ENST00000595641.1,ENST00000595618.1 |
| exon_skip_303289 | 19 | 17273797:17273932:17278752:17278874:17283145:17283287 | 17278752:17278874 | ENSG00000099331.9 | ENST00000594824.1,ENST00000397274.2,ENST00000595641.1,ENST00000595618.1 |
| exon_skip_303290 | 19 | 17283732:17283772:17286471:17286550:17291735:17291849 | 17286471:17286550 | ENSG00000099331.9 | ENST00000594824.1,ENST00000397274.2,ENST00000595641.1,ENST00000598101.1,ENST00000595618.1 |
| exon_skip_303292 | 19 | 17286471:17286550:17288605:17288695:17294637:17294677 | 17288605:17288695 | ENSG00000099331.9 | ENST00000602177.1 |
| exon_skip_303293 | 19 | 17286471:17286550:17291735:17291849:17294637:17294677 | 17291735:17291849 | ENSG00000099331.9 | ENST00000594824.1,ENST00000397274.2,ENST00000595641.1,ENST00000598101.1,ENST00000595618.1 |
| exon_skip_303296 | 19 | 17291735:17291849:17294637:17294677:17295673:17295707 | 17294637:17294677 | ENSG00000099331.9 | ENST00000594824.1,ENST00000397274.2,ENST00000595641.1,ENST00000601749.1,ENST00000595618.1 |
| exon_skip_303297 | 19 | 17295673:17295796:17296729:17296810:17298743:17298748 | 17296729:17296810 | ENSG00000099331.9 | ENST00000594824.1,ENST00000397274.2,ENST00000595641.1,ENST00000602177.1,ENST00000601749.1,ENST00000595618.1 |
| exon_skip_303298 | 19 | 17296729:17296810:17298743:17298854:17301905:17302028 | 17298743:17298854 | ENSG00000099331.9 | ENST00000594824.1,ENST00000397274.2,ENST00000595641.1,ENST00000595618.1 |
| exon_skip_303299 | 19 | 17298743:17298854:17301905:17302028:17303554:17303871 | 17301905:17302028 | ENSG00000099331.9 | ENST00000594824.1,ENST00000397274.2,ENST00000595641.1,ENST00000595618.1 |
| exon_skip_303303 | 19 | 17308600:17308667:17308992:17309117:17311101:17311235 | 17308992:17309117 | ENSG00000099331.9 | ENST00000594824.1,ENST00000397274.2,ENST00000595641.1,ENST00000595618.1 |
| exon_skip_303305 | 19 | 17320394:17320518:17321141:17321189:17321523:17321657 | 17321141:17321189 | ENSG00000099331.9 | ENST00000594824.1,ENST00000397274.2,ENST00000598419.1,ENST00000597073.1,ENST00000595618.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for MYO9B |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_303282 | 19 | 17212991:17213367:17256206:17256301:17263453:17263516 | 17256206:17256301 | ENSG00000099331.9 | ENST00000595618.1,ENST00000594824.1,ENST00000397274.2,ENST00000595641.1 |
| exon_skip_303283 | 19 | 17256206:17256301:17263453:17263516:17264776:17264876 | 17263453:17263516 | ENSG00000099331.9 | ENST00000595618.1,ENST00000594824.1,ENST00000397274.2,ENST00000595641.1 |
| exon_skip_303284 | 19 | 17267718:17267848:17270204:17270294:17273159:17273276 | 17270204:17270294 | ENSG00000099331.9 | ENST00000595618.1,ENST00000594824.1,ENST00000397274.2,ENST00000595641.1 |
| exon_skip_303285 | 19 | 17270204:17270294:17273159:17273276:17273797:17273932 | 17273159:17273276 | ENSG00000099331.9 | ENST00000595618.1,ENST00000594824.1,ENST00000397274.2,ENST00000595641.1 |
| exon_skip_303288 | 19 | 17273159:17273276:17273797:17273932:17278752:17278874 | 17273797:17273932 | ENSG00000099331.9 | ENST00000595618.1,ENST00000594824.1,ENST00000397274.2,ENST00000595641.1 |
| exon_skip_303289 | 19 | 17273797:17273932:17278752:17278874:17283145:17283287 | 17278752:17278874 | ENSG00000099331.9 | ENST00000595618.1,ENST00000594824.1,ENST00000397274.2,ENST00000595641.1 |
| exon_skip_303290 | 19 | 17283732:17283772:17286471:17286550:17291735:17291849 | 17286471:17286550 | ENSG00000099331.9 | ENST00000595618.1,ENST00000594824.1,ENST00000397274.2,ENST00000595641.1,ENST00000598101.1 |
| exon_skip_303292 | 19 | 17286471:17286550:17288605:17288695:17294637:17294677 | 17288605:17288695 | ENSG00000099331.9 | ENST00000602177.1 |
| exon_skip_303293 | 19 | 17286471:17286550:17291735:17291849:17294637:17294677 | 17291735:17291849 | ENSG00000099331.9 | ENST00000595618.1,ENST00000594824.1,ENST00000397274.2,ENST00000595641.1,ENST00000598101.1 |
| exon_skip_303296 | 19 | 17291735:17291849:17294637:17294677:17295673:17295707 | 17294637:17294677 | ENSG00000099331.9 | ENST00000595618.1,ENST00000594824.1,ENST00000397274.2,ENST00000595641.1,ENST00000601749.1 |
| exon_skip_303297 | 19 | 17295673:17295796:17296729:17296810:17298743:17298748 | 17296729:17296810 | ENSG00000099331.9 | ENST00000595618.1,ENST00000594824.1,ENST00000397274.2,ENST00000595641.1,ENST00000602177.1,ENST00000601749.1 |
| exon_skip_303298 | 19 | 17296729:17296810:17298743:17298854:17301905:17302028 | 17298743:17298854 | ENSG00000099331.9 | ENST00000595618.1,ENST00000594824.1,ENST00000397274.2,ENST00000595641.1 |
| exon_skip_303299 | 19 | 17298743:17298854:17301905:17302028:17303554:17303871 | 17301905:17302028 | ENSG00000099331.9 | ENST00000595618.1,ENST00000594824.1,ENST00000397274.2,ENST00000595641.1 |
| exon_skip_303303 | 19 | 17308600:17308667:17308992:17309117:17311101:17311235 | 17308992:17309117 | ENSG00000099331.9 | ENST00000595618.1,ENST00000594824.1,ENST00000397274.2,ENST00000595641.1 |
| exon_skip_303305 | 19 | 17320394:17320518:17321141:17321189:17321523:17321657 | 17321141:17321189 | ENSG00000099331.9 | ENST00000595618.1,ENST00000594824.1,ENST00000397274.2,ENST00000597073.1,ENST00000598419.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for MYO9B |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for MYO9B |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for MYO9B |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
MYO9B_LUAD_exon_skip_303297_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_303288 | 17273798 | 17273932 | 17273893 | 17273893 | Frame_Shift_Del | G | - | p.L544fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_303289 | 17278753 | 17278874 | 17278781 | 17278781 | Frame_Shift_Del | G | - | p.W567fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_303289 | 17278753 | 17278874 | 17278792 | 17278792 | Frame_Shift_Del | G | - | p.G571fs |
| UCEC | TCGA-D1-A101-01 | exon_skip_303293 | 17291736 | 17291849 | 17291793 | 17291793 | Frame_Shift_Del | C | - | p.D759fs |
| LIHC | TCGA-DD-AAD0-01 | exon_skip_303298 | 17298744 | 17298854 | 17298768 | 17298768 | Frame_Shift_Del | C | - | p.E867fs |
| COAD | TCGA-AZ-4615-01 | exon_skip_303303 | 17308993 | 17309117 | 17309029 | 17309029 | Frame_Shift_Del | A | - | p.A1383fs |
| ESCA | TCGA-2H-A9GG-01A-11D-A37C-09 | exon_skip_303296 | 17294638 | 17294677 | 17294679 | 17294680 | Splice_Site | - | A | e15+2 |
| ESCA | TCGA-IG-A50L-01 | exon_skip_303296 | 17294638 | 17294677 | 17294679 | 17294680 | Splice_Site | - | A | e15+2 |
| KICH | TCGA-KN-8433-01 | exon_skip_303296 | 17294638 | 17294677 | 17294679 | 17294680 | Splice_Site | - | A | . |
| LUAD | TCGA-49-6767-01 | exon_skip_303297 | 17296730 | 17296810 | 17296811 | 17296811 | Splice_Site | G | T | p.K859_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-49-6767-01 |
| Cancer type: LUAD | |
| ESID: exon_skip_303297 | |
| Skipped exon start: 17296730 | |
| Skipped exon end: 17296810 | |
| Mutation start: 17296811 | |
| Mutation end: 17296811 | |
| Mutation type: Splice_Site | |
| Reference seq: G | |
| Mutation seq: T | |
| AAchange: p.K859_splice | |
exon_skip_303297_LUAD_TCGA-49-6767-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SISO_CERVIX | 17301906 | 17302028 | 17302019 | 17302020 | Frame_Shift_Ins | - | A | p.K935fs |
| GRST_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 17301906 | 17302028 | 17302019 | 17302020 | Frame_Shift_Ins | - | A | p.K935fs |
| NCIH1793_LUNG | 17256207 | 17256301 | 17256248 | 17256248 | Missense_Mutation | C | G | p.S294R |
| KMH2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 17270205 | 17270294 | 17270248 | 17270248 | Missense_Mutation | C | T | p.T458M |
| P3HR1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 17273160 | 17273276 | 17273211 | 17273211 | Missense_Mutation | G | A | p.D491N |
| JIYOYEP2003_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 17273160 | 17273276 | 17273211 | 17273211 | Missense_Mutation | G | A | p.D491N |
| CCK81_LARGE_INTESTINE | 17273160 | 17273276 | 17273238 | 17273238 | Missense_Mutation | G | A | p.A500T |
| PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 17273798 | 17273932 | 17273879 | 17273879 | Missense_Mutation | G | A | p.A540T |
| HCT15_LARGE_INTESTINE | 17273798 | 17273932 | 17273879 | 17273879 | Missense_Mutation | G | A | p.A540T |
| SNU601_STOMACH | 17273798 | 17273932 | 17273908 | 17273908 | Missense_Mutation | C | G | p.N549K |
| HEC151_ENDOMETRIUM | 17278753 | 17278874 | 17278811 | 17278811 | Missense_Mutation | G | A | p.G577D |
| NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 17291736 | 17291849 | 17291797 | 17291797 | Missense_Mutation | C | T | p.R761C |
| SKMEL24_SKIN | 17291736 | 17291849 | 17291813 | 17291813 | Missense_Mutation | C | T | p.S766F |
| HEC59_ENDOMETRIUM | 17291736 | 17291849 | 17291837 | 17291837 | Missense_Mutation | G | A | p.R774H |
| SNU1040_LARGE_INTESTINE | 17291736 | 17291849 | 17291839 | 17291839 | Missense_Mutation | G | A | p.A775T |
| RCC10RGB_KIDNEY | 17298744 | 17298854 | 17298762 | 17298762 | Missense_Mutation | G | A | p.D866N |
| OCUM1_STOMACH | 17298744 | 17298854 | 17298810 | 17298810 | Missense_Mutation | G | A | p.V882M |
| IGROV1_OVARY | 17298744 | 17298854 | 17298820 | 17298820 | Missense_Mutation | G | A | p.R885Q |
| EW24_BONE | 17301906 | 17302028 | 17301940 | 17301940 | Missense_Mutation | A | G | p.K908R |
| AN3CA_ENDOMETRIUM | 17301906 | 17302028 | 17301958 | 17301958 | Missense_Mutation | G | T | p.R914M |
| MOLT3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 17308993 | 17309117 | 17309020 | 17309020 | Nonsense_Mutation | C | T | p.R1381* |
| SNUC4_LARGE_INTESTINE | 17273160 | 17273276 | 17273161 | 17273161 | Splice_Site | C | T | p.A474V |
| SNGM_ENDOMETRIUM | 17273160 | 17273276 | 17273276 | 17273276 | Splice_Site | G | T | p.S512S |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MYO9B |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MYO9B |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MYO9B |
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RelatedDrugs for MYO9B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MYO9B |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| MYO9B | C0036341 | Schizophrenia | 3 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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