ExonSkipDB: functional annotation of exon skipping event in human

Gene summary for MYB

Gene summary

Gene information	Gene symbol	MYB
	Gene ID	4602
	Gene name	MYB proto-oncogene, transcription factor
	Synonyms	Cmyb\|c-myb\|c-myb_CDS\|efg
	Cytomap	6q23.3
	Type of gene	protein-coding
	Description	transcriptional activator Myboncogene AMVproto-oncogene c-Mybv-myb avian myeloblastosis viral oncogene homolog
	Modification date	20180527
	UniProtAcc	P10242
	Context	PubMed: MYB [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
MYB	GO:0045944	positive regulation of transcription by RNA polymerase II	10233885\|20484083

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Exon skipping events across known transcript of Ensembl for MYB from UCSC genome browser

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Gene isoform structures and expression levels for MYB

Expression levels of gene isoforms across TCGA.

Expression levels of gene isoforms across GTEx.

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Exon skipping events with PSIs in TCGA for MYB

Information of exkip skipping event in TCGA.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_454415	6	135507155:135507158:135508971:135509043:135510928:135511021	135508971:135509043	ENSG00000118513.14	ENST00000525514.1,ENST00000533384.1,ENST00000525940.1,ENST00000529586.1,ENST00000526889.1,ENST00000525369.1,ENST00000526187.1,ENST00000531634.1,ENST00000534121.1,ENST00000528015.1,ENST00000531737.1,ENST00000533837.1,ENST00000442647.2,ENST00000529262.1,ENS
exon_skip_454417	6	135510928:135511021:135511264:135511485:135513461:135513696	135511264:135511485	ENSG00000118513.14	ENST00000525514.1,ENST00000533384.1,ENST00000528345.1,ENST00000525940.1,ENST00000529586.1,ENST00000526889.1,ENST00000525369.1,ENST00000526187.1,ENST00000534121.1,ENST00000528015.1,ENST00000531737.1,ENST00000533837.1,ENST00000442647.2,ENST00000529262.1,ENS
exon_skip_454418	6	135514975:135515056:135515493:135515589:135516885:135517055	135515493:135515589	ENSG00000118513.14	ENST00000526889.1,ENST00000526187.1,ENST00000442647.2,ENST00000529262.1,ENST00000528774.1
exon_skip_454419	6	135514975:135515056:135515493:135515598:135516885:135517055	135515493:135515598	ENSG00000118513.14	ENST00000533384.1,ENST00000525940.1,ENST00000534121.1,ENST00000524588.1,ENST00000528015.1,ENST00000531737.1,ENST00000533837.1,ENST00000438901.2,ENST00000528343.1,ENST00000534044.1,ENST00000339290.5,ENST00000341911.5,ENST00000527615.1,ENST00000525002.1,ENS
exon_skip_454420	6	135515493:135515589:135516097:135516219:135516885:135517055	135516097:135516219	ENSG00000118513.14	ENST00000526565.1,ENST00000463282.2,ENST00000531845.1
exon_skip_454421	6	135515493:135515598:135516097:135516219:135516885:135517055	135516097:135516219	ENSG00000118513.14	ENST00000525514.1,ENST00000528345.1,ENST00000529586.1,ENST00000531634.1,ENST00000525477.1
exon_skip_454422	6	135515493:135515598:135516885:135517055:135520045:135520188	135516885:135517055	ENSG00000118513.14	ENST00000525940.1,ENST00000526320.1
exon_skip_454423	6	135515493:135515598:135516885:135517140:135520045:135520188	135516885:135517140	ENSG00000118513.14	ENST00000524588.1,ENST00000528343.1,ENST00000534044.1,ENST00000339290.5,ENST00000527615.1,ENST00000525002.1,ENST00000367814.4,ENST00000367812.2,ENST00000316528.8
exon_skip_454428	6	135516885:135517055:135518098:135518461:135520045:135520188	135518098:135518461	ENSG00000118513.14	ENST00000526187.1,ENST00000528015.1
exon_skip_454429	6	135516885:135517140:135517863:135518046:135518098:135518255	135517863:135518046	ENSG00000118513.14	ENST00000534736.1
exon_skip_454430	6	135516885:135517140:135517863:135518046:135520045:135520188	135517863:135518046	ENSG00000118513.14	ENST00000533837.1,ENST00000533808.1
exon_skip_454431	6	135516885:135517140:135517863:135518461:135520045:135520188	135517863:135518461	ENSG00000118513.14	ENST00000533384.1
exon_skip_454433	6	135516885:135517140:135518098:135518461:135520045:135520188	135518098:135518461	ENSG00000118513.14	ENST00000526565.1,ENST00000528774.1,ENST00000341911.5
exon_skip_454436	6	135520045:135520188:135520663:135520719:135521222:135521337	135520663:135520719	ENSG00000118513.14	ENST00000525514.1,ENST00000529586.1,ENST00000526889.1,ENST00000531519.1,ENST00000438901.2,ENST00000339290.5,ENST00000533808.1,ENST00000526320.1
exon_skip_454438	6	135521427:135521553:135522776:135522887:135524354:135524462	135522776:135522887	ENSG00000118513.14	ENST00000525514.1,ENST00000533384.1,ENST00000528345.1,ENST00000525940.1,ENST00000529586.1,ENST00000526889.1,ENST00000525369.1,ENST00000526187.1,ENST00000531634.1,ENST00000534121.1,ENST00000524588.1,ENST00000528015.1,ENST00000531737.1,ENST00000533837.1,ENS
exon_skip_454439	6	135522776:135522887:135523551:135523807:135524354:135524462	135523551:135523807	ENSG00000118513.14	ENST00000367812.2

PSI values of skipped exons in TCGA.

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Exon skipping events with PSIs in GTEx for MYB

Information of exkip skipping event in GTEx

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_454415	6	135507155:135507158:135508971:135509043:135510928:135511021	135508971:135509043	ENSG00000118513.14	ENST00000341911.5,ENST00000367812.2,ENST00000463282.2,ENST00000525477.1,ENST00000533837.1,ENST00000339290.5,ENST00000442647.2,ENST00000316528.8,ENST00000367814.4,ENST00000527615.1,ENST00000525369.1,ENST00000528140.1,ENST00000528774.1,ENST00000534121.1,ENS
exon_skip_454417	6	135510928:135511021:135511264:135511485:135513461:135513696	135511264:135511485	ENSG00000118513.14	ENST00000341911.5,ENST00000367812.2,ENST00000463282.2,ENST00000525477.1,ENST00000533837.1,ENST00000339290.5,ENST00000442647.2,ENST00000316528.8,ENST00000367814.4,ENST00000527615.1,ENST00000420123.2,ENST00000525369.1,ENST00000528140.1,ENST00000528774.1,ENS
exon_skip_454418	6	135514975:135515056:135515493:135515589:135516885:135517055	135515493:135515589	ENSG00000118513.14	ENST00000442647.2,ENST00000528774.1,ENST00000529262.1,ENST00000526187.1,ENST00000526889.1
exon_skip_454419	6	135514975:135515056:135515493:135515598:135516885:135517055	135515493:135515598	ENSG00000118513.14	ENST00000341911.5,ENST00000367812.2,ENST00000533837.1,ENST00000339290.5,ENST00000316528.8,ENST00000367814.4,ENST00000527615.1,ENST00000528140.1,ENST00000534121.1,ENST00000525940.1,ENST00000534044.1,ENST00000528015.1,ENST00000533384.1,ENST00000531737.1,ENS
exon_skip_454420	6	135515493:135515589:135516097:135516219:135516885:135517055	135516097:135516219	ENSG00000118513.14	ENST00000463282.2,ENST00000526565.1,ENST00000531845.1
exon_skip_454421	6	135515493:135515598:135516097:135516219:135516885:135517055	135516097:135516219	ENSG00000118513.14	ENST00000525477.1,ENST00000528345.1,ENST00000531634.1,ENST00000525514.1,ENST00000529586.1
exon_skip_454425	6	135516885:135517055:135517863:135518046:135520045:135520188	135517863:135518046	ENSG00000118513.14	ENST00000528140.1
exon_skip_454426	6	135516885:135517055:135517863:135518461:135520045:135520188	135517863:135518461	ENSG00000118513.14	ENST00000529262.1,ENST00000531737.1
exon_skip_454428	6	135516885:135517055:135518098:135518461:135520045:135520188	135518098:135518461	ENSG00000118513.14	ENST00000528015.1,ENST00000526187.1
exon_skip_454429	6	135516885:135517140:135517863:135518046:135518098:135518255	135517863:135518046	ENSG00000118513.14	ENST00000534736.1
exon_skip_454430	6	135516885:135517140:135517863:135518046:135520045:135520188	135517863:135518046	ENSG00000118513.14	ENST00000533837.1,ENST00000533808.1
exon_skip_454431	6	135516885:135517140:135517863:135518461:135520045:135520188	135517863:135518461	ENSG00000118513.14	ENST00000533384.1
exon_skip_454433	6	135516885:135517140:135518098:135518461:135520045:135520188	135518098:135518461	ENSG00000118513.14	ENST00000341911.5,ENST00000528774.1,ENST00000526565.1
exon_skip_454436	6	135520045:135520188:135520663:135520719:135521222:135521337	135520663:135520719	ENSG00000118513.14	ENST00000339290.5,ENST00000438901.2,ENST00000525514.1,ENST00000531519.1,ENST00000526320.1,ENST00000526889.1,ENST00000533808.1,ENST00000529586.1
exon_skip_454439	6	135522776:135522887:135523551:135523807:135524354:135524462	135523551:135523807	ENSG00000118513.14	ENST00000367812.2

PSI values of skipped exons in GTEx.

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for MYB

Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000367814	135511264	135511485	Frame-shift
ENST00000367814	135508971	135509043	In-frame
ENST00000367814	135515493	135515598	In-frame
ENST00000367814	135516885	135517140	In-frame
ENST00000367814	135522776	135522887	In-frame

Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000367814	135511264	135511485	Frame-shift
ENST00000367814	135508971	135509043	In-frame
ENST00000367814	135515493	135515598	In-frame

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Infer the effects of exon skipping event on protein functional features for MYB

Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.

Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000367814	3319	640	135508971	135509043	328	399	47	71
ENST00000367814	3319	640	135515493	135515598	1030	1134	281	316
ENST00000367814	3319	640	135516885	135517140	1135	1389	316	401
ENST00000367814	3319	640	135522776	135522887	1774	1884	529	566

Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000367814	3319	640	135508971	135509043	328	399	47	71
ENST00000367814	3319	640	135515493	135515598	1030	1134	281	316

Lost protein functional features of individual exon skipping events in TCGA.

UniProt acc.

Start of exon skipping (AA)

End of exon skipping (AA)

Protein feature start (AA)

Protein feature end (AA)

Category of protein feature

Description of feature

Lost protein functional features of individual exon skipping events in GTEx.

UniProt acc.

Start of exon skipping (AA)

End of exon skipping (AA)

Protein feature start (AA)

Protein feature end (AA)

Category of protein feature

Description of feature

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SNVs in the skipped exons for MYB

- Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.

- Differential PSIs between mutated versus non-mutated samples.

MYB_COAD_exon_skip_454431_psi_boxplot.png
boxplot

MYB_READ_exon_skip_454431_psi_boxplot.png
boxplot

MYB_STAD_exon_skip_454431_psi_boxplot.png
boxplot

- Non-synonymous mutations located in the skipped exons in TCGA.

Cancer type	Sample	ESID	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
LIHC	TCGA-DD-A39Y-01	exon_skip_454422	135516886	135517055	135516913	135516913	Frame_Shift_Del	G	-	p.G326fs
LIHC	TCGA-DD-A39Y-01	exon_skip_454423	135516886	135517140	135516913	135516913	Frame_Shift_Del	G	-	p.G326fs
LIHC	TCGA-DD-A3A0-01	exon_skip_454422	135516886	135517055	135516913	135516913	Frame_Shift_Del	G	-	p.G326fs
LIHC	TCGA-DD-A3A0-01	exon_skip_454423	135516886	135517140	135516913	135516913	Frame_Shift_Del	G	-	p.G326fs
COAD	TCGA-F4-6570-01	exon_skip_454431	135517864	135518461	135518338	135518338	Frame_Shift_Del	A	-	p.R481fs
COAD	TCGA-F4-6570-01	exon_skip_454428 exon_skip_454433	135518099	135518461	135518338	135518338	Frame_Shift_Del	A	-	p.R481fs
LIHC	TCGA-DD-A3A0-01	exon_skip_454431	135517864	135518461	135518338	135518338	Frame_Shift_Del	A	-	p.R481fs
LIHC	TCGA-DD-A3A0-01	exon_skip_454428 exon_skip_454433	135518099	135518461	135518338	135518338	Frame_Shift_Del	A	-	p.R481fs
READ	TCGA-EI-6882-01	exon_skip_454431	135517864	135518461	135518338	135518338	Frame_Shift_Del	A	-	p.R481fs
READ	TCGA-EI-6882-01	exon_skip_454428 exon_skip_454433	135518099	135518461	135518338	135518338	Frame_Shift_Del	A	-	p.R481fs
STAD	TCGA-BR-4201-01	exon_skip_454431	135517864	135518461	135518338	135518338	Frame_Shift_Del	A	-	p.R481fs
STAD	TCGA-BR-4201-01	exon_skip_454428 exon_skip_454433	135518099	135518461	135518338	135518338	Frame_Shift_Del	A	-	p.R481fs
STAD	TCGA-BR-8081-01	exon_skip_454431	135517864	135518461	135518338	135518338	Frame_Shift_Del	A	-	p.R481fs
STAD	TCGA-BR-8081-01	exon_skip_454428 exon_skip_454433	135518099	135518461	135518338	135518338	Frame_Shift_Del	A	-	p.R481fs
STAD	TCGA-HU-A4GU-01	exon_skip_454431	135517864	135518461	135518338	135518338	Frame_Shift_Del	A	-	p.R481fs
STAD	TCGA-HU-A4GU-01	exon_skip_454428 exon_skip_454433	135518099	135518461	135518338	135518338	Frame_Shift_Del	A	-	p.R481fs
LUAD	TCGA-05-4397-01	exon_skip_454438	135522777	135522887	135522779	135522779	Frame_Shift_Del	G	-	p.V651fs
LIHC	TCGA-G3-A3CJ-01	exon_skip_454438	135522777	135522887	135522831	135522831	Frame_Shift_Del	G	-	p.G669fs
BRCA	TCGA-BH-A0HQ-01	exon_skip_454417	135511265	135511485	135511376	135511377	Frame_Shift_Ins	-	CA	p.E141fs
PRAD	TCGA-HC-8265-01	exon_skip_454415	135508972	135509043	135509019	135509019	Nonsense_Mutation	G	A	p.W63X
BRCA	TCGA-E2-A15G-01	exon_skip_454417	135511265	135511485	135511399	135511399	Nonsense_Mutation	G	A	p.W147*
BLCA	TCGA-ZF-A9RF-01	exon_skip_454418	135515494	135515589	135515530	135515530	Nonsense_Mutation	C	T	p.R294*
BLCA	TCGA-ZF-A9RF-01	exon_skip_454419	135515494	135515598	135515530	135515530	Nonsense_Mutation	C	T	p.R294*

- Depth of coverage in the three exons composing exon skipping event

Depth of coverage in three exons	Mutation description
	Sample: TCGA-F4-6570-01
	Cancer type: COAD
	ESID: exon_skip_454433
	Skipped exon start: 135518099
	Skipped exon end: 135518461
	Mutation start: 135518338
	Mutation end: 135518338
	Mutation type: Frame_Shift_Del
	Reference seq: A
	Mutation seq: -
	AAchange: p.R481fs
	Sample: TCGA-F4-6570-01
	Cancer type: COAD
	ESID: exon_skip_454431
	Skipped exon start: 135517864
	Skipped exon end: 135518461
	Mutation start: 135518338
	Mutation end: 135518338
	Mutation type: Frame_Shift_Del
	Reference seq: A
	Mutation seq: -
	AAchange: p.R481fs
exon_skip_135806_COAD_TCGA-F4-6570-01.png
exon_skip_422548_COAD_TCGA-F4-6570-01.png
exon_skip_454428_COAD_TCGA-F4-6570-01.png
exon_skip_454431_COAD_TCGA-F4-6570-01.png
exon_skip_454433_COAD_TCGA-F4-6570-01.png
exon_skip_89413_COAD_TCGA-F4-6570-01.png
	Sample: TCGA-EI-6882-01
	Cancer type: READ
	ESID: exon_skip_454433
	Skipped exon start: 135518099
	Skipped exon end: 135518461
	Mutation start: 135518338
	Mutation end: 135518338
	Mutation type: Frame_Shift_Del
	Reference seq: A
	Mutation seq: -
	AAchange: p.R481fs
	Sample: TCGA-EI-6882-01
	Cancer type: READ
	ESID: exon_skip_454431
	Skipped exon start: 135517864
	Skipped exon end: 135518461
	Mutation start: 135518338
	Mutation end: 135518338
	Mutation type: Frame_Shift_Del
	Reference seq: A
	Mutation seq: -
	AAchange: p.R481fs
exon_skip_135111_READ_TCGA-EI-6882-01.png
exon_skip_135112_READ_TCGA-EI-6882-01.png
exon_skip_135114_READ_TCGA-EI-6882-01.png
exon_skip_304901_READ_TCGA-EI-6882-01.png
exon_skip_334382_READ_TCGA-EI-6882-01.png
exon_skip_334405_READ_TCGA-EI-6882-01.png
exon_skip_372536_READ_TCGA-EI-6882-01.png
exon_skip_4028_READ_TCGA-EI-6882-01.png
exon_skip_439047_READ_TCGA-EI-6882-01.png
exon_skip_439048_READ_TCGA-EI-6882-01.png
exon_skip_454428_READ_TCGA-EI-6882-01.png
exon_skip_454431_READ_TCGA-EI-6882-01.png
exon_skip_454433_READ_TCGA-EI-6882-01.png
exon_skip_69190_READ_TCGA-EI-6882-01.png
	Sample: TCGA-BR-4201-01
	Cancer type: STAD
	ESID: exon_skip_454433
	Skipped exon start: 135518099
	Skipped exon end: 135518461
	Mutation start: 135518338
	Mutation end: 135518338
	Mutation type: Frame_Shift_Del
	Reference seq: A
	Mutation seq: -
	AAchange: p.R481fs
	Sample: TCGA-BR-4201-01
	Cancer type: STAD
	ESID: exon_skip_454431
	Skipped exon start: 135517864
	Skipped exon end: 135518461
	Mutation start: 135518338
	Mutation end: 135518338
	Mutation type: Frame_Shift_Del
	Reference seq: A
	Mutation seq: -
	AAchange: p.R481fs
exon_skip_141192_STAD_TCGA-BR-4201-01.png
exon_skip_16960_STAD_TCGA-BR-4201-01.png
exon_skip_326432_STAD_TCGA-BR-4201-01.png
exon_skip_337819_STAD_TCGA-BR-4201-01.png
exon_skip_345944_STAD_TCGA-BR-4201-01.png
exon_skip_345950_STAD_TCGA-BR-4201-01.png
exon_skip_351676_STAD_TCGA-BR-4201-01.png
exon_skip_454428_STAD_TCGA-BR-4201-01.png
exon_skip_454431_STAD_TCGA-BR-4201-01.png
exon_skip_454433_STAD_TCGA-BR-4201-01.png
exon_skip_45525_STAD_TCGA-BR-4201-01.png
exon_skip_456626_STAD_TCGA-BR-4201-01.png
exon_skip_494729_STAD_TCGA-BR-4201-01.png
exon_skip_60290_STAD_TCGA-BR-4201-01.png
exon_skip_60294_STAD_TCGA-BR-4201-01.png
	Sample: TCGA-BR-8081-01
	Cancer type: STAD
	ESID: exon_skip_454433
	Skipped exon start: 135518099
	Skipped exon end: 135518461
	Mutation start: 135518338
	Mutation end: 135518338
	Mutation type: Frame_Shift_Del
	Reference seq: A
	Mutation seq: -
	AAchange: p.R481fs
	Sample: TCGA-BR-8081-01
	Cancer type: STAD
	ESID: exon_skip_454431
	Skipped exon start: 135517864
	Skipped exon end: 135518461
	Mutation start: 135518338
	Mutation end: 135518338
	Mutation type: Frame_Shift_Del
	Reference seq: A
	Mutation seq: -
	AAchange: p.R481fs
exon_skip_105957_STAD_TCGA-BR-8081-01.png
exon_skip_105958_STAD_TCGA-BR-8081-01.png
exon_skip_148026_STAD_TCGA-BR-8081-01.png
exon_skip_349801_STAD_TCGA-BR-8081-01.png
exon_skip_360490_STAD_TCGA-BR-8081-01.png
exon_skip_454428_STAD_TCGA-BR-8081-01.png
exon_skip_454431_STAD_TCGA-BR-8081-01.png
exon_skip_454433_STAD_TCGA-BR-8081-01.png
exon_skip_57703_STAD_TCGA-BR-8081-01.png
exon_skip_75990_STAD_TCGA-BR-8081-01.png
exon_skip_94164_STAD_TCGA-BR-8081-01.png
exon_skip_94165_STAD_TCGA-BR-8081-01.png
exon_skip_95877_STAD_TCGA-BR-8081-01.png
	Sample: TCGA-HU-A4GU-01
	Cancer type: STAD
	ESID: exon_skip_454433
	Skipped exon start: 135518099
	Skipped exon end: 135518461
	Mutation start: 135518338
	Mutation end: 135518338
	Mutation type: Frame_Shift_Del
	Reference seq: A
	Mutation seq: -
	AAchange: p.R481fs
	Sample: TCGA-HU-A4GU-01
	Cancer type: STAD
	ESID: exon_skip_454431
	Skipped exon start: 135517864
	Skipped exon end: 135518461
	Mutation start: 135518338
	Mutation end: 135518338
	Mutation type: Frame_Shift_Del
	Reference seq: A
	Mutation seq: -
	AAchange: p.R481fs
exon_skip_109771_STAD_TCGA-HU-A4GU-01.png
exon_skip_133402_STAD_TCGA-HU-A4GU-01.png
exon_skip_133403_STAD_TCGA-HU-A4GU-01.png
exon_skip_146776_STAD_TCGA-HU-A4GU-01.png
exon_skip_147024_STAD_TCGA-HU-A4GU-01.png
exon_skip_149455_STAD_TCGA-HU-A4GU-01.png
exon_skip_335090_STAD_TCGA-HU-A4GU-01.png
exon_skip_382354_STAD_TCGA-HU-A4GU-01.png
exon_skip_433982_STAD_TCGA-HU-A4GU-01.png
exon_skip_433985_STAD_TCGA-HU-A4GU-01.png
exon_skip_437417_STAD_TCGA-HU-A4GU-01.png
exon_skip_437418_STAD_TCGA-HU-A4GU-01.png
exon_skip_454428_STAD_TCGA-HU-A4GU-01.png
exon_skip_454431_STAD_TCGA-HU-A4GU-01.png
exon_skip_454433_STAD_TCGA-HU-A4GU-01.png
exon_skip_465824_STAD_TCGA-HU-A4GU-01.png
exon_skip_467518_STAD_TCGA-HU-A4GU-01.png
exon_skip_480057_STAD_TCGA-HU-A4GU-01.png
exon_skip_485377_STAD_TCGA-HU-A4GU-01.png
exon_skip_500520_STAD_TCGA-HU-A4GU-01.png
	Sample: TCGA-F4-6570-01
	Cancer type: COAD
	ESID: exon_skip_454433
	Skipped exon start: 135518099
	Skipped exon end: 135518461
	Mutation start: 135518338
	Mutation end: 135518338
	Mutation type: Frame_Shift_Del
	Reference seq: A
	Mutation seq: -
	AAchange: p.R481fs
	Sample: TCGA-F4-6570-01
	Cancer type: COAD
	ESID: exon_skip_454431
	Skipped exon start: 135517864
	Skipped exon end: 135518461
	Mutation start: 135518338
	Mutation end: 135518338
	Mutation type: Frame_Shift_Del
	Reference seq: A
	Mutation seq: -
	AAchange: p.R481fs
exon_skip_135806_COAD_TCGA-F4-6570-01.png
exon_skip_422548_COAD_TCGA-F4-6570-01.png
exon_skip_454428_COAD_TCGA-F4-6570-01.png
exon_skip_454431_COAD_TCGA-F4-6570-01.png
exon_skip_454433_COAD_TCGA-F4-6570-01.png
exon_skip_89413_COAD_TCGA-F4-6570-01.png
	Sample: TCGA-EI-6882-01
	Cancer type: READ
	ESID: exon_skip_454433
	Skipped exon start: 135518099
	Skipped exon end: 135518461
	Mutation start: 135518338
	Mutation end: 135518338
	Mutation type: Frame_Shift_Del
	Reference seq: A
	Mutation seq: -
	AAchange: p.R481fs
	Sample: TCGA-EI-6882-01
	Cancer type: READ
	ESID: exon_skip_454431
	Skipped exon start: 135517864
	Skipped exon end: 135518461
	Mutation start: 135518338
	Mutation end: 135518338
	Mutation type: Frame_Shift_Del
	Reference seq: A
	Mutation seq: -
	AAchange: p.R481fs
exon_skip_135111_READ_TCGA-EI-6882-01.png
exon_skip_135112_READ_TCGA-EI-6882-01.png
exon_skip_135114_READ_TCGA-EI-6882-01.png
exon_skip_304901_READ_TCGA-EI-6882-01.png
exon_skip_334382_READ_TCGA-EI-6882-01.png
exon_skip_334405_READ_TCGA-EI-6882-01.png
exon_skip_372536_READ_TCGA-EI-6882-01.png
exon_skip_4028_READ_TCGA-EI-6882-01.png
exon_skip_439047_READ_TCGA-EI-6882-01.png
exon_skip_439048_READ_TCGA-EI-6882-01.png
exon_skip_454428_READ_TCGA-EI-6882-01.png
exon_skip_454431_READ_TCGA-EI-6882-01.png
exon_skip_454433_READ_TCGA-EI-6882-01.png
exon_skip_69190_READ_TCGA-EI-6882-01.png
	Sample: TCGA-BR-4201-01
	Cancer type: STAD
	ESID: exon_skip_454433
	Skipped exon start: 135518099
	Skipped exon end: 135518461
	Mutation start: 135518338
	Mutation end: 135518338
	Mutation type: Frame_Shift_Del
	Reference seq: A
	Mutation seq: -
	AAchange: p.R481fs
	Sample: TCGA-BR-4201-01
	Cancer type: STAD
	ESID: exon_skip_454431
	Skipped exon start: 135517864
	Skipped exon end: 135518461
	Mutation start: 135518338
	Mutation end: 135518338
	Mutation type: Frame_Shift_Del
	Reference seq: A
	Mutation seq: -
	AAchange: p.R481fs
exon_skip_141192_STAD_TCGA-BR-4201-01.png
exon_skip_16960_STAD_TCGA-BR-4201-01.png
exon_skip_326432_STAD_TCGA-BR-4201-01.png
exon_skip_337819_STAD_TCGA-BR-4201-01.png
exon_skip_345944_STAD_TCGA-BR-4201-01.png
exon_skip_345950_STAD_TCGA-BR-4201-01.png
exon_skip_351676_STAD_TCGA-BR-4201-01.png
exon_skip_454428_STAD_TCGA-BR-4201-01.png
exon_skip_454431_STAD_TCGA-BR-4201-01.png
exon_skip_454433_STAD_TCGA-BR-4201-01.png
exon_skip_45525_STAD_TCGA-BR-4201-01.png
exon_skip_456626_STAD_TCGA-BR-4201-01.png
exon_skip_494729_STAD_TCGA-BR-4201-01.png
exon_skip_60290_STAD_TCGA-BR-4201-01.png
exon_skip_60294_STAD_TCGA-BR-4201-01.png
	Sample: TCGA-BR-8081-01
	Cancer type: STAD
	ESID: exon_skip_454433
	Skipped exon start: 135518099
	Skipped exon end: 135518461
	Mutation start: 135518338
	Mutation end: 135518338
	Mutation type: Frame_Shift_Del
	Reference seq: A
	Mutation seq: -
	AAchange: p.R481fs
	Sample: TCGA-BR-8081-01
	Cancer type: STAD
	ESID: exon_skip_454431
	Skipped exon start: 135517864
	Skipped exon end: 135518461
	Mutation start: 135518338
	Mutation end: 135518338
	Mutation type: Frame_Shift_Del
	Reference seq: A
	Mutation seq: -
	AAchange: p.R481fs
exon_skip_105957_STAD_TCGA-BR-8081-01.png
exon_skip_105958_STAD_TCGA-BR-8081-01.png
exon_skip_148026_STAD_TCGA-BR-8081-01.png
exon_skip_349801_STAD_TCGA-BR-8081-01.png
exon_skip_360490_STAD_TCGA-BR-8081-01.png
exon_skip_454428_STAD_TCGA-BR-8081-01.png
exon_skip_454431_STAD_TCGA-BR-8081-01.png
exon_skip_454433_STAD_TCGA-BR-8081-01.png
exon_skip_57703_STAD_TCGA-BR-8081-01.png
exon_skip_75990_STAD_TCGA-BR-8081-01.png
exon_skip_94164_STAD_TCGA-BR-8081-01.png
exon_skip_94165_STAD_TCGA-BR-8081-01.png
exon_skip_95877_STAD_TCGA-BR-8081-01.png
	Sample: TCGA-HU-A4GU-01
	Cancer type: STAD
	ESID: exon_skip_454433
	Skipped exon start: 135518099
	Skipped exon end: 135518461
	Mutation start: 135518338
	Mutation end: 135518338
	Mutation type: Frame_Shift_Del
	Reference seq: A
	Mutation seq: -
	AAchange: p.R481fs
	Sample: TCGA-HU-A4GU-01
	Cancer type: STAD
	ESID: exon_skip_454431
	Skipped exon start: 135517864
	Skipped exon end: 135518461
	Mutation start: 135518338
	Mutation end: 135518338
	Mutation type: Frame_Shift_Del
	Reference seq: A
	Mutation seq: -
	AAchange: p.R481fs
exon_skip_109771_STAD_TCGA-HU-A4GU-01.png
exon_skip_133402_STAD_TCGA-HU-A4GU-01.png
exon_skip_133403_STAD_TCGA-HU-A4GU-01.png
exon_skip_146776_STAD_TCGA-HU-A4GU-01.png
exon_skip_147024_STAD_TCGA-HU-A4GU-01.png
exon_skip_149455_STAD_TCGA-HU-A4GU-01.png
exon_skip_335090_STAD_TCGA-HU-A4GU-01.png
exon_skip_382354_STAD_TCGA-HU-A4GU-01.png
exon_skip_433982_STAD_TCGA-HU-A4GU-01.png
exon_skip_433985_STAD_TCGA-HU-A4GU-01.png
exon_skip_437417_STAD_TCGA-HU-A4GU-01.png
exon_skip_437418_STAD_TCGA-HU-A4GU-01.png
exon_skip_454428_STAD_TCGA-HU-A4GU-01.png
exon_skip_454431_STAD_TCGA-HU-A4GU-01.png
exon_skip_454433_STAD_TCGA-HU-A4GU-01.png
exon_skip_465824_STAD_TCGA-HU-A4GU-01.png
exon_skip_467518_STAD_TCGA-HU-A4GU-01.png
exon_skip_480057_STAD_TCGA-HU-A4GU-01.png
exon_skip_485377_STAD_TCGA-HU-A4GU-01.png
exon_skip_500520_STAD_TCGA-HU-A4GU-01.png
	Sample: TCGA-F4-6570-01
	Cancer type: COAD
	ESID: exon_skip_454433
	Skipped exon start: 135518099
	Skipped exon end: 135518461
	Mutation start: 135518338
	Mutation end: 135518338
	Mutation type: Frame_Shift_Del
	Reference seq: A
	Mutation seq: -
	AAchange: p.R481fs
	Sample: TCGA-F4-6570-01
	Cancer type: COAD
	ESID: exon_skip_454431
	Skipped exon start: 135517864
	Skipped exon end: 135518461
	Mutation start: 135518338
	Mutation end: 135518338
	Mutation type: Frame_Shift_Del
	Reference seq: A
	Mutation seq: -
	AAchange: p.R481fs
exon_skip_135806_COAD_TCGA-F4-6570-01.png
exon_skip_422548_COAD_TCGA-F4-6570-01.png
exon_skip_454428_COAD_TCGA-F4-6570-01.png
exon_skip_454431_COAD_TCGA-F4-6570-01.png
exon_skip_454433_COAD_TCGA-F4-6570-01.png
exon_skip_89413_COAD_TCGA-F4-6570-01.png
	Sample: TCGA-EI-6882-01
	Cancer type: READ
	ESID: exon_skip_454433
	Skipped exon start: 135518099
	Skipped exon end: 135518461
	Mutation start: 135518338
	Mutation end: 135518338
	Mutation type: Frame_Shift_Del
	Reference seq: A
	Mutation seq: -
	AAchange: p.R481fs
	Sample: TCGA-EI-6882-01
	Cancer type: READ
	ESID: exon_skip_454431
	Skipped exon start: 135517864
	Skipped exon end: 135518461
	Mutation start: 135518338
	Mutation end: 135518338
	Mutation type: Frame_Shift_Del
	Reference seq: A
	Mutation seq: -
	AAchange: p.R481fs
exon_skip_135111_READ_TCGA-EI-6882-01.png
exon_skip_135112_READ_TCGA-EI-6882-01.png
exon_skip_135114_READ_TCGA-EI-6882-01.png
exon_skip_304901_READ_TCGA-EI-6882-01.png
exon_skip_334382_READ_TCGA-EI-6882-01.png
exon_skip_334405_READ_TCGA-EI-6882-01.png
exon_skip_372536_READ_TCGA-EI-6882-01.png
exon_skip_4028_READ_TCGA-EI-6882-01.png
exon_skip_439047_READ_TCGA-EI-6882-01.png
exon_skip_439048_READ_TCGA-EI-6882-01.png
exon_skip_454428_READ_TCGA-EI-6882-01.png
exon_skip_454431_READ_TCGA-EI-6882-01.png
exon_skip_454433_READ_TCGA-EI-6882-01.png
exon_skip_69190_READ_TCGA-EI-6882-01.png
	Sample: TCGA-BR-4201-01
	Cancer type: STAD
	ESID: exon_skip_454433
	Skipped exon start: 135518099
	Skipped exon end: 135518461
	Mutation start: 135518338
	Mutation end: 135518338
	Mutation type: Frame_Shift_Del
	Reference seq: A
	Mutation seq: -
	AAchange: p.R481fs
	Sample: TCGA-BR-4201-01
	Cancer type: STAD
	ESID: exon_skip_454431
	Skipped exon start: 135517864
	Skipped exon end: 135518461
	Mutation start: 135518338
	Mutation end: 135518338
	Mutation type: Frame_Shift_Del
	Reference seq: A
	Mutation seq: -
	AAchange: p.R481fs
exon_skip_141192_STAD_TCGA-BR-4201-01.png
exon_skip_16960_STAD_TCGA-BR-4201-01.png
exon_skip_326432_STAD_TCGA-BR-4201-01.png
exon_skip_337819_STAD_TCGA-BR-4201-01.png
exon_skip_345944_STAD_TCGA-BR-4201-01.png
exon_skip_345950_STAD_TCGA-BR-4201-01.png
exon_skip_351676_STAD_TCGA-BR-4201-01.png
exon_skip_454428_STAD_TCGA-BR-4201-01.png
exon_skip_454431_STAD_TCGA-BR-4201-01.png
exon_skip_454433_STAD_TCGA-BR-4201-01.png
exon_skip_45525_STAD_TCGA-BR-4201-01.png
exon_skip_456626_STAD_TCGA-BR-4201-01.png
exon_skip_494729_STAD_TCGA-BR-4201-01.png
exon_skip_60290_STAD_TCGA-BR-4201-01.png
exon_skip_60294_STAD_TCGA-BR-4201-01.png
	Sample: TCGA-BR-8081-01
	Cancer type: STAD
	ESID: exon_skip_454433
	Skipped exon start: 135518099
	Skipped exon end: 135518461
	Mutation start: 135518338
	Mutation end: 135518338
	Mutation type: Frame_Shift_Del
	Reference seq: A
	Mutation seq: -
	AAchange: p.R481fs
	Sample: TCGA-BR-8081-01
	Cancer type: STAD
	ESID: exon_skip_454431
	Skipped exon start: 135517864
	Skipped exon end: 135518461
	Mutation start: 135518338
	Mutation end: 135518338
	Mutation type: Frame_Shift_Del
	Reference seq: A
	Mutation seq: -
	AAchange: p.R481fs
exon_skip_105957_STAD_TCGA-BR-8081-01.png
exon_skip_105958_STAD_TCGA-BR-8081-01.png
exon_skip_148026_STAD_TCGA-BR-8081-01.png
exon_skip_349801_STAD_TCGA-BR-8081-01.png
exon_skip_360490_STAD_TCGA-BR-8081-01.png
exon_skip_454428_STAD_TCGA-BR-8081-01.png
exon_skip_454431_STAD_TCGA-BR-8081-01.png
exon_skip_454433_STAD_TCGA-BR-8081-01.png
exon_skip_57703_STAD_TCGA-BR-8081-01.png
exon_skip_75990_STAD_TCGA-BR-8081-01.png
exon_skip_94164_STAD_TCGA-BR-8081-01.png
exon_skip_94165_STAD_TCGA-BR-8081-01.png
exon_skip_95877_STAD_TCGA-BR-8081-01.png
	Sample: TCGA-HU-A4GU-01
	Cancer type: STAD
	ESID: exon_skip_454433
	Skipped exon start: 135518099
	Skipped exon end: 135518461
	Mutation start: 135518338
	Mutation end: 135518338
	Mutation type: Frame_Shift_Del
	Reference seq: A
	Mutation seq: -
	AAchange: p.R481fs
	Sample: TCGA-HU-A4GU-01
	Cancer type: STAD
	ESID: exon_skip_454431
	Skipped exon start: 135517864
	Skipped exon end: 135518461
	Mutation start: 135518338
	Mutation end: 135518338
	Mutation type: Frame_Shift_Del
	Reference seq: A
	Mutation seq: -
	AAchange: p.R481fs
exon_skip_109771_STAD_TCGA-HU-A4GU-01.png
exon_skip_133402_STAD_TCGA-HU-A4GU-01.png
exon_skip_133403_STAD_TCGA-HU-A4GU-01.png
exon_skip_146776_STAD_TCGA-HU-A4GU-01.png
exon_skip_147024_STAD_TCGA-HU-A4GU-01.png
exon_skip_149455_STAD_TCGA-HU-A4GU-01.png
exon_skip_335090_STAD_TCGA-HU-A4GU-01.png
exon_skip_382354_STAD_TCGA-HU-A4GU-01.png
exon_skip_433982_STAD_TCGA-HU-A4GU-01.png
exon_skip_433985_STAD_TCGA-HU-A4GU-01.png
exon_skip_437417_STAD_TCGA-HU-A4GU-01.png
exon_skip_437418_STAD_TCGA-HU-A4GU-01.png
exon_skip_454428_STAD_TCGA-HU-A4GU-01.png
exon_skip_454431_STAD_TCGA-HU-A4GU-01.png
exon_skip_454433_STAD_TCGA-HU-A4GU-01.png
exon_skip_465824_STAD_TCGA-HU-A4GU-01.png
exon_skip_467518_STAD_TCGA-HU-A4GU-01.png
exon_skip_480057_STAD_TCGA-HU-A4GU-01.png
exon_skip_485377_STAD_TCGA-HU-A4GU-01.png
exon_skip_500520_STAD_TCGA-HU-A4GU-01.png

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
KARPAS1106P_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	135511265	135511485	135511415	135511416	Frame_Shift_Del	AG	-	p.R153fs
L428_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	135516886	135517055	135516992	135516993	Frame_Shift_Ins	-	C	p.S353fs
L428_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	135516886	135517140	135516992	135516993	Frame_Shift_Ins	-	C	p.S353fs
MELJUSO_SKIN	135515494	135515589	135515543	135515543	Missense_Mutation	T	C	p.L298S
MELJUSO_SKIN	135515494	135515598	135515543	135515543	Missense_Mutation	T	C	p.L298S
HCC827_LUNG	135515494	135515589	135515550	135515550	Missense_Mutation	G	C	p.L300F
HCC827_LUNG	135515494	135515598	135515550	135515550	Missense_Mutation	G	C	p.L300F
NCIBL1395_MATCHED_NORMAL_TISSUE	135516886	135517055	135516899	135516899	Missense_Mutation	C	G	p.T321R
NCIBL1395_MATCHED_NORMAL_TISSUE	135516886	135517140	135516899	135516899	Missense_Mutation	C	G	p.T321R
VAL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	135516886	135517055	135516907	135516907	Missense_Mutation	T	C	p.Y324H
VAL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	135516886	135517140	135516907	135516907	Missense_Mutation	T	C	p.Y324H
SBC5_LUNG	135516886	135517055	135516911	135516911	Missense_Mutation	C	G	p.P325R
SBC5_LUNG	135516886	135517140	135516911	135516911	Missense_Mutation	C	G	p.P325R
KON_UPPER_AERODIGESTIVE_TRACT	135516886	135517055	135517025	135517025	Missense_Mutation	C	G	p.S363C
KON_UPPER_AERODIGESTIVE_TRACT	135516886	135517140	135517025	135517025	Missense_Mutation	C	G	p.S363C
CMLT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	135516886	135517140	135517137	135517137	Missense_Mutation	T	G	p.D400E
SN12C_KIDNEY	135522777	135522887	135522784	135522784	Missense_Mutation	C	T	p.S532F
HEC251_ENDOMETRIUM	135522777	135522887	135522802	135522802	Missense_Mutation	G	A	p.G538E
OVCAR4_OVARY	135522777	135522887	135522849	135522849	Missense_Mutation	C	A	p.Q554K
SNU1040_LARGE_INTESTINE	135522777	135522887	135522887	135522887	Splice_Site	G	A	p.P566P

Top

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MYB

sQTL information located at the skipped exons.

Exon skip ID	Chromosome	Three exons	Skippped exon	ENST	Cancer type	SNP id	Location	DNA change (ref/var)	P-value
exon_skip_454439	6	135522776:135522887:135523551:135523807:135524354:135524462	135523551:135523807	ENST00000367812.2	LAML	rs7762830	chr6:135523774	A/G	9.19e-07
exon_skip_454439	6	135522776:135522887:135523551:135523807:135524354:135524462	135523551:135523807	ENST00000367812.2	LAML	rs7744765	chr6:135523583	T/C	9.26e-07
exon_skip_454439	6	135522776:135522887:135523551:135523807:135524354:135524462	135523551:135523807	ENST00000367812.2	THCA	rs7744765	chr6:135523583	T/C	3.59e-03

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MYB

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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MYB

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RelatedDrugs for MYB

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for MYB

Diseases associated with this gene.
(DisGeNet 4.0)

Gene	Disease ID	Disease name	# pubmeds	Source
MYB	C0010606	Adenoid Cystic Carcinoma	2	CTD_human
MYB	C0017638	Glioma	2	CTD_human
MYB	C0004096	Asthma	1	CTD_human
MYB	C1961099	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	1	CTD_human

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in TCGA
	Exon skipping events with PSIs in GTEx
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	SNVs in the skipped exons with depth of coverage
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Splicing Quantitative Trait Methylation (sQTM) in the skipped exon
	Related drugs with this gene
	Related diseases with this gene

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