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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for TRIM37 |
 Gene summary |
| Gene information | Gene symbol | TRIM37 | Gene ID | 4591 |
| Gene name | tripartite motif containing 37 | |
| Synonyms | MUL|POB1|TEF3 | |
| Cytomap | 17q22 | |
| Type of gene | protein-coding | |
| Description | E3 ubiquitin-protein ligase TRIM37RING-B-box-coiled-coil proteinRING-type E3 ubiquitin transferase TRIM37mulibrey nanism protein | |
| Modification date | 20180522 | |
| UniProtAcc | O94972 | |
| Context | PubMed: TRIM37 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TRIM37 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 25470042 |
| TRIM37 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 11279055 |
| TRIM37 | GO:0035518 | histone H2A monoubiquitination | 25470042 |
| TRIM37 | GO:0036353 | histone H2A-K119 monoubiquitination | 25470042 |
| TRIM37 | GO:0051091 | positive regulation of DNA binding transcription factor activity | 23077300 |
| TRIM37 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 23077300 |
| TRIM37 | GO:0051865 | protein autoubiquitination | 15885686 |
| TRIM37 | GO:0070842 | aggresome assembly | 15885686 |
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Exon skipping events across known transcript of Ensembl for TRIM37 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for TRIM37 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for TRIM37 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_291925 | 17 | 57060011:57060282:57076741:57076820:57089688:57089768 | 57076741:57076820 | ENSG00000108395.9 | ENST00000583945.1 |
| exon_skip_291926 | 17 | 57076741:57076820:57078958:57079075:57089688:57089768 | 57078958:57079075 | ENSG00000108395.9 | ENST00000262294.7,ENST00000393065.2,ENST00000393066.3 |
| exon_skip_291928 | 17 | 57076741:57076820:57078958:57079102:57089688:57089768 | 57078958:57079102 | ENSG00000108395.9 | ENST00000585287.1 |
| exon_skip_291930 | 17 | 57076741:57076820:57089688:57089807:57092970:57092978 | 57089688:57089807 | ENSG00000108395.9 | ENST00000376149.3,ENST00000577554.1 |
| exon_skip_291931 | 17 | 57078958:57079075:57089688:57089807:57092970:57092978 | 57089688:57089807 | ENSG00000108395.9 | ENST00000262294.7,ENST00000393065.2,ENST00000393066.3 |
| exon_skip_291933 | 17 | 57089688:57089807:57092970:57093160:57094656:57094785 | 57092970:57093160 | ENSG00000108395.9 | ENST00000262294.7,ENST00000376149.3,ENST00000393065.2,ENST00000577554.1,ENST00000393066.3 |
| exon_skip_291936 | 17 | 57092970:57093160:57094656:57094785:57105775:57105940 | 57094656:57094785 | ENSG00000108395.9 | ENST00000262294.7,ENST00000376149.3,ENST00000393065.2,ENST00000577554.1,ENST00000393066.3 |
| exon_skip_291938 | 17 | 57094656:57094785:57105775:57106084:57109256:57109451 | 57105775:57106084 | ENSG00000108395.9 | ENST00000262294.7,ENST00000376149.3,ENST00000393065.2,ENST00000577554.1,ENST00000393066.3 |
| exon_skip_291940 | 17 | 57105775:57106084:57109256:57109451:57119173:57119259 | 57109256:57109451 | ENSG00000108395.9 | ENST00000262294.7,ENST00000376149.3,ENST00000393065.2,ENST00000577554.1,ENST00000393066.3 |
| exon_skip_291945 | 17 | 57125043:57125180:57126538:57126754:57128574:57128689 | 57126538:57126754 | ENSG00000108395.9 | ENST00000262294.7,ENST00000376149.3,ENST00000393065.2,ENST00000577554.1,ENST00000393066.3 |
| exon_skip_291946 | 17 | 57128574:57128689:57134235:57134415:57138392:57138469 | 57134235:57134415 | ENSG00000108395.9 | ENST00000262294.7,ENST00000376149.3,ENST00000393065.2,ENST00000577554.1,ENST00000393066.3 |
| exon_skip_291948 | 17 | 57139927:57140009:57141715:57141766:57148183:57148245 | 57141715:57141766 | ENSG00000108395.9 | ENST00000262294.7,ENST00000376149.3,ENST00000393065.2,ENST00000581468.1,ENST00000577554.1,ENST00000393066.3 |
| exon_skip_291953 | 17 | 57148183:57148308:57150454:57150502:57153007:57153070 | 57150454:57150502 | ENSG00000108395.9 | ENST00000581468.1 |
| exon_skip_291956 | 17 | 57148183:57148308:57153007:57153075:57157114:57157168 | 57153007:57153075 | ENSG00000108395.9 | ENST00000262294.7,ENST00000376149.3,ENST00000582852.1,ENST00000393065.2,ENST00000577554.1,ENST00000393066.3 |
| exon_skip_291961 | 17 | 57157158:57157238:57158457:57158580:57165651:57165768 | 57158457:57158580 | ENSG00000108395.9 | ENST00000580122.1 |
| exon_skip_291964 | 17 | 57158457:57158580:57161362:57161450:57165651:57165768 | 57161362:57161450 | ENSG00000108395.9 | ENST00000262294.7,ENST00000376149.3,ENST00000393065.2,ENST00000577554.1,ENST00000393066.3 |
| exon_skip_291965 | 17 | 57161362:57161450:57165651:57165768:57168660:57168701 | 57165651:57165768 | ENSG00000108395.9 | ENST00000262294.7,ENST00000376149.3,ENST00000393065.2,ENST00000393066.3 |
| exon_skip_291967 | 17 | 57165651:57165768:57167377:57167453:57168660:57168701 | 57167377:57167453 | ENSG00000108395.9 | ENST00000580620.1,ENST00000577554.1 |
| exon_skip_291969 | 17 | 57165651:57165768:57168660:57168701:57181653:57181755 | 57168660:57168701 | ENSG00000108395.9 | ENST00000262294.7,ENST00000584889.1,ENST00000376149.3,ENST00000583387.1,ENST00000393066.3,ENST00000580122.1 |
| exon_skip_291971 | 17 | 57168660:57168701:57181653:57181755:57183801:57183820 | 57181653:57181755 | ENSG00000108395.9 | ENST00000580620.1,ENST00000262294.7,ENST00000584889.1,ENST00000376149.3,ENST00000580973.1,ENST00000577554.1,ENST00000583387.1,ENST00000393066.3,ENST00000580122.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for TRIM37 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_291925 | 17 | 57060011:57060282:57076741:57076820:57089688:57089768 | 57076741:57076820 | ENSG00000108395.9 | ENST00000583945.1 |
| exon_skip_291926 | 17 | 57076741:57076820:57078958:57079075:57089688:57089768 | 57078958:57079075 | ENSG00000108395.9 | ENST00000393066.3,ENST00000262294.7,ENST00000393065.2 |
| exon_skip_291928 | 17 | 57076741:57076820:57078958:57079102:57089688:57089768 | 57078958:57079102 | ENSG00000108395.9 | ENST00000585287.1 |
| exon_skip_291930 | 17 | 57076741:57076820:57089688:57089807:57092970:57092978 | 57089688:57089807 | ENSG00000108395.9 | ENST00000577554.1,ENST00000376149.3 |
| exon_skip_291931 | 17 | 57078958:57079075:57089688:57089807:57092970:57092978 | 57089688:57089807 | ENSG00000108395.9 | ENST00000393066.3,ENST00000262294.7,ENST00000393065.2 |
| exon_skip_291933 | 17 | 57089688:57089807:57092970:57093160:57094656:57094785 | 57092970:57093160 | ENSG00000108395.9 | ENST00000393066.3,ENST00000577554.1,ENST00000262294.7,ENST00000376149.3,ENST00000393065.2 |
| exon_skip_291936 | 17 | 57092970:57093160:57094656:57094785:57105775:57105940 | 57094656:57094785 | ENSG00000108395.9 | ENST00000393066.3,ENST00000577554.1,ENST00000262294.7,ENST00000376149.3,ENST00000393065.2 |
| exon_skip_291938 | 17 | 57094656:57094785:57105775:57106084:57109256:57109451 | 57105775:57106084 | ENSG00000108395.9 | ENST00000393066.3,ENST00000577554.1,ENST00000262294.7,ENST00000376149.3,ENST00000393065.2 |
| exon_skip_291940 | 17 | 57105775:57106084:57109256:57109451:57119173:57119259 | 57109256:57109451 | ENSG00000108395.9 | ENST00000393066.3,ENST00000577554.1,ENST00000262294.7,ENST00000376149.3,ENST00000393065.2 |
| exon_skip_291945 | 17 | 57125043:57125180:57126538:57126754:57128574:57128689 | 57126538:57126754 | ENSG00000108395.9 | ENST00000393066.3,ENST00000577554.1,ENST00000262294.7,ENST00000376149.3,ENST00000393065.2 |
| exon_skip_291946 | 17 | 57128574:57128689:57134235:57134415:57138392:57138469 | 57134235:57134415 | ENSG00000108395.9 | ENST00000393066.3,ENST00000577554.1,ENST00000262294.7,ENST00000376149.3,ENST00000393065.2 |
| exon_skip_291948 | 17 | 57139927:57140009:57141715:57141766:57148183:57148245 | 57141715:57141766 | ENSG00000108395.9 | ENST00000393066.3,ENST00000577554.1,ENST00000262294.7,ENST00000376149.3,ENST00000393065.2,ENST00000581468.1 |
| exon_skip_291953 | 17 | 57148183:57148308:57150454:57150502:57153007:57153070 | 57150454:57150502 | ENSG00000108395.9 | ENST00000581468.1 |
| exon_skip_291956 | 17 | 57148183:57148308:57153007:57153075:57157114:57157168 | 57153007:57153075 | ENSG00000108395.9 | ENST00000393066.3,ENST00000577554.1,ENST00000262294.7,ENST00000376149.3,ENST00000393065.2,ENST00000582852.1 |
| exon_skip_291961 | 17 | 57157158:57157238:57158457:57158580:57165651:57165768 | 57158457:57158580 | ENSG00000108395.9 | ENST00000580122.1 |
| exon_skip_291964 | 17 | 57158457:57158580:57161362:57161450:57165651:57165768 | 57161362:57161450 | ENSG00000108395.9 | ENST00000393066.3,ENST00000577554.1,ENST00000262294.7,ENST00000376149.3,ENST00000393065.2 |
| exon_skip_291965 | 17 | 57161362:57161450:57165651:57165768:57168660:57168701 | 57165651:57165768 | ENSG00000108395.9 | ENST00000393066.3,ENST00000262294.7,ENST00000376149.3,ENST00000393065.2 |
| exon_skip_291967 | 17 | 57165651:57165768:57167377:57167453:57168660:57168701 | 57167377:57167453 | ENSG00000108395.9 | ENST00000577554.1,ENST00000580620.1 |
| exon_skip_291969 | 17 | 57165651:57165768:57168660:57168701:57181653:57181755 | 57168660:57168701 | ENSG00000108395.9 | ENST00000393066.3,ENST00000262294.7,ENST00000376149.3,ENST00000580122.1,ENST00000583387.1,ENST00000584889.1 |
| exon_skip_291971 | 17 | 57168660:57168701:57181653:57181755:57183801:57183820 | 57181653:57181755 | ENSG00000108395.9 | ENST00000393066.3,ENST00000577554.1,ENST00000262294.7,ENST00000376149.3,ENST00000580973.1,ENST00000580122.1,ENST00000580620.1,ENST00000583387.1,ENST00000584889.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for TRIM37 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000262294 | 57089688 | 57089807 | Frame-shift |
| ENST00000393066 | 57089688 | 57089807 | Frame-shift |
| ENST00000262294 | 57092970 | 57093160 | Frame-shift |
| ENST00000393066 | 57092970 | 57093160 | Frame-shift |
| ENST00000262294 | 57153007 | 57153075 | Frame-shift |
| ENST00000393066 | 57153007 | 57153075 | Frame-shift |
| ENST00000262294 | 57161362 | 57161450 | Frame-shift |
| ENST00000393066 | 57161362 | 57161450 | Frame-shift |
| ENST00000262294 | 57168660 | 57168701 | Frame-shift |
| ENST00000393066 | 57168660 | 57168701 | Frame-shift |
| ENST00000262294 | 57078958 | 57079075 | In-frame |
| ENST00000393066 | 57078958 | 57079075 | In-frame |
| ENST00000262294 | 57094656 | 57094785 | In-frame |
| ENST00000393066 | 57094656 | 57094785 | In-frame |
| ENST00000262294 | 57105775 | 57106084 | In-frame |
| ENST00000393066 | 57105775 | 57106084 | In-frame |
| ENST00000262294 | 57109256 | 57109451 | In-frame |
| ENST00000393066 | 57109256 | 57109451 | In-frame |
| ENST00000262294 | 57126538 | 57126754 | In-frame |
| ENST00000393066 | 57126538 | 57126754 | In-frame |
| ENST00000262294 | 57134235 | 57134415 | In-frame |
| ENST00000393066 | 57134235 | 57134415 | In-frame |
| ENST00000262294 | 57141715 | 57141766 | In-frame |
| ENST00000393066 | 57141715 | 57141766 | In-frame |
| ENST00000262294 | 57165651 | 57165768 | In-frame |
| ENST00000393066 | 57165651 | 57165768 | In-frame |
| ENST00000262294 | 57181653 | 57181755 | In-frame |
| ENST00000393066 | 57181653 | 57181755 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000262294 | 57089688 | 57089807 | Frame-shift |
| ENST00000393066 | 57089688 | 57089807 | Frame-shift |
| ENST00000262294 | 57092970 | 57093160 | Frame-shift |
| ENST00000393066 | 57092970 | 57093160 | Frame-shift |
| ENST00000262294 | 57153007 | 57153075 | Frame-shift |
| ENST00000393066 | 57153007 | 57153075 | Frame-shift |
| ENST00000262294 | 57161362 | 57161450 | Frame-shift |
| ENST00000393066 | 57161362 | 57161450 | Frame-shift |
| ENST00000262294 | 57168660 | 57168701 | Frame-shift |
| ENST00000393066 | 57168660 | 57168701 | Frame-shift |
| ENST00000262294 | 57078958 | 57079075 | In-frame |
| ENST00000393066 | 57078958 | 57079075 | In-frame |
| ENST00000262294 | 57094656 | 57094785 | In-frame |
| ENST00000393066 | 57094656 | 57094785 | In-frame |
| ENST00000262294 | 57105775 | 57106084 | In-frame |
| ENST00000393066 | 57105775 | 57106084 | In-frame |
| ENST00000262294 | 57109256 | 57109451 | In-frame |
| ENST00000393066 | 57109256 | 57109451 | In-frame |
| ENST00000262294 | 57126538 | 57126754 | In-frame |
| ENST00000393066 | 57126538 | 57126754 | In-frame |
| ENST00000262294 | 57134235 | 57134415 | In-frame |
| ENST00000393066 | 57134235 | 57134415 | In-frame |
| ENST00000262294 | 57141715 | 57141766 | In-frame |
| ENST00000393066 | 57141715 | 57141766 | In-frame |
| ENST00000262294 | 57165651 | 57165768 | In-frame |
| ENST00000393066 | 57165651 | 57165768 | In-frame |
| ENST00000262294 | 57181653 | 57181755 | In-frame |
| ENST00000393066 | 57181653 | 57181755 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TRIM37 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000262294 | 4347 | 964 | 57181653 | 57181755 | 282 | 383 | 7 | 41 |
| ENST00000393066 | 3639 | 964 | 57181653 | 57181755 | 482 | 583 | 7 | 41 |
| ENST00000262294 | 4347 | 964 | 57165651 | 57165768 | 425 | 541 | 55 | 93 |
| ENST00000393066 | 3639 | 964 | 57165651 | 57165768 | 625 | 741 | 55 | 93 |
| ENST00000262294 | 4347 | 964 | 57141715 | 57141766 | 1070 | 1120 | 270 | 286 |
| ENST00000393066 | 3639 | 964 | 57141715 | 57141766 | 1270 | 1320 | 270 | 286 |
| ENST00000262294 | 4347 | 964 | 57134235 | 57134415 | 1280 | 1459 | 340 | 399 |
| ENST00000393066 | 3639 | 964 | 57134235 | 57134415 | 1480 | 1659 | 340 | 399 |
| ENST00000262294 | 4347 | 964 | 57126538 | 57126754 | 1575 | 1790 | 438 | 510 |
| ENST00000393066 | 3639 | 964 | 57126538 | 57126754 | 1775 | 1990 | 438 | 510 |
| ENST00000262294 | 4347 | 964 | 57109256 | 57109451 | 2014 | 2208 | 584 | 649 |
| ENST00000393066 | 3639 | 964 | 57109256 | 57109451 | 2214 | 2408 | 584 | 649 |
| ENST00000262294 | 4347 | 964 | 57105775 | 57106084 | 2209 | 2517 | 649 | 752 |
| ENST00000393066 | 3639 | 964 | 57105775 | 57106084 | 2409 | 2717 | 649 | 752 |
| ENST00000262294 | 4347 | 964 | 57094656 | 57094785 | 2518 | 2646 | 752 | 795 |
| ENST00000393066 | 3639 | 964 | 57094656 | 57094785 | 2718 | 2846 | 752 | 795 |
| ENST00000262294 | 4347 | 964 | 57078958 | 57079075 | 2956 | 3072 | 898 | 937 |
| ENST00000393066 | 3639 | 964 | 57078958 | 57079075 | 3156 | 3272 | 898 | 937 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000262294 | 4347 | 964 | 57181653 | 57181755 | 282 | 383 | 7 | 41 |
| ENST00000393066 | 3639 | 964 | 57181653 | 57181755 | 482 | 583 | 7 | 41 |
| ENST00000262294 | 4347 | 964 | 57165651 | 57165768 | 425 | 541 | 55 | 93 |
| ENST00000393066 | 3639 | 964 | 57165651 | 57165768 | 625 | 741 | 55 | 93 |
| ENST00000262294 | 4347 | 964 | 57141715 | 57141766 | 1070 | 1120 | 270 | 286 |
| ENST00000393066 | 3639 | 964 | 57141715 | 57141766 | 1270 | 1320 | 270 | 286 |
| ENST00000262294 | 4347 | 964 | 57134235 | 57134415 | 1280 | 1459 | 340 | 399 |
| ENST00000393066 | 3639 | 964 | 57134235 | 57134415 | 1480 | 1659 | 340 | 399 |
| ENST00000262294 | 4347 | 964 | 57126538 | 57126754 | 1575 | 1790 | 438 | 510 |
| ENST00000393066 | 3639 | 964 | 57126538 | 57126754 | 1775 | 1990 | 438 | 510 |
| ENST00000262294 | 4347 | 964 | 57109256 | 57109451 | 2014 | 2208 | 584 | 649 |
| ENST00000393066 | 3639 | 964 | 57109256 | 57109451 | 2214 | 2408 | 584 | 649 |
| ENST00000262294 | 4347 | 964 | 57105775 | 57106084 | 2209 | 2517 | 649 | 752 |
| ENST00000393066 | 3639 | 964 | 57105775 | 57106084 | 2409 | 2717 | 649 | 752 |
| ENST00000262294 | 4347 | 964 | 57094656 | 57094785 | 2518 | 2646 | 752 | 795 |
| ENST00000393066 | 3639 | 964 | 57094656 | 57094785 | 2718 | 2846 | 752 | 795 |
| ENST00000262294 | 4347 | 964 | 57078958 | 57079075 | 2956 | 3072 | 898 | 937 |
| ENST00000393066 | 3639 | 964 | 57078958 | 57079075 | 3156 | 3272 | 898 | 937 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for TRIM37 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
TRIM37_COAD_exon_skip_291928_psi_boxplot.png |
TRIM37_KIRP_exon_skip_291928_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| COAD | TCGA-AD-5900-01 | exon_skip_291926 | 57078959 | 57079075 | 57078967 | 57078967 | Frame_Shift_Del | G | - | p.P935fs |
| COAD | TCGA-AD-5900-01 | exon_skip_291928 | 57078959 | 57079102 | 57078967 | 57078967 | Frame_Shift_Del | G | - | p.P935fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_291926 | 57078959 | 57079075 | 57078967 | 57078967 | Frame_Shift_Del | G | - | p.P935fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_291928 | 57078959 | 57079102 | 57078967 | 57078967 | Frame_Shift_Del | G | - | p.P935fs |
| KIRP | TCGA-A4-8515-01 | exon_skip_291926 | 57078959 | 57079075 | 57078973 | 57078974 | Frame_Shift_Del | TG | - | p.933_933del |
| KIRP | TCGA-A4-8515-01 | exon_skip_291926 | 57078959 | 57079075 | 57078973 | 57078974 | Frame_Shift_Del | TG | - | p.Q933fs |
| KIRP | TCGA-A4-8515-01 | exon_skip_291928 | 57078959 | 57079102 | 57078973 | 57078974 | Frame_Shift_Del | TG | - | p.933_933del |
| KIRP | TCGA-A4-8515-01 | exon_skip_291928 | 57078959 | 57079102 | 57078973 | 57078974 | Frame_Shift_Del | TG | - | p.Q933fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_291933 | 57092971 | 57093160 | 57092993 | 57092993 | Frame_Shift_Del | T | - | p.R731fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_291933 | 57092971 | 57093160 | 57093074 | 57093074 | Frame_Shift_Del | T | - | p.T703fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_291936 | 57094657 | 57094785 | 57094695 | 57094695 | Frame_Shift_Del | T | - | p.N661fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_291938 | 57105776 | 57106084 | 57105995 | 57105995 | Frame_Shift_Del | T | - | p.T558fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_291938 | 57105776 | 57106084 | 57106004 | 57106004 | Frame_Shift_Del | T | - | p.R555fs |
| STAD | TCGA-BR-8483-01 | exon_skip_291940 | 57109257 | 57109451 | 57109355 | 57109364 | Frame_Shift_Del | AATGGATCAA | - | p.614_617del |
| STAD | TCGA-BR-8483-01 | exon_skip_291940 | 57109257 | 57109451 | 57109355 | 57109364 | Frame_Shift_Del | AATGGATCAA | - | p.I614fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_291945 | 57126539 | 57126754 | 57126682 | 57126682 | Frame_Shift_Del | G | - | p.Q341fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_291945 | 57126539 | 57126754 | 57126682 | 57126682 | Frame_Shift_Del | G | - | p.Q341fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_291946 | 57134236 | 57134415 | 57134293 | 57134293 | Frame_Shift_Del | A | - | p.L259fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_291946 | 57134236 | 57134415 | 57134299 | 57134299 | Frame_Shift_Del | A | - | p.F257fs |
| STAD | TCGA-BR-7851-01 | exon_skip_291946 | 57134236 | 57134415 | 57134362 | 57134362 | Frame_Shift_Del | T | - | p.N358fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_291971 | 57181654 | 57181755 | 57181707 | 57181707 | Frame_Shift_Del | C | - | p.D24fs |
| LIHC | TCGA-BC-A112-01 | exon_skip_291925 | 57076742 | 57076820 | 57076803 | 57076804 | Frame_Shift_Ins | - | A | p.*783fs |
| SKCM | TCGA-GF-A4EO-06 | exon_skip_291936 | 57094657 | 57094785 | 57094671 | 57094672 | Frame_Shift_Ins | - | GACA | p.D669fs |
| BLCA | TCGA-BT-A20J-01 | exon_skip_291931 exon_skip_291930 | 57089689 | 57089807 | 57089713 | 57089713 | Nonsense_Mutation | C | A | p.G769* |
| BLCA | TCGA-BT-A20J-01 | exon_skip_291931 exon_skip_291930 | 57089689 | 57089807 | 57089713 | 57089713 | Nonsense_Mutation | C | A | p.G891* |
| SKCM | TCGA-EE-A3JD-06 | exon_skip_291936 | 57094657 | 57094785 | 57094720 | 57094720 | Nonsense_Mutation | G | A | p.R653* |
| SKCM | TCGA-EE-A3JD-06 | exon_skip_291936 | 57094657 | 57094785 | 57094720 | 57094720 | Nonsense_Mutation | G | A | p.R775X |
| UCEC | TCGA-AP-A056-01 | exon_skip_291936 | 57094657 | 57094785 | 57094720 | 57094720 | Nonsense_Mutation | G | A | p.R775* |
| UCEC | TCGA-B5-A11E-01 | exon_skip_291936 | 57094657 | 57094785 | 57094720 | 57094720 | Nonsense_Mutation | G | A | p.R775* |
| UCEC | TCGA-AP-A0LM-01 | exon_skip_291938 | 57105776 | 57106084 | 57105821 | 57105821 | Nonsense_Mutation | C | A | p.E738* |
| STAD | TCGA-B7-5816-01 | exon_skip_291945 | 57126539 | 57126754 | 57126583 | 57126583 | Nonsense_Mutation | C | A | p.E496* |
| BRCA | TCGA-E9-A228-01 | exon_skip_291945 | 57126539 | 57126754 | 57126638 | 57126638 | Nonsense_Mutation | G | T | p.C477* |
| STAD | TCGA-BR-8363-01 | exon_skip_291945 | 57126539 | 57126754 | 57126658 | 57126658 | Nonsense_Mutation | G | A | p.R471* |
| STAD | TCGA-BR-8363-01 | exon_skip_291945 | 57126539 | 57126754 | 57126658 | 57126658 | Nonsense_Mutation | G | A | p.R471X |
| UCEC | TCGA-B5-A0JY-01 | exon_skip_291946 | 57134236 | 57134415 | 57134351 | 57134351 | Nonsense_Mutation | C | A | p.E362* |
| SKCM | TCGA-GN-A266-06 | exon_skip_291946 | 57134236 | 57134415 | 57134354 | 57134354 | Nonsense_Mutation | G | A | p.R239* |
| SKCM | TCGA-GN-A266-06 | exon_skip_291946 | 57134236 | 57134415 | 57134354 | 57134354 | Nonsense_Mutation | G | A | p.R361X |
| CESC | TCGA-Q1-A6DT-01 | exon_skip_291946 | 57134236 | 57134415 | 57134235 | 57134235 | Splice_Site | C | T | e13+1 |
| SKCM | TCGA-EE-A3JD-06 | exon_skip_291969 | 57168661 | 57168701 | 57168659 | 57168659 | Splice_Site | A | T | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-AD-5900-01 |
| Cancer type: COAD | |
| ESID: exon_skip_291928 | |
| Skipped exon start: 57078959 | |
| Skipped exon end: 57079102 | |
| Mutation start: 57078967 | |
| Mutation end: 57078967 | |
| Mutation type: Frame_Shift_Del | |
| Reference seq: G | |
| Mutation seq: - | |
| AAchange: p.P935fs | |
| Sample: TCGA-AD-5900-01 |
| Cancer type: COAD | |
| ESID: exon_skip_291926 | |
| Skipped exon start: 57078959 | |
| Skipped exon end: 57079075 | |
| Mutation start: 57078967 | |
| Mutation end: 57078967 | |
| Mutation type: Frame_Shift_Del | |
| Reference seq: G | |
| Mutation seq: - | |
| AAchange: p.P935fs | |
exon_skip_123601_COAD_TCGA-AD-5900-01.png | |
exon_skip_135806_COAD_TCGA-AD-5900-01.png | |
exon_skip_146733_COAD_TCGA-AD-5900-01.png | |
exon_skip_291928_COAD_TCGA-AD-5900-01.png | |
exon_skip_303809_COAD_TCGA-AD-5900-01.png | |
exon_skip_315782_COAD_TCGA-AD-5900-01.png | |
exon_skip_367235_COAD_TCGA-AD-5900-01.png | |
exon_skip_376149_COAD_TCGA-AD-5900-01.png | |
exon_skip_457524_COAD_TCGA-AD-5900-01.png | |
exon_skip_459148_COAD_TCGA-AD-5900-01.png | |
exon_skip_68768_COAD_TCGA-AD-5900-01.png | |
 | Sample: TCGA-A4-8515-01 |
| Cancer type: KIRP | |
| ESID: exon_skip_291928 | |
| Skipped exon start: 57078959 | |
| Skipped exon end: 57079102 | |
| Mutation start: 57078973 | |
| Mutation end: 57078974 | |
| Mutation type: Frame_Shift_Del | |
| Reference seq: TG | |
| Mutation seq: - | |
| AAchange: p.933_933del | |
| Sample: TCGA-A4-8515-01 |
| Cancer type: KIRP | |
| ESID: exon_skip_291926 | |
| Skipped exon start: 57078959 | |
| Skipped exon end: 57079075 | |
| Mutation start: 57078973 | |
| Mutation end: 57078974 | |
| Mutation type: Frame_Shift_Del | |
| Reference seq: TG | |
| Mutation seq: - | |
| AAchange: p.933_933del | |
| Sample: TCGA-A4-8515-01 |
| Cancer type: KIRP | |
| ESID: exon_skip_291928 | |
| Skipped exon start: 57078959 | |
| Skipped exon end: 57079102 | |
| Mutation start: 57078973 | |
| Mutation end: 57078974 | |
| Mutation type: Frame_Shift_Del | |
| Reference seq: TG | |
| Mutation seq: - | |
| AAchange: p.Q933fs | |
| Sample: TCGA-A4-8515-01 |
| Cancer type: KIRP | |
| ESID: exon_skip_291926 | |
| Skipped exon start: 57078959 | |
| Skipped exon end: 57079075 | |
| Mutation start: 57078973 | |
| Mutation end: 57078974 | |
| Mutation type: Frame_Shift_Del | |
| Reference seq: TG | |
| Mutation seq: - | |
| AAchange: p.Q933fs | |
exon_skip_291928_KIRP_TCGA-A4-8515-01.png | |
exon_skip_67402_KIRP_TCGA-A4-8515-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| AMO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 57089689 | 57089807 | 57089751 | 57089751 | Frame_Shift_Del | T | - | p.N878fs |
| RMUGS_OVARY | 57092971 | 57093160 | 57093049 | 57093049 | Frame_Shift_Del | A | - | p.L833fs |
| IM95_STOMACH | 57126539 | 57126754 | 57126678 | 57126678 | Frame_Shift_Del | T | - | p.N464fs |
| EN_ENDOMETRIUM | 57134236 | 57134415 | 57134361 | 57134362 | Frame_Shift_Ins | - | T | p.N358fs |
| SNU1040_LARGE_INTESTINE | 57076742 | 57076820 | 57076815 | 57076815 | Missense_Mutation | G | A | p.H940Y |
| CW2_LARGE_INTESTINE | 57078959 | 57079102 | 57078967 | 57078967 | Missense_Mutation | G | C | p.P935R |
| CW2_LARGE_INTESTINE | 57078959 | 57079075 | 57078967 | 57078967 | Missense_Mutation | G | C | p.P935R |
| AN3CA_ENDOMETRIUM | 57078959 | 57079102 | 57079007 | 57079007 | Missense_Mutation | C | A | p.G922C |
| AN3CA_ENDOMETRIUM | 57078959 | 57079075 | 57079007 | 57079007 | Missense_Mutation | C | A | p.G922C |
| SCMCRM2_SOFT_TISSUE | 57089689 | 57089807 | 57089761 | 57089761 | Missense_Mutation | A | C | p.L875V |
| GP2D_LARGE_INTESTINE | 57089689 | 57089807 | 57089766 | 57089766 | Missense_Mutation | G | A | p.T873I |
| GP5D_LARGE_INTESTINE | 57089689 | 57089807 | 57089766 | 57089766 | Missense_Mutation | G | A | p.T873I |
| WM88_SKIN | 57092971 | 57093160 | 57092982 | 57092982 | Missense_Mutation | C | T | p.M855I |
| COLO668_LUNG | 57092971 | 57093160 | 57093064 | 57093064 | Missense_Mutation | C | A | p.R828L |
| HCC1569_BREAST | 57092971 | 57093160 | 57093119 | 57093119 | Missense_Mutation | G | A | p.P810S |
| MCC13_SKIN | 57094657 | 57094785 | 57094690 | 57094691 | Missense_Mutation | GA | AG | p.R785C |
| MCC13_SKIN | 57094657 | 57094785 | 57094690 | 57094690 | Missense_Mutation | G | A | p.R785C |
| MDST8_LARGE_INTESTINE | 57105776 | 57106084 | 57105781 | 57105781 | Missense_Mutation | C | A | p.R751L |
| CORL47_LUNG | 57105776 | 57106084 | 57105805 | 57105805 | Missense_Mutation | G | A | p.S743L |
| TGBC11TKB_STOMACH | 57105776 | 57106084 | 57105896 | 57105896 | Missense_Mutation | G | A | p.L713F |
| NUGC3_STOMACH | 57105776 | 57106084 | 57105947 | 57105947 | Missense_Mutation | G | C | p.L696V |
| SNU449_LIVER | 57105776 | 57106084 | 57105952 | 57105952 | Missense_Mutation | T | C | p.N694S |
| HCC2998_LARGE_INTESTINE | 57105776 | 57106084 | 57105966 | 57105966 | Missense_Mutation | T | G | p.K689N |
| NCIH630_LARGE_INTESTINE | 57109257 | 57109451 | 57109259 | 57109259 | Missense_Mutation | G | A | p.T649I |
| FU97_STOMACH | 57109257 | 57109451 | 57109323 | 57109323 | Missense_Mutation | G | A | p.R628W |
| CA922_UPPER_AERODIGESTIVE_TRACT | 57109257 | 57109451 | 57109431 | 57109431 | Missense_Mutation | C | G | p.G592R |
| HCT15_LARGE_INTESTINE | 57109257 | 57109451 | 57109445 | 57109445 | Missense_Mutation | C | T | p.S587N |
| HRT18_LARGE_INTESTINE | 57109257 | 57109451 | 57109445 | 57109445 | Missense_Mutation | C | T | p.S587N |
| NCIH1385_LUNG | 57126539 | 57126754 | 57126574 | 57126574 | Missense_Mutation | C | T | p.E499K |
| NCIH2126_LUNG | 57126539 | 57126754 | 57126579 | 57126579 | Missense_Mutation | T | A | p.D497V |
| ISHIKAWAHERAKLIO02ER_ENDOMETRIUM | 57126539 | 57126754 | 57126675 | 57126675 | Missense_Mutation | T | A | p.D465V |
| ESS1_ENDOMETRIUM | 57126539 | 57126754 | 57126732 | 57126732 | Missense_Mutation | C | T | p.R446Q |
| HEC108_ENDOMETRIUM | 57134236 | 57134415 | 57134303 | 57134303 | Missense_Mutation | A | C | p.F378V |
| BCP1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 57153008 | 57153075 | 57153016 | 57153016 | Missense_Mutation | C | T | p.E226K |
| SNU46_UPPER_AERODIGESTIVE_TRACT | 57158458 | 57158580 | 57158493 | 57158493 | Missense_Mutation | G | A | p.R153C |
| COLO684_ENDOMETRIUM | 57158458 | 57158580 | 57158495 | 57158495 | Missense_Mutation | C | T | p.R152Q |
| COLO704_OVARY | 57158458 | 57158580 | 57158495 | 57158495 | Missense_Mutation | C | T | p.R152Q |
| SKRC20_KIDNEY | 57158458 | 57158580 | 57158498 | 57158498 | Missense_Mutation | C | T | p.R151H |
| U87MG_CENTRAL_NERVOUS_SYSTEM | 57158458 | 57158580 | 57158519 | 57158519 | Missense_Mutation | T | C | p.N144S |
| OE33_OESOPHAGUS | 57161363 | 57161450 | 57161406 | 57161406 | Missense_Mutation | C | G | p.C109S |
| SNU685_ENDOMETRIUM | 57161363 | 57161450 | 57161411 | 57161412 | Missense_Mutation | CC | AG | p.W107S |
| SNU685_ENDOMETRIUM | 57161363 | 57161450 | 57161411 | 57161411 | Missense_Mutation | C | A | p.W107C |
| SNU685_ENDOMETRIUM | 57161363 | 57161450 | 57161412 | 57161412 | Missense_Mutation | C | G | p.W107S |
| SARC9371_BONE | 57165652 | 57165768 | 57165671 | 57165671 | Missense_Mutation | C | T | p.E88K |
| ZR7530_BREAST | 57181654 | 57181755 | 57181663 | 57181663 | Missense_Mutation | G | T | p.S38R |
| HEC1_ENDOMETRIUM | 57181654 | 57181755 | 57181700 | 57181700 | Missense_Mutation | C | T | p.R26H |
| MDAMB157_BREAST | 57181654 | 57181755 | 57181718 | 57181718 | Missense_Mutation | T | C | p.E20G |
| HEC265_ENDOMETRIUM | 57181654 | 57181755 | 57181727 | 57181727 | Missense_Mutation | A | G | p.I17T |
| HCC2998_LARGE_INTESTINE | 57105776 | 57106084 | 57105805 | 57105805 | Nonsense_Mutation | G | T | p.S743* |
| GCIY_STOMACH | 57105776 | 57106084 | 57105941 | 57105941 | Nonsense_Mutation | C | A | p.E698* |
| CHP126_AUTONOMIC_GANGLIA | 57105776 | 57106084 | 57106034 | 57106034 | Nonsense_Mutation | G | A | p.R667* |
| CORL24_LUNG | 57109257 | 57109451 | 57109355 | 57109355 | Nonsense_Mutation | A | T | p.L617* |
| L540_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 57109257 | 57109451 | 57109412 | 57109412 | Nonsense_Mutation | G | C | p.S598* |
| NCIH2110_LUNG | 57109257 | 57109451 | 57109419 | 57109419 | Nonsense_Mutation | T | A | p.R596* |
| EFM19_BREAST | 57161363 | 57161450 | 57161434 | 57161434 | Nonsense_Mutation | C | A | p.E100* |
| HT115_LARGE_INTESTINE | 57165652 | 57165768 | 57165668 | 57165668 | Nonsense_Mutation | C | A | p.E89* |
| M07E_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 57181654 | 57181755 | 57181655 | 57181655 | Splice_Site | C | T | p.R41K |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TRIM37 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TRIM37 |
Top |
Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TRIM37 |
Top |
RelatedDrugs for TRIM37 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRIM37 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| TRIM37 | C0524582 | Mulibrey Nanism | 4 | CTD_human;ORPHANET;UNIPROT |
| TRIM37 | C0016063 | Osteitis Fibrosa Disseminata | 1 | CTD_human |
| TRIM37 | C0019209 | Hepatomegaly | 1 | CTD_human;HPO |
| TRIM37 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
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