ExonSkipDB: functional annotation of exon skipping event in human

Gene summary for MST1R

Gene summary

Gene information	Gene symbol	MST1R
	Gene ID	4486
	Gene name	macrophage stimulating 1 receptor
	Synonyms	CD136\|CDw136\|NPCA3\|PTK8\|RON
	Cytomap	3p21.31
	Type of gene	protein-coding
	Description	macrophage-stimulating protein receptorMSP receptorPTK8 protein tyrosine kinase 8c-met-related tyrosine kinasep185-Ron
	Modification date	20180523
	UniProtAcc	Q04912
	Context	PubMed: MST1R [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
MST1R	GO:0009615	response to virus	12676986
MST1R	GO:0043406	positive regulation of MAP kinase activity	12676986
MST1R	GO:0051897	positive regulation of protein kinase B signaling	12676986

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Exon skipping events across known transcript of Ensembl for MST1R from UCSC genome browser

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Gene isoform structures and expression levels for MST1R

Expression levels of gene isoforms across TCGA.

Expression levels of gene isoforms across GTEx.

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Exon skipping events with PSIs in TCGA for MST1R

Information of exkip skipping event in TCGA.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_384461	3	49924597:49924995:49927356:49927493:49927917:49928083	49927356:49927493	ENSG00000164078.8	ENST00000411578.2,ENST00000296474.3,ENST00000344206.4
exon_skip_384468	3	49928629:49928739:49928831:49929013:49929190:49929271	49928831:49929013	ENSG00000164078.8	ENST00000463789.1,ENST00000411578.2,ENST00000296474.3,ENST00000434765.1,ENST00000440292.1,ENST00000344206.4
exon_skip_384470	3	49929203:49929271:49932599:49932806:49932879:49932981	49932599:49932806	ENSG00000164078.8	ENST00000296474.3,ENST00000344206.4
exon_skip_384479	3	49929203:49929271:49932879:49932981:49933147:49933249	49932879:49932981	ENSG00000164078.8	ENST00000434765.1
exon_skip_384481	3	49932663:49932806:49932879:49932981:49933147:49933249	49932879:49932981	ENSG00000164078.8	ENST00000296474.3,ENST00000344206.4
exon_skip_384487	3	49933300:49933313:49933393:49933540:49933627:49933837	49933393:49933540	ENSG00000164078.8	ENST00000411578.2,ENST00000296474.3
exon_skip_384490	3	49933972:49934066:49934161:49934323:49934712:49934849	49934161:49934323	ENSG00000164078.8	ENST00000411578.2,ENST00000468525.1,ENST00000296474.3,ENST00000344206.4
exon_skip_384492	3	49934712:49934849:49934952:49935118:49935483:49935644	49934952:49935118	ENSG00000164078.8	ENST00000411578.2,ENST00000468525.1,ENST00000296474.3,ENST00000344206.4
exon_skip_384502	3	49935950:49936121:49936299:49936428:49936507:49936696	49936299:49936428	ENSG00000164078.8	ENST00000485044.1,ENST00000411578.2,ENST00000468525.1,ENST00000296474.3,ENST00000344206.4
exon_skip_384505	3	49936299:49936428:49936507:49936696:49939812:49941042	49936507:49936696	ENSG00000164078.8	ENST00000485044.1,ENST00000411578.2,ENST00000468525.1,ENST00000344206.4

PSI values of skipped exons in TCGA.

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Exon skipping events with PSIs in GTEx for MST1R

Information of exkip skipping event in GTEx

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_384461	3	49924597:49924995:49927356:49927493:49927917:49928083	49927356:49927493	ENSG00000164078.8	ENST00000296474.3,ENST00000411578.2,ENST00000344206.4
exon_skip_384468	3	49928629:49928739:49928831:49929013:49929190:49929271	49928831:49929013	ENSG00000164078.8	ENST00000296474.3,ENST00000411578.2,ENST00000344206.4,ENST00000434765.1,ENST00000440292.1,ENST00000463789.1
exon_skip_384470	3	49929203:49929271:49932599:49932806:49932879:49932981	49932599:49932806	ENSG00000164078.8	ENST00000296474.3,ENST00000344206.4
exon_skip_384474	3	49929203:49929271:49932599:49932829:49933147:49933313	49932599:49932829	ENSG00000164078.8	ENST00000411578.2
exon_skip_384479	3	49929203:49929271:49932879:49932981:49933147:49933249	49932879:49932981	ENSG00000164078.8	ENST00000434765.1
exon_skip_384481	3	49932663:49932806:49932879:49932981:49933147:49933249	49932879:49932981	ENSG00000164078.8	ENST00000296474.3,ENST00000344206.4
exon_skip_384487	3	49933300:49933313:49933393:49933540:49933627:49933837	49933393:49933540	ENSG00000164078.8	ENST00000296474.3,ENST00000411578.2
exon_skip_384490	3	49933972:49934066:49934161:49934323:49934712:49934849	49934161:49934323	ENSG00000164078.8	ENST00000296474.3,ENST00000411578.2,ENST00000344206.4,ENST00000468525.1
exon_skip_384492	3	49934712:49934849:49934952:49935118:49935483:49935644	49934952:49935118	ENSG00000164078.8	ENST00000296474.3,ENST00000411578.2,ENST00000344206.4,ENST00000468525.1
exon_skip_384502	3	49935950:49936121:49936299:49936428:49936507:49936696	49936299:49936428	ENSG00000164078.8	ENST00000296474.3,ENST00000411578.2,ENST00000344206.4,ENST00000468525.1,ENST00000485044.1
exon_skip_384505	3	49936299:49936428:49936507:49936696:49939812:49941042	49936507:49936696	ENSG00000164078.8	ENST00000411578.2,ENST00000344206.4,ENST00000468525.1,ENST00000485044.1

PSI values of skipped exons in GTEx.

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for MST1R

Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000296474	49927356	49927493	Frame-shift
ENST00000296474	49928831	49929013	Frame-shift
ENST00000296474	49934952	49935118	Frame-shift
ENST00000296474	49932599	49932806	In-frame
ENST00000296474	49932879	49932981	In-frame
ENST00000296474	49933393	49933540	In-frame
ENST00000296474	49934161	49934323	In-frame
ENST00000296474	49936299	49936428	In-frame

Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000296474	49927356	49927493	Frame-shift
ENST00000296474	49928831	49929013	Frame-shift
ENST00000296474	49934952	49935118	Frame-shift
ENST00000296474	49932599	49932806	In-frame
ENST00000296474	49932879	49932981	In-frame
ENST00000296474	49933393	49933540	In-frame
ENST00000296474	49934161	49934323	In-frame
ENST00000296474	49936299	49936428	In-frame

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Infer the effects of exon skipping event on protein functional features for MST1R

Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.

Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000296474	4553	1400	49936299	49936428	1448	1576	473	516
ENST00000296474	4553	1400	49934161	49934323	2212	2373	728	781
ENST00000296474	4553	1400	49933393	49933540	2678	2824	883	932
ENST00000296474	4553	1400	49932879	49932981	2991	3092	987	1021
ENST00000296474	4553	1400	49932599	49932806	3093	3299	1021	1090

Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000296474	4553	1400	49936299	49936428	1448	1576	473	516
ENST00000296474	4553	1400	49934161	49934323	2212	2373	728	781
ENST00000296474	4553	1400	49933393	49933540	2678	2824	883	932
ENST00000296474	4553	1400	49932879	49932981	2991	3092	987	1021
ENST00000296474	4553	1400	49932599	49932806	3093	3299	1021	1090

Lost protein functional features of individual exon skipping events in TCGA.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q04912	473	516	411	516	Alternative sequence	ID=VSP_038919;Note=In isoform RON-2 and isoform RON-5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18593464;Dbxref=PMID:18593464
Q04912	473	516	475	495	Alternative sequence	ID=VSP_038920;Note=In isoform RON-1. ELVRSLNYLLYVSNFSLGDSG->GPHPHSPLALGPCLHPHFAHI;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18593464;Dbxref=PMID:18593464
Q04912	473	516	496	1400	Alternative sequence	ID=VSP_038921;Note=In isoform RON-1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18593464;Dbxref=PMID:18593464
Q04912	473	516	469	475	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4FWW
Q04912	473	516	485	491	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4FWW
Q04912	473	516	503	505	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4FWW
Q04912	473	516	508	513	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4FWW
Q04912	473	516	516	521	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4FWW
Q04912	473	516	25	1400	Chain	ID=PRO_0000024452;Note=Macrophage-stimulating protein receptor
Q04912	473	516	310	1400	Chain	ID=PRO_0000024454;Note=Macrophage-stimulating protein receptor beta chain;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q04912	473	516	31	522	Domain	Note=Sema;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00352
Q04912	473	516	488	488	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:22848655;Dbxref=PMID:22848655
Q04912	473	516	504	504	Natural variant	ID=VAR_041773;Note=R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs34350470,PMID:17344846
Q04912	473	516	25	957	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q04912	728	781	496	1400	Alternative sequence	ID=VSP_038921;Note=In isoform RON-1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18593464;Dbxref=PMID:18593464
Q04912	728	781	648	1400	Alternative sequence	ID=VSP_038923;Note=In isoform RON-2 and isoform RON-4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18593464;Dbxref=PMID:18593464
Q04912	728	781	25	1400	Chain	ID=PRO_0000024452;Note=Macrophage-stimulating protein receptor
Q04912	728	781	310	1400	Chain	ID=PRO_0000024454;Note=Macrophage-stimulating protein receptor beta chain;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q04912	728	781	684	767	Domain	Note=IPT/TIG 2
Q04912	728	781	770	860	Domain	Note=IPT/TIG 3
Q04912	728	781	25	957	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q04912	883	932	496	1400	Alternative sequence	ID=VSP_038921;Note=In isoform RON-1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18593464;Dbxref=PMID:18593464
Q04912	883	932	648	1400	Alternative sequence	ID=VSP_038923;Note=In isoform RON-2 and isoform RON-4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18593464;Dbxref=PMID:18593464
Q04912	883	932	884	932	Alternative sequence	ID=VSP_005007;Note=In isoform Delta-RON. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q04912	883	932	884	907	Alternative sequence	ID=VSP_038924;Note=In isoform RON-3. YIGLGAVADCVGINVTVGGESCQH->VSVRDRGRDSWGSESRGQPTGWSS;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18593464;Dbxref=PMID:18593464
Q04912	883	932	908	1400	Alternative sequence	ID=VSP_038925;Note=In isoform RON-3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18593464;Dbxref=PMID:18593464
Q04912	883	932	25	1400	Chain	ID=PRO_0000024452;Note=Macrophage-stimulating protein receptor
Q04912	883	932	310	1400	Chain	ID=PRO_0000024454;Note=Macrophage-stimulating protein receptor beta chain;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q04912	883	932	897	897	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q04912	883	932	900	900	Natural variant	ID=VAR_041776;Note=V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs56091918,PMID:17344846
Q04912	883	932	25	957	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q04912	987	1021	496	1400	Alternative sequence	ID=VSP_038921;Note=In isoform RON-1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18593464;Dbxref=PMID:18593464
Q04912	987	1021	648	1400	Alternative sequence	ID=VSP_038923;Note=In isoform RON-2 and isoform RON-4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18593464;Dbxref=PMID:18593464
Q04912	987	1021	908	1400	Alternative sequence	ID=VSP_038925;Note=In isoform RON-3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18593464;Dbxref=PMID:18593464
Q04912	987	1021	25	1400	Chain	ID=PRO_0000024452;Note=Macrophage-stimulating protein receptor
Q04912	987	1021	310	1400	Chain	ID=PRO_0000024454;Note=Macrophage-stimulating protein receptor beta chain;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q04912	987	1021	979	1400	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q04912	1021	1090	496	1400	Alternative sequence	ID=VSP_038921;Note=In isoform RON-1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18593464;Dbxref=PMID:18593464
Q04912	1021	1090	648	1400	Alternative sequence	ID=VSP_038923;Note=In isoform RON-2 and isoform RON-4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18593464;Dbxref=PMID:18593464
Q04912	1021	1090	908	1400	Alternative sequence	ID=VSP_038925;Note=In isoform RON-3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18593464;Dbxref=PMID:18593464
Q04912	1021	1090	1080	1091	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3PLS
Q04912	1021	1090	25	1400	Chain	ID=PRO_0000024452;Note=Macrophage-stimulating protein receptor
Q04912	1021	1090	310	1400	Chain	ID=PRO_0000024454;Note=Macrophage-stimulating protein receptor beta chain;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q04912	1021	1090	1082	1345	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q04912	1021	1090	1064	1069	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3PLS
Q04912	1021	1090	1071	1073	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3PLS
Q04912	1021	1090	1077	1079	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3PLS
Q04912	1021	1090	1088	1096	Nucleotide binding	Note=ATP
Q04912	1021	1090	979	1400	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255

Lost protein functional features of individual exon skipping events in GTEx.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q04912	473	516	411	516	Alternative sequence	ID=VSP_038919;Note=In isoform RON-2 and isoform RON-5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18593464;Dbxref=PMID:18593464
Q04912	473	516	475	495	Alternative sequence	ID=VSP_038920;Note=In isoform RON-1. ELVRSLNYLLYVSNFSLGDSG->GPHPHSPLALGPCLHPHFAHI;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18593464;Dbxref=PMID:18593464
Q04912	473	516	496	1400	Alternative sequence	ID=VSP_038921;Note=In isoform RON-1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18593464;Dbxref=PMID:18593464
Q04912	473	516	469	475	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4FWW
Q04912	473	516	485	491	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4FWW
Q04912	473	516	503	505	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4FWW
Q04912	473	516	508	513	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4FWW
Q04912	473	516	516	521	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4FWW
Q04912	473	516	25	1400	Chain	ID=PRO_0000024452;Note=Macrophage-stimulating protein receptor
Q04912	473	516	310	1400	Chain	ID=PRO_0000024454;Note=Macrophage-stimulating protein receptor beta chain;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q04912	473	516	31	522	Domain	Note=Sema;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00352
Q04912	473	516	488	488	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:22848655;Dbxref=PMID:22848655
Q04912	473	516	504	504	Natural variant	ID=VAR_041773;Note=R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs34350470,PMID:17344846
Q04912	473	516	25	957	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q04912	728	781	496	1400	Alternative sequence	ID=VSP_038921;Note=In isoform RON-1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18593464;Dbxref=PMID:18593464
Q04912	728	781	648	1400	Alternative sequence	ID=VSP_038923;Note=In isoform RON-2 and isoform RON-4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18593464;Dbxref=PMID:18593464
Q04912	728	781	25	1400	Chain	ID=PRO_0000024452;Note=Macrophage-stimulating protein receptor
Q04912	728	781	310	1400	Chain	ID=PRO_0000024454;Note=Macrophage-stimulating protein receptor beta chain;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q04912	728	781	684	767	Domain	Note=IPT/TIG 2
Q04912	728	781	770	860	Domain	Note=IPT/TIG 3
Q04912	728	781	25	957	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q04912	883	932	496	1400	Alternative sequence	ID=VSP_038921;Note=In isoform RON-1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18593464;Dbxref=PMID:18593464
Q04912	883	932	648	1400	Alternative sequence	ID=VSP_038923;Note=In isoform RON-2 and isoform RON-4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18593464;Dbxref=PMID:18593464
Q04912	883	932	884	932	Alternative sequence	ID=VSP_005007;Note=In isoform Delta-RON. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q04912	883	932	884	907	Alternative sequence	ID=VSP_038924;Note=In isoform RON-3. YIGLGAVADCVGINVTVGGESCQH->VSVRDRGRDSWGSESRGQPTGWSS;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18593464;Dbxref=PMID:18593464
Q04912	883	932	908	1400	Alternative sequence	ID=VSP_038925;Note=In isoform RON-3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18593464;Dbxref=PMID:18593464
Q04912	883	932	25	1400	Chain	ID=PRO_0000024452;Note=Macrophage-stimulating protein receptor
Q04912	883	932	310	1400	Chain	ID=PRO_0000024454;Note=Macrophage-stimulating protein receptor beta chain;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q04912	883	932	897	897	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q04912	883	932	900	900	Natural variant	ID=VAR_041776;Note=V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=dbSNP:rs56091918,PMID:17344846
Q04912	883	932	25	957	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q04912	987	1021	496	1400	Alternative sequence	ID=VSP_038921;Note=In isoform RON-1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18593464;Dbxref=PMID:18593464
Q04912	987	1021	648	1400	Alternative sequence	ID=VSP_038923;Note=In isoform RON-2 and isoform RON-4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18593464;Dbxref=PMID:18593464
Q04912	987	1021	908	1400	Alternative sequence	ID=VSP_038925;Note=In isoform RON-3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18593464;Dbxref=PMID:18593464
Q04912	987	1021	25	1400	Chain	ID=PRO_0000024452;Note=Macrophage-stimulating protein receptor
Q04912	987	1021	310	1400	Chain	ID=PRO_0000024454;Note=Macrophage-stimulating protein receptor beta chain;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q04912	987	1021	979	1400	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q04912	1021	1090	496	1400	Alternative sequence	ID=VSP_038921;Note=In isoform RON-1. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18593464;Dbxref=PMID:18593464
Q04912	1021	1090	648	1400	Alternative sequence	ID=VSP_038923;Note=In isoform RON-2 and isoform RON-4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18593464;Dbxref=PMID:18593464
Q04912	1021	1090	908	1400	Alternative sequence	ID=VSP_038925;Note=In isoform RON-3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:18593464;Dbxref=PMID:18593464
Q04912	1021	1090	1080	1091	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3PLS
Q04912	1021	1090	25	1400	Chain	ID=PRO_0000024452;Note=Macrophage-stimulating protein receptor
Q04912	1021	1090	310	1400	Chain	ID=PRO_0000024454;Note=Macrophage-stimulating protein receptor beta chain;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q04912	1021	1090	1082	1345	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q04912	1021	1090	1064	1069	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3PLS
Q04912	1021	1090	1071	1073	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3PLS
Q04912	1021	1090	1077	1079	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3PLS
Q04912	1021	1090	1088	1096	Nucleotide binding	Note=ATP
Q04912	1021	1090	979	1400	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255

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SNVs in the skipped exons for MST1R

- Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.

- Differential PSIs between mutated versus non-mutated samples.

- Non-synonymous mutations located in the skipped exons in TCGA.

Cancer type	Sample	ESID	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
LIHC	TCGA-DD-A3A0-01	exon_skip_384461	49927357	49927493	49927447	49927447	Frame_Shift_Del	G	-	p.P1287fs
UCEC	TCGA-D1-A17H-01	exon_skip_384468	49928832	49929013	49928970	49928970	Frame_Shift_Del	C	-	p.G1132fs
LIHC	TCGA-G3-A3CJ-01		49932600	49932806	49932624	49932624	Frame_Shift_Del	G	-	p.H1083fs
COAD	TCGA-CM-6171-01	exon_skip_384490	49934162	49934323	49934243	49934243	Frame_Shift_Del	C	-	p.G755fs
UCEC	TCGA-BS-A0TA-01	exon_skip_384490	49934162	49934323	49934243	49934243	Frame_Shift_Del	C	-	p.G755fs
LIHC	TCGA-DD-A39Y-01	exon_skip_384492	49934953	49935118	49935057	49935057	Frame_Shift_Del	G	-	p.Q648fs
BLCA	TCGA-BT-A20P-01	exon_skip_384468	49928832	49929013	49929005	49929005	Nonsense_Mutation	C	A	p.E1121*
ESCA	TCGA-R6-A6Y2-01		49932600	49932806	49932735	49932735	Nonsense_Mutation	C	A	p.E1046*
ESCA	TCGA-R6-A6Y2-01		49932600	49932806	49932735	49932735	Nonsense_Mutation	C	A	p.E1046X
STAD	TCGA-HU-A4G9-01	exon_skip_384468	49928832	49929013	49929015	49929015	Splice_Site	T	C	.
STAD	TCGA-HU-A4G9-01	exon_skip_384468	49928832	49929013	49929015	49929015	Splice_Site	T	C	p.R1118_splice
THCA	TCGA-L6-A4EU-01	exon_skip_384487	49933394	49933540	49933541	49933541	Splice_Site	C	T	.

- Depth of coverage in the three exons composing exon skipping event

Depth of coverage in three exons

Mutation description

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
SNGM_ENDOMETRIUM	49934162	49934323	49934243	49934243	Frame_Shift_Del	C	-	p.G755fs
LS411N_LARGE_INTESTINE	49934162	49934323	49934243	49934243	Frame_Shift_Del	C	-	p.G755fs
SKGT2_STOMACH	49927357	49927493	49927398	49927398	Missense_Mutation	C	G	p.Q1302H
KM12_LARGE_INTESTINE	49927357	49927493	49927403	49927403	Missense_Mutation	C	T	p.A1301T
JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	49928832	49929013	49928866	49928866	Missense_Mutation	C	T	p.G1167D
NCIH2818_PLEURA	49928832	49929013	49928913	49928913	Missense_Mutation	C	A	p.L1151F
MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	49932600	49932806	49932684	49932684	Missense_Mutation	C	T	p.D1063N
SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	49932600	49932806	49932687	49932687	Missense_Mutation	G	T	p.L1062M
HEC59_ENDOMETRIUM	49932600	49932806	49932723	49932723	Missense_Mutation	G	A	p.P1050S
SNU216_STOMACH	49932600	49932806	49932735	49932735	Missense_Mutation	C	T	p.E1046K
CAL72_BONE	49933394	49933540	49933451	49933451	Missense_Mutation	C	A	p.M913I
FTC238_THYROID	49933394	49933540	49933458	49933458	Missense_Mutation	C	A	p.G911V
FTC133_THYROID	49933394	49933540	49933458	49933458	Missense_Mutation	C	A	p.G911V
MZ7MEL_SKIN	49933394	49933540	49933485	49933485	Missense_Mutation	C	T	p.G902D
SUDHL8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	49933394	49933540	49933498	49933498	Missense_Mutation	C	T	p.V898M
MZ7MEL_SKIN	49933394	49933540	49933522	49933522	Missense_Mutation	C	T	p.V890M
SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	49934162	49934323	49934186	49934186	Missense_Mutation	C	T	p.S774N
COLO792_SKIN	49934162	49934323	49934199	49934200	Missense_Mutation	GG	AT	p.769_770DP>ES
NCIH1339_LUNG	49934162	49934323	49934241	49934241	Missense_Mutation	C	T	p.A756T
GP2D_LARGE_INTESTINE	49934953	49935118	49934984	49934984	Missense_Mutation	C	T	p.G672D
KYSE510_OESOPHAGUS	49936300	49936428	49936337	49936337	Missense_Mutation	C	T	p.R504H
KPL1_BREAST	49936508	49936696	49936602	49936602	Missense_Mutation	A	C	p.L442R
NCC021_KIDNEY	49936508	49936696	49936614	49936614	Missense_Mutation	A	T	p.L438Q
SW48_LARGE_INTESTINE	49936300	49936428	49936300	49936300	Splice_Site	C	A	p.Q516H

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MST1R

sQTL information located at the skipped exons.

Exon skip ID

Chromosome

Three exons

Skippped exon

ENST

Cancer type

SNP id

Location

DNA change (ref/var)

P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MST1R

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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MST1R

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RelatedDrugs for MST1R

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
	Q04912	DB12010	Fostamatinib	Macrophage-stimulating protein receptor	small molecule	approved\|investigational

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RelatedDiseases for MST1R

Diseases associated with this gene.
(DisGeNet 4.0)

Gene	Disease ID	Disease name	# pubmeds	Source
MST1R	C0029463	Osteosarcoma	1	CTD_human
MST1R	C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in TCGA
	Exon skipping events with PSIs in GTEx
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	SNVs in the skipped exons with depth of coverage
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Splicing Quantitative Trait Methylation (sQTM) in the skipped exon
	Related drugs with this gene
	Related diseases with this gene

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