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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for MSRA |
 Gene summary |
| Gene information | Gene symbol | MSRA | Gene ID | 4482 |
| Gene name | methionine sulfoxide reductase A | |
| Synonyms | PMSR | |
| Cytomap | 8p23.1 | |
| Type of gene | protein-coding | |
| Description | mitochondrial peptide methionine sulfoxide reductasecytosolic methionine-S-sulfoxide reductasepeptide Met(O) reductasepeptide met (O) reductasepeptide-methionine (S)-S-oxide reductase | |
| Modification date | 20180519 | |
| UniProtAcc | Q9UJ68 | |
| Context | PubMed: MSRA [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for MSRA from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for MSRA |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for MSRA |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_481103 | 8 | 9912010:9912168:10065342:10065411:10102613:10102733 | 10065342:10065411 | ENSG00000175806.10 | ENST00000518255.1 |
| exon_skip_481104 | 8 | 9912010:9912168:10065342:10065411:10159043:10159148 | 10065342:10065411 | ENSG00000175806.10 | ENST00000441698.2 |
| exon_skip_481107 | 8 | 9953236:9953553:9953753:9953828:10065342:10065411 | 9953753:9953828 | ENSG00000175806.10 | ENST00000528246.1,ENST00000522907.1 |
| exon_skip_481110 | 8 | 9953236:9953553:10065342:10065411:10102613:10102733 | 10065342:10065411 | ENSG00000175806.10 | ENST00000523637.2,ENST00000382490.5 |
| exon_skip_481113 | 8 | 10065342:10065411:10102613:10102733:10159043:10159148 | 10102613:10102733 | ENSG00000175806.10 | ENST00000317173.4,ENST00000523637.2,ENST00000382490.5,ENST00000528246.1,ENST00000518255.1,ENST00000522907.1 |
| exon_skip_481114 | 8 | 10102613:10102733:10159043:10159148:10177392:10177401 | 10159043:10159148 | ENSG00000175806.10 | ENST00000317173.4,ENST00000523637.2,ENST00000382490.5,ENST00000528246.1,ENST00000518255.1,ENST00000522907.1 |
| exon_skip_481118 | 8 | 10159044:10159148:10177392:10177499:10285657:10285875 | 10177392:10177499 | ENSG00000175806.10 | ENST00000317173.4,ENST00000441698.2,ENST00000382490.5,ENST00000528246.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for MSRA |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_481103 | 8 | 9912010:9912168:10065342:10065411:10102613:10102733 | 10065342:10065411 | ENSG00000175806.10 | ENST00000518255.1 |
| exon_skip_481104 | 8 | 9912010:9912168:10065342:10065411:10159043:10159148 | 10065342:10065411 | ENSG00000175806.10 | ENST00000441698.2 |
| exon_skip_481107 | 8 | 9953236:9953553:9953753:9953828:10065342:10065411 | 9953753:9953828 | ENSG00000175806.10 | ENST00000522907.1,ENST00000528246.1 |
| exon_skip_481110 | 8 | 9953236:9953553:10065342:10065411:10102613:10102733 | 10065342:10065411 | ENSG00000175806.10 | ENST00000523637.2,ENST00000382490.5 |
| exon_skip_481113 | 8 | 10065342:10065411:10102613:10102733:10159043:10159148 | 10102613:10102733 | ENSG00000175806.10 | ENST00000317173.4,ENST00000518255.1,ENST00000522907.1,ENST00000528246.1,ENST00000523637.2,ENST00000382490.5 |
| exon_skip_481114 | 8 | 10102613:10102733:10159043:10159148:10177392:10177401 | 10159043:10159148 | ENSG00000175806.10 | ENST00000317173.4,ENST00000518255.1,ENST00000522907.1,ENST00000528246.1,ENST00000523637.2,ENST00000382490.5 |
| exon_skip_481118 | 8 | 10159044:10159148:10177392:10177499:10285657:10285875 | 10177392:10177499 | ENSG00000175806.10 | ENST00000317173.4,ENST00000441698.2,ENST00000528246.1,ENST00000382490.5 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for MSRA |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for MSRA |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for MSRA |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| BLCA | TCGA-GU-AATO-01 | exon_skip_481114 | 10159044 | 10159148 | 10159133 | 10159133 | Frame_Shift_Del | C | - | p.H75fs |
| LUAD | TCGA-05-4397-01 | exon_skip_481118 | 10177393 | 10177499 | 10177494 | 10177494 | Nonsense_Mutation | C | T | p.Q114* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HEC251_ENDOMETRIUM | 10102614 | 10102733 | 10102657 | 10102658 | Frame_Shift_Ins | - | A | p.K86fs |
| HO1U1_UPPER_AERODIGESTIVE_TRACT | 10065343 | 10065411 | 10065366 | 10065366 | Missense_Mutation | A | G | p.R56G |
| LS180_LARGE_INTESTINE | 10065343 | 10065411 | 10065388 | 10065388 | Missense_Mutation | A | C | p.E63A |
| NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 10102614 | 10102733 | 10102691 | 10102691 | Missense_Mutation | G | A | p.G97R |
| GP2D_LARGE_INTESTINE | 10159044 | 10159148 | 10159058 | 10159058 | Missense_Mutation | G | A | p.A116T |
| GP5D_LARGE_INTESTINE | 10159044 | 10159148 | 10159058 | 10159058 | Missense_Mutation | G | A | p.A116T |
| MZ7MEL_SKIN | 10159044 | 10159148 | 10159073 | 10159073 | Missense_Mutation | G | A | p.V121M |
| HCT15_LARGE_INTESTINE | 10159044 | 10159148 | 10159085 | 10159085 | Missense_Mutation | C | T | p.P125S |
| MHHPREB1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 10177393 | 10177499 | 10177417 | 10177417 | Missense_Mutation | G | A | p.G154D |
| NCIH2227_LUNG | 10177393 | 10177499 | 10177419 | 10177419 | Missense_Mutation | A | T | p.T155S |
| PWR1E_PROSTATE | 10177393 | 10177499 | 10177428 | 10177428 | Missense_Mutation | C | G | p.R158G |
| NCIH322_LUNG | 10177393 | 10177499 | 10177450 | 10177450 | Missense_Mutation | C | G | p.S165C |
| KPNYN_AUTONOMIC_GANGLIA | 10177393 | 10177499 | 10177466 | 10177466 | Missense_Mutation | G | C | p.E170D |
| NB5_AUTONOMIC_GANGLIA | 10177393 | 10177499 | 10177484 | 10177484 | Missense_Mutation | A | T | p.K176N |
| SNU719_STOMACH | 10102614 | 10102733 | 10102629 | 10102629 | Nonsense_Mutation | G | A | p.W76* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MSRA |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MSRA |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MSRA |
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RelatedDrugs for MSRA |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MSRA |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| MSRA | C0036341 | Schizophrenia | 2 | PSYGENET |
| MSRA | C0236969 | Substance-Related Disorders | 1 | CTD_human |
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