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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for MYO1B

check button Gene summary
Gene informationGene symbol

MYO1B

Gene ID

4430

Gene namemyosin IB
SynonymsMMI-alpha|MMIa|MYH-1c|myr1
Cytomap

2q32.3

Type of geneprotein-coding
Descriptionunconventional myosin-IbMYO1B variant proteinmyosin-I alpha
Modification date20180522
UniProtAcc

O43795

ContextPubMed: MYO1B [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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Exon skipping events across known transcript of Ensembl for MYO1B from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for MYO1B

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for MYO1B

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_3320522192110114:192110352:192141612:192141756:192160836:192160952192141612:192141756ENSG00000128641.13ENST00000339514.4,ENST00000392318.3
exon_skip_3320552192194660:192194755:192206186:192206291:192210961:192211000192206186:192206291ENSG00000128641.13ENST00000339514.4,ENST00000304164.4,ENST00000451437.1,ENST00000392318.3,ENST00000418908.1,ENST00000392316.1,ENST00000471904.1
exon_skip_3320562192214887:192214951:192225356:192225455:192226993:192227097192225356:192225455ENSG00000128641.13ENST00000339514.4,ENST00000304164.4,ENST00000451437.1,ENST00000392318.3,ENST00000392316.1
exon_skip_3320572192228883:192229002:192234267:192234354:192234952:192235018192234267:192234354ENSG00000128641.13ENST00000339514.4,ENST00000304164.4,ENST00000392318.3,ENST00000392316.1
exon_skip_3320602192248005:192248068:192250609:192250810:192251949:192252176192250609:192250810ENSG00000128641.13ENST00000339514.4,ENST00000304164.4,ENST00000494129.1,ENST00000392318.3,ENST00000392316.1
exon_skip_3320622192257798:192257948:192261154:192261223:192265107:192265194192261154:192261223ENSG00000128641.13ENST00000339514.4,ENST00000304164.4,ENST00000439065.2,ENST00000392318.3,ENST00000392316.1
exon_skip_3320642192265107:192265194:192265474:192265561:192267357:192267444192265474:192265561ENSG00000128641.13ENST00000304164.4,ENST00000392318.3
exon_skip_3320682192265107:192265194:192267357:192267444:192272840:192272915192267357:192267444ENSG00000128641.13ENST00000439065.2,ENST00000392316.1
exon_skip_3320712192265474:192265561:192267357:192267444:192272840:192272915192267357:192267444ENSG00000128641.13ENST00000304164.4,ENST00000392318.3
exon_skip_3320732192279242:192279395:192280840:192280968:192288562:192288763192280840:192280968ENSG00000128641.13ENST00000339514.4,ENST00000304164.4,ENST00000439065.2,ENST00000490069.1,ENST00000392318.3,ENST00000392316.1

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for MYO1B

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_3320522192110114:192110352:192141612:192141756:192160836:192160952192141612:192141756ENSG00000128641.13ENST00000339514.4,ENST00000392318.3
exon_skip_3320552192194660:192194755:192206186:192206291:192210961:192211000192206186:192206291ENSG00000128641.13ENST00000418908.1,ENST00000339514.4,ENST00000392318.3,ENST00000304164.4,ENST00000451437.1,ENST00000471904.1,ENST00000392316.1
exon_skip_3320562192214887:192214951:192225356:192225455:192226993:192227097192225356:192225455ENSG00000128641.13ENST00000339514.4,ENST00000392318.3,ENST00000304164.4,ENST00000451437.1,ENST00000392316.1
exon_skip_3320572192228883:192229002:192234267:192234354:192234952:192235018192234267:192234354ENSG00000128641.13ENST00000339514.4,ENST00000392318.3,ENST00000304164.4,ENST00000392316.1
exon_skip_3320602192248005:192248068:192250609:192250810:192251949:192252176192250609:192250810ENSG00000128641.13ENST00000339514.4,ENST00000392318.3,ENST00000304164.4,ENST00000392316.1,ENST00000494129.1
exon_skip_3320622192257798:192257948:192261154:192261223:192265107:192265194192261154:192261223ENSG00000128641.13ENST00000339514.4,ENST00000392318.3,ENST00000304164.4,ENST00000392316.1,ENST00000439065.2
exon_skip_3320642192265107:192265194:192265474:192265561:192267357:192267444192265474:192265561ENSG00000128641.13ENST00000392318.3,ENST00000304164.4
exon_skip_3320682192265107:192265194:192267357:192267444:192272840:192272915192267357:192267444ENSG00000128641.13ENST00000392316.1,ENST00000439065.2
exon_skip_3320712192265474:192265561:192267357:192267444:192272840:192272915192267357:192267444ENSG00000128641.13ENST00000392318.3,ENST00000304164.4
exon_skip_3320732192279242:192279395:192280840:192280968:192288562:192288763192280840:192280968ENSG00000128641.13ENST00000339514.4,ENST00000392318.3,ENST00000304164.4,ENST00000392316.1,ENST00000439065.2,ENST00000490069.1

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for MYO1B

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003923181921416121921417565CDS-5UTR
ENST00000304164192280840192280968Frame-shift
ENST00000392318192280840192280968Frame-shift
ENST00000304164192206186192206291In-frame
ENST00000392318192206186192206291In-frame
ENST00000304164192225356192225455In-frame
ENST00000392318192225356192225455In-frame
ENST00000304164192234267192234354In-frame
ENST00000392318192234267192234354In-frame
ENST00000304164192250609192250810In-frame
ENST00000392318192250609192250810In-frame
ENST00000304164192261154192261223In-frame
ENST00000392318192261154192261223In-frame
ENST00000304164192265474192265561In-frame
ENST00000392318192265474192265561In-frame
ENST00000304164192267357192267444In-frame
ENST00000392318192267357192267444In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003923181921416121921417565CDS-5UTR
ENST00000304164192280840192280968Frame-shift
ENST00000392318192280840192280968Frame-shift
ENST00000304164192206186192206291In-frame
ENST00000392318192206186192206291In-frame
ENST00000304164192225356192225455In-frame
ENST00000392318192225356192225455In-frame
ENST00000304164192234267192234354In-frame
ENST00000392318192234267192234354In-frame
ENST00000304164192250609192250810In-frame
ENST00000392318192250609192250810In-frame
ENST00000304164192261154192261223In-frame
ENST00000392318192261154192261223In-frame
ENST00000304164192265474192265561In-frame
ENST00000392318192265474192265561In-frame
ENST00000304164192267357192267444In-frame
ENST00000392318192267357192267444In-frame

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Infer the effects of exon skipping event on protein functional features for MYO1B

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000030416449501136192206186192206291440544115150
ENST0000039231850991136192206186192206291594698115150
ENST0000030416449501136192225356192225455656754187220
ENST0000039231850991136192225356192225455810908187220
ENST000003041644950113619223426719223435411261212344373
ENST000003923185099113619223426719223435412801366344373
ENST000003041644950113619225060919225081014471647451518
ENST000003923185099113619225060919225081016011801451518
ENST000003041644950113619226115419226122323202388742765
ENST000003923185099113619226115419226122324742542742765
ENST000003041644950113619226547419226556124762562794823
ENST000003923185099113619226547419226556126302716794823
ENST000003041644950113619226735719226744425632649823852
ENST000003923185099113619226735719226744427172803823852

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000030416449501136192206186192206291440544115150
ENST0000039231850991136192206186192206291594698115150
ENST0000030416449501136192225356192225455656754187220
ENST0000039231850991136192225356192225455810908187220
ENST000003041644950113619223426719223435411261212344373
ENST000003923185099113619223426719223435412801366344373
ENST000003041644950113619225060919225081014471647451518
ENST000003923185099113619225060919225081016011801451518
ENST000003041644950113619226115419226122323202388742765
ENST000003923185099113619226115419226122324742542742765
ENST000003041644950113619226547419226556124762562794823
ENST000003923185099113619226547419226556126302716794823
ENST000003041644950113619226735719226744425632649823852
ENST000003923185099113619226735719226744427172803823852

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
O4379511515011136ChainID=PRO_0000123442;Note=Unconventional myosin-Ib
O4379511515011136ChainID=PRO_0000123442;Note=Unconventional myosin-Ib
O4379511515015701DomainNote=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
O4379511515015701DomainNote=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
O43795115150108115Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
O43795115150108115Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
O4379518722011136ChainID=PRO_0000123442;Note=Unconventional myosin-Ib
O4379518722011136ChainID=PRO_0000123442;Note=Unconventional myosin-Ib
O4379518722015701DomainNote=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
O4379518722015701DomainNote=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
O4379534437311136ChainID=PRO_0000123442;Note=Unconventional myosin-Ib
O4379534437311136ChainID=PRO_0000123442;Note=Unconventional myosin-Ib
O4379534437315701DomainNote=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
O4379534437315701DomainNote=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
O4379545151811136ChainID=PRO_0000123442;Note=Unconventional myosin-Ib
O4379545151811136ChainID=PRO_0000123442;Note=Unconventional myosin-Ib
O4379545151815701DomainNote=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
O4379545151815701DomainNote=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
O4379574276511136ChainID=PRO_0000123442;Note=Unconventional myosin-Ib
O4379574276511136ChainID=PRO_0000123442;Note=Unconventional myosin-Ib
O43795742765728748DomainNote=IQ 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
O43795742765728748DomainNote=IQ 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
O43795742765750779DomainNote=IQ 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
O43795742765750779DomainNote=IQ 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
O43795794823795852Alternative sequenceID=VSP_012759;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
O43795794823795852Alternative sequenceID=VSP_012759;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
O4379579482311136ChainID=PRO_0000123442;Note=Unconventional myosin-Ib
O4379579482311136ChainID=PRO_0000123442;Note=Unconventional myosin-Ib
O43795794823779808DomainNote=IQ 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
O43795794823779808DomainNote=IQ 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
O43795794823808837DomainNote=IQ 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
O43795794823808837DomainNote=IQ 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
O43795823852795852Alternative sequenceID=VSP_012759;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
O43795823852795852Alternative sequenceID=VSP_012759;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
O4379582385211136ChainID=PRO_0000123442;Note=Unconventional myosin-Ib
O4379582385211136ChainID=PRO_0000123442;Note=Unconventional myosin-Ib
O43795823852808837DomainNote=IQ 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
O43795823852808837DomainNote=IQ 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
O43795823852837866DomainNote=IQ 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
O43795823852837866DomainNote=IQ 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
O4379511515011136ChainID=PRO_0000123442;Note=Unconventional myosin-Ib
O4379511515011136ChainID=PRO_0000123442;Note=Unconventional myosin-Ib
O4379511515015701DomainNote=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
O4379511515015701DomainNote=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
O43795115150108115Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
O43795115150108115Nucleotide bindingNote=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
O4379518722011136ChainID=PRO_0000123442;Note=Unconventional myosin-Ib
O4379518722011136ChainID=PRO_0000123442;Note=Unconventional myosin-Ib
O4379518722015701DomainNote=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
O4379518722015701DomainNote=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
O4379534437311136ChainID=PRO_0000123442;Note=Unconventional myosin-Ib
O4379534437311136ChainID=PRO_0000123442;Note=Unconventional myosin-Ib
O4379534437315701DomainNote=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
O4379534437315701DomainNote=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
O4379545151811136ChainID=PRO_0000123442;Note=Unconventional myosin-Ib
O4379545151811136ChainID=PRO_0000123442;Note=Unconventional myosin-Ib
O4379545151815701DomainNote=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
O4379545151815701DomainNote=Myosin motor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00782
O4379574276511136ChainID=PRO_0000123442;Note=Unconventional myosin-Ib
O4379574276511136ChainID=PRO_0000123442;Note=Unconventional myosin-Ib
O43795742765728748DomainNote=IQ 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
O43795742765728748DomainNote=IQ 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
O43795742765750779DomainNote=IQ 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
O43795742765750779DomainNote=IQ 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
O43795794823795852Alternative sequenceID=VSP_012759;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
O43795794823795852Alternative sequenceID=VSP_012759;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
O4379579482311136ChainID=PRO_0000123442;Note=Unconventional myosin-Ib
O4379579482311136ChainID=PRO_0000123442;Note=Unconventional myosin-Ib
O43795794823779808DomainNote=IQ 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
O43795794823779808DomainNote=IQ 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
O43795794823808837DomainNote=IQ 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
O43795794823808837DomainNote=IQ 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
O43795823852795852Alternative sequenceID=VSP_012759;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
O43795823852795852Alternative sequenceID=VSP_012759;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2
O4379582385211136ChainID=PRO_0000123442;Note=Unconventional myosin-Ib
O4379582385211136ChainID=PRO_0000123442;Note=Unconventional myosin-Ib
O43795823852808837DomainNote=IQ 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
O43795823852808837DomainNote=IQ 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
O43795823852837866DomainNote=IQ 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116
O43795823852837866DomainNote=IQ 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00116


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SNVs in the skipped exons for MYO1B

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.
MYO1B_KIRC_exon_skip_332060_psi_boxplot.png
boxplot

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LIHCTCGA-DD-A3A0-01exon_skip_332052
192141613192141756192141628192141628Frame_Shift_DelA-p.K3fs
LIHCTCGA-G3-A3CJ-01exon_skip_332052
192141613192141756192141628192141628Frame_Shift_DelA-p.K3fs
LIHCTCGA-DD-A1EG-01exon_skip_332052
192141613192141756192141640192141640Frame_Shift_DelA-p.K7fs
LIHCTCGA-DD-A39Y-01exon_skip_332056
192225357192225455192225403192225403Frame_Shift_DelA-p.R203fs
LIHCTCGA-DD-A3A0-01exon_skip_332062
192261155192261223192261178192261178Frame_Shift_DelA-p.T750fs
KIRPTCGA-SX-A7SS-01exon_skip_332055
192206187192206291192206229192206230Frame_Shift_Ins-Ap.G130fs
HNSCTCGA-CR-6484-01exon_skip_332056
192225357192225455192225422192225422Nonsense_MutationCTp.Q210*
LGGTCGA-HW-7493-01exon_skip_332057
192234268192234354192234306192234306Nonsense_MutationCGp.Y357*
PAADTCGA-IB-7651-01exon_skip_332057
192234268192234354192234334192234334Nonsense_MutationCTp.R367*
PAADTCGA-IB-7651-01exon_skip_332057
192234268192234354192234334192234334Nonsense_MutationCTp.R367X
ESCATCGA-R6-A6Y0-01exon_skip_332068
exon_skip_332071
192267358192267444192267361192267361Nonsense_MutationCTp.R825*
ESCATCGA-R6-A6Y0-01exon_skip_332068
exon_skip_332071
192267358192267444192267361192267361Nonsense_MutationCTp.R825X
KIRCTCGA-B2-3924-01exon_skip_332060
192250610192250810192250811192250811Splice_SiteGT.

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description
MYO1B_192265107_192265194_192267357_192267444_192272840_192272915_TCGA-R6-A6Y0-01Sample: TCGA-R6-A6Y0-01
Cancer type: ESCA
ESID: exon_skip_332071
Skipped exon start: 192267358
Skipped exon end: 192267444
Mutation start: 192267361
Mutation end: 192267361
Mutation type: Nonsense_Mutation
Reference seq: C
Mutation seq: T
AAchange: p.R825X
MYO1B_192265107_192265194_192267357_192267444_192272840_192272915_TCGA-R6-A6Y0-01Sample: TCGA-R6-A6Y0-01
Cancer type: ESCA
ESID: exon_skip_332071
Skipped exon start: 192267358
Skipped exon end: 192267444
Mutation start: 192267361
Mutation end: 192267361
Mutation type: Nonsense_Mutation
Reference seq: C
Mutation seq: T
AAchange: p.R825*
exon_skip_308211_ESCA_TCGA-R6-A6Y0-01.png
boxplot
exon_skip_328488_ESCA_TCGA-R6-A6Y0-01.png
boxplot
exon_skip_332068_ESCA_TCGA-R6-A6Y0-01.png
boxplot
MYO1B_192248005_192248068_192250609_192250810_192251949_192252176_TCGA-B2-3924-01Sample: TCGA-B2-3924-01
Cancer type: KIRC
ESID: exon_skip_332060
Skipped exon start: 192250610
Skipped exon end: 192250810
Mutation start: 192250811
Mutation end: 192250811
Mutation type: Splice_Site
Reference seq: G
Mutation seq: T
AAchange: .
exon_skip_332060_KIRC_TCGA-B2-3924-01.png
boxplot

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
SW48_LARGE_INTESTINE192141613192141756192141734192141734Missense_MutationGAp.R38H
OCIAML2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE192206187192206291192206276192206276Missense_MutationACp.N146H
GP5D_LARGE_INTESTINE192234268192234354192234352192234352Missense_MutationAGp.K373E
SW684_SOFT_TISSUE192250610192250810192250629192250629Missense_MutationCTp.A458V
SNU1040_LARGE_INTESTINE192250610192250810192250701192250701Missense_MutationTCp.V482A
SNU175_LARGE_INTESTINE192250610192250810192250743192250743Missense_MutationGAp.C496Y
JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE192267358192267444192267377192267377Missense_MutationGAp.R830H
CASKI_CERVIX192267358192267444192267381192267381Missense_MutationGCp.L831F
LOVO_LARGE_INTESTINE192267358192267444192267395192267395Missense_MutationGTp.R836M
LXF289_LUNG192280841192280968192280868192280868Missense_MutationTGp.F1063V
NCIH211_LUNG192280841192280968192280910192280910Missense_MutationCGp.L1077V
GMEL_SKIN192280841192280968192280962192280962Missense_MutationCTp.S1094F
SARC9371_BONE192280841192280968192280962192280962Missense_MutationCTp.S1094F
JHUEM7_ENDOMETRIUM192206187192206291192206258192206258Nonsense_MutationGTp.E140*

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MYO1B

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MYO1B


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MYO1B


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RelatedDrugs for MYO1B

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MYO1B

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
MYO1BC0043094Weight Gain1CTD_human