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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for MAOB |
 Gene summary |
| Gene information | Gene symbol | MAOB | Gene ID | 4129 |
| Gene name | monoamine oxidase B | |
| Synonyms | - | |
| Cytomap | Xp11.3 | |
| Type of gene | protein-coding | |
| Description | amine oxidase [flavin-containing] BMAO, brainMAO, plateletMAO-Badrenalin oxidasemonoamine oxidase type Btyramine oxidase | |
| Modification date | 20180520 | |
| UniProtAcc | P27338 | |
| Context | PubMed: MAOB [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for MAOB from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for MAOB |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for MAOB |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_514533 | X | 43627903:43627963:43628553:43628665:43634421:43634519 | 43628553:43628665 | ENSG00000069535.12 | ENST00000536181.1,ENST00000378069.4 |
| exon_skip_514534 | X | 43627900:43627963:43628553:43628665:43637928:43637986 | 43628553:43628665 | ENSG00000069535.12 | ENST00000538942.1 |
| exon_skip_514537 | X | 43628553:43628665:43634421:43634519:43637928:43637986 | 43634421:43634519 | ENSG00000069535.12 | ENST00000536181.1,ENST00000378069.4 |
| exon_skip_514538 | X | 43661418:43661510:43662546:43662651:43698113:43698251 | 43662546:43662651 | ENSG00000069535.12 | ENST00000536181.1,ENST00000538942.1,ENST00000378069.4,ENST00000487544.1 |
| exon_skip_514541 | X | 43662546:43662651:43698113:43698251:43702915:43703010 | 43698113:43698251 | ENSG00000069535.12 | ENST00000536181.1,ENST00000538942.1,ENST00000378069.4,ENST00000487544.1 |
| exon_skip_514548 | X | 43702915:43703010:43703137:43703180:43741499:43741549 | 43703137:43703180 | ENSG00000069535.12 | ENST00000536181.1 |
| exon_skip_514550 | X | 43702915:43703010:43703701:43703891:43741499:43741549 | 43703701:43703891 | ENSG00000069535.12 | ENST00000487544.1 |
| exon_skip_514557 | X | 43703137:43703180:43703751:43703891:43741499:43741549 | 43703751:43703891 | ENSG00000069535.12 | ENST00000468431.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for MAOB |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_514533 | X | 43627903:43627963:43628553:43628665:43634421:43634519 | 43628553:43628665 | ENSG00000069535.12 | ENST00000378069.4,ENST00000536181.1 |
| exon_skip_514534 | X | 43627900:43627963:43628553:43628665:43637928:43637986 | 43628553:43628665 | ENSG00000069535.12 | ENST00000538942.1 |
| exon_skip_514537 | X | 43628553:43628665:43634421:43634519:43637928:43637986 | 43634421:43634519 | ENSG00000069535.12 | ENST00000378069.4,ENST00000536181.1 |
| exon_skip_514538 | X | 43661418:43661510:43662546:43662651:43698113:43698251 | 43662546:43662651 | ENSG00000069535.12 | ENST00000378069.4,ENST00000536181.1,ENST00000538942.1,ENST00000487544.1 |
| exon_skip_514541 | X | 43662546:43662651:43698113:43698251:43702915:43703010 | 43698113:43698251 | ENSG00000069535.12 | ENST00000378069.4,ENST00000536181.1,ENST00000538942.1,ENST00000487544.1 |
| exon_skip_514548 | X | 43702915:43703010:43703137:43703180:43741499:43741549 | 43703137:43703180 | ENSG00000069535.12 | ENST00000536181.1 |
| exon_skip_514550 | X | 43702915:43703010:43703701:43703891:43741499:43741549 | 43703701:43703891 | ENSG00000069535.12 | ENST00000487544.1 |
| exon_skip_514557 | X | 43703137:43703180:43703751:43703891:43741499:43741549 | 43703751:43703891 | ENSG00000069535.12 | ENST00000468431.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for MAOB |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000378069 | 43628553 | 43628665 | Frame-shift |
| ENST00000378069 | 43634421 | 43634519 | Frame-shift |
| ENST00000378069 | 43662546 | 43662651 | In-frame |
| ENST00000378069 | 43698113 | 43698251 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000378069 | 43628553 | 43628665 | Frame-shift |
| ENST00000378069 | 43634421 | 43634519 | Frame-shift |
| ENST00000378069 | 43662546 | 43662651 | In-frame |
| ENST00000378069 | 43698113 | 43698251 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MAOB |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000378069 | 2583 | 520 | 43698113 | 43698251 | 290 | 427 | 47 | 93 |
| ENST00000378069 | 2583 | 520 | 43662546 | 43662651 | 428 | 532 | 93 | 128 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000378069 | 2583 | 520 | 43698113 | 43698251 | 290 | 427 | 47 | 93 |
| ENST00000378069 | 2583 | 520 | 43662546 | 43662651 | 428 | 532 | 93 | 128 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P27338 | 47 | 93 | 45 | 48 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XFN |
| P27338 | 47 | 93 | 54 | 57 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S3E |
| P27338 | 47 | 93 | 79 | 81 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S3E |
| P27338 | 47 | 93 | 85 | 92 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S3E |
| P27338 | 47 | 93 | 2 | 520 | Chain | ID=PRO_0000099859;Note=Amine oxidase [flavin-containing] B |
| P27338 | 47 | 93 | 36 | 52 | Compositional bias | Note=Arg/Lys-rich (basic) |
| P27338 | 47 | 93 | 66 | 74 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S3E |
| P27338 | 47 | 93 | 52 | 52 | Modified residue | Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BW75 |
| P27338 | 47 | 93 | 2 | 489 | Topological domain | Note=Cytoplasmic |
| P27338 | 47 | 93 | 49 | 51 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S3E |
| P27338 | 93 | 128 | 95 | 99 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S3E |
| P27338 | 93 | 128 | 101 | 103 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S3E |
| P27338 | 93 | 128 | 2 | 520 | Chain | ID=PRO_0000099859;Note=Amine oxidase [flavin-containing] B |
| P27338 | 93 | 128 | 109 | 126 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S3E |
| P27338 | 93 | 128 | 2 | 489 | Topological domain | Note=Cytoplasmic |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P27338 | 47 | 93 | 45 | 48 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2XFN |
| P27338 | 47 | 93 | 54 | 57 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S3E |
| P27338 | 47 | 93 | 79 | 81 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S3E |
| P27338 | 47 | 93 | 85 | 92 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S3E |
| P27338 | 47 | 93 | 2 | 520 | Chain | ID=PRO_0000099859;Note=Amine oxidase [flavin-containing] B |
| P27338 | 47 | 93 | 36 | 52 | Compositional bias | Note=Arg/Lys-rich (basic) |
| P27338 | 47 | 93 | 66 | 74 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S3E |
| P27338 | 47 | 93 | 52 | 52 | Modified residue | Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BW75 |
| P27338 | 47 | 93 | 2 | 489 | Topological domain | Note=Cytoplasmic |
| P27338 | 47 | 93 | 49 | 51 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S3E |
| P27338 | 93 | 128 | 95 | 99 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S3E |
| P27338 | 93 | 128 | 101 | 103 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S3E |
| P27338 | 93 | 128 | 2 | 520 | Chain | ID=PRO_0000099859;Note=Amine oxidase [flavin-containing] B |
| P27338 | 93 | 128 | 109 | 126 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1S3E |
| P27338 | 93 | 128 | 2 | 489 | Topological domain | Note=Cytoplasmic |
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SNVs in the skipped exons for MAOB |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
MAOB_LIHC_exon_skip_514541_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| READ | TCGA-AF-6136-01 | exon_skip_514538 | 43662547 | 43662651 | 43662574 | 43662574 | Nonsense_Mutation | C | T | p.W119X |
| SKCM | TCGA-EE-A3J5-06 | exon_skip_514538 | 43662547 | 43662651 | 43662611 | 43662611 | Nonsense_Mutation | C | T | p.W107* |
| SKCM | TCGA-EE-A3J5-06 | exon_skip_514538 | 43662547 | 43662651 | 43662611 | 43662611 | Nonsense_Mutation | C | T | p.W107X |
| LUAD | TCGA-97-7554-01 | exon_skip_514538 | 43662547 | 43662651 | 43662545 | 43662545 | Splice_Site | A | T | p.E128_splice |
| UCEC | TCGA-B5-A11E-01 | exon_skip_514538 | 43662547 | 43662651 | 43662652 | 43662652 | Splice_Site | C | G | e4-1 |
| LIHC | TCGA-DD-AAD3-01 | exon_skip_514541 | 43698114 | 43698251 | 43698252 | 43698252 | Splice_Site | C | A | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-DD-AAD3-01 |
| Cancer type: LIHC | |
| ESID: exon_skip_514541 | |
| Skipped exon start: 43698114 | |
| Skipped exon end: 43698251 | |
| Mutation start: 43698252 | |
| Mutation end: 43698252 | |
| Mutation type: Splice_Site | |
| Reference seq: C | |
| Mutation seq: A | |
| AAchange: . | |
exon_skip_514541_LIHC_TCGA-DD-AAD3-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| 2313287_STOMACH | 43628554 | 43628665 | 43628627 | 43628627 | Missense_Mutation | C | T | p.G425D |
| KMRC3_KIDNEY | 43634422 | 43634519 | 43634503 | 43634503 | Missense_Mutation | T | G | p.E385A |
| NCIH1436_LUNG | 43662547 | 43662651 | 43662583 | 43662583 | Missense_Mutation | G | T | p.N116K |
| JHUEM1_ENDOMETRIUM | 43698114 | 43698251 | 43698243 | 43698243 | Missense_Mutation | C | A | p.K50N |
| WM35_SKIN | 43634422 | 43634519 | 43634422 | 43634422 | Splice_Site | C | T | p.R412K |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAOB |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAOB |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAOB |
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RelatedDrugs for MAOB |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P27338 | DB00780 | Phenelzine | Amine oxidase [flavin-containing] B | small molecule | approved | |
| P27338 | DB01247 | Isocarboxazid | Amine oxidase [flavin-containing] B | small molecule | approved | |
| P27338 | DB01367 | Rasagiline | Amine oxidase [flavin-containing] B | small molecule | approved | |
| P27338 | DB01626 | Pargyline | Amine oxidase [flavin-containing] B | small molecule | approved | |
| P27338 | DB00191 | Phentermine | Amine oxidase [flavin-containing] B | small molecule | approved|illicit | |
| P27338 | DB01577 | Metamfetamine | Amine oxidase [flavin-containing] B | small molecule | approved|illicit | |
| P27338 | DB00182 | Amphetamine | Amine oxidase [flavin-containing] B | small molecule | approved|illicit|investigational | |
| P27338 | DB00752 | Tranylcypromine | Amine oxidase [flavin-containing] B | small molecule | approved|investigational | |
| P27338 | DB00909 | Zonisamide | Amine oxidase [flavin-containing] B | small molecule | approved|investigational | |
| P27338 | DB01132 | Pioglitazone | Amine oxidase [flavin-containing] B | small molecule | approved|investigational | |
| P27338 | DB01171 | Moclobemide | Amine oxidase [flavin-containing] B | small molecule | approved|investigational | |
| P27338 | DB06654 | Safinamide | Amine oxidase [flavin-containing] B | small molecule | approved|investigational | |
| P27338 | DB01037 | Selegiline | Amine oxidase [flavin-containing] B | small molecule | approved|investigational|vet_approved | |
| P27338 | DB04820 | Nialamide | Amine oxidase [flavin-containing] B | small molecule | approved|withdrawn | |
| P27338 | DB04821 | Nomifensine | Amine oxidase [flavin-containing] B | small molecule | approved|withdrawn | |
| P27338 | DB04832 | Zimelidine | Amine oxidase [flavin-containing] B | small molecule | approved|withdrawn |
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RelatedDiseases for MAOB |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| MAOB | C0001973 | Alcoholic Intoxication, Chronic | 5 | PSYGENET |
| MAOB | C0005586 | Bipolar Disorder | 3 | PSYGENET |
| MAOB | C0011570 | Mental Depression | 3 | PSYGENET |
| MAOB | C0011581 | Depressive disorder | 3 | PSYGENET |
| MAOB | C0525045 | Mood Disorders | 3 | PSYGENET |
| MAOB | C0002395 | Alzheimer's Disease | 2 | CTD_human |
| MAOB | C0041696 | Unipolar Depression | 2 | PSYGENET |
| MAOB | C1269683 | Major Depressive Disorder | 2 | PSYGENET |
| MAOB | C0002888 | Anemia, Megaloblastic | 1 | CTD_human |
| MAOB | C0004352 | Autistic Disorder | 1 | CTD_human |
| MAOB | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| MAOB | C0014175 | Endometriosis | 1 | CTD_human |
| MAOB | C0019151 | Hepatic Encephalopathy | 1 | CTD_human |
| MAOB | C0020179 | Huntington Disease | 1 | CTD_human |
| MAOB | C0020649 | Hypotension | 1 | CTD_human |
| MAOB | C0030567 | Parkinson Disease | 1 | CTD_human |
| MAOB | C0031511 | Pheochromocytoma | 1 | CTD_human |
| MAOB | C0036341 | Schizophrenia | 1 | CTD_human |
| MAOB | C2936349 | Plaque, Amyloid | 1 | CTD_human |
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