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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for LPP |
 Gene summary |
| Gene information | Gene symbol | LPP | Gene ID | 4026 |
| Gene name | LIM domain containing preferred translocation partner in lipoma | |
| Synonyms | - | |
| Cytomap | 3q27.3-q28 | |
| Type of gene | protein-coding | |
| Description | lipoma-preferred partnerLIM proteinlipoma preferred partner | |
| Modification date | 20180519 | |
| UniProtAcc | Q93052 | |
| Context | PubMed: LPP [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for LPP from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for LPP |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for LPP |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_380364 | 3 | 187925985:187926106:188059450:188059507:188123899:188123945 | 188059450:188059507 | ENSG00000145012.8 | ENST00000426274.1 |
| exon_skip_380372 | 3 | 187930491:187930619:187943192:187943315:188123899:188123945 | 187943192:187943315 | ENSG00000145012.8 | ENST00000443217.1 |
| exon_skip_380380 | 3 | 187930720:187930834:187943192:187943315:188123899:188124048 | 187943192:187943315 | ENSG00000145012.8 | ENST00000312675.4 |
| exon_skip_380382 | 3 | 187943192:187943315:188030622:188030706:188123899:188124066 | 188030622:188030706 | ENSG00000145012.8 | ENST00000430340.1 |
| exon_skip_380392 | 3 | 187943192:187943315:188059450:188059507:188123899:188123945 | 188059450:188059507 | ENSG00000145012.8 | ENST00000543006.1 |
| exon_skip_380396 | 3 | 187943192:187943315:188123899:188124101:188202379:188202383 | 188123899:188124101 | ENSG00000145012.8 | ENST00000414139.1,ENST00000312675.4 |
| exon_skip_380408 | 3 | 188059450:188059507:188123899:188124101:188202379:188202383 | 188123899:188124101 | ENSG00000145012.8 | ENST00000426274.1,ENST00000454789.1,ENST00000448637.1,ENST00000543006.1 |
| exon_skip_380409 | 3 | 188123899:188124101:188202379:188202492:188242452:188242481 | 188202379:188202492 | ENSG00000145012.8 | ENST00000416784.1,ENST00000448637.1,ENST00000420410.1,ENST00000543006.1,ENST00000312675.4 |
| exon_skip_380411 | 3 | 188202379:188202492:188242452:188242575:188326948:188326972 | 188242452:188242575 | ENSG00000145012.8 | ENST00000416784.1,ENST00000448637.1,ENST00000494233.1,ENST00000543006.1,ENST00000312675.4 |
| exon_skip_380413 | 3 | 188242452:188242575:188326948:188327632:188426054:188426181 | 188326948:188327632 | ENSG00000145012.8 | ENST00000448637.1,ENST00000543006.1,ENST00000312675.4 |
| exon_skip_380414 | 3 | 188327008:188327632:188426054:188426181:188477900:188477989 | 188426054:188426181 | ENSG00000145012.8 | ENST00000471917.1,ENST00000543006.1,ENST00000312675.4 |
| exon_skip_380417 | 3 | 188476526:188476556:188477050:188477288:188477900:188477989 | 188477050:188477288 | ENSG00000145012.8 | ENST00000459897.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for LPP |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_380364 | 3 | 187925985:187926106:188059450:188059507:188123899:188123945 | 188059450:188059507 | ENSG00000145012.8 | ENST00000426274.1 |
| exon_skip_380372 | 3 | 187930491:187930619:187943192:187943315:188123899:188123945 | 187943192:187943315 | ENSG00000145012.8 | ENST00000443217.1 |
| exon_skip_380380 | 3 | 187930720:187930834:187943192:187943315:188123899:188124048 | 187943192:187943315 | ENSG00000145012.8 | ENST00000312675.4 |
| exon_skip_380382 | 3 | 187943192:187943315:188030622:188030706:188123899:188124066 | 188030622:188030706 | ENSG00000145012.8 | ENST00000430340.1 |
| exon_skip_380392 | 3 | 187943192:187943315:188059450:188059507:188123899:188123945 | 188059450:188059507 | ENSG00000145012.8 | ENST00000543006.1 |
| exon_skip_380396 | 3 | 187943192:187943315:188123899:188124101:188202379:188202383 | 188123899:188124101 | ENSG00000145012.8 | ENST00000414139.1,ENST00000312675.4 |
| exon_skip_380408 | 3 | 188059450:188059507:188123899:188124101:188202379:188202383 | 188123899:188124101 | ENSG00000145012.8 | ENST00000448637.1,ENST00000454789.1,ENST00000426274.1,ENST00000543006.1 |
| exon_skip_380409 | 3 | 188123899:188124101:188202379:188202492:188242452:188242481 | 188202379:188202492 | ENSG00000145012.8 | ENST00000448637.1,ENST00000416784.1,ENST00000420410.1,ENST00000312675.4,ENST00000543006.1 |
| exon_skip_380411 | 3 | 188202379:188202492:188242452:188242575:188326948:188326972 | 188242452:188242575 | ENSG00000145012.8 | ENST00000448637.1,ENST00000416784.1,ENST00000312675.4,ENST00000543006.1,ENST00000494233.1 |
| exon_skip_380413 | 3 | 188242452:188242575:188326948:188327632:188426054:188426181 | 188326948:188327632 | ENSG00000145012.8 | ENST00000448637.1,ENST00000312675.4,ENST00000543006.1 |
| exon_skip_380414 | 3 | 188327008:188327632:188426054:188426181:188477900:188477989 | 188426054:188426181 | ENSG00000145012.8 | ENST00000312675.4,ENST00000543006.1,ENST00000471917.1 |
| exon_skip_380417 | 3 | 188476526:188476556:188477050:188477288:188477900:188477989 | 188477050:188477288 | ENSG00000145012.8 | ENST00000459897.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for LPP |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for LPP |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for LPP |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LUAD | TCGA-91-6847-01 | 188123900 | 188124101 | 188124020 | 188124024 | Frame_Shift_Del | ACACA | - | p.T38fs | |
| LUAD | TCGA-91-6847-01 | 188123900 | 188124101 | 188124020 | 188124024 | Frame_Shift_Del | ACACA | - | p.TQ38fs | |
| LIHC | TCGA-G3-A3CJ-01 | 188123900 | 188124101 | 188124041 | 188124041 | Frame_Shift_Del | T | - | p.F45fs | |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_380413 | 188326949 | 188327632 | 188327045 | 188327045 | Frame_Shift_Del | A | - | p.K177fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_380413 | 188326949 | 188327632 | 188327247 | 188327247 | Frame_Shift_Del | T | - | p.I243fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_380413 | 188326949 | 188327632 | 188327346 | 188327346 | Frame_Shift_Del | T | - | p.I276fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_380413 | 188326949 | 188327632 | 188327388 | 188327388 | Frame_Shift_Del | C | - | p.A290fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_380413 | 188326949 | 188327632 | 188327540 | 188327540 | Frame_Shift_Del | A | - | p.N341fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_380414 | 188426055 | 188426181 | 188426133 | 188426133 | Frame_Shift_Del | A | - | p.K399fs |
| STAD | TCGA-HU-8602-01 | exon_skip_380413 | 188326949 | 188327632 | 188327440 | 188327441 | Frame_Shift_Ins | - | G | p.Y307fs |
| STAD | TCGA-HU-8602-01 | exon_skip_380413 | 188326949 | 188327632 | 188327441 | 188327442 | Frame_Shift_Ins | - | G | p.Y307fs |
| GBM | TCGA-06-0219-01 | exon_skip_380413 | 188326949 | 188327632 | 188327129 | 188327129 | Nonsense_Mutation | C | T | p.Q204* |
| LUAD | TCGA-05-4397-01 | exon_skip_380413 | 188326949 | 188327632 | 188327238 | 188327238 | Nonsense_Mutation | C | G | p.S240* |
| THYM | TCGA-ZB-A96G-01 | exon_skip_380413 | 188326949 | 188327632 | 188327238 | 188327238 | Nonsense_Mutation | C | A | p.S240X |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| CL34_LARGE_INTESTINE | 188202380 | 188202492 | 188202394 | 188202394 | Frame_Shift_Del | C | - | p.P74fs |
| SNU175_LARGE_INTESTINE | 188123900 | 188124101 | 188124034 | 188124035 | Frame_Shift_Ins | - | A | p.K43fs |
| CHAGOK1_LUNG | 188326949 | 188327632 | 188327007 | 188327008 | Frame_Shift_Ins | - | A | p.M164fs |
| SNU1_STOMACH | 188123900 | 188124101 | 188123957 | 188123957 | Missense_Mutation | G | A | p.G17S |
| NCIH2882_LUNG | 188123900 | 188124101 | 188123964 | 188123964 | Missense_Mutation | T | C | p.V19A |
| NCIH2342_LUNG | 188123900 | 188124101 | 188123997 | 188123997 | Missense_Mutation | G | T | p.G30V |
| NALM19_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 188123900 | 188124101 | 188123999 | 188123999 | Missense_Mutation | A | T | p.N31Y |
| IGR1_SKIN | 188123900 | 188124101 | 188124060 | 188124060 | Missense_Mutation | C | T | p.P51L |
| CW2_LARGE_INTESTINE | 188123900 | 188124101 | 188124092 | 188124092 | Missense_Mutation | G | A | p.G62R |
| NCIH630_LARGE_INTESTINE | 188202380 | 188202492 | 188202415 | 188202415 | Missense_Mutation | G | C | p.D77H |
| GRST_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 188242453 | 188242575 | 188242462 | 188242462 | Missense_Mutation | G | A | p.G106R |
| NCIH1155_LUNG | 188242453 | 188242575 | 188242462 | 188242462 | Missense_Mutation | G | A | p.G106R |
| HCC2450_LUNG | 188242453 | 188242575 | 188242463 | 188242463 | Missense_Mutation | G | A | p.G106E |
| FTC238_THYROID | 188326949 | 188327632 | 188327039 | 188327039 | Missense_Mutation | G | A | p.A174T |
| MCAS_OVARY | 188326949 | 188327632 | 188327112 | 188327112 | Missense_Mutation | C | T | p.T198I |
| NCIH2342_LUNG | 188326949 | 188327632 | 188327135 | 188327135 | Missense_Mutation | G | T | p.V206F |
| KYSE180_OESOPHAGUS | 188326949 | 188327632 | 188327223 | 188327223 | Missense_Mutation | T | A | p.M235K |
| HEC1A_ENDOMETRIUM | 188326949 | 188327632 | 188327289 | 188327289 | Missense_Mutation | C | T | p.P257L |
| HEC1_ENDOMETRIUM | 188326949 | 188327632 | 188327289 | 188327289 | Missense_Mutation | C | T | p.P257L |
| HEC1B_ENDOMETRIUM | 188326949 | 188327632 | 188327289 | 188327289 | Missense_Mutation | C | T | p.P257L |
| TTC549_SOFT_TISSUE | 188326949 | 188327632 | 188327390 | 188327390 | Missense_Mutation | C | T | p.P291S |
| MLMA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 188326949 | 188327632 | 188327391 | 188327391 | Missense_Mutation | C | G | p.P291R |
| SHP77_LUNG | 188326949 | 188327632 | 188327526 | 188327526 | Missense_Mutation | G | T | p.G336V |
| SW1088_CENTRAL_NERVOUS_SYSTEM | 188326949 | 188327632 | 188327544 | 188327544 | Missense_Mutation | C | G | p.P342R |
| CTV1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 188326949 | 188327632 | 188327550 | 188327550 | Missense_Mutation | G | A | p.G344E |
| HS944T_SKIN | 188326949 | 188327632 | 188327553 | 188327553 | Missense_Mutation | T | G | p.M345R |
| CORL32_LUNG | 188326949 | 188327632 | 188327585 | 188327585 | Missense_Mutation | A | G | p.I356V |
| PLB985_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 188326949 | 188327632 | 188327603 | 188327603 | Missense_Mutation | G | T | p.A362S |
| MON_SOFT_TISSUE | 188326949 | 188327632 | 188327607 | 188327607 | Missense_Mutation | C | T | p.P363L |
| COLO792_SKIN | 188426055 | 188426181 | 188426098 | 188426098 | Missense_Mutation | C | T | p.S386L |
| KMS11_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 188426055 | 188426181 | 188426160 | 188426160 | Missense_Mutation | C | T | p.P407S |
| CP66MEL_SKIN | 188426055 | 188426181 | 188426161 | 188426161 | Missense_Mutation | C | T | p.P407L |
| LB771HNC_UPPER_AERODIGESTIVE_TRACT | 188326949 | 188327632 | 188327497 | 188327497 | Nonsense_Mutation | G | A | p.W326* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for LPP |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for LPP |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for LPP |
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RelatedDrugs for LPP |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LPP |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| LPP | C3495559 | Juvenile arthritis | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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