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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for LMO2 |
 Gene summary |
| Gene information | Gene symbol | LMO2 | Gene ID | 4005 |
| Gene name | LIM domain only 2 | |
| Synonyms | LMO-2|RBTN2|RBTNL1|RHOM2|TTG2 | |
| Cytomap | 11p13 | |
| Type of gene | protein-coding | |
| Description | rhombotin-2LIM domain only protein 2T-cell translocation gene 2T-cell translocation protein 2cysteine-rich protein TTG-2rhombotin-like 1 | |
| Modification date | 20180522 | |
| UniProtAcc | P25791 | |
| Context | PubMed: LMO2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| LMO2 | GO:0042789 | mRNA transcription by RNA polymerase II | 16314316 |
| LMO2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 16314316 |
| LMO2 | GO:0097067 | cellular response to thyroid hormone stimulus | 19375645 |
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Exon skipping events across known transcript of Ensembl for LMO2 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for LMO2 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for LMO2 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_70225 | 11 | 33891090:33891132:33891255:33891533:33903369:33903433 | 33891255:33891533 | ENSG00000135363.7 | ENST00000257818.2 |
| exon_skip_70229 | 11 | 33891090:33891132:33891370:33891533:33891890:33892075 | 33891370:33891533 | ENSG00000135363.7 | ENST00000493667.1 |
| exon_skip_70251 | 11 | 33891370:33891533:33903369:33903433:33913341:33913836 | 33903369:33903433 | ENSG00000135363.7 | ENST00000257818.2 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for LMO2 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_70225 | 11 | 33891090:33891132:33891255:33891533:33903369:33903433 | 33891255:33891533 | ENSG00000135363.7 | ENST00000257818.2 |
| exon_skip_70229 | 11 | 33891090:33891132:33891370:33891533:33891890:33892075 | 33891370:33891533 | ENSG00000135363.7 | ENST00000493667.1 |
| exon_skip_70251 | 11 | 33891370:33891533:33903369:33903433:33913341:33913836 | 33903369:33903433 | ENSG00000135363.7 | ENST00000257818.2 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for LMO2 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for LMO2 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for LMO2 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for LMO2 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for LMO2 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for LMO2 |
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RelatedDrugs for LMO2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LMO2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| LMO2 | C1961099 | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 2 | CTD_human |
| LMO2 | C0023492 | Leukemia, T-Cell | 1 | CTD_human |
| LMO2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
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