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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ZNF470 |
 Gene summary |
| Gene information | Gene symbol | ZNF470 | Gene ID | 388566 |
| Gene name | zinc finger protein 470 | |
| Synonyms | CZF-1 | |
| Cytomap | 19q13.43 | |
| Type of gene | protein-coding | |
| Description | zinc finger protein 470chondrogenesis zinc finger protein 1 | |
| Modification date | 20180522 | |
| UniProtAcc | Q6ECI4 | |
| Context | PubMed: ZNF470 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for ZNF470 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ZNF470 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ZNF470 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_311900 | 19 | 57080126:57080252:57081648:57081740:57085762:57085889 | 57081648:57081740 | ENSG00000197016.7 | ENST00000330619.8,ENST00000601902.1 |
| exon_skip_311902 | 19 | 57081648:57081740:57085762:57085889:57086006:57086102 | 57085762:57085889 | ENSG00000197016.7 | ENST00000391709.3,ENST00000330619.8,ENST00000601902.1 |
| exon_skip_311905 | 19 | 57086015:57086102:57095387:57095480:57099593:57099774 | 57095387:57095480 | ENSG00000197016.7 | ENST00000601059.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ZNF470 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_311900 | 19 | 57080126:57080252:57081648:57081740:57085762:57085889 | 57081648:57081740 | ENSG00000197016.7 | ENST00000330619.8,ENST00000601902.1 |
| exon_skip_311902 | 19 | 57081648:57081740:57085762:57085889:57086006:57086102 | 57085762:57085889 | ENSG00000197016.7 | ENST00000330619.8,ENST00000391709.3,ENST00000601902.1 |
| exon_skip_311905 | 19 | 57086015:57086102:57095387:57095480:57099593:57099774 | 57095387:57095480 | ENSG00000197016.7 | ENST00000601059.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ZNF470 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000330619 | 57081648 | 57081740 | 5CDS-5UTR |
| ENST00000330619 | 57085762 | 57085889 | Frame-shift |
| ENST00000391709 | 57085762 | 57085889 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000330619 | 57081648 | 57081740 | 5CDS-5UTR |
| ENST00000330619 | 57085762 | 57085889 | Frame-shift |
| ENST00000391709 | 57085762 | 57085889 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for ZNF470 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for ZNF470 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| BLCA | TCGA-XF-A9T5-01 | exon_skip_311902 | 57085763 | 57085889 | 57085884 | 57085884 | Nonsense_Mutation | C | G | p.S61* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| KYSE150_OESOPHAGUS | 57081649 | 57081740 | 57081712 | 57081712 | Missense_Mutation | G | A | p.G11E |
| SBC1_LUNG | 57085763 | 57085889 | 57085794 | 57085794 | Missense_Mutation | A | C | p.D31A |
| HEC151_ENDOMETRIUM | 57085763 | 57085889 | 57085875 | 57085875 | Missense_Mutation | A | G | p.N58S |
| SISO_CERVIX | 57081649 | 57081740 | 57081739 | 57081739 | Splice_Site | T | C | p.L20P |
| GRST_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 57081649 | 57081740 | 57081739 | 57081739 | Splice_Site | T | C | p.L20P |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZNF470 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
| exon_skip_311902 | 19 | 57081648:57081740:57085762:57085889:57086006:57086102 | 57085762:57085889 | ENST00000391709.3,ENST00000330619.8,ENST00000601902.1 | BRCA | rs10421285 | chr19:57085769 | C/G | 6.05e-08 |
| exon_skip_311902 | 19 | 57081648:57081740:57085762:57085889:57086006:57086102 | 57085762:57085889 | ENST00000391709.3,ENST00000330619.8,ENST00000601902.1 | BRCA | rs10421285 | chr19:57085769 | C/G | 6.06e-08 |
| exon_skip_311902 | 19 | 57081648:57081740:57085762:57085889:57086006:57086102 | 57085762:57085889 | ENST00000391709.3,ENST00000330619.8,ENST00000601902.1 | LGG | rs10421285 | chr19:57085769 | C/G | 2.76e-12 |
| exon_skip_311902 | 19 | 57081648:57081740:57085762:57085889:57086006:57086102 | 57085762:57085889 | ENST00000391709.3,ENST00000330619.8,ENST00000601902.1 | LGG | rs10421285 | chr19:57085769 | C/G | 2.77e-12 |
| exon_skip_311902 | 19 | 57081648:57081740:57085762:57085889:57086006:57086102 | 57085762:57085889 | ENST00000391709.3,ENST00000330619.8,ENST00000601902.1 | KIRC | rs10421285 | chr19:57085769 | C/G | 3.18e-04 |
| exon_skip_311902 | 19 | 57081648:57081740:57085762:57085889:57086006:57086102 | 57085762:57085889 | ENST00000391709.3,ENST00000330619.8,ENST00000601902.1 | KIRC | rs10421285 | chr19:57085769 | C/G | 3.18e-04 |
| exon_skip_311902 | 19 | 57081648:57081740:57085762:57085889:57086006:57086102 | 57085762:57085889 | ENST00000391709.3,ENST00000330619.8,ENST00000601902.1 | LUSC | rs10421285 | chr19:57085769 | C/G | 2.32e-03 |
| exon_skip_311902 | 19 | 57081648:57081740:57085762:57085889:57086006:57086102 | 57085762:57085889 | ENST00000391709.3,ENST00000330619.8,ENST00000601902.1 | LUSC | rs10421285 | chr19:57085769 | C/G | 2.32e-03 |
| exon_skip_311902 | 19 | 57081648:57081740:57085762:57085889:57086006:57086102 | 57085762:57085889 | ENST00000391709.3,ENST00000330619.8,ENST00000601902.1 | PRAD | rs10421285 | chr19:57085769 | C/G | 3.14e-08 |
| exon_skip_311902 | 19 | 57081648:57081740:57085762:57085889:57086006:57086102 | 57085762:57085889 | ENST00000391709.3,ENST00000330619.8,ENST00000601902.1 | PRAD | rs10421285 | chr19:57085769 | C/G | 3.14e-08 |
| exon_skip_311902 | 19 | 57081648:57081740:57085762:57085889:57086006:57086102 | 57085762:57085889 | ENST00000391709.3,ENST00000330619.8,ENST00000601902.1 | SARC | rs10421285 | chr19:57085769 | C/G | 1.53e-04 |
| exon_skip_311902 | 19 | 57081648:57081740:57085762:57085889:57086006:57086102 | 57085762:57085889 | ENST00000391709.3,ENST00000330619.8,ENST00000601902.1 | SARC | rs10421285 | chr19:57085769 | C/G | 1.53e-04 |
| exon_skip_311902 | 19 | 57081648:57081740:57085762:57085889:57086006:57086102 | 57085762:57085889 | ENST00000391709.3,ENST00000330619.8,ENST00000601902.1 | THCA | rs10421285 | chr19:57085769 | C/G | 2.86e-05 |
| exon_skip_311902 | 19 | 57081648:57081740:57085762:57085889:57086006:57086102 | 57085762:57085889 | ENST00000391709.3,ENST00000330619.8,ENST00000601902.1 | THCA | rs10421285 | chr19:57085769 | C/G | 2.87e-05 |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZNF470 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZNF470 |
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RelatedDrugs for ZNF470 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF470 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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