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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for KRAS

check button Gene summary
Gene informationGene symbol

KRAS

Gene ID

3845

Gene nameKRAS proto-oncogene, GTPase
SynonymsC-K-RAS|CFC2|K-RAS2A|K-RAS2B|K-RAS4A|K-RAS4B|K-Ras|KI-RAS|KRAS1|KRAS2|NS|NS3|RALD|RASK2|c-Ki-ras2
Cytomap

12p12.1

Type of geneprotein-coding
DescriptionGTPase KRasK-Ras 2K-ras p21 proteinKirsten rat sarcoma viral oncogene homologKirsten rat sarcoma viral proto-oncogenePR310 c-K-ras oncogenec-Ki-rasc-Kirsten-ras proteincellular c-Ki-ras2 proto-oncogenecellular transforming proto-oncogeneoncogene
Modification date20180527
UniProtAcc

P01116

ContextPubMed: KRAS [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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Exon skipping events across known transcript of Ensembl for KRAS from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for KRAS

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for KRAS

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_906591225362744:25362845:25368370:25368494:25378547:2537870725368370:25368494ENSG00000133703.7ENST00000256078.4
exon_skip_906611225378547:25378707:25380167:25380346:25398207:2539832925380167:25380346ENSG00000133703.7ENST00000311936.3,ENST00000256078.4
exon_skip_906621225380167:25380346:25398207:25398329:25403684:2540373725398207:25398329ENSG00000133703.7ENST00000256078.4

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for KRAS

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_906591225362744:25362845:25368370:25368494:25378547:2537870725368370:25368494ENSG00000133703.7ENST00000256078.4
exon_skip_906611225378547:25378707:25380167:25380346:25398207:2539832925380167:25380346ENSG00000133703.7ENST00000311936.3,ENST00000256078.4
exon_skip_906621225380167:25380346:25398207:25398329:25403684:2540373725398207:25398329ENSG00000133703.7ENST00000256078.4

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for KRAS

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST0000025607825398207253983293UTR-3CDS
ENST0000025607825368370253684945CDS-5UTR
ENST000002560782538016725380346Frame-shift

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST0000025607825398207253983293UTR-3CDS
ENST0000025607825368370253684945CDS-5UTR
ENST000002560782538016725380346Frame-shift

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Infer the effects of exon skipping event on protein functional features for KRAS

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature


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SNVs in the skipped exons for KRAS

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LIHCTCGA-DD-A3A0-01exon_skip_90661
25380168253803462538023925380239Frame_Shift_DelC-p.R73fs
LUADTCGA-55-7911-01exon_skip_90661
25380168253803462538019625380196Nonsense_MutationTAp.K88*

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
SISO_CERVIX25368371253684942536839025368390Frame_Shift_DelT-p.K185fs
DND41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE25368371253684942536839025368390Frame_Shift_DelT-p.K185fs
GRST_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE25368371253684942536839025368390Frame_Shift_DelT-p.K185fs
MUTZ3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE25398208253983292539828725398288In_Frame_Ins-CTCp.10_11insG
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE25368371253684942536838625368386Missense_MutationTCp.I187V
BICR18_UPPER_AERODIGESTIVE_TRACT25368371253684942536838625368386Missense_MutationTCp.I187V
SUDHL10_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE25368371253684942536843225368432Missense_MutationGCp.I171M
HEC6_ENDOMETRIUM25368371253684942536846625368466Missense_MutationAGp.V160A
TEN_ENDOMETRIUM25380168253803462538023825380238Missense_MutationTGp.T74P
CL11_LARGE_INTESTINE25380168253803462538027525380275Missense_MutationTGp.Q61H
HS766T_PANCREAS25380168253803462538027525380275Missense_MutationTGp.Q61H
T3M4_PANCREAS25380168253803462538027525380275Missense_MutationTGp.Q61H
NCIH460_LUNG25380168253803462538027525380275Missense_MutationTAp.Q61H
NCIH1155_LUNG25380168253803462538027525380275Missense_MutationTAp.Q61H
SJSA1_BONE25380168253803462538027525380275Missense_MutationTAp.Q61H
HCC2108_LUNG25380168253803462538027525380275Missense_MutationTGp.Q61H
PANC0213_PANCREAS25380168253803462538027625380276Missense_MutationTCp.Q61R
NCIH650_LUNG25380168253803462538027625380276Missense_MutationTAp.Q61L
SW948_LARGE_INTESTINE25380168253803462538027625380276Missense_MutationTAp.Q61L
SNU668_STOMACH25380168253803462538027725380278Missense_MutationGATCp.Q61K
CALU6_LUNG25380168253803462538027725380277Missense_MutationGTp.Q61K
CALU6_LUNG25380168253803462538027725380278Missense_MutationGATGp.Q61K
SNU668_STOMACH25380168253803462538027725380277Missense_MutationGTp.Q61K
OVK18_OVARY25380168253803462538028225380282Missense_MutationGCp.A59G
SNU175_LARGE_INTESTINE25380168253803462538028325380283Missense_MutationCTp.A59T
HTK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE25380168253803462538028325380283Missense_MutationCTp.A59T
NUGC2_STOMACH25380168253803462538028525380285Missense_MutationGAp.T58I
JHUEM3_ENDOMETRIUM25398208253983292539822025398220Missense_MutationACp.D33E
MHHCALL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE25398208253983292539825125398251Missense_MutationACp.L23R
NCIH2347_LUNG25398208253983292539826225398262Missense_MutationCAp.L19F
NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE25398208253983292539826625398266Missense_MutationGTp.A18D
CL11_LARGE_INTESTINE25398208253983292539827925398279Missense_MutationCTp.V14I
KASUMI2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE25398208253983292539827925398279Missense_MutationCGp.V14L
RCHACV_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE25398208253983292539827925398279Missense_MutationCTp.V14I
HCC515_LUNG25398208253983292539828125398281Missense_MutationCTp.G13D
NCIH647_LUNG25398208253983292539828125398281Missense_MutationCTp.G13D
DV90_LUNG25398208253983292539828125398281Missense_MutationCTp.G13D
NCIH1944_LUNG25398208253983292539828125398281Missense_MutationCTp.G13D
TOLEDO_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE25398208253983292539828125398281Missense_MutationCTp.G13D
HCT116_LARGE_INTESTINE25398208253983292539828125398281Missense_MutationCTp.G13D
HCT15_LARGE_INTESTINE25398208253983292539828125398281Missense_MutationCTp.G13D
NCIH747_LARGE_INTESTINE25398208253983292539828125398281Missense_MutationCTp.G13D
LOVO_LARGE_INTESTINE25398208253983292539828125398281Missense_MutationCTp.G13D
MDAMB231_BREAST25398208253983292539828125398281Missense_MutationCTp.G13D
T84_LARGE_INTESTINE25398208253983292539828125398281Missense_MutationCTp.G13D
NOMO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE25398208253983292539828125398281Missense_MutationCTp.G13D
HRT18_LARGE_INTESTINE25398208253983292539828125398281Missense_MutationCTp.G13D
HCC2108_LUNG25398208253983292539828225398282Missense_MutationCAp.G13C
MORCPR_LUNG25398208253983292539828225398282Missense_MutationCAp.G13C
TOV21G_OVARY25398208253983292539828225398282Missense_MutationCAp.G13C
NCIH1355_LUNG25398208253983292539828225398282Missense_MutationCAp.G13C
NCIH1734_LUNG25398208253983292539828225398282Missense_MutationCAp.G13C
A427_LUNG25398208253983292539828425398284Missense_MutationCTp.G12D
C84_LARGE_INTESTINE25398208253983292539828425398284Missense_MutationCGp.G12A
EGI1_BILIARY_TRACT25398208253983292539828425398284Missense_MutationCTp.G12D
HCC461_LUNG25398208253983292539828425398284Missense_MutationCTp.G12D
JOPACA1_PANCREAS25398208253983292539828425398284Missense_MutationCAp.G12V
KHYG_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE25398208253983292539828425398284Missense_MutationCGp.G12A
LCLC97TM1_LUNG25398208253983292539828425398284Missense_MutationCAp.G12V
NCIH2887_LUNG25398208253983292539828425398284Missense_MutationCAp.G12V
PACADD119_PANCREAS25398208253983292539828425398284Missense_MutationCGp.G12A
PACADD135_PANCREAS25398208253983292539828425398284Missense_MutationCAp.G12V
PACADD161_PANCREAS25398208253983292539828425398284Missense_MutationCAp.G12V
PACADD188_PANCREAS25398208253983292539828425398284Missense_MutationCTp.G12D
PK45H_PANCREAS25398208253983292539828425398284Missense_MutationCTp.G12D
SKGT4_OESOPHAGUS25398208253983292539828425398284Missense_MutationCGp.G12A
SNU410_PANCREAS25398208253983292539828425398284Missense_MutationCTp.G12D
SUM229PE_BREAST25398208253983292539828425398284Missense_MutationCTp.G12D
SW626_OVARY25398208253983292539828425398284Missense_MutationCAp.G12V
CL40_LARGE_INTESTINE25398208253983292539828425398284Missense_MutationCTp.G12D
GSU_STOMACH25398208253983292539828425398284Missense_MutationCTp.G12D
HEC50B_ENDOMETRIUM25398208253983292539828425398284Missense_MutationCTp.G12D
HEYA8_OVARY25398208253983292539828425398284Missense_MutationCTp.G12D
HMC18_BREAST25398208253983292539828425398284Missense_MutationCAp.G12V
KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE25398208253983292539828425398284Missense_MutationCTp.G12D
KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE25398208253983292539828425398284Missense_MutationCTp.G12D
KPNSI9S_AUTONOMIC_GANGLIA25398208253983292539828425398284Missense_MutationCGp.G12A
L33_PANCREAS25398208253983292539828425398284Missense_MutationCTp.G12D
MCAS_OVARY25398208253983292539828425398284Missense_MutationCTp.G12D
MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE25398208253983292539828425398284Missense_MutationCGp.G12A
NCIH684_LIVER25398208253983292539828425398284Missense_MutationCTp.G12D
PANC0203_PANCREAS25398208253983292539828425398284Missense_MutationCTp.G12D
PANC0403_PANCREAS25398208253983292539828425398284Missense_MutationCTp.G12D
PANC0504_PANCREAS25398208253983292539828425398284Missense_MutationCTp.G12D
PATU8902_PANCREAS25398208253983292539828425398284Missense_MutationCAp.G12V
PK1_PANCREAS25398208253983292539828425398284Missense_MutationCTp.G12D
PK59_PANCREAS25398208253983292539828425398284Missense_MutationCTp.G12D
RKN_SOFT_TISSUE25398208253983292539828425398284Missense_MutationCAp.G12V
SH10TC_STOMACH25398208253983292539828425398284Missense_MutationCAp.G12V
SKCO1_LARGE_INTESTINE25398208253983292539828425398284Missense_MutationCAp.G12V
SNGM_ENDOMETRIUM25398208253983292539828425398284Missense_MutationCAp.G12V
SNU1033_LARGE_INTESTINE25398208253983292539828425398284Missense_MutationCTp.G12D
SNU1197_LARGE_INTESTINE25398208253983292539828425398284Missense_MutationCTp.G12D
SNU213_PANCREAS25398208253983292539828425398284Missense_MutationCAp.G12V
SNU601_STOMACH25398208253983292539828425398284Missense_MutationCTp.G12D
SNU61_LARGE_INTESTINE25398208253983292539828425398284Missense_MutationCTp.G12D
SNU869_BILIARY_TRACT25398208253983292539828425398284Missense_MutationCTp.G12D
SNUC2A_LARGE_INTESTINE25398208253983292539828425398284Missense_MutationCTp.G12D
T3M10_LUNG25398208253983292539828425398284Missense_MutationCTp.G12D
AGS_STOMACH25398208253983292539828425398284Missense_MutationCTp.G12D
COLO668_LUNG25398208253983292539828425398284Missense_MutationCAp.G12V
SHP77_LUNG25398208253983292539828425398284Missense_MutationCAp.G12V
SNU1_STOMACH25398208253983292539828425398284Missense_MutationCTp.G12D
SW480_LARGE_INTESTINE25398208253983292539828425398284Missense_MutationCAp.G12V
SW900_LUNG25398208253983292539828425398284Missense_MutationCAp.G12V
CAPAN1_PANCREAS25398208253983292539828425398284Missense_MutationCAp.G12V
CORL23_LUNG25398208253983292539828425398284Missense_MutationCAp.G12V
DANG_PANCREAS25398208253983292539828425398284Missense_MutationCAp.G12V
GP2D_LARGE_INTESTINE25398208253983292539828425398284Missense_MutationCTp.G12D
HEC1A_ENDOMETRIUM25398208253983292539828425398284Missense_MutationCTp.G12D
HPAC_PANCREAS25398208253983292539828425398284Missense_MutationCTp.G12D
LS180_LARGE_INTESTINE25398208253983292539828425398284Missense_MutationCTp.G12D
LS513_LARGE_INTESTINE25398208253983292539828425398284Missense_MutationCTp.G12D
OV7_OVARY25398208253983292539828425398284Missense_MutationCTp.G12D
PANC0327_PANCREAS25398208253983292539828425398284Missense_MutationCAp.G12V
PANC1005_PANCREAS25398208253983292539828425398284Missense_MutationCTp.G12D
PANC1_PANCREAS25398208253983292539828425398284Missense_MutationCTp.G12D
PATU8988T_PANCREAS25398208253983292539828425398284Missense_MutationCAp.G12V
QGP1_PANCREAS25398208253983292539828425398284Missense_MutationCAp.G12V
RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE25398208253983292539828425398284Missense_MutationCGp.G12A
SKLU1_LUNG25398208253983292539828425398284Missense_MutationCTp.G12D
SNU407_LARGE_INTESTINE25398208253983292539828425398284Missense_MutationCTp.G12D
SUIT2_PANCREAS25398208253983292539828425398284Missense_MutationCTp.G12D
SW1990_PANCREAS25398208253983292539828425398284Missense_MutationCTp.G12D
ASPC1_PANCREAS25398208253983292539828425398284Missense_MutationCTp.G12D
CAPAN2_PANCREAS25398208253983292539828425398284Missense_MutationCAp.G12V
CCRFCEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE25398208253983292539828425398284Missense_MutationCTp.G12D
CFPAC1_PANCREAS25398208253983292539828425398284Missense_MutationCAp.G12V
COLO678_LARGE_INTESTINE25398208253983292539828425398284Missense_MutationCTp.G12D
EMCBAC2_LUNG25398208253983292539828425398284Missense_MutationCGp.G12A
GEO_LARGE_INTESTINE25398208253983292539828425398284Missense_MutationCGp.G12A
GP5D_LARGE_INTESTINE25398208253983292539828425398284Missense_MutationCTp.G12D
HCC56_LARGE_INTESTINE25398208253983292539828425398284Missense_MutationCAp.G12V
HEC1_ENDOMETRIUM25398208253983292539828425398284Missense_MutationCTp.G12D
HEY_OVARY25398208253983292539828425398284Missense_MutationCTp.G12D
HPAFII_PANCREAS25398208253983292539828425398284Missense_MutationCTp.G12D
HUCCT1_BILIARY_TRACT25398208253983292539828425398284Missense_MutationCTp.G12D
HUPT4_PANCREAS25398208253983292539828425398284Missense_MutationCAp.G12V
KP1N_PANCREAS25398208253983292539828425398284Missense_MutationCTp.G12D
KP3_PANCREAS25398208253983292539828425398284Missense_MutationCAp.G12V
KP4_PANCREAS25398208253983292539828425398284Missense_MutationCTp.G12D
MZ1PC_PANCREAS25398208253983292539828425398284Missense_MutationCAp.G12V
NCIH1573_LUNG25398208253983292539828425398284Missense_MutationCGp.G12A
NCIH2009_LUNG25398208253983292539828425398284Missense_MutationCGp.G12A
NCIH2291_LUNG25398208253983292539828425398284Missense_MutationCAp.G12V
NCIH2444_LUNG25398208253983292539828425398284Missense_MutationCAp.G12V
NCIH441_LUNG25398208253983292539828425398284Missense_MutationCAp.G12V
NCIH727_LUNG25398208253983292539828425398284Missense_MutationCAp.G12V
OVCAR5_OVARY25398208253983292539828425398284Missense_MutationCAp.G12V
PANC0813_PANCREAS25398208253983292539828425398284Missense_MutationCTp.G12D
PL4_PANCREAS25398208253983292539828425398284Missense_MutationCTp.G12D
RCM1_LARGE_INTESTINE25398208253983292539828425398284Missense_MutationCAp.G12V
SISO_CERVIX25398208253983292539828425398284Missense_MutationCTp.G12D
SNUC2B_LARGE_INTESTINE25398208253983292539828425398284Missense_MutationCTp.G12D
SU8686_PANCREAS25398208253983292539828425398284Missense_MutationCTp.G12D
SW1116_LARGE_INTESTINE25398208253983292539828425398284Missense_MutationCGp.G12A
SW403_LARGE_INTESTINE25398208253983292539828425398284Missense_MutationCAp.G12V
SW620_LARGE_INTESTINE25398208253983292539828425398284Missense_MutationCAp.G12V
TGBC11TKB_STOMACH25398208253983292539828425398284Missense_MutationCTp.G12D
YAPC_PANCREAS25398208253983292539828425398284Missense_MutationCAp.G12V
NCIH2291_LUNG25398208253983292539828425398285Missense_MutationCCAAp.G12F
639V_URINARY_TRACT25398208253983292539828425398284Missense_MutationCTp.G12D
HCC1588_LUNG25398208253983292539828425398284Missense_MutationCTp.G12D
HEC1B_ENDOMETRIUM25398208253983292539828425398284Missense_MutationCTp.G12D
KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE25398208253983292539828425398284Missense_MutationCGp.G12A
PATU8988S_PANCREAS25398208253983292539828425398284Missense_MutationCAp.G12V
RERFLCAD1_LUNG25398208253983292539828425398284Missense_MutationCGp.G12A
RERFLCAD2_LUNG25398208253983292539828425398284Missense_MutationCAp.G12V
SNU8_OVARY25398208253983292539828425398284Missense_MutationCTp.G12D
COLO775_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE25398208253983292539828425398284Missense_MutationCGp.G12A
KP1NL_PANCREAS25398208253983292539828425398284Missense_MutationCTp.G12D
SNU16_STOMACH25398208253983292539828425398284Missense_MutationCTp.G12D
CALU1_LUNG25398208253983292539828525398285Missense_MutationCAp.G12C
HKA1_SKIN25398208253983292539828525398285Missense_MutationCTp.G12S
SW756_CERVIX25398208253983292539828525398285Missense_MutationCAp.G12C
KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE25398208253983292539828525398285Missense_MutationCAp.G12C
KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE25398208253983292539828525398285Missense_MutationCTp.G12S
KP2_PANCREAS25398208253983292539828525398285Missense_MutationCGp.G12R
NCIH1339_LUNG25398208253983292539828525398285Missense_MutationCGp.G12R
NCIH1373_LUNG25398208253983292539828525398285Missense_MutationCAp.G12C
SW1573_LUNG25398208253983292539828525398285Missense_MutationCAp.G12C
TCCPAN2_PANCREAS25398208253983292539828525398285Missense_MutationCGp.G12R
A549_LUNG25398208253983292539828525398285Missense_MutationCTp.G12S
HCC44_LUNG25398208253983292539828525398285Missense_MutationCAp.G12C
KYSE410_OESOPHAGUS25398208253983292539828525398285Missense_MutationCAp.G12C
NCIH2122_LUNG25398208253983292539828525398285Missense_MutationCAp.G12C
LU99_LUNG25398208253983292539828525398285Missense_MutationCAp.G12C
MIAPACA2_PANCREAS25398208253983292539828525398285Missense_MutationCAp.G12C
NCIH1792_LUNG25398208253983292539828525398285Missense_MutationCAp.G12C
NCIH2030_LUNG25398208253983292539828525398285Missense_MutationCAp.G12C
NCIH23_LUNG25398208253983292539828525398285Missense_MutationCAp.G12C
NCIH358_LUNG25398208253983292539828525398285Missense_MutationCAp.G12C
OV56_OVARY25398208253983292539828525398285Missense_MutationCAp.G12C
CAL62_THYROID25398208253983292539828525398285Missense_MutationCGp.G12R
HOP62_LUNG25398208253983292539828525398285Missense_MutationCAp.G12C
HUPT3_PANCREAS25398208253983292539828525398285Missense_MutationCGp.G12R
IALM_LUNG25398208253983292539828525398285Missense_MutationCAp.G12C
LAN6_AUTONOMIC_GANGLIA25398208253983292539828525398285Missense_MutationCAp.G12C
LS123_LARGE_INTESTINE25398208253983292539828525398285Missense_MutationCTp.G12S
LU65_LUNG25398208253983292539828525398285Missense_MutationCAp.G12C
NCIH2291_LUNG25398208253983292539828525398285Missense_MutationCAp.G12C
PSN1_PANCREAS25398208253983292539828525398285Missense_MutationCGp.G12R
SW1463_LARGE_INTESTINE25398208253983292539828525398285Missense_MutationCAp.G12C
SW837_LARGE_INTESTINE25398208253983292539828525398285Missense_MutationCAp.G12C
UMUC3_URINARY_TRACT25398208253983292539828525398285Missense_MutationCAp.G12C
JHU028_LUNG25398208253983292539828525398285Missense_MutationCTp.G12S
HCC1171_LUNG25398208253983292539828525398285Missense_MutationCAp.G12C
NCIH1385_LUNG25398208253983292539828525398285Missense_MutationCAp.G12C
GRM_SKIN25398208253983292539828525398285Missense_MutationCGp.G12R
HTK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE25398208253983292539828525398285Missense_MutationCTp.G12S
KMM1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE25398208253983292539829425398294Missense_MutationCTp.V9I
HEC251_ENDOMETRIUM25368371253684942536845525368455Nonsense_MutationGAp.R164*
NCIH716_LARGE_INTESTINE25380168253803462538016825380168Splice_SiteCAp.R97I

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for KRAS

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for KRAS


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for KRAS


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RelatedDrugs for KRAS

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KRAS

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
KRASC0024121Lung Neoplasms31CTD_human
KRASC0699791Stomach Carcinoma9HPO;UNIPROT
KRASC0007131Non-Small Cell Lung Carcinoma6CTD_human
KRASC0009375Colonic Neoplasms6CTD_human
KRASC0030297Pancreatic Neoplasm6CTD_human;HPO
KRASC0027659Neoplasms, Experimental5CTD_human
KRASC0152013Adenocarcinoma of lung (disorder)5CTD_human
KRASC3809005CARDIOFACIOCUTANEOUS SYNDROME 25UNIPROT
KRASC0001430Adenoma4CTD_human
KRASC0018923Hemangiosarcoma4CTD_human
KRASC0028326Noonan Syndrome4CTD_human;ORPHANET
KRASC0001418Adenocarcinoma3CTD_human
KRASC0009404Colorectal Neoplasms3CTD_human
KRASC1860991NOONAN SYNDROME 33CTD_human;UNIPROT
KRASC0007137Squamous cell carcinoma2CTD_human
KRASC0023903Liver neoplasms2CTD_human
KRASC0038356Stomach Neoplasms2CTD_human
KRASC0206698Cholangiocarcinoma2CTD_human
KRASC0587248Costello syndrome (disorder)2CTD_human
KRASC2239176Liver carcinoma2CTD_human
KRASC0004114Astrocytoma1CTD_human
KRASC0007528Cecal Neoplasms1CTD_human
KRASC0007621Neoplastic Cell Transformation1CTD_human
KRASC0014175Endometriosis1CTD_human
KRASC0016978gallbladder neoplasm1CTD_human
KRASC0023897Liver Diseases, Parasitic1CTD_human
KRASC0023904Liver Neoplasms, Experimental1CTD_human
KRASC0024299Lymphoma1CTD_human
KRASC0026640Mouth Neoplasms1CTD_human
KRASC0027627Neoplasm Metastasis1CTD_human
KRASC0027819Neuroblastoma1CTD_human
KRASC0030849Penile Neoplasms1CTD_human
KRASC0040136Thyroid Neoplasm1CTD_human
KRASC0042138Uterine Neoplasms1CTD_human
KRASC0206682Follicular thyroid carcinoma1CTD_human
KRASC0349639Juvenile Myelomonocytic Leukemia1CTD_human;HPO;ORPHANET
KRASC0596263Carcinogenesis1CTD_human
KRASC0887833Carcinoma, Pancreatic Ductal1CTD_human
KRASC0919267ovarian neoplasm1CTD_human
KRASC1275081Cardio-facio-cutaneous syndrome1CTD_human;ORPHANET
KRASC2931822Nasopharyngeal carcinoma1CTD_human
KRASC3495559Juvenile arthritis1CTD_human
KRASC3854181Nevus sebaceous1CTD_human;HPO;ORPHANET