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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for ITGB6

check button Gene summary
Gene informationGene symbol

ITGB6

Gene ID

3694

Gene nameintegrin subunit beta 6
SynonymsAI1H
Cytomap

2q24.2

Type of geneprotein-coding
Descriptionintegrin beta-6integrin, beta 6
Modification date20180523
UniProtAcc

P18564

ContextPubMed: ITGB6 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
ITGB6

GO:0033627

cell adhesion mediated by integrin

17158881


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Exon skipping events across known transcript of Ensembl for ITGB6 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for ITGB6

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for ITGB6

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_3443422160964189:160964356:160968590:160968710:160980301:160980399160968590:160968710ENSG00000115221.6ENST00000409872.1,ENST00000409583.1,ENST00000428609.2,ENST00000283249.2
exon_skip_3443442160968590:160968710:160980301:160980399:160982889:160983075160980301:160980399ENSG00000115221.6ENST00000409872.1,ENST00000409583.1,ENST00000428609.2,ENST00000283249.2
exon_skip_3443522160994136:160994362:160994575:160994710:160998492:160998582160994575:160994710ENSG00000115221.6ENST00000409872.1,ENST00000409583.1,ENST00000428609.2,ENST00000283249.2,ENST00000409967.2
exon_skip_3443532160994575:160994710:160998492:160998582:161025722:161025818160998492:160998582ENSG00000115221.6ENST00000409872.1,ENST00000409583.1,ENST00000428609.2,ENST00000283249.2,ENST00000409967.2
exon_skip_3443552160998492:160998582:161025722:161025818:161029079:161029241161025722:161025818ENSG00000115221.6ENST00000409872.1,ENST00000409583.1,ENST00000428609.2,ENST00000283249.2,ENST00000409967.2,ENST00000485635.1
exon_skip_3443602161030484:161030650:161035406:161035537:161051879:161052126161035406:161035537ENSG00000115221.6ENST00000485635.1
exon_skip_3443622161051879:161052126:161052726:161052931:161055689:161055769161052726:161052931ENSG00000115221.6ENST00000409872.1,ENST00000283249.2,ENST00000409967.2
exon_skip_3443632161051879:161052126:161052726:161052931:161056513:161056534161052726:161052931ENSG00000115221.6ENST00000428609.2
exon_skip_3443642161051879:161052126:161052899:161052931:161055689:161055769161052899:161052931ENSG00000115221.6ENST00000409583.1
exon_skip_3443682161052899:161052931:161055689:161055769:161056513:161056534161055689:161055769ENSG00000115221.6ENST00000409872.1,ENST00000409583.1,ENST00000409967.2

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for ITGB6

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_3443422160964189:160964356:160968590:160968710:160980301:160980399160968590:160968710ENSG00000115221.6ENST00000283249.2,ENST00000409583.1,ENST00000428609.2,ENST00000409872.1
exon_skip_3443442160968590:160968710:160980301:160980399:160982889:160983075160980301:160980399ENSG00000115221.6ENST00000283249.2,ENST00000409583.1,ENST00000428609.2,ENST00000409872.1
exon_skip_3443522160994136:160994362:160994575:160994710:160998492:160998582160994575:160994710ENSG00000115221.6ENST00000283249.2,ENST00000409583.1,ENST00000428609.2,ENST00000409967.2,ENST00000409872.1
exon_skip_3443532160994575:160994710:160998492:160998582:161025722:161025818160998492:160998582ENSG00000115221.6ENST00000283249.2,ENST00000409583.1,ENST00000428609.2,ENST00000409967.2,ENST00000409872.1
exon_skip_3443552160998492:160998582:161025722:161025818:161029079:161029241161025722:161025818ENSG00000115221.6ENST00000283249.2,ENST00000409583.1,ENST00000428609.2,ENST00000409967.2,ENST00000409872.1,ENST00000485635.1
exon_skip_3443602161030484:161030650:161035406:161035537:161051879:161052126161035406:161035537ENSG00000115221.6ENST00000485635.1
exon_skip_3443622161051879:161052126:161052726:161052931:161055689:161055769161052726:161052931ENSG00000115221.6ENST00000283249.2,ENST00000409967.2,ENST00000409872.1
exon_skip_3443632161051879:161052126:161052726:161052931:161056513:161056534161052726:161052931ENSG00000115221.6ENST00000428609.2
exon_skip_3443642161051879:161052126:161052899:161052931:161055689:161055769161052899:161052931ENSG00000115221.6ENST00000409583.1
exon_skip_3443682161052899:161052931:161055689:161055769:161056513:161056534161055689:161055769ENSG00000115221.6ENST00000409583.1,ENST00000409967.2,ENST00000409872.1

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for ITGB6

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST00000283249160980301160980399Frame-shift
ENST00000409872160980301160980399Frame-shift
ENST00000283249161052726161052931Frame-shift
ENST00000409872161052726161052931Frame-shift
ENST00000409872161055689161055769Frame-shift
ENST00000283249160968590160968710In-frame
ENST00000409872160968590160968710In-frame
ENST00000283249160994575160994710In-frame
ENST00000409872160994575160994710In-frame
ENST00000283249160998492160998582In-frame
ENST00000409872160998492160998582In-frame
ENST00000283249161025722161025818In-frame
ENST00000409872161025722161025818In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST00000283249160980301160980399Frame-shift
ENST00000409872160980301160980399Frame-shift
ENST00000283249161052726161052931Frame-shift
ENST00000409872161052726161052931Frame-shift
ENST00000409872161055689161055769Frame-shift
ENST00000283249160968590160968710In-frame
ENST00000409872160968590160968710In-frame
ENST00000283249160994575160994710In-frame
ENST00000409872160994575160994710In-frame
ENST00000283249160998492160998582In-frame
ENST00000409872160998492160998582In-frame
ENST00000283249161025722161025818In-frame
ENST00000409872161025722161025818In-frame

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Infer the effects of exon skipping event on protein functional features for ITGB6

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST00000283249469278816102572216102581811601255307339
ENST00000409872251878816102572216102581810561151307339
ENST00000283249469278816099849216099858212561345339369
ENST00000409872251878816099849216099858211521241339369
ENST00000283249469278816099457516099471013461480369414
ENST00000409872251878816099457516099471012421376369414
ENST00000283249469278816096859016096871022202339660700
ENST00000409872251878816096859016096871021162235660700

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST00000283249469278816102572216102581811601255307339
ENST00000409872251878816102572216102581810561151307339
ENST00000283249469278816099849216099858212561345339369
ENST00000409872251878816099849216099858211521241339369
ENST00000283249469278816099457516099471013461480369414
ENST00000409872251878816099457516099471012421376369414
ENST00000283249469278816096859016096871022202339660700
ENST00000409872251878816096859016096871021162235660700

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
P18564307339324330Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
P18564307339324330Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
P1856430733922788ChainID=PRO_0000016350;Note=Integrin beta-6
P1856430733922788ChainID=PRO_0000016350;Note=Integrin beta-6
P1856430733923454Disulfide bondOntology_term=ECO:0000250;evidence=ECO:0000250
P1856430733923454Disulfide bondOntology_term=ECO:0000250;evidence=ECO:0000250
P18564307339131371DomainNote=VWFA
P18564307339131371DomainNote=VWFA
P18564307339312321HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
P18564307339312321HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
P18564307339332344HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
P18564307339332344HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
P1856430733922709Topological domainNote=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P1856430733922709Topological domainNote=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P18564339369349352Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
P18564339369349352Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
P1856433936922788ChainID=PRO_0000016350;Note=Integrin beta-6
P1856433936922788ChainID=PRO_0000016350;Note=Integrin beta-6
P1856433936923454Disulfide bondOntology_term=ECO:0000250;evidence=ECO:0000250
P1856433936923454Disulfide bondOntology_term=ECO:0000250;evidence=ECO:0000250
P18564339369131371DomainNote=VWFA
P18564339369131371DomainNote=VWFA
P18564339369332344HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
P18564339369332344HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
P18564339369360371HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
P18564339369360371HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
P1856433936922709Topological domainNote=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P1856433936922709Topological domainNote=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P18564369414375382Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM9
P18564369414375382Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM9
P18564369414387393Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM9
P18564369414387393Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM9
P18564369414399401Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM9
P18564369414399401Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM9
P18564369414414422Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM9
P18564369414414422Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM9
P1856436941422788ChainID=PRO_0000016350;Note=Integrin beta-6
P1856436941422788ChainID=PRO_0000016350;Note=Integrin beta-6
P1856436941423454Disulfide bondOntology_term=ECO:0000250;evidence=ECO:0000250
P1856436941423454Disulfide bondOntology_term=ECO:0000250;evidence=ECO:0000250
P18564369414394406Disulfide bondOntology_term=ECO:0000250;evidence=ECO:0000250
P18564369414394406Disulfide bondOntology_term=ECO:0000250;evidence=ECO:0000250
P18564369414131371DomainNote=VWFA
P18564369414131371DomainNote=VWFA
P18564369414387387GlycosylationNote=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P18564369414387387GlycosylationNote=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P18564369414396396GlycosylationNote=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P18564369414396396GlycosylationNote=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P18564369414360371HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
P18564369414360371HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
P1856436941422709Topological domainNote=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P1856436941422709Topological domainNote=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P18564369414395397TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM8
P18564369414395397TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM8
P18564660700554660Alternative sequenceID=VSP_055189;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
P18564660700554660Alternative sequenceID=VSP_055189;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
P1856466070022788ChainID=PRO_0000016350;Note=Integrin beta-6
P1856466070022788ChainID=PRO_0000016350;Note=Integrin beta-6
P18564660700426670Disulfide bondOntology_term=ECO:0000250;evidence=ECO:0000250
P18564660700426670Disulfide bondOntology_term=ECO:0000250;evidence=ECO:0000250
P18564660700630702Disulfide bondOntology_term=ECO:0000250;evidence=ECO:0000250
P18564660700630702Disulfide bondOntology_term=ECO:0000250;evidence=ECO:0000250
P18564660700649678Disulfide bondOntology_term=ECO:0000250;evidence=ECO:0000250
P18564660700649678Disulfide bondOntology_term=ECO:0000250;evidence=ECO:0000250
P1856466070022709Topological domainNote=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P1856466070022709Topological domainNote=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
P18564307339324330Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
P18564307339324330Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
P1856430733922788ChainID=PRO_0000016350;Note=Integrin beta-6
P1856430733922788ChainID=PRO_0000016350;Note=Integrin beta-6
P1856430733923454Disulfide bondOntology_term=ECO:0000250;evidence=ECO:0000250
P1856430733923454Disulfide bondOntology_term=ECO:0000250;evidence=ECO:0000250
P18564307339131371DomainNote=VWFA
P18564307339131371DomainNote=VWFA
P18564307339312321HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
P18564307339312321HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
P18564307339332344HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
P18564307339332344HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
P1856430733922709Topological domainNote=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P1856430733922709Topological domainNote=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P18564339369349352Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
P18564339369349352Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
P1856433936922788ChainID=PRO_0000016350;Note=Integrin beta-6
P1856433936922788ChainID=PRO_0000016350;Note=Integrin beta-6
P1856433936923454Disulfide bondOntology_term=ECO:0000250;evidence=ECO:0000250
P1856433936923454Disulfide bondOntology_term=ECO:0000250;evidence=ECO:0000250
P18564339369131371DomainNote=VWFA
P18564339369131371DomainNote=VWFA
P18564339369332344HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
P18564339369332344HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
P18564339369360371HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
P18564339369360371HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
P1856433936922709Topological domainNote=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P1856433936922709Topological domainNote=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P18564369414375382Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM9
P18564369414375382Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM9
P18564369414387393Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM9
P18564369414387393Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM9
P18564369414399401Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM9
P18564369414399401Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM9
P18564369414414422Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM9
P18564369414414422Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM9
P1856436941422788ChainID=PRO_0000016350;Note=Integrin beta-6
P1856436941422788ChainID=PRO_0000016350;Note=Integrin beta-6
P1856436941423454Disulfide bondOntology_term=ECO:0000250;evidence=ECO:0000250
P1856436941423454Disulfide bondOntology_term=ECO:0000250;evidence=ECO:0000250
P18564369414394406Disulfide bondOntology_term=ECO:0000250;evidence=ECO:0000250
P18564369414394406Disulfide bondOntology_term=ECO:0000250;evidence=ECO:0000250
P18564369414131371DomainNote=VWFA
P18564369414131371DomainNote=VWFA
P18564369414387387GlycosylationNote=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P18564369414387387GlycosylationNote=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P18564369414396396GlycosylationNote=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P18564369414396396GlycosylationNote=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P18564369414360371HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
P18564369414360371HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5FFG
P1856436941422709Topological domainNote=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P1856436941422709Topological domainNote=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P18564369414395397TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM8
P18564369414395397TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:4UM8
P18564660700554660Alternative sequenceID=VSP_055189;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
P18564660700554660Alternative sequenceID=VSP_055189;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
P1856466070022788ChainID=PRO_0000016350;Note=Integrin beta-6
P1856466070022788ChainID=PRO_0000016350;Note=Integrin beta-6
P18564660700426670Disulfide bondOntology_term=ECO:0000250;evidence=ECO:0000250
P18564660700426670Disulfide bondOntology_term=ECO:0000250;evidence=ECO:0000250
P18564660700630702Disulfide bondOntology_term=ECO:0000250;evidence=ECO:0000250
P18564660700630702Disulfide bondOntology_term=ECO:0000250;evidence=ECO:0000250
P18564660700649678Disulfide bondOntology_term=ECO:0000250;evidence=ECO:0000250
P18564660700649678Disulfide bondOntology_term=ECO:0000250;evidence=ECO:0000250
P1856466070022709Topological domainNote=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P1856466070022709Topological domainNote=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255


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SNVs in the skipped exons for ITGB6

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LIHCTCGA-DD-A39Y-01exon_skip_344342
160968591160968710160968665160968665Frame_Shift_DelT-p.N676fs
LIHCTCGA-DD-A3A0-01exon_skip_344363
exon_skip_344362
161052727161052931161052783161052783Frame_Shift_DelT-p.N97fs
UCECTCGA-AP-A056-01exon_skip_344342
160968591160968710160968663160968663Nonsense_MutationCAp.E677*
HNSCTCGA-BB-4223-01exon_skip_344363
exon_skip_344362
161052727161052931161052754161052754Nonsense_MutationGAp.Q107*
SKCMTCGA-EE-A20C-06exon_skip_344355
161025723161025818161025819161025819Splice_SiteCT.
SKCMTCGA-D9-A4Z6-06exon_skip_344363
exon_skip_344362
161052727161052931161052932161052932Splice_SiteCT.
SKCMTCGA-D9-A4Z6-06161052900161052931161052932161052932Splice_SiteCT.

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
SNU324_PANCREAS160968591160968710160968601160968601Frame_Shift_DelG-p.I697fs
SLR23_KIDNEY160968591160968710160968696160968696Missense_MutationCAp.G666C
GP5D_LARGE_INTESTINE160994576160994710160994595160994595Missense_MutationTCp.H408R
NCIH460_LUNG161052727161052931161052906161052906Missense_MutationCAp.G56V
NCIH460_LUNG161052900161052931161052906161052906Missense_MutationCAp.G56V
SNUC2A_LARGE_INTESTINE161055690161055769161055734161055734Missense_MutationCAp.D33Y
SNU1040_LARGE_INTESTINE160994576160994710160994600160994600Nonsense_MutationGTp.C406*
CHAGOK1_LUNG161055690161055769161055713161055713Nonsense_MutationGAp.Q40*

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ITGB6

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ITGB6


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ITGB6


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RelatedDrugs for ITGB6

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ITGB6

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
ITGB6C4015557AMELOGENESIS IMPERFECTA, TYPE IH2UNIPROT
ITGB6C0000786Spontaneous abortion1CTD_human
ITGB6C0004364Autoimmune Diseases1CTD_human
ITGB6C0008311Cholangitis1CTD_human
ITGB6C0023893Liver Cirrhosis, Experimental1CTD_human
ITGB6C0023895Liver diseases1CTD_human
ITGB6C0034067Pulmonary Emphysema1CTD_human
ITGB6C0524910Hepatitis C, Chronic1CTD_human