ExonSkipDB: functional annotation of exon skipping event in human

Gene summary for IL6ST

Gene summary

Gene information	Gene symbol	IL6ST
	Gene ID	3572
	Gene name	interleukin 6 signal transducer
	Synonyms	CD130\|CDW130\|GP130\|IL-6RB
	Cytomap	5q11.2
	Type of gene	protein-coding
	Description	interleukin-6 receptor subunit betaCD130 antigenIL-6 receptor subunit betaIL-6R subunit betagp130 of the rheumatoid arthritis antigenic peptide-bearing soluble formgp130, oncostatin M receptorinterleukin receptor beta chainmembrane glycoprotein 130
	Modification date	20180527
	UniProtAcc	P40189
	Context	PubMed: IL6ST [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
IL6ST	GO:0008284	positive regulation of cell proliferation	2261637
IL6ST	GO:0019221	cytokine-mediated signaling pathway	2261637
IL6ST	GO:0034097	response to cytokine	2261637\|8999038
IL6ST	GO:0048861	leukemia inhibitory factor signaling pathway	8999038\|12643274
IL6ST	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway	12643274

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Exon skipping events across known transcript of Ensembl for IL6ST from UCSC genome browser

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Gene isoform structures and expression levels for IL6ST

Expression levels of gene isoforms across TCGA.

Expression levels of gene isoforms across GTEx.

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Exon skipping events with PSIs in TCGA for IL6ST

Information of exkip skipping event in TCGA.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_442252	5	55238497:55238579:55243320:55243417:55247291:55247334	55243320:55243417	ENSG00000134352.15	ENST00000502326.3,ENST00000536319.1,ENST00000381294.3,ENST00000381287.4,ENST00000503773.2,ENST00000583149.1,ENST00000336909.5,ENST00000381298.2
exon_skip_442255	5	55243392:55243417:55244725:55244810:55247291:55247334	55244725:55244810	ENSG00000134352.15	ENST00000423954.3
exon_skip_442257	5	55243392:55243417:55247291:55247432:55247756:55247903	55247291:55247432	ENSG00000134352.15	ENST00000502326.3,ENST00000522633.2,ENST00000536319.1,ENST00000381294.3,ENST00000381287.4,ENST00000503773.2,ENST00000336909.5,ENST00000381298.2
exon_skip_442259	5	55247336:55247432:55247756:55247903:55248077:55248179	55247756:55247903	ENSG00000134352.15	ENST00000502326.3,ENST00000522633.2,ENST00000536319.1,ENST00000381294.3,ENST00000381287.4,ENST00000503773.2,ENST00000336909.5,ENST00000381298.2
exon_skip_442261	5	55247756:55247903:55248077:55248179:55250637:55250820	55248077:55248179	ENSG00000134352.15	ENST00000502326.3,ENST00000522633.2,ENST00000381287.4,ENST00000503773.2,ENST00000336909.5,ENST00000381298.2
exon_skip_442262	5	55247756:55247903:55248077:55248179:55251852:55252063	55248077:55248179	ENSG00000134352.15	ENST00000536319.1,ENST00000381294.3
exon_skip_442265	5	55248077:55248179:55250637:55250820:55251852:55252063	55250637:55250820	ENSG00000134352.15	ENST00000502326.3,ENST00000522633.2,ENST00000381287.4,ENST00000503773.2,ENST00000336909.5,ENST00000381298.2
exon_skip_442266	5	55250637:55250820:55251852:55252063:55256229:55256308	55251852:55252063	ENSG00000134352.15	ENST00000522633.2,ENST00000381287.4
exon_skip_442267	5	55251852:55252063:55253036:55253119:55256229:55256308	55253036:55253119	ENSG00000134352.15	ENST00000502326.3,ENST00000381294.3,ENST00000336909.5,ENST00000381298.2,ENST00000506241.1
exon_skip_442269	5	55253036:55253119:55255453:55255499:55256229:55256308	55255453:55255499	ENSG00000134352.15	ENST00000503773.2
exon_skip_442281	5	55259179:55259334:55259973:55260140:55264103:55264215	55259973:55260140	ENSG00000134352.15	ENST00000502326.3,ENST00000522633.2,ENST00000536319.1,ENST00000381294.3,ENST00000381287.4,ENST00000503773.2,ENST00000336909.5,ENST00000381298.2
exon_skip_442292	5	55260036:55260140:55264103:55264224:55265377:55265683	55264103:55264224	ENSG00000134352.15	ENST00000502326.3,ENST00000522633.2,ENST00000536319.1,ENST00000381294.3,ENST00000381287.4,ENST00000503773.2,ENST00000336909.5,ENST00000381298.2
exon_skip_442297	5	55264103:55264224:55265377:55265683:55272042:55272106	55265377:55265683	ENSG00000134352.15	ENST00000502326.3,ENST00000522633.2,ENST00000536319.1,ENST00000381294.3,ENST00000381287.4,ENST00000503773.2,ENST00000336909.5,ENST00000381298.2
exon_skip_442300	5	55272042:55272121:55278551:55278639:55290611:55290620	55278551:55278639	ENSG00000134352.15	ENST00000577363.1,ENST00000503773.2

PSI values of skipped exons in TCGA.

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Exon skipping events with PSIs in GTEx for IL6ST

Information of exkip skipping event in GTEx

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_442252	5	55238497:55238579:55243320:55243417:55247291:55247334	55243320:55243417	ENSG00000134352.15	ENST00000381298.2,ENST00000336909.5,ENST00000381287.4,ENST00000503773.2,ENST00000502326.3,ENST00000381294.3,ENST00000536319.1,ENST00000583149.1
exon_skip_442255	5	55243392:55243417:55244725:55244810:55247291:55247334	55244725:55244810	ENSG00000134352.15	ENST00000423954.3
exon_skip_442257	5	55243392:55243417:55247291:55247432:55247756:55247903	55247291:55247432	ENSG00000134352.15	ENST00000381298.2,ENST00000336909.5,ENST00000381287.4,ENST00000503773.2,ENST00000502326.3,ENST00000381294.3,ENST00000536319.1,ENST00000522633.2
exon_skip_442259	5	55247336:55247432:55247756:55247903:55248077:55248179	55247756:55247903	ENSG00000134352.15	ENST00000381298.2,ENST00000336909.5,ENST00000381287.4,ENST00000503773.2,ENST00000502326.3,ENST00000381294.3,ENST00000536319.1,ENST00000522633.2
exon_skip_442261	5	55247756:55247903:55248077:55248179:55250637:55250820	55248077:55248179	ENSG00000134352.15	ENST00000381298.2,ENST00000336909.5,ENST00000381287.4,ENST00000503773.2,ENST00000502326.3,ENST00000522633.2
exon_skip_442262	5	55247756:55247903:55248077:55248179:55251852:55252063	55248077:55248179	ENSG00000134352.15	ENST00000381294.3,ENST00000536319.1
exon_skip_442265	5	55248077:55248179:55250637:55250820:55251852:55252063	55250637:55250820	ENSG00000134352.15	ENST00000381298.2,ENST00000336909.5,ENST00000381287.4,ENST00000503773.2,ENST00000502326.3,ENST00000522633.2
exon_skip_442266	5	55250637:55250820:55251852:55252063:55256229:55256308	55251852:55252063	ENSG00000134352.15	ENST00000381287.4,ENST00000522633.2
exon_skip_442267	5	55251852:55252063:55253036:55253119:55256229:55256308	55253036:55253119	ENSG00000134352.15	ENST00000381298.2,ENST00000336909.5,ENST00000502326.3,ENST00000381294.3,ENST00000506241.1
exon_skip_442269	5	55253036:55253119:55255453:55255499:55256229:55256308	55255453:55255499	ENSG00000134352.15	ENST00000503773.2
exon_skip_442281	5	55259179:55259334:55259973:55260140:55264103:55264215	55259973:55260140	ENSG00000134352.15	ENST00000381298.2,ENST00000336909.5,ENST00000381287.4,ENST00000503773.2,ENST00000502326.3,ENST00000381294.3,ENST00000536319.1,ENST00000522633.2
exon_skip_442292	5	55260036:55260140:55264103:55264224:55265377:55265683	55264103:55264224	ENSG00000134352.15	ENST00000381298.2,ENST00000336909.5,ENST00000381287.4,ENST00000503773.2,ENST00000502326.3,ENST00000381294.3,ENST00000536319.1,ENST00000522633.2
exon_skip_442297	5	55264103:55264224:55265377:55265683:55272042:55272106	55265377:55265683	ENSG00000134352.15	ENST00000381298.2,ENST00000336909.5,ENST00000381287.4,ENST00000503773.2,ENST00000502326.3,ENST00000381294.3,ENST00000536319.1,ENST00000522633.2
exon_skip_442300	5	55272042:55272121:55278551:55278639:55290611:55290620	55278551:55278639	ENSG00000134352.15	ENST00000503773.2,ENST00000577363.1

PSI values of skipped exons in GTEx.

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for IL6ST

Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000336909	55243320	55243417	Frame-shift
ENST00000381298	55243320	55243417	Frame-shift
ENST00000502326	55243320	55243417	Frame-shift
ENST00000336909	55253036	55253119	Frame-shift
ENST00000381298	55253036	55253119	Frame-shift
ENST00000502326	55253036	55253119	Frame-shift
ENST00000336909	55259973	55260140	Frame-shift
ENST00000381298	55259973	55260140	Frame-shift
ENST00000502326	55259973	55260140	Frame-shift
ENST00000336909	55264103	55264224	Frame-shift
ENST00000381298	55264103	55264224	Frame-shift
ENST00000502326	55264103	55264224	Frame-shift
ENST00000336909	55247291	55247432	In-frame
ENST00000381298	55247291	55247432	In-frame
ENST00000502326	55247291	55247432	In-frame
ENST00000336909	55247756	55247903	In-frame
ENST00000381298	55247756	55247903	In-frame
ENST00000502326	55247756	55247903	In-frame
ENST00000336909	55248077	55248179	In-frame
ENST00000381298	55248077	55248179	In-frame
ENST00000502326	55248077	55248179	In-frame
ENST00000336909	55250637	55250820	In-frame
ENST00000381298	55250637	55250820	In-frame
ENST00000502326	55250637	55250820	In-frame
ENST00000336909	55265377	55265683	In-frame
ENST00000381298	55265377	55265683	In-frame
ENST00000502326	55265377	55265683	In-frame

Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000336909	55243320	55243417	Frame-shift
ENST00000381298	55243320	55243417	Frame-shift
ENST00000502326	55243320	55243417	Frame-shift
ENST00000336909	55253036	55253119	Frame-shift
ENST00000381298	55253036	55253119	Frame-shift
ENST00000502326	55253036	55253119	Frame-shift
ENST00000336909	55259973	55260140	Frame-shift
ENST00000381298	55259973	55260140	Frame-shift
ENST00000502326	55259973	55260140	Frame-shift
ENST00000336909	55264103	55264224	Frame-shift
ENST00000381298	55264103	55264224	Frame-shift
ENST00000502326	55264103	55264224	Frame-shift
ENST00000336909	55247291	55247432	In-frame
ENST00000381298	55247291	55247432	In-frame
ENST00000502326	55247291	55247432	In-frame
ENST00000336909	55247756	55247903	In-frame
ENST00000381298	55247756	55247903	In-frame
ENST00000502326	55247756	55247903	In-frame
ENST00000336909	55248077	55248179	In-frame
ENST00000381298	55248077	55248179	In-frame
ENST00000502326	55248077	55248179	In-frame
ENST00000336909	55250637	55250820	In-frame
ENST00000381298	55250637	55250820	In-frame
ENST00000502326	55250637	55250820	In-frame
ENST00000336909	55265377	55265683	In-frame
ENST00000381298	55265377	55265683	In-frame
ENST00000502326	55265377	55265683	In-frame

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Infer the effects of exon skipping event on protein functional features for IL6ST

Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.

Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000336909	8767	918	55265377	55265683	101	406	21	123
ENST00000381298	9074	918	55265377	55265683	378	683	21	123
ENST00000502326	3024	918	55265377	55265683	261	566	21	123
ENST00000336909	8767	918	55250637	55250820	1304	1486	422	483
ENST00000381298	9074	918	55250637	55250820	1581	1763	422	483
ENST00000502326	3024	918	55250637	55250820	1464	1646	422	483
ENST00000336909	8767	918	55248077	55248179	1487	1588	483	517
ENST00000381298	9074	918	55248077	55248179	1764	1865	483	517
ENST00000502326	3024	918	55248077	55248179	1647	1748	483	517
ENST00000336909	8767	918	55247756	55247903	1589	1735	517	566
ENST00000381298	9074	918	55247756	55247903	1866	2012	517	566
ENST00000502326	3024	918	55247756	55247903	1749	1895	517	566
ENST00000336909	8767	918	55247291	55247432	1736	1876	566	613
ENST00000381298	9074	918	55247291	55247432	2013	2153	566	613
ENST00000502326	3024	918	55247291	55247432	1896	2036	566	613

Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000336909	8767	918	55265377	55265683	101	406	21	123
ENST00000381298	9074	918	55265377	55265683	378	683	21	123
ENST00000502326	3024	918	55265377	55265683	261	566	21	123
ENST00000336909	8767	918	55250637	55250820	1304	1486	422	483
ENST00000381298	9074	918	55250637	55250820	1581	1763	422	483
ENST00000502326	3024	918	55250637	55250820	1464	1646	422	483
ENST00000336909	8767	918	55248077	55248179	1487	1588	483	517
ENST00000381298	9074	918	55248077	55248179	1764	1865	483	517
ENST00000502326	3024	918	55248077	55248179	1647	1748	483	517
ENST00000336909	8767	918	55247756	55247903	1589	1735	517	566
ENST00000381298	9074	918	55247756	55247903	1866	2012	517	566
ENST00000502326	3024	918	55247756	55247903	1749	1895	517	566
ENST00000336909	8767	918	55247291	55247432	1736	1876	566	613
ENST00000381298	9074	918	55247291	55247432	2013	2153	566	613
ENST00000502326	3024	918	55247291	55247432	1896	2036	566	613

Lost protein functional features of individual exon skipping events in TCGA.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P40189	21	123	28	35	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	28	35	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	28	35	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	37	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	37	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	37	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	44	50	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	44	50	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	44	50	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	65	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	65	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	65	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	80	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	80	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	80	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	86	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	86	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	86	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	97	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	97	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	97	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	111	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	111	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	111	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	21	123	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	21	123	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	21	123	28	54	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	28	54	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	28	54	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	48	103	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	48	103	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	48	103	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	26	120	Domain	Note=Ig-like C2-type
P40189	21	123	26	120	Domain	Note=Ig-like C2-type
P40189	21	123	26	120	Domain	Note=Ig-like C2-type
P40189	21	123	43	43	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	43	43	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	43	43	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	83	83	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	83	83	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	83	83	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	52	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	52	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	52	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	62	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	62	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	62	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	76	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	76	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	76	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	1	22	Signal peptide	.
P40189	21	123	1	22	Signal peptide	.
P40189	21	123	1	22	Signal peptide	.
P40189	21	123	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	21	123	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	21	123	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	21	123	108	110	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	108	110	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	108	110	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	422	483	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	422	483	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	422	483	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	422	483	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3
P40189	422	483	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3
P40189	422	483	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3
P40189	422	483	428	435	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	428	435	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	428	435	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	438	444	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	438	444	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	438	444	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	452	460	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	452	460	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	452	460	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	462	464	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	462	464	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	462	464	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	469	474	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	469	474	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	469	474	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	478	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	478	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	478	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	422	483	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	422	483	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	422	483	458	466	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	422	483	458	466	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	422	483	458	466	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	422	483	329	424	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	422	483	329	424	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	422	483	329	424	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	422	483	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	422	483	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	422	483	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	422	483	454	454	Natural variant	ID=VAR_047785;Note=I->T;Dbxref=dbSNP:rs2228046
P40189	422	483	454	454	Natural variant	ID=VAR_047785;Note=I->T;Dbxref=dbSNP:rs2228046
P40189	422	483	454	454	Natural variant	ID=VAR_047785;Note=I->T;Dbxref=dbSNP:rs2228046
P40189	422	483	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	422	483	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	422	483	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	483	517	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	483	517	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	483	517	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	483	517	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3
P40189	483	517	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3
P40189	483	517	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3
P40189	483	517	491	500	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	483	517	491	500	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	483	517	491	500	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	483	517	508	515	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	483	517	508	515	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	483	517	508	515	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	483	517	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	483	517	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	483	517	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	483	517	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	483	517	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	483	517	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	483	517	499	499	Natural variant	ID=VAR_047786;Note=V->I;Dbxref=dbSNP:rs34417936
P40189	483	517	499	499	Natural variant	ID=VAR_047786;Note=V->I;Dbxref=dbSNP:rs34417936
P40189	483	517	499	499	Natural variant	ID=VAR_047786;Note=V->I;Dbxref=dbSNP:rs34417936
P40189	483	517	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	483	517	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	483	517	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	517	566	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	517	566	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	517	566	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	517	566	525	530	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	525	530	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	525	530	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	535	539	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	535	539	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	535	539	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	553	560	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	553	560	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	553	560	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	517	566	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	517	566	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	517	566	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	517	566	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	517	566	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	517	566	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	517	566	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	517	566	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	517	566	553	553	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	517	566	553	553	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	517	566	553	553	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	517	566	564	564	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11098061;Dbxref=PMID:11098061
P40189	517	566	564	564	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11098061;Dbxref=PMID:11098061
P40189	517	566	564	564	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11098061;Dbxref=PMID:11098061
P40189	517	566	544	547	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	544	547	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	544	547	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	517	566	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	517	566	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	566	613	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	566	613	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	566	613	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	566	613	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	575	579	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	575	579	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	575	579	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	587	596	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	587	596	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	587	596	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	599	602	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	599	602	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	599	602	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	606	609	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	606	609	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	606	609	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	566	613	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	566	613	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	566	613	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	566	613	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	566	613	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	566	613	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	566	613	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	566	613	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255

Lost protein functional features of individual exon skipping events in GTEx.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P40189	21	123	28	35	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	28	35	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	28	35	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	37	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	37	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	37	39	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	44	50	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	44	50	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	44	50	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	65	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	65	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	65	69	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	80	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	80	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	80	83	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	86	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	86	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	86	91	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	97	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	97	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	97	107	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	111	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	111	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	111	123	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	21	123	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	21	123	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	21	123	28	54	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	28	54	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	28	54	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	48	103	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	48	103	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	48	103	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	26	120	Domain	Note=Ig-like C2-type
P40189	21	123	26	120	Domain	Note=Ig-like C2-type
P40189	21	123	26	120	Domain	Note=Ig-like C2-type
P40189	21	123	43	43	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	43	43	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	43	43	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	83	83	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	83	83	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	83	83	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	21	123	52	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	52	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	52	58	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	62	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	62	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	62	64	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	76	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	76	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	76	78	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	1	22	Signal peptide	.
P40189	21	123	1	22	Signal peptide	.
P40189	21	123	1	22	Signal peptide	.
P40189	21	123	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	21	123	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	21	123	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	21	123	108	110	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	108	110	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	21	123	108	110	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1I1R
P40189	422	483	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	422	483	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	422	483	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	422	483	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3
P40189	422	483	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3
P40189	422	483	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3
P40189	422	483	428	435	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	428	435	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	428	435	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	438	444	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	438	444	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	438	444	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	452	460	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	452	460	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	452	460	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	462	464	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	462	464	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	462	464	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	469	474	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	469	474	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	469	474	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	478	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	478	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	478	481	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	422	483	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	422	483	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	422	483	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	422	483	458	466	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	422	483	458	466	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	422	483	458	466	Disulfide bond	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	422	483	329	424	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	422	483	329	424	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	422	483	329	424	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	422	483	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	422	483	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	422	483	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	422	483	454	454	Natural variant	ID=VAR_047785;Note=I->T;Dbxref=dbSNP:rs2228046
P40189	422	483	454	454	Natural variant	ID=VAR_047785;Note=I->T;Dbxref=dbSNP:rs2228046
P40189	422	483	454	454	Natural variant	ID=VAR_047785;Note=I->T;Dbxref=dbSNP:rs2228046
P40189	422	483	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	422	483	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	422	483	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	483	517	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	483	517	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	483	517	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	483	517	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3
P40189	483	517	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3
P40189	483	517	423	483	Alternative sequence	ID=VSP_043716;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.3
P40189	483	517	491	500	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	483	517	491	500	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	483	517	491	500	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	483	517	508	515	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	483	517	508	515	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	483	517	508	515	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	483	517	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	483	517	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	483	517	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	483	517	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	483	517	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	483	517	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	483	517	499	499	Natural variant	ID=VAR_047786;Note=V->I;Dbxref=dbSNP:rs34417936
P40189	483	517	499	499	Natural variant	ID=VAR_047786;Note=V->I;Dbxref=dbSNP:rs34417936
P40189	483	517	499	499	Natural variant	ID=VAR_047786;Note=V->I;Dbxref=dbSNP:rs34417936
P40189	483	517	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	483	517	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	483	517	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	517	566	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	517	566	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	517	566	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	517	566	525	530	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	525	530	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	525	530	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	535	539	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	535	539	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	535	539	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	553	560	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	553	560	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	553	560	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	517	566	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	517	566	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	517	566	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	517	566	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	517	566	426	517	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	517	566	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	517	566	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	517	566	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	517	566	553	553	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	517	566	553	553	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	517	566	553	553	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:11098061,ECO:0000269\|PubMed:20489211;Dbxref=PMID:11098061,PMID:20489211
P40189	517	566	564	564	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11098061;Dbxref=PMID:11098061
P40189	517	566	564	564	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11098061;Dbxref=PMID:11098061
P40189	517	566	564	564	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:11098061;Dbxref=PMID:11098061
P40189	517	566	544	547	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	544	547	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	544	547	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	517	566	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	517	566	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	517	566	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	566	613	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	566	613	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	566	613	330	918	Alternative sequence	ID=VSP_001685;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:10880057;Dbxref=PMID:10880057
P40189	566	613	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	566	571	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	575	579	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	575	579	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	575	579	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	587	596	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	587	596	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	587	596	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	599	602	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	599	602	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	599	602	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	606	609	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	606	609	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	606	609	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:3L5I
P40189	566	613	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	566	613	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	566	613	23	918	Chain	ID=PRO_0000010899;Note=Interleukin-6 receptor subunit beta
P40189	566	613	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	566	613	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	566	613	518	613	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P40189	566	613	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	566	613	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P40189	566	613	23	619	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255

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SNVs in the skipped exons for IL6ST

- Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.

- Differential PSIs between mutated versus non-mutated samples.

- Non-synonymous mutations located in the skipped exons in TCGA.

Cancer type	Sample	ESID	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
LIHC	TCGA-DD-A1EG-01	exon_skip_442252	55243321	55243417	55243370	55243370	Frame_Shift_Del	G	-	p.L631fs
LIHC	TCGA-DD-A3A0-01	exon_skip_442252	55243321	55243417	55243370	55243370	Frame_Shift_Del	G	-	p.L631fs
LIHC	TCGA-G3-A3CJ-01	exon_skip_442252	55243321	55243417	55243370	55243370	Frame_Shift_Del	G	-	p.L631fs
ESCA	TCGA-LN-A49M-01	exon_skip_442257	55247292	55247432	55247381	55247385	Frame_Shift_Del	CTAGT	-	p.583_584del
ESCA	TCGA-LN-A49M-01	exon_skip_442257	55247292	55247432	55247381	55247385	Frame_Shift_Del	CTAGT	-	p.TS583fs
HNSC	TCGA-F7-A624-01	exon_skip_442259	55247757	55247903	55247869	55247869	Frame_Shift_Del	T	-	p.K529fs
LIHC	TCGA-DD-A1EG-01	exon_skip_442259	55247757	55247903	55247869	55247869	Frame_Shift_Del	T	-	p.K529fs
LIHC	TCGA-DD-A39Y-01	exon_skip_442259	55247757	55247903	55247869	55247869	Frame_Shift_Del	T	-	p.K529fs
UCEC	TCGA-AX-A060-01	exon_skip_442259	55247757	55247903	55247869	55247869	Frame_Shift_Del	T	-	p.K529fs
UCEC	TCGA-B5-A0K2-01	exon_skip_442259	55247757	55247903	55247869	55247869	Frame_Shift_Del	T	-	p.K529fs
UCEC	TCGA-D1-A177-01	exon_skip_442259	55247757	55247903	55247869	55247869	Frame_Shift_Del	T	-	p.K529fs
PRAD	TCGA-EJ-5526-01	exon_skip_442265	55250638	55250820	55250760	55250772	Frame_Shift_Del	CATTCCACCCAAA	-	p.LWVEW439fs
LIHC	TCGA-DD-A1EG-01	exon_skip_442292	55264104	55264224	55264171	55264171	Frame_Shift_Del	T	-	p.M142fs
UCEC	TCGA-D1-A174-01	exon_skip_442259	55247757	55247903	55247829	55247830	Frame_Shift_Ins	-	A	p.L542fs
UCEC	TCGA-D1-A174-01	exon_skip_442259	55247757	55247903	55247829	55247830	Frame_Shift_Ins	-	A	p.P542fs
UCEC	TCGA-BS-A0TC-01	exon_skip_442257	55247292	55247432	55247319	55247319	Nonsense_Mutation	C	A	p.E605*
COAD	TCGA-CK-5913-01	exon_skip_442259	55247757	55247903	55247869	55247869	Nonsense_Mutation	T	-	p.V530X
UCEC	TCGA-AX-A060-01	exon_skip_442297	55265378	55265683	55265400	55265400	Nonsense_Mutation	A	T	p.Y116*
UCEC	TCGA-BG-A0MQ-01	exon_skip_442292	55264104	55264224	55264102	55264102	Splice_Site	A	G	p.W164_splice

- Depth of coverage in the three exons composing exon skipping event

Depth of coverage in three exons

Mutation description

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
LIM1215_LARGE_INTESTINE	55247757	55247903	55247869	55247869	Frame_Shift_Del	T	-	p.K529fs
CW2_LARGE_INTESTINE	55247757	55247903	55247869	55247869	Frame_Shift_Del	T	-	p.K529fs
HS706T_BONE	55251853	55252063	55251977	55251978	Frame_Shift_Del	TG	-	p.T381fs
22RV1_PROSTATE	55243321	55243417	55243400	55243400	Missense_Mutation	C	T	p.A620T
CTV1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	55247292	55247432	55247375	55247375	Missense_Mutation	G	A	p.T586I
HCC2998_LARGE_INTESTINE	55247757	55247903	55247807	55247807	Missense_Mutation	A	C	p.F550C
HCC2157_MATCHED_NORMAL_TISSUE	55247757	55247903	55247826	55247826	Missense_Mutation	C	T	p.V544I
MN60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	55250638	55250820	55250652	55250652	Missense_Mutation	C	T	p.R479H
HEC1B_ENDOMETRIUM	55250638	55250820	55250811	55250811	Missense_Mutation	G	T	p.P426H
HPBALL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	55251853	55252063	55251856	55251856	Missense_Mutation	G	T	p.Q422K
NCIH82_LUNG	55251853	55252063	55251981	55251981	Missense_Mutation	T	C	p.Y380C
639V_URINARY_TRACT	55253037	55253119	55253059	55253059	Missense_Mutation	C	T	p.R345K
SNU46_UPPER_AERODIGESTIVE_TRACT	55253037	55253119	55253086	55253086	Missense_Mutation	A	G	p.I336T
SNU475_LIVER	55253037	55253119	55253086	55253086	Missense_Mutation	A	G	p.I336T
SLR24_KIDNEY	55259974	55260140	55260029	55260029	Missense_Mutation	C	A	p.E201D
KU1919_URINARY_TRACT	55259974	55260140	55260057	55260057	Missense_Mutation	A	C	p.V192G
SISO_CERVIX	55264104	55264224	55264192	55264192	Missense_Mutation	T	G	p.I135L
OC316_OVARY	55265378	55265683	55265428	55265428	Missense_Mutation	G	T	p.T107K
OC314_OVARY	55265378	55265683	55265428	55265428	Missense_Mutation	G	T	p.T107K
JJN3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	55265378	55265683	55265588	55265588	Missense_Mutation	A	T	p.C54S
PCM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	55265378	55265683	55265588	55265588	Missense_Mutation	A	T	p.C54S
SW780_URINARY_TRACT	55247292	55247432	55247361	55247361	Nonsense_Mutation	G	A	p.R591*
BICR56_UPPER_AERODIGESTIVE_TRACT	55259974	55260140	55260006	55260006	Nonsense_Mutation	G	C	p.S209*

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for IL6ST

sQTL information located at the skipped exons.

Exon skip ID	Chromosome	Three exons	Skippped exon	ENST	Cancer type	SNP id	Location	DNA change (ref/var)	P-value
exon_skip_442292	5	55260036:55260140:55264103:55264224:55265377:55265683	55264103:55264224	ENST00000502326.3,ENST00000522633.2,ENST00000536319.1,ENST00000381294.3,ENST00000381287.4,ENST00000503773.2,ENST00000336909.5,ENST00000381298.2	LGG	rs2228044	chr5:55264153	C/G	1.85e-03
exon_skip_442255	5	55243392:55243417:55244725:55244810:55247291:55247334	55244725:55244810	ENST00000423954.3	LGG	rs7719246	chr5:55244777	A/T	6.98e-04
exon_skip_442266	5	55250637:55250820:55251852:55252063:55256229:55256308	55251852:55252063	ENST00000522633.2,ENST00000381287.4	LGG	rs2228043	chr5:55251931	G/C	7.49e-04

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for IL6ST

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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for IL6ST

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RelatedDrugs for IL6ST

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for IL6ST

Diseases associated with this gene.
(DisGeNet 4.0)

Gene	Disease ID	Disease name	# pubmeds	Source
IL6ST	C0003873	Rheumatoid Arthritis	1	CTD_human
IL6ST	C0009404	Colorectal Neoplasms	1	CTD_human
IL6ST	C0020517	Hypersensitivity	1	CTD_human
IL6ST	C0024667	Animal Mammary Neoplasms	1	CTD_human
IL6ST	C0024668	Mammary Neoplasms, Experimental	1	CTD_human
IL6ST	C0032285	Pneumonia	1	CTD_human
IL6ST	C0035126	Reperfusion Injury	1	CTD_human
IL6ST	C0151744	Myocardial Ischemia	1	CTD_human
IL6ST	C0740392	Infarction, Middle Cerebral Artery	1	CTD_human
IL6ST	C0919267	ovarian neoplasm	1	CTD_human

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in TCGA
	Exon skipping events with PSIs in GTEx
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	SNVs in the skipped exons with depth of coverage
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Splicing Quantitative Trait Methylation (sQTM) in the skipped exon
	Related drugs with this gene
	Related diseases with this gene

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