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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for TREML1 |
 Gene summary |
| Gene information | Gene symbol | TREML1 | Gene ID | 340205 |
| Gene name | triggering receptor expressed on myeloid cells like 1 | |
| Synonyms | GLTL1825|PRO3438|TLT-1|TLT1|dJ238O23.3 | |
| Cytomap | 6p21.1 | |
| Type of gene | protein-coding | |
| Description | trem-like transcript 1 proteintriggering receptor expressed on myeloid cells-like protein 1 | |
| Modification date | 20180519 | |
| UniProtAcc | Q86YW5 | |
| Context | PubMed: TREML1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for TREML1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for TREML1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for TREML1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_459334 | 6 | 41117541:41117656:41117998:41118051:41118556:41118645 | 41117998:41118051 | ENSG00000161911.7 | ENST00000426005.2,ENST00000590581.1,ENST00000437044.2 |
| exon_skip_459335 | 6 | 41119019:41119122:41121495:41121828:41121983:41122070 | 41121495:41121828 | ENSG00000161911.7 | ENST00000426005.2 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for TREML1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_459334 | 6 | 41117541:41117656:41117998:41118051:41118556:41118645 | 41117998:41118051 | ENSG00000161911.7 | ENST00000426005.2,ENST00000437044.2,ENST00000590581.1 |
| exon_skip_459335 | 6 | 41119019:41119122:41121495:41121828:41121983:41122070 | 41121495:41121828 | ENSG00000161911.7 | ENST00000426005.2 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for TREML1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000426005 | 41117998 | 41118051 | Frame-shift |
| ENST00000426005 | 41121495 | 41121828 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000426005 | 41117998 | 41118051 | Frame-shift |
| ENST00000426005 | 41121495 | 41121828 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TREML1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000426005 | 998 | 311 | 41121495 | 41121828 | 88 | 420 | 14 | 125 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000426005 | 998 | 311 | 41121495 | 41121828 | 88 | 420 | 14 | 125 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q86YW5 | 14 | 125 | 15 | 125 | Alternative sequence | ID=VSP_021124;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q86YW5 | 14 | 125 | 24 | 28 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 34 | 39 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 47 | 55 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 58 | 64 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 70 | 73 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 77 | 83 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 86 | 91 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 100 | 108 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 111 | 122 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 16 | 311 | Chain | ID=PRO_0000253855;Note=Trem-like transcript 1 protein |
| Q86YW5 | 14 | 125 | 38 | 104 | Disulfide bond | Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16505478;Dbxref=PMID:16505478 |
| Q86YW5 | 14 | 125 | 52 | 59 | Disulfide bond | Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16505478;Dbxref=PMID:16505478 |
| Q86YW5 | 14 | 125 | 16 | 121 | Domain | Note=Ig-like V-type |
| Q86YW5 | 14 | 125 | 42 | 44 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 96 | 98 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 1 | 15 | Signal peptide | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q86YW5 | 14 | 125 | 16 | 162 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q86YW5 | 14 | 125 | 74 | 76 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q86YW5 | 14 | 125 | 15 | 125 | Alternative sequence | ID=VSP_021124;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q86YW5 | 14 | 125 | 24 | 28 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 34 | 39 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 47 | 55 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 58 | 64 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 70 | 73 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 77 | 83 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 86 | 91 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 100 | 108 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 111 | 122 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 16 | 311 | Chain | ID=PRO_0000253855;Note=Trem-like transcript 1 protein |
| Q86YW5 | 14 | 125 | 38 | 104 | Disulfide bond | Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16505478;Dbxref=PMID:16505478 |
| Q86YW5 | 14 | 125 | 52 | 59 | Disulfide bond | Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16505478;Dbxref=PMID:16505478 |
| Q86YW5 | 14 | 125 | 16 | 121 | Domain | Note=Ig-like V-type |
| Q86YW5 | 14 | 125 | 42 | 44 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 96 | 98 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
| Q86YW5 | 14 | 125 | 1 | 15 | Signal peptide | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q86YW5 | 14 | 125 | 16 | 162 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q86YW5 | 14 | 125 | 74 | 76 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2FRG |
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SNVs in the skipped exons for TREML1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_459335 | 41121496 | 41121828 | 41121528 | 41121528 | Frame_Shift_Del | A | - | p.L115fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_459335 | 41121496 | 41121828 | 41121528 | 41121528 | Frame_Shift_Del | A | - | p.L115fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_459335 | 41121496 | 41121828 | 41121539 | 41121539 | Frame_Shift_Del | C | - | p.G111fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_459335 | 41121496 | 41121828 | 41121734 | 41121734 | Frame_Shift_Del | T | - | p.K46fs |
| BLCA | TCGA-DK-A1AC-01 | exon_skip_459335 | 41121496 | 41121828 | 41121535 | 41121535 | Nonsense_Mutation | G | A | p.Q113* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 41121496 | 41121828 | 41121539 | 41121539 | Frame_Shift_Del | C | - | p.G111fs |
| CW2_LARGE_INTESTINE | 41121496 | 41121828 | 41121498 | 41121498 | Missense_Mutation | G | A | p.P125L |
| MDAMB231_BREAST | 41121496 | 41121828 | 41121537 | 41121537 | Missense_Mutation | G | T | p.P112H |
| HEC265_ENDOMETRIUM | 41121496 | 41121828 | 41121538 | 41121538 | Missense_Mutation | G | C | p.P112A |
| NCIH2342_LUNG | 41121496 | 41121828 | 41121547 | 41121547 | Missense_Mutation | C | G | p.A109P |
| CTV1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 41121496 | 41121828 | 41121555 | 41121555 | Missense_Mutation | A | C | p.V106G |
| KATOIII_STOMACH | 41121496 | 41121828 | 41121557 | 41121557 | Missense_Mutation | C | G | p.M105I |
| SNUC4_LARGE_INTESTINE | 41121496 | 41121828 | 41121661 | 41121661 | Missense_Mutation | C | T | p.A71T |
| CAS1_CENTRAL_NERVOUS_SYSTEM | 41121496 | 41121828 | 41121672 | 41121672 | Missense_Mutation | A | G | p.V67A |
| LNCAPCLONEFGC_PROSTATE | 41121496 | 41121828 | 41121673 | 41121673 | Missense_Mutation | C | T | p.V67M |
| ONS76_CENTRAL_NERVOUS_SYSTEM | 41121496 | 41121828 | 41121695 | 41121695 | Missense_Mutation | G | C | p.C59W |
| ONS76_CENTRAL_NERVOUS_SYSTEM | 41121496 | 41121828 | 41121696 | 41121696 | Missense_Mutation | C | T | p.C59Y |
| NCIH1436_LUNG | 41121496 | 41121828 | 41121714 | 41121714 | Missense_Mutation | C | A | p.R53L |
| IGROV1_OVARY | 41121496 | 41121828 | 41121736 | 41121736 | Missense_Mutation | T | C | p.K46E |
| SNU324_PANCREAS | 41121496 | 41121828 | 41121738 | 41121738 | Missense_Mutation | A | G | p.V45A |
| HEC50B_ENDOMETRIUM | 41121496 | 41121828 | 41121742 | 41121742 | Missense_Mutation | C | T | p.D44N |
| DOHH2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 41121496 | 41121828 | 41121753 | 41121753 | Missense_Mutation | T | C | p.Y40C |
| MFE319_ENDOMETRIUM | 41121496 | 41121828 | 41121745 | 41121745 | Nonsense_Mutation | G | A | p.Q43* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TREML1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TREML1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TREML1 |
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RelatedDrugs for TREML1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TREML1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| TREML1 | C3495559 | Juvenile arthritis | 1 | CTD_human |
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