ExonSkipDB Logo

Home

Download

Statistics

Landscape

Help

Contact
Center for Computational Systems Medicine
leaf

Gene summary

leaf

Gene structures and expression levels

leaf

Exon skipping events with PSIs in TCGA

leaf

Exon skipping events with PSIs in GTEx

leaf

Open reading frame (ORF) annotation in the exon skipping event

leaf

Exon skipping events in the canonical protein sequence

leaf

SNVs in the skipped exons with depth of coverage

leaf

Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

leaf

Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

leaf

Related drugs with this gene

leaf

Related diseases with this gene

Gene summary for HSP90AB1

check button Gene summary
Gene informationGene symbol

HSP90AB1

Gene ID

3326

Gene nameheat shock protein 90 alpha family class B member 1
SynonymsD6S182|HSP84|HSP90B|HSPC2|HSPCB
Cytomap

6p21.1

Type of geneprotein-coding
Descriptionheat shock protein HSP 90-betaHSP90-betaheat shock 84 kDaheat shock 90kD protein 1, betaheat shock protein 90 kDaheat shock protein 90kDa alpha (cytosolic), class B member 1heat shock protein 90kDa alpha family class B member 1
Modification date20180522
UniProtAcc

P08238

ContextPubMed: HSP90AB1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
HSP90AB1

GO:0007004

telomere maintenance via telomerase

10197982

HSP90AB1

GO:0030511

positive regulation of transforming growth factor beta receptor signaling pathway

24613385

HSP90AB1

GO:0031396

regulation of protein ubiquitination

16809764

HSP90AB1

GO:0032435

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

24613385

HSP90AB1

GO:0032516

positive regulation of phosphoprotein phosphatase activity

26593036

HSP90AB1

GO:0051131

chaperone-mediated protein complex assembly

10811660

HSP90AB1

GO:0051973

positive regulation of telomerase activity

10197982

HSP90AB1

GO:1901389

negative regulation of transforming growth factor beta activation

20599762

HSP90AB1

GO:1905323

telomerase holoenzyme complex assembly

10197982

HSP90AB1

GO:2000010

positive regulation of protein localization to cell surface

23431407


Top

Exon skipping events across known transcript of Ensembl for HSP90AB1 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

Top

Gene isoform structures and expression levels for HSP90AB1

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


Top

Exon skipping events with PSIs in TCGA for HSP90AB1

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_452427644214823:44214932:44216353:44216513:44217113:4421732044216353:44216513ENSG00000096384.15ENST00000353801.3
exon_skip_452435644216366:44216513:44217113:44217320:44217411:4421757144217113:44217320ENSG00000096384.15ENST00000353801.3,ENST00000371646.5,ENST00000371554.1
exon_skip_452440644217411:44217571:44217757:44217891:44218027:4421833644217757:44217891ENSG00000096384.15ENST00000353801.3,ENST00000371646.5,ENST00000371554.1
exon_skip_452441644217757:44217891:44218027:44218336:44218784:4421895044218027:44218336ENSG00000096384.15ENST00000353801.3,ENST00000371646.5,ENST00000371554.1
exon_skip_452447644219473:44219621:44219735:44220004:44220781:4422111544219735:44220004ENSG00000096384.15ENST00000353801.3,ENST00000371646.5,ENST00000371554.1

check button PSI values of skipped exons in TCGA.
psi tcga

Top

Exon skipping events with PSIs in GTEx for HSP90AB1

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_452427644214823:44214932:44216353:44216513:44217113:4421732044216353:44216513ENSG00000096384.15ENST00000353801.3
exon_skip_452435644216366:44216513:44217113:44217320:44217411:4421757144217113:44217320ENSG00000096384.15ENST00000371646.5,ENST00000353801.3,ENST00000371554.1
exon_skip_452440644217411:44217571:44217757:44217891:44218027:4421833644217757:44217891ENSG00000096384.15ENST00000371646.5,ENST00000353801.3,ENST00000371554.1
exon_skip_452441644217757:44217891:44218027:44218336:44218784:4421895044218027:44218336ENSG00000096384.15ENST00000371646.5,ENST00000353801.3,ENST00000371554.1
exon_skip_452447644219473:44219621:44219735:44220004:44220781:4422111544219735:44220004ENSG00000096384.15ENST00000371646.5,ENST00000353801.3,ENST00000371554.1

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

Top

Open reading frame (ORF) annotation in the exon skipping event for HSP90AB1

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST0000035380144216353442165135CDS-5UTR
ENST000003538014421775744217891Frame-shift
ENST000003715544421775744217891Frame-shift
ENST000003716464421775744217891Frame-shift
ENST000003538014421973544220004Frame-shift
ENST000003715544421973544220004Frame-shift
ENST000003716464421973544220004Frame-shift
ENST000003538014421711344217320In-frame
ENST000003715544421711344217320In-frame
ENST000003716464421711344217320In-frame
ENST000003538014421802744218336In-frame
ENST000003715544421802744218336In-frame
ENST000003716464421802744218336In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST0000035380144216353442165135CDS-5UTR
ENST000003538014421775744217891Frame-shift
ENST000003715544421775744217891Frame-shift
ENST000003716464421775744217891Frame-shift
ENST000003538014421973544220004Frame-shift
ENST000003715544421973544220004Frame-shift
ENST000003716464421973544220004Frame-shift
ENST000003538014421711344217320In-frame
ENST000003715544421711344217320In-frame
ENST000003716464421711344217320In-frame
ENST000003538014421802744218336In-frame
ENST000003715544421802744218336In-frame
ENST000003716464421802744218336In-frame

Top

Infer the effects of exon skipping event on protein functional features for HSP90AB1

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST000003538012599724442171134421732027047649118
ENST000003715542691724442171134421732036256849118
ENST000003716462586724442171134421732025746349118
ENST00000353801259972444218027442183367711079216319
ENST00000371554269172444218027442183368631171216319
ENST00000371646258672444218027442183367581066216319

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST000003538012599724442171134421732027047649118
ENST000003715542691724442171134421732036256849118
ENST000003716462586724442171134421732025746349118
ENST00000353801259972444218027442183367711079216319
ENST00000371554269172444218027442183368631171216319
ENST00000371646258672444218027442183367581066216319

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
P08238491187378Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P08238491187378Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P08238491187378Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P08238491188388Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P08238491188388Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P08238491188388Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P08238491188888Binding siteNote=ATP
P08238491188888Binding siteNote=ATP
P08238491188888Binding siteNote=ATP
P0823849118107107Binding siteNote=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
P0823849118107107Binding siteNote=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
P0823849118107107Binding siteNote=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
P08238491182724ChainID=PRO_0000062917;Note=Heat shock protein HSP 90-beta
P08238491182724ChainID=PRO_0000062917;Note=Heat shock protein HSP 90-beta
P08238491182724ChainID=PRO_0000062917;Note=Heat shock protein HSP 90-beta
P08238491183860HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P08238491183860HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P08238491183860HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P08238491186265HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P08238491186265HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P08238491186265HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P082384911895103HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P082384911895103HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P082384911895103HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P0823849118107118HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P0823849118107118HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P0823849118107118HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P08238491188888MutagenesisNote=Impaired ATP-binding. Strong interaction with HIF1A%2C MET%2C KEAP1 and RHOBTB2. Loss of interaction with HSF1 and ERBB2. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26517842;Dbxref=PMID:26517842
P08238491188888MutagenesisNote=Impaired ATP-binding. Strong interaction with HIF1A%2C MET%2C KEAP1 and RHOBTB2. Loss of interaction with HSF1 and ERBB2. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26517842;Dbxref=PMID:26517842
P08238491188888MutagenesisNote=Impaired ATP-binding. Strong interaction with HIF1A%2C MET%2C KEAP1 and RHOBTB2. Loss of interaction with HSF1 and ERBB2. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26517842;Dbxref=PMID:26517842
P08238491182527RegionNote=Interaction with TP53;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15358771;Dbxref=PMID:15358771
P08238491182527RegionNote=Interaction with TP53;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15358771;Dbxref=PMID:15358771
P08238491182527RegionNote=Interaction with TP53;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15358771;Dbxref=PMID:15358771
P08238491182214RegionNote=Interaction with BIRC2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25486457;Dbxref=PMID:25486457
P08238491182214RegionNote=Interaction with BIRC2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25486457;Dbxref=PMID:25486457
P08238491182214RegionNote=Interaction with BIRC2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25486457;Dbxref=PMID:25486457
P08238491187982TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P08238491187982TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P08238491187982TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P0823849118104106TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P0823849118104106TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P0823849118104106TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P08238216319316323Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
P08238216319316323Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
P08238216319316323Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
P082382163192724ChainID=PRO_0000062917;Note=Heat shock protein HSP 90-beta
P082382163192724ChainID=PRO_0000062917;Note=Heat shock protein HSP 90-beta
P082382163192724ChainID=PRO_0000062917;Note=Heat shock protein HSP 90-beta
P08238216319288290HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
P08238216319288290HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
P08238216319288290HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
P08238216319293295HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
P08238216319293295HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
P08238216319293295HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
P08238216319298309HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
P08238216319298309HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
P08238216319298309HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
P08238216319219219Modified residueNote=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11499
P08238216319219219Modified residueNote=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11499
P08238216319219219Modified residueNote=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11499
P08238216319226226Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:18318008,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:1
P08238216319226226Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:18318008,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:1
P08238216319226226Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:18318008,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:1
P08238216319255255Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:23186163,ECO:0000269|Ref.12;Dbxref=PMID:17081983,PMID:23186163
P08238216319255255Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:23186163,ECO:0000269|Ref.12;Dbxref=PMID:17081983,PMID:23186163
P08238216319255255Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:23186163,ECO:0000269|Ref.12;Dbxref=PMID:17081983,PMID:23186163
P08238216319261261Modified residueNote=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11499
P08238216319261261Modified residueNote=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11499
P08238216319261261Modified residueNote=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11499
P08238216319297297Modified residueNote=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17525332,ECO:0000244|PubMed:23186163;Dbxref=PMID:17525332,PMID:23186163
P08238216319297297Modified residueNote=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17525332,ECO:0000244|PubMed:23186163;Dbxref=PMID:17525332,PMID:23186163
P08238216319297297Modified residueNote=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17525332,ECO:0000244|PubMed:23186163;Dbxref=PMID:17525332,PMID:23186163
P08238216319301301Modified residueNote=Phosphotyrosine%3B by SRC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23585225;Dbxref=PMID:23585225
P08238216319301301Modified residueNote=Phosphotyrosine%3B by SRC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23585225;Dbxref=PMID:23585225
P08238216319301301Modified residueNote=Phosphotyrosine%3B by SRC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23585225;Dbxref=PMID:23585225
P08238216319305305Modified residueNote=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11499
P08238216319305305Modified residueNote=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11499
P08238216319305305Modified residueNote=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11499
P08238216319307307Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
P08238216319307307Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
P08238216319307307Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
P08238216319226226MutagenesisNote=Increases the binding affinity for AHR%3B when associated with A-255. Increases AHR transcription activity%3B when associated with A-255. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
P08238216319226226MutagenesisNote=Increases the binding affinity for AHR%3B when associated with A-255. Increases AHR transcription activity%3B when associated with A-255. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
P08238216319226226MutagenesisNote=Increases the binding affinity for AHR%3B when associated with A-255. Increases AHR transcription activity%3B when associated with A-255. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
P08238216319226226MutagenesisNote=No effect on the interaction with AHR%3B when associated with E-255. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
P08238216319226226MutagenesisNote=No effect on the interaction with AHR%3B when associated with E-255. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
P08238216319226226MutagenesisNote=No effect on the interaction with AHR%3B when associated with E-255. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
P08238216319255255MutagenesisNote=Increases the binding affinity for AHR%3B when associated with A-226. Increases AHR transcription activity%3B when associated with A-226. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
P08238216319255255MutagenesisNote=Increases the binding affinity for AHR%3B when associated with A-226. Increases AHR transcription activity%3B when associated with A-226. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
P08238216319255255MutagenesisNote=Increases the binding affinity for AHR%3B when associated with A-226. Increases AHR transcription activity%3B when associated with A-226. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
P08238216319255255MutagenesisNote=No effect on the interaction with AHR%3B when associated with E-226. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
P08238216319255255MutagenesisNote=No effect on the interaction with AHR%3B when associated with E-226. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
P08238216319255255MutagenesisNote=No effect on the interaction with AHR%3B when associated with E-226. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
P08238216319301301MutagenesisNote=Decreases interaction with NOS3 and SRC. impairs resists LPS-induced tyrosine phosphorylation. Does not block LPS-induced pp60src phosphorylation. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23585225;Dbxref=PMID:23585225
P08238216319301301MutagenesisNote=Decreases interaction with NOS3 and SRC. impairs resists LPS-induced tyrosine phosphorylation. Does not block LPS-induced pp60src phosphorylation. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23585225;Dbxref=PMID:23585225
P08238216319301301MutagenesisNote=Decreases interaction with NOS3 and SRC. impairs resists LPS-induced tyrosine phosphorylation. Does not block LPS-induced pp60src phosphorylation. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23585225;Dbxref=PMID:23585225
P082382163192527RegionNote=Interaction with TP53;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15358771;Dbxref=PMID:15358771
P082382163192527RegionNote=Interaction with TP53;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15358771;Dbxref=PMID:15358771
P082382163192527RegionNote=Interaction with TP53;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15358771;Dbxref=PMID:15358771
P08238216319215552RegionNote=Interaction with AHSA1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25486457;Dbxref=PMID:25486457
P08238216319215552RegionNote=Interaction with AHSA1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25486457;Dbxref=PMID:25486457
P08238216319215552RegionNote=Interaction with AHSA1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25486457;Dbxref=PMID:25486457


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
P08238491187378Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P08238491187378Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P08238491187378Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P08238491188388Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P08238491188388Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P08238491188388Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P08238491188888Binding siteNote=ATP
P08238491188888Binding siteNote=ATP
P08238491188888Binding siteNote=ATP
P0823849118107107Binding siteNote=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
P0823849118107107Binding siteNote=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
P0823849118107107Binding siteNote=ATP;Ontology_term=ECO:0000250;evidence=ECO:0000250
P08238491182724ChainID=PRO_0000062917;Note=Heat shock protein HSP 90-beta
P08238491182724ChainID=PRO_0000062917;Note=Heat shock protein HSP 90-beta
P08238491182724ChainID=PRO_0000062917;Note=Heat shock protein HSP 90-beta
P08238491183860HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P08238491183860HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P08238491183860HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P08238491186265HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P08238491186265HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P08238491186265HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P082384911895103HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P082384911895103HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P082384911895103HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P0823849118107118HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P0823849118107118HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P0823849118107118HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P08238491188888MutagenesisNote=Impaired ATP-binding. Strong interaction with HIF1A%2C MET%2C KEAP1 and RHOBTB2. Loss of interaction with HSF1 and ERBB2. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26517842;Dbxref=PMID:26517842
P08238491188888MutagenesisNote=Impaired ATP-binding. Strong interaction with HIF1A%2C MET%2C KEAP1 and RHOBTB2. Loss of interaction with HSF1 and ERBB2. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26517842;Dbxref=PMID:26517842
P08238491188888MutagenesisNote=Impaired ATP-binding. Strong interaction with HIF1A%2C MET%2C KEAP1 and RHOBTB2. Loss of interaction with HSF1 and ERBB2. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26517842;Dbxref=PMID:26517842
P08238491182527RegionNote=Interaction with TP53;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15358771;Dbxref=PMID:15358771
P08238491182527RegionNote=Interaction with TP53;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15358771;Dbxref=PMID:15358771
P08238491182527RegionNote=Interaction with TP53;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15358771;Dbxref=PMID:15358771
P08238491182214RegionNote=Interaction with BIRC2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25486457;Dbxref=PMID:25486457
P08238491182214RegionNote=Interaction with BIRC2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25486457;Dbxref=PMID:25486457
P08238491182214RegionNote=Interaction with BIRC2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25486457;Dbxref=PMID:25486457
P08238491187982TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P08238491187982TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P08238491187982TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P0823849118104106TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P0823849118104106TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P0823849118104106TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5UCJ
P08238216319316323Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
P08238216319316323Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
P08238216319316323Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
P082382163192724ChainID=PRO_0000062917;Note=Heat shock protein HSP 90-beta
P082382163192724ChainID=PRO_0000062917;Note=Heat shock protein HSP 90-beta
P082382163192724ChainID=PRO_0000062917;Note=Heat shock protein HSP 90-beta
P08238216319288290HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
P08238216319288290HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
P08238216319288290HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
P08238216319293295HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
P08238216319293295HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
P08238216319293295HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
P08238216319298309HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
P08238216319298309HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
P08238216319298309HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PRY
P08238216319219219Modified residueNote=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11499
P08238216319219219Modified residueNote=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11499
P08238216319219219Modified residueNote=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11499
P08238216319226226Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:18318008,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:1
P08238216319226226Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:18318008,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:1
P08238216319226226Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18088087,ECO:0000244|PubMed:18318008,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:1
P08238216319255255Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:23186163,ECO:0000269|Ref.12;Dbxref=PMID:17081983,PMID:23186163
P08238216319255255Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:23186163,ECO:0000269|Ref.12;Dbxref=PMID:17081983,PMID:23186163
P08238216319255255Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:23186163,ECO:0000269|Ref.12;Dbxref=PMID:17081983,PMID:23186163
P08238216319261261Modified residueNote=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11499
P08238216319261261Modified residueNote=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11499
P08238216319261261Modified residueNote=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11499
P08238216319297297Modified residueNote=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17525332,ECO:0000244|PubMed:23186163;Dbxref=PMID:17525332,PMID:23186163
P08238216319297297Modified residueNote=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17525332,ECO:0000244|PubMed:23186163;Dbxref=PMID:17525332,PMID:23186163
P08238216319297297Modified residueNote=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17525332,ECO:0000244|PubMed:23186163;Dbxref=PMID:17525332,PMID:23186163
P08238216319301301Modified residueNote=Phosphotyrosine%3B by SRC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23585225;Dbxref=PMID:23585225
P08238216319301301Modified residueNote=Phosphotyrosine%3B by SRC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23585225;Dbxref=PMID:23585225
P08238216319301301Modified residueNote=Phosphotyrosine%3B by SRC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23585225;Dbxref=PMID:23585225
P08238216319305305Modified residueNote=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11499
P08238216319305305Modified residueNote=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11499
P08238216319305305Modified residueNote=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11499
P08238216319307307Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
P08238216319307307Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
P08238216319307307Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648
P08238216319226226MutagenesisNote=Increases the binding affinity for AHR%3B when associated with A-255. Increases AHR transcription activity%3B when associated with A-255. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
P08238216319226226MutagenesisNote=Increases the binding affinity for AHR%3B when associated with A-255. Increases AHR transcription activity%3B when associated with A-255. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
P08238216319226226MutagenesisNote=Increases the binding affinity for AHR%3B when associated with A-255. Increases AHR transcription activity%3B when associated with A-255. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
P08238216319226226MutagenesisNote=No effect on the interaction with AHR%3B when associated with E-255. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
P08238216319226226MutagenesisNote=No effect on the interaction with AHR%3B when associated with E-255. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
P08238216319226226MutagenesisNote=No effect on the interaction with AHR%3B when associated with E-255. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
P08238216319255255MutagenesisNote=Increases the binding affinity for AHR%3B when associated with A-226. Increases AHR transcription activity%3B when associated with A-226. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
P08238216319255255MutagenesisNote=Increases the binding affinity for AHR%3B when associated with A-226. Increases AHR transcription activity%3B when associated with A-226. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
P08238216319255255MutagenesisNote=Increases the binding affinity for AHR%3B when associated with A-226. Increases AHR transcription activity%3B when associated with A-226. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
P08238216319255255MutagenesisNote=No effect on the interaction with AHR%3B when associated with E-226. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
P08238216319255255MutagenesisNote=No effect on the interaction with AHR%3B when associated with E-226. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
P08238216319255255MutagenesisNote=No effect on the interaction with AHR%3B when associated with E-226. S->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15581363;Dbxref=PMID:15581363
P08238216319301301MutagenesisNote=Decreases interaction with NOS3 and SRC. impairs resists LPS-induced tyrosine phosphorylation. Does not block LPS-induced pp60src phosphorylation. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23585225;Dbxref=PMID:23585225
P08238216319301301MutagenesisNote=Decreases interaction with NOS3 and SRC. impairs resists LPS-induced tyrosine phosphorylation. Does not block LPS-induced pp60src phosphorylation. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23585225;Dbxref=PMID:23585225
P08238216319301301MutagenesisNote=Decreases interaction with NOS3 and SRC. impairs resists LPS-induced tyrosine phosphorylation. Does not block LPS-induced pp60src phosphorylation. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23585225;Dbxref=PMID:23585225
P082382163192527RegionNote=Interaction with TP53;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15358771;Dbxref=PMID:15358771
P082382163192527RegionNote=Interaction with TP53;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15358771;Dbxref=PMID:15358771
P082382163192527RegionNote=Interaction with TP53;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15358771;Dbxref=PMID:15358771
P08238216319215552RegionNote=Interaction with AHSA1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25486457;Dbxref=PMID:25486457
P08238216319215552RegionNote=Interaction with AHSA1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25486457;Dbxref=PMID:25486457
P08238216319215552RegionNote=Interaction with AHSA1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25486457;Dbxref=PMID:25486457


Top

SNVs in the skipped exons for HSP90AB1

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
PRADTCGA-SU-A7E7-01exon_skip_452427
44216354442165134421640844216409Frame_Shift_DelTT-p.F15fs
PRADTCGA-SU-A7E7-01exon_skip_452427
44216354442165134421640844216409Frame_Shift_DelTT-p.TF14fs
BRCATCGA-A8-A08O-01exon_skip_452435
44217114442173204421718144217197Frame_Shift_DelAAATTGACATCATCCCC-p.I73fs
ESCATCGA-JY-A6FG-01exon_skip_452440
44217758442178914421780844217811Frame_Shift_DelCAGA-p.188_189del
ESCATCGA-JY-A6FG-01exon_skip_452440
44217758442178914421780844217811Frame_Shift_DelCAGA-p.QT189fs
ESCATCGA-JY-A6FG-01exon_skip_452440
44217758442178914421780844217811Frame_Shift_DelCAGA-p.T190fs
LIHCTCGA-DD-A1EG-01exon_skip_452441
44218028442183364421807944218079Frame_Shift_DelA-p.E233fs
LIHCTCGA-DD-A1EG-01exon_skip_452441
44218028442183364421807944218079Frame_Shift_DelA-p.K234fs
LIHCTCGA-DD-A39Y-01exon_skip_452441
44218028442183364421811644218116Frame_Shift_DelA-p.E246fs
LIHCTCGA-DD-A3A0-01exon_skip_452441
44218028442183364421811644218116Frame_Shift_DelA-p.E246fs
BLCATCGA-C4-A0F7-01exon_skip_452427
44216354442165134421641844216418Nonsense_MutationCTp.Q18*
BLCATCGA-DK-A6B6-01exon_skip_452427
44216354442165134421641844216418Nonsense_MutationCTp.Q18*
BLCATCGA-4Z-AA7Y-01exon_skip_452435
44217114442173204421715444217154Nonsense_MutationCAp.S63*
HNSCTCGA-CQ-6219-01exon_skip_452435
44217114442173204421720444217204Nonsense_MutationCTp.Q80*
UCECTCGA-AP-A059-01exon_skip_452440
44217758442178914421784144217841Nonsense_MutationGTp.E200*
BLCATCGA-G2-A2EO-01exon_skip_452447
44219736442200044421987744219877Nonsense_MutationCGp.S535*
UCECTCGA-B5-A11R-01exon_skip_452447
44219736442200044421987744219877Nonsense_MutationCGp.S535*
HNSCTCGA-CR-7398-01exon_skip_452447
44219736442200044421999044219990Nonsense_MutationATp.K573*
GBMTCGA-26-5136-01exon_skip_452435
44217114442173204421732144217321Splice_SiteGTp.Q118_splice

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
CMLT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE44219736442200044421991244219914In_Frame_DelGAG-p.E549del
KG1C_CENTRAL_NERVOUS_SYSTEM44219736442200044421991244219914In_Frame_DelGAG-p.E549del
NBSUSSR_AUTONOMIC_GANGLIA44219736442200044421991944219921In_Frame_DelAGA-p.K552del
RT112_URINARY_TRACT44216354442165134421641844216418Missense_MutationCGp.Q18E
RT11284_URINARY_TRACT44216354442165134421641844216418Missense_MutationCGp.Q18E
SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE44216354442165134421643044216430Missense_MutationGTp.A22S
OVK18_OVARY44217114442173204421715144217151Missense_MutationCAp.P62H
HRT18_LARGE_INTESTINE44217114442173204421716444217164Missense_MutationCAp.D66E
CL34_LARGE_INTESTINE44217114442173204421722044217220Missense_MutationCGp.T85S
SNGM_ENDOMETRIUM44217114442173204421724144217241Missense_MutationGAp.G92D
TM31_CENTRAL_NERVOUS_SYSTEM44217114442173204421726844217268Missense_MutationAGp.N101S
NCIH322_LUNG44217114442173204421727744217277Missense_MutationCTp.T104I
SUPHD1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE44217114442173204421730044217300Missense_MutationGAp.A112T
EFO27_OVARY44217758442178914421783344217833Missense_MutationGAp.R197Q
HEC151_ENDOMETRIUM44217758442178914421787744217877Missense_MutationCTp.P212S
LAMA84_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE44218028442183364421805244218052Missense_MutationAGp.I225V
DU145_PROSTATE44218028442183364421810944218109Missense_MutationGAp.D244N
HS229T_FIBROBLAST44218028442183364421811544218115Missense_MutationGCp.E246Q
BC3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE44218028442183364421813044218130Missense_MutationGAp.E251K
KYAE1_OESOPHAGUS44218028442183364421814844218148Missense_MutationGCp.E257Q
SKRC20_KIDNEY44218028442183364421824244218242Missense_MutationTCp.I288T
JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE44219736442200044421976644219766Missense_MutationCTp.A498V
MC1010_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE44219736442200044421978344219783Missense_MutationCTp.R504W
KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE44219736442200044421985944219859Missense_MutationATp.D529V
MKN1_STOMACH44219736442200044421993844219938Missense_MutationGCp.E555D
SNU423_LIVER44219736442200044421999744219997Missense_MutationTCp.V575A
JAR_PLACENTA44218028442183364421828344218283Nonsense_MutationGTp.G302*
SNU1040_LARGE_INTESTINE44219736442200044421977744219777Nonsense_MutationCTp.R502*
OCIM1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE44216354442165134421636944216369Start_Codon_SNPGAp.M1I

Top

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for HSP90AB1

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value
exon_skip_452441644217757:44217891:44218027:44218336:44218784:4421895044218027:44218336ENST00000353801.3,ENST00000371646.5,ENST00000371554.1GBMrs13296chr6:44218120A/G7.63e-07
exon_skip_452441644217757:44217891:44218027:44218336:44218784:4421895044218027:44218336ENST00000353801.3,ENST00000371646.5,ENST00000371554.1GBMrs13296chr6:44218120A/G7.70e-07
exon_skip_452441644217757:44217891:44218027:44218336:44218784:4421895044218027:44218336ENST00000353801.3,ENST00000371646.5,ENST00000371554.1COADrs13296chr6:44218120A/G8.11e-07
exon_skip_452441644217757:44217891:44218027:44218336:44218784:4421895044218027:44218336ENST00000353801.3,ENST00000371646.5,ENST00000371554.1COADrs13296chr6:44218120A/G8.91e-07
exon_skip_452441644217757:44217891:44218027:44218336:44218784:4421895044218027:44218336ENST00000353801.3,ENST00000371646.5,ENST00000371554.1BLCArs13296chr6:44218120A/G1.58e-03
exon_skip_452441644217757:44217891:44218027:44218336:44218784:4421895044218027:44218336ENST00000353801.3,ENST00000371646.5,ENST00000371554.1BLCArs13296chr6:44218120A/G1.58e-03
exon_skip_452441644217757:44217891:44218027:44218336:44218784:4421895044218027:44218336ENST00000353801.3,ENST00000371646.5,ENST00000371554.1BRCArs13296chr6:44218120A/G3.42e-07
exon_skip_452441644217757:44217891:44218027:44218336:44218784:4421895044218027:44218336ENST00000353801.3,ENST00000371646.5,ENST00000371554.1BRCArs13296chr6:44218120A/G3.52e-07
exon_skip_452441644217757:44217891:44218027:44218336:44218784:4421895044218027:44218336ENST00000353801.3,ENST00000371646.5,ENST00000371554.1LGGrs13296chr6:44218120A/G1.33e-07
exon_skip_452441644217757:44217891:44218027:44218336:44218784:4421895044218027:44218336ENST00000353801.3,ENST00000371646.5,ENST00000371554.1LGGrs13296chr6:44218120A/G1.33e-07
exon_skip_452441644217757:44217891:44218027:44218336:44218784:4421895044218027:44218336ENST00000353801.3,ENST00000371646.5,ENST00000371554.1LUADrs13296chr6:44218120A/G1.97e-05
exon_skip_452441644217757:44217891:44218027:44218336:44218784:4421895044218027:44218336ENST00000353801.3,ENST00000371646.5,ENST00000371554.1LUADrs13296chr6:44218120A/G1.99e-05
exon_skip_452441644217757:44217891:44218027:44218336:44218784:4421895044218027:44218336ENST00000353801.3,ENST00000371646.5,ENST00000371554.1LUSCrs13296chr6:44218120A/G8.35e-05
exon_skip_452441644217757:44217891:44218027:44218336:44218784:4421895044218027:44218336ENST00000353801.3,ENST00000371646.5,ENST00000371554.1LUSCrs13296chr6:44218120A/G8.42e-05
exon_skip_452441644217757:44217891:44218027:44218336:44218784:4421895044218027:44218336ENST00000353801.3,ENST00000371646.5,ENST00000371554.1OVrs13296chr6:44218120A/G1.04e-05
exon_skip_452441644217757:44217891:44218027:44218336:44218784:4421895044218027:44218336ENST00000353801.3,ENST00000371646.5,ENST00000371554.1OVrs13296chr6:44218120A/G1.05e-05
exon_skip_452441644217757:44217891:44218027:44218336:44218784:4421895044218027:44218336ENST00000353801.3,ENST00000371646.5,ENST00000371554.1PCPGrs13296chr6:44218120A/G6.43e-04
exon_skip_452441644217757:44217891:44218027:44218336:44218784:4421895044218027:44218336ENST00000353801.3,ENST00000371646.5,ENST00000371554.1PCPGrs13296chr6:44218120A/G6.52e-04
exon_skip_452441644217757:44217891:44218027:44218336:44218784:4421895044218027:44218336ENST00000353801.3,ENST00000371646.5,ENST00000371554.1PAADrs13296chr6:44218120A/G8.77e-04
exon_skip_452441644217757:44217891:44218027:44218336:44218784:4421895044218027:44218336ENST00000353801.3,ENST00000371646.5,ENST00000371554.1PAADrs13296chr6:44218120A/G8.77e-04
exon_skip_452441644217757:44217891:44218027:44218336:44218784:4421895044218027:44218336ENST00000353801.3,ENST00000371646.5,ENST00000371554.1PRADrs13296chr6:44218120A/G2.72e-04
exon_skip_452441644217757:44217891:44218027:44218336:44218784:4421895044218027:44218336ENST00000353801.3,ENST00000371646.5,ENST00000371554.1PRADrs13296chr6:44218120A/G2.78e-04
exon_skip_452441644217757:44217891:44218027:44218336:44218784:4421895044218027:44218336ENST00000353801.3,ENST00000371646.5,ENST00000371554.1SARCrs13296chr6:44218120A/G8.50e-05
exon_skip_452441644217757:44217891:44218027:44218336:44218784:4421895044218027:44218336ENST00000353801.3,ENST00000371646.5,ENST00000371554.1SARCrs13296chr6:44218120A/G8.50e-05
exon_skip_452441644217757:44217891:44218027:44218336:44218784:4421895044218027:44218336ENST00000353801.3,ENST00000371646.5,ENST00000371554.1STADrs13296chr6:44218120A/G4.20e-04
exon_skip_452441644217757:44217891:44218027:44218336:44218784:4421895044218027:44218336ENST00000353801.3,ENST00000371646.5,ENST00000371554.1STADrs13296chr6:44218120A/G4.20e-04

Top

Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for HSP90AB1


Top

Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for HSP90AB1


Top

RelatedDrugs for HSP90AB1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for HSP90AB1

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
HSP90AB1C0019693HIV Infections1CTD_human
HSP90AB1C0033578Prostatic Neoplasms1CTD_human