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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for HSPA9

check button Gene summary
Gene informationGene symbol

HSPA9

Gene ID

3313

Gene nameheat shock protein family A (Hsp70) member 9
SynonymsCRP40|CSA|EVPLS|GRP-75|GRP75|HEL-S-124m|HSPA9B|MOT|MOT2|MTHSP75|PBP74|SAAN|SIDBA4
Cytomap

5q31.2

Type of geneprotein-coding
Descriptionstress-70 protein, mitochondrial75 kDa glucose-regulated proteincatecholamine-regulated protein 40epididymis secretory sperm binding protein Li 124mheat shock 70kD protein 9Bheat shock 70kDa protein 9 (mortalin)mortalin, perinuclearmortalin-2morta
Modification date20180523
UniProtAcc

P38646

ContextPubMed: HSPA9 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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Exon skipping events across known transcript of Ensembl for HSPA9 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for HSPA9

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for HSPA9

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_4445915137892140:137892281:137892462:137892555:137893090:137893185137892462:137892555ENSG00000113013.8ENST00000297185.3
exon_skip_4445935137893090:137893185:137893557:137893675:137894241:137894320137893557:137893675ENSG00000113013.8ENST00000297185.3,ENST00000512328.1
exon_skip_4445945137893557:137893675:137894241:137894346:137895552:137895780137894241:137894346ENSG00000113013.8ENST00000297185.3
exon_skip_4445955137894241:137894346:137895552:137895780:137897268:137897478137895552:137895780ENSG00000113013.8ENST00000297185.3,ENST00000507097.1
exon_skip_4445995137895686:137895780:137896469:137896620:137897268:137897478137896469:137896620ENSG00000113013.8ENST00000523929.1
exon_skip_4446005137895552:137895780:137897268:137897478:137902314:137902400137897268:137897478ENSG00000113013.8ENST00000297185.3,ENST00000507097.1
exon_skip_4446025137897268:137897478:137902314:137902407:137902689:137902852137902314:137902407ENSG00000113013.8ENST00000297185.3,ENST00000507097.1
exon_skip_4446045137903143:137903250:137903337:137903411:137904613:137904738137903337:137903411ENSG00000113013.8ENST00000297185.3,ENST00000507097.1,ENST00000504902.1
exon_skip_4446055137903337:137903411:137904613:137904738:137906648:137906830137904613:137904738ENSG00000113013.8ENST00000297185.3,ENST00000507097.1,ENST00000504902.1
exon_skip_4446105137909465:137909539:137909756:137909815:137910926:137911029137909756:137909815ENSG00000113013.8ENST00000506477.1,ENST00000504902.1
exon_skip_4446115137909465:137909539:137909756:137909858:137910926:137911029137909756:137909858ENSG00000113013.8ENST00000507097.1,ENST00000507115.1

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for HSPA9

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_4445915137892140:137892281:137892462:137892555:137893090:137893185137892462:137892555ENSG00000113013.8ENST00000297185.3
exon_skip_4445935137893090:137893185:137893557:137893675:137894241:137894320137893557:137893675ENSG00000113013.8ENST00000297185.3,ENST00000512328.1
exon_skip_4445945137893557:137893675:137894241:137894346:137895552:137895780137894241:137894346ENSG00000113013.8ENST00000297185.3
exon_skip_4445955137894241:137894346:137895552:137895780:137897268:137897478137895552:137895780ENSG00000113013.8ENST00000297185.3,ENST00000507097.1
exon_skip_4445995137895686:137895780:137896469:137896620:137897268:137897478137896469:137896620ENSG00000113013.8ENST00000523929.1
exon_skip_4446005137895552:137895780:137897268:137897478:137902314:137902400137897268:137897478ENSG00000113013.8ENST00000297185.3,ENST00000507097.1
exon_skip_4446025137897268:137897478:137902314:137902407:137902689:137902852137902314:137902407ENSG00000113013.8ENST00000297185.3,ENST00000507097.1
exon_skip_4446045137903143:137903250:137903337:137903411:137904613:137904738137903337:137903411ENSG00000113013.8ENST00000297185.3,ENST00000507097.1,ENST00000504902.1
exon_skip_4446055137903337:137903411:137904613:137904738:137906648:137906830137904613:137904738ENSG00000113013.8ENST00000297185.3,ENST00000507097.1,ENST00000504902.1
exon_skip_4446105137909465:137909539:137909756:137909815:137910926:137911029137909756:137909815ENSG00000113013.8ENST00000504902.1,ENST00000506477.1
exon_skip_4446115137909465:137909539:137909756:137909858:137910926:137911029137909756:137909858ENSG00000113013.8ENST00000507097.1,ENST00000507115.1

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for HSPA9

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST00000297185137893557137893675Frame-shift
ENST00000297185137903337137903411Frame-shift
ENST00000297185137904613137904738Frame-shift
ENST00000297185137892462137892555In-frame
ENST00000297185137894241137894346In-frame
ENST00000297185137895552137895780In-frame
ENST00000297185137897268137897478In-frame
ENST00000297185137902314137902407In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST00000297185137893557137893675Frame-shift
ENST00000297185137903337137903411Frame-shift
ENST00000297185137904613137904738Frame-shift
ENST00000297185137892462137892555In-frame
ENST00000297185137894241137894346In-frame
ENST00000297185137895552137895780In-frame
ENST00000297185137897268137897478In-frame
ENST00000297185137902314137902407In-frame

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Infer the effects of exon skipping event on protein functional features for HSPA9

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST00000297185333867913790231413790240710061098293324
ENST00000297185333867913789726813789747810991308324394
ENST00000297185333867913789555213789578013091536394470
ENST00000297185333867913789424113789434615371641470505
ENST00000297185333867913789246213789255518551947576607

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST00000297185333867913790231413790240710061098293324
ENST00000297185333867913789726813789747810991308324394
ENST00000297185333867913789555213789578013091536394470
ENST00000297185333867913789424113789434615371641470505
ENST00000297185333867913789246213789255518551947576607

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature


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SNVs in the skipped exons for HSPA9

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.
HSPA9_KIRC_exon_skip_444602_psi_boxplot.png
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HSPA9_LIHC_exon_skip_444593_psi_boxplot.png
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check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LIHCTCGA-G3-A3CJ-01exon_skip_444593
137893558137893675137893625137893625Frame_Shift_DelA-p.F522fs
LIHCTCGA-DD-A1EG-01exon_skip_444595
137895553137895780137895754137895754Frame_Shift_DelA-p.F403fs
LIHCTCGA-DD-A39Y-01exon_skip_444595
137895553137895780137895754137895754Frame_Shift_DelA-p.F403fs
LIHCTCGA-DD-A39Y-01exon_skip_444604
137903338137903411137903384137903384Frame_Shift_DelT-p.N188fs
LIHCTCGA-DD-A3A0-01exon_skip_444604
137903338137903411137903384137903384Frame_Shift_DelT-p.N188fs
KIRPTCGA-GL-8500-01exon_skip_444605
137904614137904738137904733137904733Frame_Shift_DelT-p.N139fs
CESCTCGA-DS-A1OC-01exon_skip_444591
137892463137892555137892546137892546Nonsense_MutationCAp.E580*
BLCATCGA-KQ-A41R-01exon_skip_444595
137895553137895780137895693137895693Nonsense_MutationGAp.Q424*
COADTCGA-AA-3510-01exon_skip_444600
137897269137897478137897307137897307Nonsense_MutationCAp.E382X
KIRCTCGA-A3-3323-01exon_skip_444602
137902315137902407137902359137902359Nonsense_MutationCAp.E310*
KIRCTCGA-A3-3323-01exon_skip_444602
137902315137902407137902359137902359Nonsense_MutationCAp.E310X
UCECTCGA-D1-A103-01exon_skip_444610
137909757137909815137909756137909756Splice_SiteCTe2+1
UCECTCGA-D1-A103-01exon_skip_444611
137909757137909858137909756137909756Splice_SiteCTe2+1

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description
HSPA9_137897268_137897478_137902314_137902407_137902689_137902852_TCGA-A3-3323-01Sample: TCGA-A3-3323-01
Cancer type: KIRC
ESID: exon_skip_444602
Skipped exon start: 137902315
Skipped exon end: 137902407
Mutation start: 137902359
Mutation end: 137902359
Mutation type: Nonsense_Mutation
Reference seq: C
Mutation seq: A
AAchange: p.E310X
HSPA9_137897268_137897478_137902314_137902407_137902689_137902852_TCGA-A3-3323-01Sample: TCGA-A3-3323-01
Cancer type: KIRC
ESID: exon_skip_444602
Skipped exon start: 137902315
Skipped exon end: 137902407
Mutation start: 137902359
Mutation end: 137902359
Mutation type: Nonsense_Mutation
Reference seq: C
Mutation seq: A
AAchange: p.E310*
exon_skip_444602_KIRC_TCGA-A3-3323-01.png
boxplot
HSPA9_137893090_137893185_137893557_137893675_137894241_137894320_TCGA-G3-A3CJ-01Sample: TCGA-G3-A3CJ-01
Cancer type: LIHC
ESID: exon_skip_444593
Skipped exon start: 137893558
Skipped exon end: 137893675
Mutation start: 137893625
Mutation end: 137893625
Mutation type: Frame_Shift_Del
Reference seq: A
Mutation seq: -
AAchange: p.F522fs
exon_skip_101516_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_106378_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_106524_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_109529_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_109778_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_11286_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_11289_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_11349_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_113894_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_113898_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_11611_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_11638_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_11641_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_11926_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_11933_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_11937_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_11939_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_124065_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_124066_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_126824_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_1268_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_1270_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_127101_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_1274_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_129795_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_131474_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_135553_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_13626_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_138373_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_138676_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_141657_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_143728_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_1873_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_289275_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_289905_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_291218_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_293221_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_300058_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_354387_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_365019_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_382000_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_382738_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_387684_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_421130_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_426528_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_427391_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_433655_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_434375_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_43567_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_436327_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_436618_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_444593_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_445559_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_447600_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_452739_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_4535_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_457245_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_470485_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_478117_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_483502_LIHC_TCGA-G3-A3CJ-01.png
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exon_skip_483618_LIHC_TCGA-G3-A3CJ-01.png
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check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
SW480_LARGE_INTESTINE137903338137903411137903383137903384Frame_Shift_Ins-Tp.N188fs
SNUC5_LARGE_INTESTINE137892463137892555137892501137892501Missense_MutationTCp.K595E
DOV13_OVARY137892463137892555137892542137892542Missense_MutationGAp.A581V
SNU1040_LARGE_INTESTINE137893558137893675137893567137893567Missense_MutationCTp.E542K
CMK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE137893558137893675137893573137893573Missense_MutationCTp.G540R
KYSE270_OESOPHAGUS137893558137893675137893587137893587Missense_MutationTGp.K535T
PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE137894242137894346137894247137894247Missense_MutationTCp.T504A
OVCAR8_OVARY137895553137895780137895575137895575Missense_MutationGCp.T463S
NUDUL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE137895553137895780137895731137895731Missense_MutationAGp.V411A
H2369_PLEURA137895553137895780137895747137895747Missense_MutationCAp.A406S
KYSE270_OESOPHAGUS137895553137895780137895772137895772Missense_MutationCAp.Q397H
ASH3_THYROID137897269137897478137897331137897331Missense_MutationCTp.E374K
CW2_LARGE_INTESTINE137897269137897478137897393137897393Missense_MutationCAp.G353V
CMLT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE137897269137897478137897453137897453Missense_MutationGAp.T333I
NCIH1573_LUNG137903338137903411137903382137903382Missense_MutationCAp.A189S
HT1376_URINARY_TRACT137904614137904738137904627137904627Missense_MutationCAp.M174I
KYSE150_OESOPHAGUS137904614137904738137904685137904685Missense_MutationTCp.E155G
RCC10RGB_KIDNEY137909757137909815137909793137909793Missense_MutationTAp.H35L
RCC10RGB_KIDNEY137909757137909858137909793137909793Missense_MutationTAp.H35L
TE14_OESOPHAGUS137895553137895780137895555137895555Nonsense_MutationGAp.Q470*

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for HSPA9

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for HSPA9


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for HSPA9


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RelatedDrugs for HSPA9

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HSPA9

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
HSPA9C0004364Autoimmune Diseases1CTD_human
HSPA9C0007134Renal Cell Carcinoma1CTD_human
HSPA9C0019693HIV Infections1CTD_human
HSPA9C0030567Parkinson Disease1CTD_human
HSPA9C0036341Schizophrenia1PSYGENET
HSPA9C0042164Uveitis1CTD_human
HSPA9C0151744Myocardial Ischemia1CTD_human
HSPA9C0221765Chronic schizophrenia1PSYGENET
HSPA9C0376618Endotoxemia1CTD_human
HSPA9C0520459Necrotizing Enterocolitis1CTD_human
HSPA9C2239176Liver carcinoma1CTD_human
HSPA9C4225180EVEN-PLUS SYNDROME1UNIPROT