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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for HRAS |
 Gene summary |
| Gene information | Gene symbol | HRAS | Gene ID | 3265 |
| Gene name | HRas proto-oncogene, GTPase | |
| Synonyms | C-BAS/HAS|C-H-RAS|C-HA-RAS1|CTLO|H-RASIDX|HAMSV|HRAS1|RASH1|p21ras | |
| Cytomap | 11p15.5 | |
| Type of gene | protein-coding | |
| Description | GTPase HRasGTP- and GDP-binding peptide BHa-Ras1 proto-oncoproteinHarvey rat sarcoma viral oncogene homologHarvey rat sarcoma viral oncoproteinRas family small GTP binding protein H-Rasc-has/bas p21 proteinc-ras-Ki-2 activated oncogenep19 H-RasIDX | |
| Modification date | 20180522 | |
| UniProtAcc | P01112 | |
| Context | PubMed: HRAS [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| HRAS | GO:0001934 | positive regulation of protein phosphorylation | 22065586 |
| HRAS | GO:0007050 | cell cycle arrest | 9054499 |
| HRAS | GO:0007093 | mitotic cell cycle checkpoint | 9054499 |
| HRAS | GO:0007265 | Ras protein signal transduction | 23027131 |
| HRAS | GO:0008284 | positive regulation of cell proliferation | 9765203 |
| HRAS | GO:0008285 | negative regulation of cell proliferation | 9054499 |
| HRAS | GO:0010629 | negative regulation of gene expression | 23027131 |
| HRAS | GO:0010863 | positive regulation of phospholipase C activity | 11022048 |
| HRAS | GO:0030335 | positive regulation of cell migration | 23027131 |
| HRAS | GO:0034260 | negative regulation of GTPase activity | 23027131 |
| HRAS | GO:0043406 | positive regulation of MAP kinase activity | 23027131 |
| HRAS | GO:0043410 | positive regulation of MAPK cascade | 9765203 |
| HRAS | GO:0043547 | positive regulation of GTPase activity | 23027131 |
| HRAS | GO:0045944 | positive regulation of transcription by RNA polymerase II | 22065586|23027131 |
| HRAS | GO:0046330 | positive regulation of JNK cascade | 22065586 |
| HRAS | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 22065586 |
| HRAS | GO:0071480 | cellular response to gamma radiation | 16213212 |
| HRAS | GO:0090303 | positive regulation of wound healing | 23027131 |
| HRAS | GO:0090398 | cellular senescence | 9054499 |
| HRAS | GO:1900029 | positive regulation of ruffle assembly | 23027131 |
| HRAS | GO:2000251 | positive regulation of actin cytoskeleton reorganization | 23027131 |
| HRAS | GO:2000630 | positive regulation of miRNA metabolic process | 23027131 |
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Exon skipping events across known transcript of Ensembl for HRAS from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for HRAS |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for HRAS |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_67261 | 11 | 532375:532522:532630:532755:533452:533595 | 532630:532755 | ENSG00000174775.12 | ENST00000311189.7 |
| exon_skip_67269 | 11 | 532728:532755:533276:533358:533452:533595 | 533276:533358 | ENSG00000174775.12 | ENST00000493230.1,ENST00000417302.1,ENST00000462734.1,ENST00000397594.1 |
| exon_skip_67273 | 11 | 533452:533612:533765:533944:534211:534375 | 533765:533944 | ENSG00000174775.12 | ENST00000397596.2,ENST00000451590.1,ENST00000493230.1,ENST00000417302.1,ENST00000397594.1,ENST00000311189.7 |
| exon_skip_67278 | 11 | 533794:533944:534211:534375:535256:535339 | 534211:534375 | ENSG00000174775.12 | ENST00000397596.2 |
| exon_skip_67279 | 11 | 533794:533944:534211:534375:535415:535534 | 534211:534375 | ENSG00000174775.12 | ENST00000451590.1,ENST00000493230.1,ENST00000417302.1,ENST00000311189.7 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for HRAS |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_67261 | 11 | 532375:532522:532630:532755:533452:533595 | 532630:532755 | ENSG00000174775.12 | ENST00000311189.7 |
| exon_skip_67269 | 11 | 532728:532755:533276:533358:533452:533595 | 533276:533358 | ENSG00000174775.12 | ENST00000397594.1,ENST00000493230.1,ENST00000417302.1,ENST00000462734.1 |
| exon_skip_67273 | 11 | 533452:533612:533765:533944:534211:534375 | 533765:533944 | ENSG00000174775.12 | ENST00000397594.1,ENST00000397596.2,ENST00000493230.1,ENST00000451590.1,ENST00000417302.1,ENST00000311189.7 |
| exon_skip_67278 | 11 | 533794:533944:534211:534375:535256:535339 | 534211:534375 | ENSG00000174775.12 | ENST00000397596.2 |
| exon_skip_67279 | 11 | 533794:533944:534211:534375:535415:535534 | 534211:534375 | ENSG00000174775.12 | ENST00000493230.1,ENST00000451590.1,ENST00000417302.1,ENST00000311189.7 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for HRAS |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for HRAS |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for HRAS |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
HRAS_SKCM_exon_skip_67269_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| BLCA | TCGA-XF-A9T4-01 | exon_skip_67269 | 533277 | 533358 | 533309 | 533309 | Frame_Shift_Del | G | - | p.P167fs |
| BLCA | TCGA-BT-A3PH-01 | exon_skip_67269 | 533277 | 533358 | 533312 | 533321 | Frame_Shift_Del | GGGTCCCAGA | - | p.LWDP163fs |
| SKCM | TCGA-ER-A19F-06 | exon_skip_67269 | 533277 | 533358 | 533312 | 533321 | Frame_Shift_Del | GGGTCCCAGA | - | p.163_166del |
| SKCM | TCGA-ER-A19F-06 | exon_skip_67269 | 533277 | 533358 | 533312 | 533321 | Frame_Shift_Del | GGGTCCCAGA | - | p.LWDP163fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_67273 | 533766 | 533944 | 533851 | 533851 | Frame_Shift_Del | C | - | p.D69fs |
| SKCM | TCGA-EE-A2MF-06 | exon_skip_67273 | 533766 | 533944 | 533880 | 533881 | Frame_Shift_Del | GC | - | p.59_59del |
| SKCM | TCGA-EE-A2MF-06 | exon_skip_67273 | 533766 | 533944 | 533880 | 533881 | Frame_Shift_Del | GC | - | p.A59fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_67278 exon_skip_67279 | 534212 | 534375 | 534288 | 534288 | Frame_Shift_Del | C | - | p.G13fs |
| HNSC | TCGA-CV-7568-01 | exon_skip_67273 | 533766 | 533944 | 533830 | 533830 | Nonsense_Mutation | C | A | p.E76* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-ER-A19F-06 |
| Cancer type: SKCM | |
| ESID: exon_skip_67269 | |
| Skipped exon start: 533277 | |
| Skipped exon end: 533358 | |
| Mutation start: 533312 | |
| Mutation end: 533321 | |
| Mutation type: Frame_Shift_Del | |
| Reference seq: GGGTCCCAGA | |
| Mutation seq: - | |
| AAchange: p.163_166del | |
| Sample: TCGA-ER-A19F-06 |
| Cancer type: SKCM | |
| ESID: exon_skip_67269 | |
| Skipped exon start: 533277 | |
| Skipped exon end: 533358 | |
| Mutation start: 533312 | |
| Mutation end: 533321 | |
| Mutation type: Frame_Shift_Del | |
| Reference seq: GGGTCCCAGA | |
| Mutation seq: - | |
| AAchange: p.LWDP163fs | |
exon_skip_376012_SKCM_TCGA-ER-A19F-06.png | |
exon_skip_67269_SKCM_TCGA-ER-A19F-06.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| ES1_BONE | 532631 | 532755 | 532715 | 532715 | Missense_Mutation | C | T | p.R164Q |
| SNU1040_LARGE_INTESTINE | 532631 | 532755 | 532721 | 532721 | Missense_Mutation | T | C | p.E162G |
| ZR751_BREAST | 532631 | 532755 | 532722 | 532722 | Missense_Mutation | C | T | p.E162K |
| YMB1E_BREAST | 532631 | 532755 | 532722 | 532722 | Missense_Mutation | C | T | p.E162K |
| AN3CA_ENDOMETRIUM | 533766 | 533944 | 533812 | 533812 | Missense_Mutation | A | G | p.F82L |
| SKUT1_SOFT_TISSUE | 533766 | 533944 | 533839 | 533839 | Missense_Mutation | G | A | p.R73C |
| RL952_ENDOMETRIUM | 533766 | 533944 | 533873 | 533873 | Missense_Mutation | C | A | p.Q61H |
| MCC13_SKIN | 533766 | 533944 | 533874 | 533874 | Missense_Mutation | T | C | p.Q61R |
| NCIH1915_LUNG | 533766 | 533944 | 533874 | 533874 | Missense_Mutation | T | A | p.Q61L |
| KYSE30_OESOPHAGUS | 533766 | 533944 | 533874 | 533874 | Missense_Mutation | T | A | p.Q61L |
| KNS62_LUNG | 533766 | 533944 | 533874 | 533874 | Missense_Mutation | T | A | p.Q61L |
| BB49HNC_UPPER_AERODIGESTIVE_TRACT | 533766 | 533944 | 533874 | 533874 | Missense_Mutation | T | A | p.Q61L |
| MCCAR_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 533766 | 533944 | 533874 | 533874 | Missense_Mutation | T | C | p.Q61R |
| CJM_SKIN | 533766 | 533944 | 533874 | 533874 | Missense_Mutation | T | A | p.Q61L |
| RH36_SOFT_TISSUE | 533766 | 533944 | 533875 | 533875 | Missense_Mutation | G | T | p.Q61K |
| MELJUSO_SKIN | 534212 | 534375 | 534285 | 534285 | Missense_Mutation | C | T | p.G13D |
| KASUMI2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 534212 | 534375 | 534286 | 534286 | Missense_Mutation | C | T | p.G13S |
| SNU899_UPPER_AERODIGESTIVE_TRACT | 534212 | 534375 | 534286 | 534286 | Missense_Mutation | C | G | p.G13R |
| MCC26_SKIN | 534212 | 534375 | 534288 | 534288 | Missense_Mutation | C | T | p.G12D |
| SUM159PT_BREAST | 534212 | 534375 | 534288 | 534288 | Missense_Mutation | C | T | p.G12D |
| HS578T_BREAST | 534212 | 534375 | 534288 | 534288 | Missense_Mutation | C | T | p.G12D |
| T24_URINARY_TRACT | 534212 | 534375 | 534288 | 534288 | Missense_Mutation | C | A | p.G12V |
| SLR20_KIDNEY | 534212 | 534375 | 534288 | 534288 | Missense_Mutation | C | A | p.G12V |
| RCHACV_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 534212 | 534375 | 534292 | 534292 | Missense_Mutation | C | T | p.A11T |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for HRAS |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
| exon_skip_67278 | 11 | 533794:533944:534211:534375:535256:535339 | 534211:534375 | ENST00000397596.2 | BLCA | rs12628 | chr11:534242 | A/G | 2.69e-04 |
| exon_skip_67279 | 11 | 533794:533944:534211:534375:535415:535534 | 534211:534375 | ENST00000451590.1,ENST00000493230.1,ENST00000417302.1,ENST00000311189.7 | BLCA | rs12628 | chr11:534242 | A/G | 2.69e-04 |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for HRAS |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for HRAS |
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RelatedDrugs for HRAS |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HRAS |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| HRAS | C0587248 | Costello syndrome (disorder) | 13 | CTD_human;ORPHANET;UNIPROT |
| HRAS | C0037286 | Skin Neoplasms | 7 | CTD_human |
| HRAS | C0023903 | Liver neoplasms | 5 | CTD_human |
| HRAS | C0024121 | Lung Neoplasms | 5 | CTD_human |
| HRAS | C0007621 | Neoplastic Cell Transformation | 4 | CTD_human |
| HRAS | C1458155 | Mammary Neoplasms | 4 | CTD_human |
| HRAS | C0005695 | Bladder Neoplasm | 3 | CTD_human |
| HRAS | C0023904 | Liver Neoplasms, Experimental | 3 | CTD_human |
| HRAS | C0027659 | Neoplasms, Experimental | 3 | CTD_human |
| HRAS | C2239176 | Liver carcinoma | 3 | CTD_human |
| HRAS | C0007137 | Squamous cell carcinoma | 2 | CTD_human |
| HRAS | C0024668 | Mammary Neoplasms, Experimental | 2 | CTD_human |
| HRAS | C0027819 | Neuroblastoma | 2 | CTD_human |
| HRAS | C0038356 | Stomach Neoplasms | 2 | CTD_human |
| HRAS | C4225426 | THYROID CANCER, NONMEDULLARY, 2 | 2 | UNIPROT |
| HRAS | C0004352 | Autistic Disorder | 1 | CTD_human |
| HRAS | C0007138 | Carcinoma, Transitional Cell | 1 | CTD_human |
| HRAS | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| HRAS | C0018923 | Hemangiosarcoma | 1 | CTD_human |
| HRAS | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| HRAS | C0026640 | Mouth Neoplasms | 1 | CTD_human |
| HRAS | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| HRAS | C0028326 | Noonan Syndrome | 1 | CTD_human |
| HRAS | C0030354 | Papilloma | 1 | CTD_human;HPO |
| HRAS | C0030849 | Penile Neoplasms | 1 | CTD_human |
| HRAS | C0032927 | Precancerous Conditions | 1 | CTD_human |
| HRAS | C0036631 | Seminoma | 1 | CTD_human |
| HRAS | C0037999 | Splenic Neoplasms | 1 | CTD_human |
| HRAS | C0040136 | Thyroid Neoplasm | 1 | CTD_human |
| HRAS | C0040411 | Tongue Neoplasms | 1 | CTD_human |
| HRAS | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
| HRAS | C0206669 | Hepatocellular Adenoma | 1 | CTD_human |
| HRAS | C1275081 | Cardio-facio-cutaneous syndrome | 1 | CTD_human |
| HRAS | C3854181 | Nevus sebaceous | 1 | CTD_human;HPO;ORPHANET;UNIPROT |
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