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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for HGF |
 Gene summary |
| Gene information | Gene symbol | HGF | Gene ID | 3082 |
| Gene name | hepatocyte growth factor | |
| Synonyms | DFNB39|F-TCF|HGFB|HPTA|SF | |
| Cytomap | 7q21.11 | |
| Type of gene | protein-coding | |
| Description | hepatocyte growth factorfibroblast-derived tumor cytotoxic factorhepatocyte growth factor (hepapoietin A; scatter factor)hepatopoietin-Alung fibroblast-derived mitogen | |
| Modification date | 20180527 | |
| UniProtAcc | P14210 | |
| Context | PubMed: HGF [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| HGF | GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling | 20655899 |
| HGF | GO:0030335 | positive regulation of cell migration | 21245381 |
| HGF | GO:0035729 | cellular response to hepatocyte growth factor stimulus | 21245381 |
| HGF | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 20655899 |
| HGF | GO:0048012 | hepatocyte growth factor receptor signaling pathway | 21245381 |
| HGF | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 21245381 |
| HGF | GO:0060326 | cell chemotaxis | 21245381 |
| HGF | GO:0060665 | regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling | 14517989 |
| HGF | GO:0090201 | negative regulation of release of cytochrome c from mitochondria | 20655899 |
| HGF | GO:1901299 | negative regulation of hydrogen peroxide-mediated programmed cell death | 20655899 |
| HGF | GO:2000573 | positive regulation of DNA biosynthetic process | 2531289 |
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Exon skipping events across known transcript of Ensembl for HGF from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for HGF |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for HGF |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_476732 | 7 | 81374315:81374436:81381435:81381563:81386504:81386619 | 81381435:81381563 | ENSG00000019991.11 | ENST00000453411.1,ENST00000457544.2 |
| exon_skip_476733 | 7 | 81374315:81374436:81381435:81381578:81386504:81386619 | 81381435:81381578 | ENSG00000019991.11 | ENST00000444829.2,ENST00000222390.5 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for HGF |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_476732 | 7 | 81374315:81374436:81381435:81381563:81386504:81386619 | 81381435:81381563 | ENSG00000019991.11 | ENST00000457544.2,ENST00000453411.1 |
| exon_skip_476733 | 7 | 81374315:81374436:81381435:81381578:81386504:81386619 | 81381435:81381578 | ENSG00000019991.11 | ENST00000222390.5,ENST00000444829.2 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for HGF |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000222390 | 81381435 | 81381578 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000222390 | 81381435 | 81381578 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for HGF |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for HGF |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| COAD | TCGA-AM-5820-01 | exon_skip_476733 | 81381436 | 81381578 | 81381573 | 81381573 | Frame_Shift_Del | A | - | p.L163fs |
| STAD | TCGA-CG-4474-01 | exon_skip_476732 | 81381436 | 81381563 | 81381520 | 81381520 | Nonsense_Mutation | G | A | p.R181* |
| STAD | TCGA-CG-4474-01 | exon_skip_476732 | 81381436 | 81381563 | 81381520 | 81381520 | Nonsense_Mutation | G | A | p.R181X |
| STAD | TCGA-CG-4474-01 | exon_skip_476733 | 81381436 | 81381578 | 81381520 | 81381520 | Nonsense_Mutation | G | A | p.R181* |
| STAD | TCGA-CG-4474-01 | exon_skip_476733 | 81381436 | 81381578 | 81381520 | 81381520 | Nonsense_Mutation | G | A | p.R181X |
| SKCM | TCGA-D3-A5GU-06 | exon_skip_476732 | 81381436 | 81381563 | 81381529 | 81381529 | Nonsense_Mutation | G | A | p.R178* |
| SKCM | TCGA-D3-A5GU-06 | exon_skip_476732 | 81381436 | 81381563 | 81381529 | 81381529 | Nonsense_Mutation | G | A | p.R178X |
| SKCM | TCGA-D3-A5GU-06 | exon_skip_476733 | 81381436 | 81381578 | 81381529 | 81381529 | Nonsense_Mutation | G | A | p.R178* |
| SKCM | TCGA-D3-A5GU-06 | exon_skip_476733 | 81381436 | 81381578 | 81381529 | 81381529 | Nonsense_Mutation | G | A | p.R178X |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| JJN3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 81381436 | 81381563 | 81381471 | 81381471 | Missense_Mutation | C | T | p.R197H |
| JJN3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 81381436 | 81381578 | 81381471 | 81381471 | Missense_Mutation | C | T | p.R197H |
| WM2664_SKIN | 81381436 | 81381563 | 81381472 | 81381472 | Missense_Mutation | G | A | p.R197C |
| WM2664_SKIN | 81381436 | 81381578 | 81381472 | 81381472 | Missense_Mutation | G | A | p.R197C |
| WM115_SKIN | 81381436 | 81381563 | 81381472 | 81381472 | Missense_Mutation | G | A | p.R197C |
| WM115_SKIN | 81381436 | 81381578 | 81381472 | 81381472 | Missense_Mutation | G | A | p.R197C |
| MM426_SKIN | 81381436 | 81381563 | 81381481 | 81381481 | Missense_Mutation | G | A | p.P194S |
| MM426_SKIN | 81381436 | 81381578 | 81381481 | 81381481 | Missense_Mutation | G | A | p.P194S |
| SKN_ENDOMETRIUM | 81381436 | 81381563 | 81381486 | 81381486 | Missense_Mutation | C | T | p.S192N |
| SKN_ENDOMETRIUM | 81381436 | 81381578 | 81381486 | 81381486 | Missense_Mutation | C | T | p.S192N |
| KYSE510_OESOPHAGUS | 81381436 | 81381563 | 81381504 | 81381504 | Missense_Mutation | C | T | p.G186E |
| KYSE510_OESOPHAGUS | 81381436 | 81381578 | 81381504 | 81381504 | Missense_Mutation | C | T | p.G186E |
| JAR_PLACENTA | 81381436 | 81381563 | 81381519 | 81381519 | Missense_Mutation | C | T | p.R181Q |
| JAR_PLACENTA | 81381436 | 81381578 | 81381519 | 81381519 | Missense_Mutation | C | T | p.R181Q |
| CP66MEL_SKIN | 81381436 | 81381563 | 81381541 | 81381541 | Missense_Mutation | C | T | p.E174K |
| CP66MEL_SKIN | 81381436 | 81381578 | 81381541 | 81381541 | Missense_Mutation | C | T | p.E174K |
| SKMEL1_SKIN | 81381436 | 81381563 | 81381541 | 81381541 | Missense_Mutation | C | T | p.E174K |
| SKMEL1_SKIN | 81381436 | 81381578 | 81381541 | 81381541 | Missense_Mutation | C | T | p.E174K |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for HGF |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for HGF |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for HGF |
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RelatedDrugs for HGF |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P14210 | DB01109 | Heparin | Hepatocyte growth factor | small molecule | approved|investigational |
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RelatedDiseases for HGF |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| HGF | C0023893 | Liver Cirrhosis, Experimental | 7 | CTD_human |
| HGF | C0027626 | Neoplasm Invasiveness | 2 | CTD_human |
| HGF | C0878544 | Cardiomyopathies | 2 | CTD_human |
| HGF | C2239176 | Liver carcinoma | 2 | CTD_human |
| HGF | C0004114 | Astrocytoma | 1 | CTD_human |
| HGF | C0004763 | Barrett Esophagus | 1 | CTD_human |
| HGF | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| HGF | C0011882 | Diabetic Neuropathies | 1 | CTD_human |
| HGF | C0019189 | Hepatitis, Chronic | 1 | CTD_human |
| HGF | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
| HGF | C0023890 | Liver Cirrhosis | 1 | CTD_human |
| HGF | C0023903 | Liver neoplasms | 1 | CTD_human |
| HGF | C0023904 | Liver Neoplasms, Experimental | 1 | CTD_human |
| HGF | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| HGF | C0027659 | Neoplasms, Experimental | 1 | CTD_human |
| HGF | C0027819 | Neuroblastoma | 1 | CTD_human |
| HGF | C0030193 | Pain | 1 | CTD_human |
| HGF | C0030305 | Pancreatitis | 1 | CTD_human |
| HGF | C0030567 | Parkinson Disease | 1 | CTD_human |
| HGF | C0034069 | Pulmonary Fibrosis | 1 | CTD_human |
| HGF | C0035126 | Reperfusion Injury | 1 | CTD_human |
| HGF | C0040053 | Thrombosis | 1 | CTD_human |
| HGF | C0042373 | Vascular Diseases | 1 | CTD_human |
| HGF | C0151744 | Myocardial Ischemia | 1 | CTD_human |
| HGF | C0162557 | Liver Failure, Acute | 1 | CTD_human |
| HGF | C0345967 | Malignant mesothelioma | 1 | CTD_human |
| HGF | C0949804 | Polyomavirus Infections | 1 | CTD_human |
| HGF | C1876165 | Copper-Overload Cirrhosis | 1 | CTD_human |
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