|
||||||
|
 | |
| |
| |
| |
| Open reading frame (ORF) annotation in the exon skipping event |
| |
| |
| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
| |
|
Gene summary for GPR132 |
 Gene summary |
| Gene information | Gene symbol | GPR132 | Gene ID | 29933 |
| Gene name | G protein-coupled receptor 132 | |
| Synonyms | G2A | |
| Cytomap | 14q32.33 | |
| Type of gene | protein-coding | |
| Description | probable G-protein coupled receptor 132G2 accumulation protein | |
| Modification date | 20180422 | |
| UniProtAcc | Q9UNW8 | |
| Context | PubMed: GPR132 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
Exon skipping events across known transcript of Ensembl for GPR132 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
Top |
Gene isoform structures and expression levels for GPR132 |
| Expression levels of gene isoforms across TCGA. |
 |
| Expression levels of gene isoforms across GTEx. |
 |
Top |
Exon skipping events with PSIs in TCGA for GPR132 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_120368 | 14 | 105517943:105518439:105520269:105520502:105521723:105522128 | 105520269:105520502 | ENSG00000183484.7 | ENST00000551869.1 |
| exon_skip_120370 | 14 | 105517943:105518439:105521723:105522503:105523503:105523617 | 105521723:105522503 | ENSG00000183484.7 | ENST00000539291.2,ENST00000329797.3 |
| exon_skip_120373 | 14 | 105517943:105518439:105523503:105523617:105531715:105531767 | 105523503:105523617 | ENSG00000183484.7 | ENST00000392585.2 |
| exon_skip_120379 | 14 | 105523503:105523617:105524274:105524364:105531715:105531767 | 105524274:105524364 | ENSG00000183484.7 | ENST00000539291.2 |
| PSI values of skipped exons in TCGA. |
 |
Top |
Exon skipping events with PSIs in GTEx for GPR132 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_120368 | 14 | 105517943:105518439:105520269:105520502:105521723:105522128 | 105520269:105520502 | ENSG00000183484.7 | ENST00000551869.1 |
| exon_skip_120370 | 14 | 105517943:105518439:105521723:105522503:105523503:105523617 | 105521723:105522503 | ENSG00000183484.7 | ENST00000329797.3,ENST00000539291.2 |
| exon_skip_120373 | 14 | 105517943:105518439:105523503:105523617:105531715:105531767 | 105523503:105523617 | ENSG00000183484.7 | ENST00000392585.2 |
| exon_skip_120379 | 14 | 105523503:105523617:105524274:105524364:105531715:105531767 | 105524274:105524364 | ENSG00000183484.7 | ENST00000539291.2 |
| PSI values of skipped exons in GTEx. |
 |
| * Skipped exon sequences. |
Top |
Open reading frame (ORF) annotation in the exon skipping event for GPR132 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000329797 | 105521723 | 105522503 | 3UTR-3CDS |
| ENST00000539291 | 105521723 | 105522503 | 3UTR-3CDS |
| ENST00000539291 | 105524274 | 105524364 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000329797 | 105521723 | 105522503 | 3UTR-3CDS |
| ENST00000539291 | 105521723 | 105522503 | 3UTR-3CDS |
| ENST00000539291 | 105524274 | 105524364 | 3UTR-3UTR |
Top |
Infer the effects of exon skipping event on protein functional features for GPR132 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
 |
| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Top |
SNVs in the skipped exons for GPR132 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for GPR132 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
Top |
Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for GPR132 |
Top |
Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for GPR132 |
Top |
RelatedDrugs for GPR132 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for GPR132 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|