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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for SENP1 |
 Gene summary |
| Gene information | Gene symbol | SENP1 | Gene ID | 29843 |
| Gene name | SUMO specific peptidase 1 | |
| Synonyms | SuPr-2 | |
| Cytomap | 12q13.11 | |
| Type of gene | protein-coding | |
| Description | sentrin-specific protease 1SUMO1/sentrin specific peptidase 1SUMO1/sentrin specific protease 1sentrin/SUMO-specific protease SENP1 | |
| Modification date | 20180523 | |
| UniProtAcc | Q9P0U3 | |
| Context | PubMed: SENP1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for SENP1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for SENP1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for SENP1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_91566 | 12 | 48459378:48459463:48460709:48460748:48465449:48465504 | 48460709:48460748 | ENSG00000079387.9 | ENST00000551330.1,ENST00000552189.1,ENST00000339976.6,ENST00000549518.1,ENST00000004980.5,ENST00000549595.1,ENST00000448372.1 |
| exon_skip_91567 | 12 | 48468472:48468576:48477373:48477545:48482583:48482743 | 48477373:48477545 | ENSG00000079387.9 | ENST00000551330.1,ENST00000552189.1,ENST00000339976.6,ENST00000549518.1,ENST00000004980.5,ENST00000549595.1,ENST00000448372.1 |
| exon_skip_91568 | 12 | 48482583:48482743:48482945:48483076:48490125:48490196 | 48482945:48483076 | ENSG00000079387.9 | ENST00000552189.1,ENST00000339976.6,ENST00000547886.1 |
| exon_skip_91571 | 12 | 48482583:48482743:48490125:48490210:48491776:48491817 | 48490125:48490210 | ENSG00000079387.9 | ENST00000551330.1,ENST00000551592.1,ENST00000547181.1,ENST00000551798.1,ENST00000549518.1,ENST00000004980.5,ENST00000549595.1,ENST00000448372.1 |
| exon_skip_91574 | 12 | 48482945:48483076:48490125:48490210:48491776:48491817 | 48490125:48490210 | ENSG00000079387.9 | ENST00000552189.1,ENST00000339976.6 |
| exon_skip_91575 | 12 | 48490125:48490210:48491776:48491907:48495251:48495255 | 48491776:48491907 | ENSG00000079387.9 | ENST00000551330.1,ENST00000552189.1,ENST00000547181.1,ENST00000339976.6,ENST00000549518.1,ENST00000004980.5,ENST00000549595.1,ENST00000448372.1 |
| exon_skip_91577 | 12 | 48491776:48491907:48492844:48492937:48499810:48499835 | 48492844:48492937 | ENSG00000079387.9 | ENST00000551798.1 |
| exon_skip_91578 | 12 | 48491776:48491907:48495251:48495299:48499184:48499617 | 48495251:48495299 | ENSG00000079387.9 | ENST00000339976.6,ENST00000004980.5 |
| exon_skip_91579 | 12 | 48491776:48491907:48495251:48495299:48499810:48499829 | 48495251:48495299 | ENSG00000079387.9 | ENST00000547181.1,ENST00000549518.1,ENST00000549882.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for SENP1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_91566 | 12 | 48459378:48459463:48460709:48460748:48465449:48465504 | 48460709:48460748 | ENSG00000079387.9 | ENST00000552189.1,ENST00000004980.5,ENST00000339976.6,ENST00000448372.1,ENST00000551330.1,ENST00000549595.1,ENST00000549518.1 |
| exon_skip_91567 | 12 | 48468472:48468576:48477373:48477545:48482583:48482743 | 48477373:48477545 | ENSG00000079387.9 | ENST00000552189.1,ENST00000004980.5,ENST00000339976.6,ENST00000448372.1,ENST00000551330.1,ENST00000549595.1,ENST00000549518.1 |
| exon_skip_91568 | 12 | 48482583:48482743:48482945:48483076:48490125:48490196 | 48482945:48483076 | ENSG00000079387.9 | ENST00000552189.1,ENST00000339976.6,ENST00000547886.1 |
| exon_skip_91571 | 12 | 48482583:48482743:48490125:48490210:48491776:48491817 | 48490125:48490210 | ENSG00000079387.9 | ENST00000004980.5,ENST00000448372.1,ENST00000551330.1,ENST00000549595.1,ENST00000549518.1,ENST00000551592.1,ENST00000551798.1,ENST00000547181.1 |
| exon_skip_91574 | 12 | 48482945:48483076:48490125:48490210:48491776:48491817 | 48490125:48490210 | ENSG00000079387.9 | ENST00000552189.1,ENST00000339976.6 |
| exon_skip_91575 | 12 | 48490125:48490210:48491776:48491907:48495251:48495255 | 48491776:48491907 | ENSG00000079387.9 | ENST00000552189.1,ENST00000004980.5,ENST00000339976.6,ENST00000448372.1,ENST00000551330.1,ENST00000549595.1,ENST00000549518.1,ENST00000547181.1 |
| exon_skip_91577 | 12 | 48491776:48491907:48492844:48492937:48499810:48499835 | 48492844:48492937 | ENSG00000079387.9 | ENST00000551798.1 |
| exon_skip_91578 | 12 | 48491776:48491907:48495251:48495299:48499184:48499617 | 48495251:48495299 | ENSG00000079387.9 | ENST00000004980.5,ENST00000339976.6 |
| exon_skip_91579 | 12 | 48491776:48491907:48495251:48495299:48499810:48499829 | 48495251:48495299 | ENSG00000079387.9 | ENST00000549518.1,ENST00000547181.1,ENST00000549882.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for SENP1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000549518 | 48495251 | 48495299 | 3UTR-3CDS |
| ENST00000448372 | 48477373 | 48477545 | Frame-shift |
| ENST00000549518 | 48477373 | 48477545 | Frame-shift |
| ENST00000448372 | 48490125 | 48490210 | Frame-shift |
| ENST00000549518 | 48490125 | 48490210 | Frame-shift |
| ENST00000448372 | 48491776 | 48491907 | Frame-shift |
| ENST00000549518 | 48491776 | 48491907 | Frame-shift |
| ENST00000448372 | 48460709 | 48460748 | In-frame |
| ENST00000549518 | 48460709 | 48460748 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000549518 | 48495251 | 48495299 | 3UTR-3CDS |
| ENST00000448372 | 48477373 | 48477545 | Frame-shift |
| ENST00000549518 | 48477373 | 48477545 | Frame-shift |
| ENST00000448372 | 48490125 | 48490210 | Frame-shift |
| ENST00000549518 | 48490125 | 48490210 | Frame-shift |
| ENST00000448372 | 48491776 | 48491907 | Frame-shift |
| ENST00000549518 | 48491776 | 48491907 | Frame-shift |
| ENST00000448372 | 48460709 | 48460748 | In-frame |
| ENST00000549518 | 48460709 | 48460748 | In-frame |
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Infer the effects of exon skipping event on protein functional features for SENP1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000448372 | 4743 | 644 | 48460709 | 48460748 | 1442 | 1480 | 332 | 344 |
| ENST00000549518 | 2277 | 644 | 48460709 | 48460748 | 1321 | 1359 | 332 | 344 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000448372 | 4743 | 644 | 48460709 | 48460748 | 1442 | 1480 | 332 | 344 |
| ENST00000549518 | 2277 | 644 | 48460709 | 48460748 | 1321 | 1359 | 332 | 344 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9P0U3 | 332 | 344 | 1 | 644 | Chain | ID=PRO_0000101716;Note=Sentrin-specific protease 1 |
| Q9P0U3 | 332 | 344 | 1 | 644 | Chain | ID=PRO_0000101716;Note=Sentrin-specific protease 1 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9P0U3 | 332 | 344 | 1 | 644 | Chain | ID=PRO_0000101716;Note=Sentrin-specific protease 1 |
| Q9P0U3 | 332 | 344 | 1 | 644 | Chain | ID=PRO_0000101716;Note=Sentrin-specific protease 1 |
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SNVs in the skipped exons for SENP1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
SENP1_SKCM_exon_skip_91575_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_91567 | 48477374 | 48477545 | 48477476 | 48477476 | Frame_Shift_Del | A | - | p.F150fs |
| PRAD | TCGA-XK-AAIW-01 | exon_skip_91567 | 48477374 | 48477545 | 48477397 | 48477397 | Nonsense_Mutation | G | A | p.R177* |
| STAD | TCGA-BR-4184-01 | exon_skip_91567 | 48477374 | 48477545 | 48477397 | 48477397 | Nonsense_Mutation | G | A | p.R177* |
| STAD | TCGA-BR-4184-01 | exon_skip_91567 | 48477374 | 48477545 | 48477397 | 48477397 | Nonsense_Mutation | G | A | p.R177X |
| UCEC | TCGA-AP-A056-01 | exon_skip_91567 | 48477374 | 48477545 | 48477430 | 48477430 | Nonsense_Mutation | G | A | p.R166* |
| UCEC | TCGA-D1-A103-01 | exon_skip_91567 | 48477374 | 48477545 | 48477430 | 48477430 | Nonsense_Mutation | G | A | p.R166* |
| HNSC | TCGA-CV-7095-01 | exon_skip_91567 | 48477374 | 48477545 | 48477537 | 48477537 | Nonsense_Mutation | G | C | p.S130* |
| SKCM | TCGA-D9-A4Z3-01 | exon_skip_91575 | 48491777 | 48491907 | 48491775 | 48491775 | Splice_Site | A | G | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-D9-A4Z3-01 |
| Cancer type: SKCM | |
| ESID: exon_skip_91575 | |
| Skipped exon start: 48491777 | |
| Skipped exon end: 48491907 | |
| Mutation start: 48491775 | |
| Mutation end: 48491775 | |
| Mutation type: Splice_Site | |
| Reference seq: A | |
| Mutation seq: G | |
| AAchange: . | |
exon_skip_91575_SKCM_TCGA-D9-A4Z3-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| T47D_BREAST | 48460710 | 48460748 | 48460739 | 48460739 | Missense_Mutation | G | T | p.F335L |
| RCCAB_KIDNEY | 48477374 | 48477545 | 48477459 | 48477459 | Missense_Mutation | G | A | p.P156L |
| COLO741_SKIN | 48491777 | 48491907 | 48491859 | 48491859 | Missense_Mutation | A | C | p.V18G |
| BT20_BREAST | 48491777 | 48491907 | 48491896 | 48491896 | Missense_Mutation | C | A | p.D6Y |
| MOLT3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 48491777 | 48491907 | 48491902 | 48491902 | Missense_Mutation | T | C | p.I4V |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 48491777 | 48491907 | 48491902 | 48491902 | Missense_Mutation | T | C | p.I4V |
| NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 48490126 | 48490210 | 48490180 | 48490180 | Nonsense_Mutation | G | A | p.R56* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SENP1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
| exon_skip_91567 | 12 | 48468472:48468576:48477373:48477545:48482583:48482743 | 48477373:48477545 | ENST00000551330.1,ENST00000552189.1,ENST00000339976.6,ENST00000549518.1,ENST00000004980.5,ENST00000549595.1,ENST00000448372.1 | OV | rs886588 | chr12:48477422 | A/G | 1.52e-03 |
| exon_skip_91567 | 12 | 48468472:48468576:48477373:48477545:48482583:48482743 | 48477373:48477545 | ENST00000551330.1,ENST00000552189.1,ENST00000339976.6,ENST00000549518.1,ENST00000004980.5,ENST00000549595.1,ENST00000448372.1 | PRAD | rs886588 | chr12:48477422 | A/G | 1.05e-03 |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SENP1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SENP1 |
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RelatedDrugs for SENP1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SENP1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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