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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ZDHHC1 |
 Gene summary |
| Gene information | Gene symbol | ZDHHC1 | Gene ID | 29800 |
| Gene name | zinc finger DHHC-type containing 1 | |
| Synonyms | C16orf1|DHHC-1|HSU90653|ZNF377 | |
| Cytomap | 16q22.1 | |
| Type of gene | protein-coding | |
| Description | probable palmitoyltransferase ZDHHC1DHHC domain-containing cysteine-rich protein 1zinc finger DHHC domain-containing protein 1zinc finger protein 377zinc finger, DHHC domain containing 1 | |
| Modification date | 20180523 | |
| UniProtAcc | Q8WTX9 | |
| Context | PubMed: ZDHHC1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| ZDHHC1 | GO:0018345 | protein palmitoylation | 23034182 |
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Exon skipping events across known transcript of Ensembl for ZDHHC1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ZDHHC1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ZDHHC1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_145297 | 16 | 67428904:67428965:67429089:67429183:67429386:67429466 | 67429089:67429183 | ENSG00000159714.6 | ENST00000566075.1,ENST00000565726.1 |
| exon_skip_145299 | 16 | 67429407:67429469:67432114:67432227:67432475:67432634 | 67432114:67432227 | ENSG00000159714.6 | ENST00000348579.2,ENST00000565726.1 |
| exon_skip_145302 | 16 | 67432114:67432227:67432475:67432634:67432722:67432832 | 67432475:67432634 | ENSG00000159714.6 | ENST00000348579.2,ENST00000565726.1 |
| exon_skip_145305 | 16 | 67432722:67432847:67433257:67433359:67434859:67434894 | 67433257:67433359 | ENSG00000159714.6 | ENST00000348579.2,ENST00000562122.1,ENST00000565726.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ZDHHC1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_145297 | 16 | 67428904:67428965:67429089:67429183:67429386:67429466 | 67429089:67429183 | ENSG00000159714.6 | ENST00000566075.1,ENST00000565726.1 |
| exon_skip_145299 | 16 | 67429407:67429469:67432114:67432227:67432475:67432634 | 67432114:67432227 | ENSG00000159714.6 | ENST00000348579.2,ENST00000565726.1 |
| exon_skip_145302 | 16 | 67432114:67432227:67432475:67432634:67432722:67432832 | 67432475:67432634 | ENSG00000159714.6 | ENST00000348579.2,ENST00000565726.1 |
| exon_skip_145305 | 16 | 67432722:67432847:67433257:67433359:67434859:67434894 | 67433257:67433359 | ENSG00000159714.6 | ENST00000348579.2,ENST00000565726.1,ENST00000562122.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ZDHHC1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000348579 | 67432114 | 67432227 | Frame-shift |
| ENST00000348579 | 67432475 | 67432634 | In-frame |
| ENST00000348579 | 67433257 | 67433359 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000348579 | 67432114 | 67432227 | Frame-shift |
| ENST00000348579 | 67432475 | 67432634 | In-frame |
| ENST00000348579 | 67433257 | 67433359 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ZDHHC1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000348579 | 2064 | 485 | 67433257 | 67433359 | 771 | 872 | 143 | 176 |
| ENST00000348579 | 2064 | 485 | 67432475 | 67432634 | 998 | 1156 | 218 | 271 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000348579 | 2064 | 485 | 67433257 | 67433359 | 771 | 872 | 143 | 176 |
| ENST00000348579 | 2064 | 485 | 67432475 | 67432634 | 998 | 1156 | 218 | 271 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8WTX9 | 143 | 176 | 1 | 485 | Chain | ID=PRO_0000212857;Note=Probable palmitoyltransferase ZDHHC1 |
| Q8WTX9 | 143 | 176 | 134 | 184 | Domain | Note=DHHC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00067 |
| Q8WTX9 | 218 | 271 | 1 | 485 | Chain | ID=PRO_0000212857;Note=Probable palmitoyltransferase ZDHHC1 |
| Q8WTX9 | 218 | 271 | 242 | 262 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8WTX9 | 143 | 176 | 1 | 485 | Chain | ID=PRO_0000212857;Note=Probable palmitoyltransferase ZDHHC1 |
| Q8WTX9 | 143 | 176 | 134 | 184 | Domain | Note=DHHC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00067 |
| Q8WTX9 | 218 | 271 | 1 | 485 | Chain | ID=PRO_0000212857;Note=Probable palmitoyltransferase ZDHHC1 |
| Q8WTX9 | 218 | 271 | 242 | 262 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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SNVs in the skipped exons for ZDHHC1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SKCM | TCGA-D3-A8GC-06 | exon_skip_145302 | 67432476 | 67432634 | 67432540 | 67432540 | Frame_Shift_Del | G | - | p.L250fs |
| BLCA | TCGA-K4-A54R-01 | exon_skip_145299 | 67432115 | 67432227 | 67432117 | 67432117 | Nonsense_Mutation | G | A | p.Q309* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| CMLT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 67433258 | 67433359 | 67433290 | 67433294 | Frame_Shift_Del | CCACT | - | p.KW165fs |
| SNU685_ENDOMETRIUM | 67433258 | 67433359 | 67433290 | 67433294 | Frame_Shift_Del | CCACT | - | p.KW165fs |
| IOMMLEE_CENTRAL_NERVOUS_SYSTEM | 67429090 | 67429183 | 67429113 | 67429113 | Missense_Mutation | G | A | p.P341L |
| TYKNU_OVARY | 67432115 | 67432227 | 67432126 | 67432126 | Missense_Mutation | G | A | p.R306W |
| CCRFCEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 67432115 | 67432227 | 67432185 | 67432185 | Missense_Mutation | C | T | p.R286H |
| SNU1033_LARGE_INTESTINE | 67432476 | 67432634 | 67432514 | 67432514 | Missense_Mutation | G | A | p.A259V |
| TE4_OESOPHAGUS | 67432476 | 67432634 | 67432580 | 67432580 | Missense_Mutation | T | A | p.E237V |
| NCIH1155_LUNG | 67432476 | 67432634 | 67432619 | 67432619 | Missense_Mutation | G | A | p.T224M |
| GP2D_LARGE_INTESTINE | 67433258 | 67433359 | 67433273 | 67433273 | Missense_Mutation | C | T | p.G172D |
| GP5D_LARGE_INTESTINE | 67433258 | 67433359 | 67433273 | 67433273 | Missense_Mutation | C | T | p.G172D |
| EFO27_OVARY | 67433258 | 67433359 | 67433319 | 67433319 | Missense_Mutation | C | T | p.V157M |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 67432476 | 67432634 | 67432477 | 67432477 | Splice_Site | G | T | p.L271L |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZDHHC1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZDHHC1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZDHHC1 |
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RelatedDrugs for ZDHHC1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZDHHC1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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