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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ARHGAP35 |
 Gene summary |
| Gene information | Gene symbol | ARHGAP35 | Gene ID | 2909 |
| Gene name | Rho GTPase activating protein 35 | |
| Synonyms | GRF-1|GRLF1|P190-A|P190A|p190ARhoGAP|p190RhoGAP | |
| Cytomap | 19q13.32 | |
| Type of gene | protein-coding | |
| Description | rho GTPase-activating protein 35glucocorticoid receptor DNA-binding factor 1glucocorticoid receptor repression factor 1rho GAP p190A | |
| Modification date | 20180522 | |
| UniProtAcc | Q9NRY4 | |
| Context | PubMed: ARHGAP35 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| ARHGAP35 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 1894621 |
| ARHGAP35 | GO:0045892 | negative regulation of transcription, DNA-templated | 1894621 |
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Exon skipping events across known transcript of Ensembl for ARHGAP35 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ARHGAP35 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ARHGAP35 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_308592 | 19 | 47440576:47440665:47491245:47492932:47502560:47502666 | 47491245:47492932 | ENSG00000160007.13 | ENST00000595822.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ARHGAP35 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_308592 | 19 | 47440576:47440665:47491245:47492932:47502560:47502666 | 47491245:47492932 | ENSG00000160007.13 | ENST00000595822.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ARHGAP35 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for ARHGAP35 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for ARHGAP35 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
ARHGAP35_KIRC_exon_skip_308592_psi_boxplot.png |
ARHGAP35_UCS_exon_skip_308592_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| UCS | TCGA-N7-A4Y5-01 | exon_skip_308592 | 47491246 | 47492932 | 47491244 | 47491249 | Splice_Site | AGGACT | - | p.1276_splice |
| KIRC | TCGA-CJ-5682-01 | exon_skip_308592 | 47491246 | 47492932 | 47491245 | 47491245 | Splice_Site | G | C | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-CJ-5682-01 |
| Cancer type: KIRC | |
| ESID: exon_skip_308592 | |
| Skipped exon start: 47491246 | |
| Skipped exon end: 47492932 | |
| Mutation start: 47491245 | |
| Mutation end: 47491245 | |
| Mutation type: Splice_Site | |
| Reference seq: G | |
| Mutation seq: C | |
| AAchange: . | |
exon_skip_308592_KIRC_TCGA-CJ-5682-01.png | |
 | Sample: TCGA-N7-A4Y5-01 |
| Cancer type: UCS | |
| ESID: exon_skip_308592 | |
| Skipped exon start: 47491246 | |
| Skipped exon end: 47492932 | |
| Mutation start: 47491244 | |
| Mutation end: 47491249 | |
| Mutation type: Splice_Site | |
| Reference seq: AGGACT | |
| Mutation seq: - | |
| AAchange: p.1276_splice | |
exon_skip_308592_UCS_TCGA-N7-A4Y5-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| MHHPREB1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 47491246 | 47492932 | 47491291 | 47491291 | Missense_Mutation | A | C | p.E1291A |
| MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 47491246 | 47492932 | 47492894 | 47492894 | Missense_Mutation | T | C | p.V1333A |
| FTC238_THYROID | 47491246 | 47492932 | 47492899 | 47492899 | Missense_Mutation | T | C | p.Y1335H |
| DMS273_LUNG | 47491246 | 47492932 | 47491246 | 47491246 | Splice_Site | G | T | p.G1276V |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ARHGAP35 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ARHGAP35 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ARHGAP35 |
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RelatedDrugs for ARHGAP35 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ARHGAP35 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| ARHGAP35 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
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