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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ZNF326 |
 Gene summary |
| Gene information | Gene symbol | ZNF326 | Gene ID | 284695 |
| Gene name | zinc finger protein 326 | |
| Synonyms | ZAN75|ZIRD|Zfp326|dJ871E2.1 | |
| Cytomap | 1p22.2 | |
| Type of gene | protein-coding | |
| Description | DBIRD complex subunit ZNF326ZNF-protein interacting with nuclear mRNPs and DBC1dJ871E2.1 (novel protein (ortholog of mouse zinc finger protein Zan75))zinc finger protein interacting with mRNPs and DBC1 | |
| Modification date | 20180523 | |
| UniProtAcc | Q5BKZ1 | |
| Context | PubMed: ZNF326 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for ZNF326 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ZNF326 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ZNF326 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_7753 | 1 | 90470691:90470803:90472903:90473309:90475646:90475845 | 90472903:90473309 | ENSG00000162664.12 | ENST00000340281.4 |
| exon_skip_7757 | 1 | 90470691:90470803:90473170:90473309:90475646:90475845 | 90473170:90473309 | ENSG00000162664.12 | ENST00000370447.3 |
| exon_skip_7767 | 1 | 90475646:90475845:90478684:90478796:90482875:90483023 | 90478684:90478796 | ENSG00000162664.12 | ENST00000370447.3,ENST00000455342.2,ENST00000340281.4,ENST00000394583.3 |
| exon_skip_7768 | 1 | 90484243:90484343:90486350:90486481:90487808:90487904 | 90486350:90486481 | ENSG00000162664.12 | ENST00000370447.3,ENST00000455342.2,ENST00000340281.4,ENST00000394583.3 |
| exon_skip_7771 | 1 | 90486350:90486481:90487808:90487904:90492912:90493375 | 90487808:90487904 | ENSG00000162664.12 | ENST00000370447.3,ENST00000455342.2,ENST00000340281.4,ENST00000394583.3 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ZNF326 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_7753 | 1 | 90470691:90470803:90472903:90473309:90475646:90475845 | 90472903:90473309 | ENSG00000162664.12 | ENST00000340281.4 |
| exon_skip_7757 | 1 | 90470691:90470803:90473170:90473309:90475646:90475845 | 90473170:90473309 | ENSG00000162664.12 | ENST00000370447.3 |
| exon_skip_7767 | 1 | 90475646:90475845:90478684:90478796:90482875:90483023 | 90478684:90478796 | ENSG00000162664.12 | ENST00000394583.3,ENST00000340281.4,ENST00000370447.3,ENST00000455342.2 |
| exon_skip_7768 | 1 | 90484243:90484343:90486350:90486481:90487808:90487904 | 90486350:90486481 | ENSG00000162664.12 | ENST00000394583.3,ENST00000340281.4,ENST00000370447.3,ENST00000455342.2 |
| exon_skip_7771 | 1 | 90486350:90486481:90487808:90487904:90492912:90493375 | 90487808:90487904 | ENSG00000162664.12 | ENST00000394583.3,ENST00000340281.4,ENST00000370447.3,ENST00000455342.2 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ZNF326 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000340281 | 90472903 | 90473309 | Frame-shift |
| ENST00000340281 | 90478684 | 90478796 | Frame-shift |
| ENST00000340281 | 90486350 | 90486481 | Frame-shift |
| ENST00000340281 | 90487808 | 90487904 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000340281 | 90472903 | 90473309 | Frame-shift |
| ENST00000340281 | 90478684 | 90478796 | Frame-shift |
| ENST00000340281 | 90486350 | 90486481 | Frame-shift |
| ENST00000340281 | 90487808 | 90487904 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ZNF326 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000340281 | 2746 | 582 | 90487808 | 90487904 | 1449 | 1544 | 435 | 467 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000340281 | 2746 | 582 | 90487808 | 90487904 | 1449 | 1544 | 435 | 467 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for ZNF326 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_7753 | 90472904 | 90473309 | 90472974 | 90472974 | Frame_Shift_Del | G | - | p.G94fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_7753 | 90472904 | 90473309 | 90473089 | 90473089 | Frame_Shift_Del | G | - | p.W132fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_7753 | 90472904 | 90473309 | 90473111 | 90473111 | Frame_Shift_Del | A | - | p.S139fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_7767 | 90478685 | 90478796 | 90478699 | 90478699 | Frame_Shift_Del | A | - | p.K277fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_7767 | 90478685 | 90478796 | 90478763 | 90478763 | Frame_Shift_Del | A | - | p.E298fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_7767 | 90478685 | 90478796 | 90478763 | 90478763 | Frame_Shift_Del | A | - | p.E298fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_7767 | 90478685 | 90478796 | 90478763 | 90478763 | Frame_Shift_Del | A | - | p.E298fs |
| STAD | TCGA-SW-A7EA-01 | exon_skip_7767 | 90478685 | 90478796 | 90478763 | 90478763 | Frame_Shift_Del | A | - | p.E298fs |
| UCEC | TCGA-AP-A0LE-01 | exon_skip_7767 | 90478685 | 90478796 | 90478763 | 90478763 | Frame_Shift_Del | A | - | p.E298fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_7768 | 90486351 | 90486481 | 90486424 | 90486424 | Frame_Shift_Del | T | - | p.A416fs |
| COAD | TCGA-A6-2676-01 | exon_skip_7771 | 90487809 | 90487904 | 90487830 | 90487831 | Frame_Shift_Del | AG | - | p.443_443del |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_7771 | 90487809 | 90487904 | 90487858 | 90487858 | Frame_Shift_Del | T | - | p.I452fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_7771 | 90487809 | 90487904 | 90487862 | 90487862 | Frame_Shift_Del | A | - | p.L453fs |
| READ | TCGA-EI-6882-01 | exon_skip_7767 | 90478685 | 90478796 | 90478762 | 90478763 | Frame_Shift_Ins | - | A | p.E298fs |
| CHOL | TCGA-W5-AA36-01 | exon_skip_7753 | 90472904 | 90473309 | 90473298 | 90473298 | Nonsense_Mutation | C | T | p.R202X |
| CHOL | TCGA-W5-AA36-01 | exon_skip_7757 | 90473171 | 90473309 | 90473298 | 90473298 | Nonsense_Mutation | C | T | p.R202X |
| COAD | TCGA-F4-6570-01 | exon_skip_7753 | 90472904 | 90473309 | 90473298 | 90473298 | Nonsense_Mutation | C | T | p.R202X |
| COAD | TCGA-F4-6570-01 | exon_skip_7757 | 90473171 | 90473309 | 90473298 | 90473298 | Nonsense_Mutation | C | T | p.R202X |
| HNSC | TCGA-QK-A6V9-01 | exon_skip_7753 | 90472904 | 90473309 | 90473298 | 90473298 | Nonsense_Mutation | C | T | p.R202* |
| HNSC | TCGA-QK-A6V9-01 | exon_skip_7757 | 90473171 | 90473309 | 90473298 | 90473298 | Nonsense_Mutation | C | T | p.R202* |
| UCEC | TCGA-D1-A103-01 | exon_skip_7767 | 90478685 | 90478796 | 90478723 | 90478723 | Nonsense_Mutation | C | T | p.R285* |
| COAD | TCGA-D5-6930-01 | exon_skip_7771 | 90487809 | 90487904 | 90487884 | 90487884 | Nonsense_Mutation | C | T | p.R461X |
| LUAD | TCGA-95-7947-01 | exon_skip_7767 | 90478685 | 90478796 | 90478797 | 90478797 | Splice_Site | G | T | p.R309_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| OC316_OVARY | 90478685 | 90478796 | 90478763 | 90478763 | Frame_Shift_Del | A | - | p.E298fs |
| OC314_OVARY | 90478685 | 90478796 | 90478763 | 90478763 | Frame_Shift_Del | A | - | p.E298fs |
| RKO_LARGE_INTESTINE | 90478685 | 90478796 | 90478763 | 90478763 | Frame_Shift_Del | A | - | p.E298fs |
| SNU1040_LARGE_INTESTINE | 90478685 | 90478796 | 90478763 | 90478763 | Frame_Shift_Del | A | - | p.E298fs |
| MHHPREB1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 90487809 | 90487904 | 90487829 | 90487830 | Frame_Shift_Ins | - | AG | p.R443fs |
| OVCAR8_OVARY | 90472904 | 90473309 | 90472986 | 90472986 | Missense_Mutation | C | T | p.P98S |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 90472904 | 90473309 | 90472996 | 90472996 | Missense_Mutation | G | C | p.S101T |
| DND41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 90472904 | 90473309 | 90472996 | 90472996 | Missense_Mutation | G | C | p.S101T |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 90472904 | 90473309 | 90472996 | 90472996 | Missense_Mutation | G | C | p.S101T |
| OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 90472904 | 90473309 | 90472996 | 90472996 | Missense_Mutation | G | C | p.S101T |
| NCIBL128_MATCHED_NORMAL_TISSUE | 90472904 | 90473309 | 90473041 | 90473041 | Missense_Mutation | G | A | p.R116Q |
| MZ7MEL_SKIN | 90472904 | 90473309 | 90473077 | 90473077 | Missense_Mutation | G | A | p.G128D |
| NCIH23_LUNG | 90472904 | 90473309 | 90473079 | 90473079 | Missense_Mutation | G | A | p.G129R |
| ISTMEL1_SKIN | 90472904 | 90473309 | 90473121 | 90473121 | Missense_Mutation | C | T | p.P143S |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 90473171 | 90473309 | 90473260 | 90473260 | Missense_Mutation | A | G | p.N189S |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 90472904 | 90473309 | 90473260 | 90473260 | Missense_Mutation | A | G | p.N189S |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 90473171 | 90473309 | 90473260 | 90473260 | Missense_Mutation | A | G | p.N189S |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 90472904 | 90473309 | 90473260 | 90473260 | Missense_Mutation | A | G | p.N189S |
| OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 90473171 | 90473309 | 90473260 | 90473260 | Missense_Mutation | A | G | p.N189S |
| OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 90472904 | 90473309 | 90473260 | 90473260 | Missense_Mutation | A | G | p.N189S |
| 2313287_STOMACH | 90473171 | 90473309 | 90473272 | 90473272 | Missense_Mutation | T | G | p.F193C |
| 2313287_STOMACH | 90472904 | 90473309 | 90473272 | 90473272 | Missense_Mutation | T | G | p.F193C |
| HEC251_ENDOMETRIUM | 90473171 | 90473309 | 90473301 | 90473301 | Missense_Mutation | G | T | p.G203C |
| HEC251_ENDOMETRIUM | 90472904 | 90473309 | 90473301 | 90473301 | Missense_Mutation | G | T | p.G203C |
| IGR39_SKIN | 90478685 | 90478796 | 90478708 | 90478708 | Missense_Mutation | G | C | p.E280Q |
| IGR37_SKIN | 90478685 | 90478796 | 90478708 | 90478708 | Missense_Mutation | G | C | p.E280Q |
| WSUNHL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 90478685 | 90478796 | 90478721 | 90478721 | Missense_Mutation | G | A | p.R284Q |
| EN_ENDOMETRIUM | 90478685 | 90478796 | 90478739 | 90478739 | Missense_Mutation | G | A | p.R290Q |
| 22RV1_PROSTATE | 90478685 | 90478796 | 90478754 | 90478754 | Missense_Mutation | G | A | p.R295H |
| HCC1187_MATCHED_NORMAL_TISSUE | 90486351 | 90486481 | 90486365 | 90486365 | Missense_Mutation | G | A | p.D397N |
| LN464_CENTRAL_NERVOUS_SYSTEM | 90486351 | 90486481 | 90486383 | 90486383 | Missense_Mutation | G | A | p.E403K |
| ACN_AUTONOMIC_GANGLIA | 90486351 | 90486481 | 90486383 | 90486383 | Missense_Mutation | G | A | p.E403K |
| HEC1_ENDOMETRIUM | 90487809 | 90487904 | 90487852 | 90487852 | Missense_Mutation | C | A | p.T450K |
| SNU81_LARGE_INTESTINE | 90487809 | 90487904 | 90487855 | 90487855 | Missense_Mutation | G | T | p.S451I |
| CTV1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 90487809 | 90487904 | 90487868 | 90487868 | Missense_Mutation | T | A | p.N455K |
| CROAP2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 90472904 | 90473309 | 90473022 | 90473022 | Nonsense_Mutation | C | T | p.R110* |
| NCIH1770_LUNG | 90473171 | 90473309 | 90473298 | 90473298 | Nonsense_Mutation | C | T | p.R202* |
| NCIH1770_LUNG | 90472904 | 90473309 | 90473298 | 90473298 | Nonsense_Mutation | C | T | p.R202* |
| UMCHOR1_BONE | 90486351 | 90486481 | 90486351 | 90486351 | Splice_Site | G | C | p.G392A |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZNF326 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZNF326 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZNF326 |
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RelatedDrugs for ZNF326 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF326 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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