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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for GNAI2 |
 Gene summary |
| Gene information | Gene symbol | GNAI2 | Gene ID | 2771 |
| Gene name | G protein subunit alpha i2 | |
| Synonyms | GIP|GNAI2B|H_LUCA15.1|H_LUCA16.1 | |
| Cytomap | 3p21.31 | |
| Type of gene | protein-coding | |
| Description | guanine nucleotide-binding protein G(i) subunit alpha-2GTP-binding regulatory protein Gi alpha-2 chainadenylate cyclase-inhibiting G alpha proteinguanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2guanine nucleotide | |
| Modification date | 20180523 | |
| UniProtAcc | P04899 | |
| Context | PubMed: GNAI2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for GNAI2 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for GNAI2 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for GNAI2 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_374618 | 3 | 50264168:50264625:50289051:50289175:50289531:50289574 | 50289051:50289175 | ENSG00000114353.12 | ENST00000446079.1 |
| exon_skip_374619 | 3 | 50273797:50273885:50289531:50289574:50289828:50289970 | 50289531:50289574 | ENSG00000114353.12 | ENST00000313601.6 |
| exon_skip_374621 | 3 | 50289828:50289970:50290455:50290616:50293623:50293752 | 50290455:50290616 | ENSG00000114353.12 | ENST00000491100.1,ENST00000441156.1,ENST00000490122.1,ENST00000451956.1,ENST00000446079.1,ENST00000266027.5,ENST00000440628.1,ENST00000536647.1,ENST00000422163.1,ENST00000313601.6 |
| exon_skip_374625 | 3 | 50294154:50294284:50294368:50294522:50294931:50295146 | 50294368:50294522 | ENSG00000114353.12 | ENST00000491100.1,ENST00000441156.1,ENST00000490122.1,ENST00000451956.1,ENST00000492383.1,ENST00000446079.1,ENST00000266027.5,ENST00000440628.1,ENST00000536647.1,ENST00000422163.1,ENST00000313601.6 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for GNAI2 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_374618 | 3 | 50264168:50264625:50289051:50289175:50289531:50289574 | 50289051:50289175 | ENSG00000114353.12 | ENST00000446079.1 |
| exon_skip_374619 | 3 | 50273797:50273885:50289531:50289574:50289828:50289970 | 50289531:50289574 | ENSG00000114353.12 | ENST00000313601.6 |
| exon_skip_374621 | 3 | 50289828:50289970:50290455:50290616:50293623:50293752 | 50290455:50290616 | ENSG00000114353.12 | ENST00000422163.1,ENST00000446079.1,ENST00000491100.1,ENST00000313601.6,ENST00000441156.1,ENST00000536647.1,ENST00000440628.1,ENST00000451956.1,ENST00000490122.1,ENST00000266027.5 |
| exon_skip_374625 | 3 | 50294154:50294284:50294368:50294522:50294931:50295146 | 50294368:50294522 | ENSG00000114353.12 | ENST00000422163.1,ENST00000446079.1,ENST00000491100.1,ENST00000313601.6,ENST00000441156.1,ENST00000536647.1,ENST00000440628.1,ENST00000451956.1,ENST00000490122.1,ENST00000266027.5,ENST00000492383.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for GNAI2 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000313601 | 50289531 | 50289574 | Frame-shift |
| ENST00000313601 | 50290455 | 50290616 | Frame-shift |
| ENST00000313601 | 50294368 | 50294522 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000313601 | 50289531 | 50289574 | Frame-shift |
| ENST00000313601 | 50290455 | 50290616 | Frame-shift |
| ENST00000313601 | 50294368 | 50294522 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for GNAI2 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for GNAI2 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| UCS | TCGA-QN-A5NN-01 | exon_skip_374621 | 50290456 | 50290616 | 50290582 | 50290582 | Frame_Shift_Del | T | - | p.S144fs |
| UCEC | TCGA-D1-A15X-01 | exon_skip_374621 | 50290456 | 50290616 | 50290564 | 50290564 | Nonsense_Mutation | C | T | p.Q138* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 50290456 | 50290616 | 50290599 | 50290600 | Frame_Shift_Ins | - | A | p.N150fs |
| BL70_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 50294369 | 50294522 | 50294456 | 50294458 | In_Frame_Del | AAG | - | p.K272del |
| SUDHL10_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 50294369 | 50294522 | 50294456 | 50294458 | In_Frame_Del | AAG | - | p.K272del |
| SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 50294369 | 50294522 | 50294456 | 50294458 | In_Frame_Del | AAG | - | p.K272del |
| MN60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 50294369 | 50294522 | 50294456 | 50294458 | In_Frame_Del | AAG | - | p.K272del |
| RL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 50294369 | 50294522 | 50294456 | 50294458 | In_Frame_Del | AAG | - | p.K272del |
| CTV1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 50289532 | 50289574 | 50289546 | 50289546 | Missense_Mutation | G | A | p.G45R |
| HT115_LARGE_INTESTINE | 50289532 | 50289574 | 50289553 | 50289553 | Missense_Mutation | G | A | p.S47N |
| TT_OESOPHAGUS | 50290456 | 50290616 | 50290507 | 50290507 | Missense_Mutation | G | A | p.V119M |
| HUPT4_PANCREAS | 50290456 | 50290616 | 50290538 | 50290538 | Missense_Mutation | G | A | p.R129Q |
| L542_MATCHED_NORMAL_TISSUE | 50294369 | 50294522 | 50294378 | 50294378 | Missense_Mutation | C | T | p.H245Y |
| OCILY7_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 50294369 | 50294522 | 50294456 | 50294456 | Missense_Mutation | A | G | p.K271E |
| TC106_BONE | 50294369 | 50294522 | 50294458 | 50294458 | Missense_Mutation | G | T | p.K271N |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for GNAI2 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for GNAI2 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for GNAI2 |
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RelatedDrugs for GNAI2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GNAI2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| GNAI2 | C0004245 | Atrioventricular Block | 1 | CTD_human |
| GNAI2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| GNAI2 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| GNAI2 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| GNAI2 | C0027643 | Neoplasm Recurrence, Local | 1 | CTD_human |
| GNAI2 | C0428977 | Bradycardia | 1 | CTD_human |
| GNAI2 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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