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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for SULT1B1 |
 Gene summary |
| Gene information | Gene symbol | SULT1B1 | Gene ID | 27284 |
| Gene name | sulfotransferase family 1B member 1 | |
| Synonyms | ST1B1|ST1B2|SULT1B2 | |
| Cytomap | 4q13.3 | |
| Type of gene | protein-coding | |
| Description | sulfotransferase family cytosolic 1B member 1sulfotransferase 1B1sulfotransferase 1B2sulfotransferase family, cytosolic, 1B, member 1thyroid hormone sulfotransferase | |
| Modification date | 20180519 | |
| UniProtAcc | O43704 | |
| Context | PubMed: SULT1B1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| SULT1B1 | GO:0006068 | ethanol catabolic process | 23207770 |
| SULT1B1 | GO:0006805 | xenobiotic metabolic process | 20056724 |
| SULT1B1 | GO:0009812 | flavonoid metabolic process | 20056724 |
| SULT1B1 | GO:0018958 | phenol-containing compound metabolic process | 9463486 |
| SULT1B1 | GO:0042403 | thyroid hormone metabolic process | 9443824 |
| SULT1B1 | GO:0050427 | 3'-phosphoadenosine 5'-phosphosulfate metabolic process | 23207770 |
| SULT1B1 | GO:0051923 | sulfation | 19548878|20056724|23207770 |
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Exon skipping events across known transcript of Ensembl for SULT1B1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for SULT1B1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for SULT1B1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_429947 | 4 | 70596218:70596399:70599130:70599225:70599855:70599982 | 70599130:70599225 | ENSG00000173597.4 | ENST00000310613.3 |
| exon_skip_429949 | 4 | 70615438:70615536:70620387:70620516:70620787:70620919 | 70620387:70620516 | ENSG00000173597.4 | ENST00000510821.1,ENST00000310613.3 |
| exon_skip_429953 | 4 | 70620387:70620516:70620787:70620919:70626176:70626289 | 70620787:70620919 | ENSG00000173597.4 | ENST00000512870.1 |
| exon_skip_429958 | 4 | 70620787:70620979:70625925:70625968:70626176:70626289 | 70625925:70625968 | ENSG00000173597.4 | ENST00000510821.1 |
| exon_skip_429960 | 4 | 70626176:70626289:70639145:70639215:70653551:70653679 | 70639145:70639215 | ENSG00000173597.4 | ENST00000512870.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for SULT1B1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_429949 | 4 | 70615438:70615536:70620387:70620516:70620787:70620919 | 70620387:70620516 | ENSG00000173597.4 | ENST00000310613.3,ENST00000510821.1 |
| exon_skip_429953 | 4 | 70620387:70620516:70620787:70620919:70626176:70626289 | 70620787:70620919 | ENSG00000173597.4 | ENST00000512870.1 |
| exon_skip_429958 | 4 | 70620787:70620979:70625925:70625968:70626176:70626289 | 70625925:70625968 | ENSG00000173597.4 | ENST00000510821.1 |
| exon_skip_429960 | 4 | 70626176:70626289:70639145:70639215:70653551:70653679 | 70639145:70639215 | ENSG00000173597.4 | ENST00000512870.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for SULT1B1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000310613 | 70599130 | 70599225 | Frame-shift |
| ENST00000310613 | 70620387 | 70620516 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000310613 | 70620387 | 70620516 | In-frame |
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Infer the effects of exon skipping event on protein functional features for SULT1B1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000310613 | 7132 | 296 | 70620387 | 70620516 | 447 | 575 | 49 | 92 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000310613 | 7132 | 296 | 70620387 | 70620516 | 447 | 575 | 49 | 92 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O43704 | 49 | 92 | 1 | 296 | Chain | ID=PRO_0000085161;Note=Sulfotransferase family cytosolic 1B member 1 |
| O43704 | 49 | 92 | 51 | 62 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CKL |
| O43704 | 49 | 92 | 67 | 70 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CKL |
| O43704 | 49 | 92 | 75 | 78 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CKL |
| O43704 | 49 | 92 | 48 | 53 | Nucleotide binding | Note=PAPS |
| O43704 | 49 | 92 | 63 | 65 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CKL |
| O43704 | 49 | 92 | 87 | 89 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5F |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O43704 | 49 | 92 | 1 | 296 | Chain | ID=PRO_0000085161;Note=Sulfotransferase family cytosolic 1B member 1 |
| O43704 | 49 | 92 | 51 | 62 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CKL |
| O43704 | 49 | 92 | 67 | 70 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CKL |
| O43704 | 49 | 92 | 75 | 78 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CKL |
| O43704 | 49 | 92 | 48 | 53 | Nucleotide binding | Note=PAPS |
| O43704 | 49 | 92 | 63 | 65 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CKL |
| O43704 | 49 | 92 | 87 | 89 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2Z5F |
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SNVs in the skipped exons for SULT1B1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| COAD | TCGA-D5-6927-01 | exon_skip_429947 | 70599131 | 70599225 | 70599153 | 70599153 | Frame_Shift_Del | A | - | p.L192fs |
| STAD | TCGA-BR-8081-01 | exon_skip_429947 | 70599131 | 70599225 | 70599153 | 70599153 | Frame_Shift_Del | A | - | p.L192fs |
| UCEC | TCGA-AX-A06H-01 | exon_skip_429947 | 70599131 | 70599225 | 70599153 | 70599153 | Frame_Shift_Del | A | - | p.L192fs |
| LUAD | TCGA-86-8673-01 | exon_skip_429949 | 70620388 | 70620516 | 70620405 | 70620405 | Frame_Shift_Del | G | - | p.P87fs |
| UCS | TCGA-NA-A4R1-01 | exon_skip_429953 | 70620788 | 70620919 | 70620807 | 70620807 | Frame_Shift_Del | T | - | p.A44fs |
| UCS | TCGA-NA-A4R1-01 | exon_skip_429953 | 70620788 | 70620919 | 70620807 | 70620807 | Frame_Shift_Del | T | - | p.I43fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_429953 | 70620788 | 70620919 | 70620845 | 70620845 | Frame_Shift_Del | T | - | p.I31fs |
| STAD | TCGA-BR-7707-01 | exon_skip_429953 | 70620788 | 70620919 | 70620845 | 70620845 | Frame_Shift_Del | T | - | p.I31fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_429953 | 70620788 | 70620919 | 70620879 | 70620879 | Frame_Shift_Del | G | - | p.P19fs |
| SKCM | TCGA-EE-A2MS-06 | exon_skip_429947 | 70599131 | 70599225 | 70599185 | 70599185 | Nonsense_Mutation | C | T | p.W181* |
| SKCM | TCGA-EE-A2MS-06 | exon_skip_429947 | 70599131 | 70599225 | 70599185 | 70599185 | Nonsense_Mutation | C | T | p.W181X |
| HNSC | TCGA-CV-7250-01 | exon_skip_429949 | 70620388 | 70620516 | 70620403 | 70620403 | Nonsense_Mutation | C | A | p.G88* |
| STAD | TCGA-HF-A5NB-01 | exon_skip_429949 | 70620388 | 70620516 | 70620451 | 70620451 | Nonsense_Mutation | G | A | p.R72* |
| BLCA | TCGA-ZF-AA4V-01 | exon_skip_429953 | 70620788 | 70620919 | 70620790 | 70620790 | Nonsense_Mutation | G | C | p.S49* |
| UCEC | TCGA-BS-A0UM-01 | exon_skip_429953 | 70620788 | 70620919 | 70620787 | 70620787 | Splice_Site | C | A | e1+1 |
| UCEC | TCGA-BS-A0UM-01 | exon_skip_429953 | 70620788 | 70620919 | 70620787 | 70620787 | Splice_Site | C | A | p.G50_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| AN3CA_ENDOMETRIUM | 70599131 | 70599225 | 70599153 | 70599153 | Frame_Shift_Del | A | - | p.L192fs |
| SNUC5_LARGE_INTESTINE | 70599131 | 70599225 | 70599153 | 70599153 | Frame_Shift_Del | A | - | p.L192fs |
| JHOM2B_OVARY | 70620788 | 70620919 | 70620844 | 70620845 | Frame_Shift_Ins | - | T | p.I31fs |
| KASUMI6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 70620788 | 70620919 | 70620844 | 70620845 | Frame_Shift_Ins | - | T | p.I31fs |
| OV90_OVARY | 70620788 | 70620919 | 70620844 | 70620845 | Frame_Shift_Ins | - | T | p.I31fs |
| SNU175_LARGE_INTESTINE | 70620788 | 70620919 | 70620844 | 70620845 | Frame_Shift_Ins | - | T | p.I31fs |
| SNU719_STOMACH | 70620788 | 70620919 | 70620844 | 70620845 | Frame_Shift_Ins | - | T | p.I31fs |
| NCIH358_LUNG | 70599131 | 70599225 | 70599133 | 70599133 | Missense_Mutation | C | G | p.E199Q |
| EN_ENDOMETRIUM | 70599131 | 70599225 | 70599201 | 70599201 | Missense_Mutation | T | G | p.H176P |
| CW2_LARGE_INTESTINE | 70620388 | 70620516 | 70620468 | 70620468 | Missense_Mutation | T | A | p.D66V |
| HCC1395_BREAST | 70620388 | 70620516 | 70620471 | 70620471 | Missense_Mutation | C | A | p.G65V |
| RKO_LARGE_INTESTINE | 70620388 | 70620516 | 70620486 | 70620486 | Missense_Mutation | A | T | p.M60K |
| SNUC4_LARGE_INTESTINE | 70620788 | 70620919 | 70620829 | 70620829 | Missense_Mutation | C | T | p.S36N |
| C33A_CERVIX | 70620788 | 70620919 | 70620844 | 70620844 | Missense_Mutation | A | T | p.I31N |
| NH6_AUTONOMIC_GANGLIA | 70620388 | 70620516 | 70620506 | 70620506 | Nonsense_Mutation | C | T | p.W53* |
| SKMEL31_SKIN | 70620788 | 70620919 | 70620852 | 70620852 | Nonsense_Mutation | C | T | p.W28* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SULT1B1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SULT1B1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SULT1B1 |
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RelatedDrugs for SULT1B1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SULT1B1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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