ExonSkipDB: functional annotation of exon skipping event in human

Gene summary for PDCD4

Gene summary

Gene information	Gene symbol	PDCD4
	Gene ID	27250
	Gene name	programmed cell death 4
	Synonyms	H731
	Cytomap	10q25.2
	Type of gene	protein-coding
	Description	programmed cell death protein 4neoplastic transformation inhibitor proteinnuclear antigen H731programmed cell death 4 (neoplastic transformation inhibitor)protein 197/15a
	Modification date	20180527
	UniProtAcc	Q53EL6
	Context	PubMed: PDCD4 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
PDCD4	GO:0007569	cell aging	12054647
PDCD4	GO:0030509	BMP signaling pathway	18548003
PDCD4	GO:0045892	negative regulation of transcription, DNA-templated	16357133
PDCD4	GO:1905064	negative regulation of vascular smooth muscle cell differentiation	18548003

Top

Exon skipping events across known transcript of Ensembl for PDCD4 from UCSC genome browser

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Gene isoform structures and expression levels for PDCD4

Expression levels of gene isoforms across TCGA.

Expression levels of gene isoforms across GTEx.

Top

Exon skipping events with PSIs in TCGA for PDCD4

Information of exkip skipping event in TCGA.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_45032	10	112631712:112631776:112635723:112635828:112641032:112641293	112635723:112635828	ENSG00000150593.11	ENST00000444997.1
exon_skip_45043	10	112635723:112635828:112636427:112636511:112640990:112641293	112636427:112636511	ENSG00000150593.11	ENST00000483670.1,ENST00000393104.2
exon_skip_45056	10	112642760:112642855:112645010:112645124:112647422:112647519	112645010:112645124	ENSG00000150593.11	ENST00000467574.1,ENST00000492932.1,ENST00000444997.1,ENST00000280154.7,ENST00000393104.2
exon_skip_45062	10	112645010:112645124:112647422:112647644:112649290:112649388	112647422:112647644	ENSG00000150593.11	ENST00000481353.1,ENST00000280154.7,ENST00000393104.2
exon_skip_45063	10	112650395:112650428:112653848:112653956:112654169:112654280	112653848:112653956	ENSG00000150593.11	ENST00000280154.7,ENST00000462577.1,ENST00000393104.2
exon_skip_45065	10	112653848:112653956:112654169:112654280:112655705:112655801	112654169:112654280	ENSG00000150593.11	ENST00000280154.7,ENST00000462577.1,ENST00000393104.2
exon_skip_45066	10	112654169:112654280:112655705:112655845:112657785:112657880	112655705:112655845	ENSG00000150593.11	ENST00000498367.1,ENST00000280154.7,ENST00000462577.1,ENST00000393104.2

PSI values of skipped exons in TCGA.

Top

Exon skipping events with PSIs in GTEx for PDCD4

Information of exkip skipping event in GTEx

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_45032	10	112631712:112631776:112635723:112635828:112641032:112641293	112635723:112635828	ENSG00000150593.11	ENST00000444997.1
exon_skip_45043	10	112635723:112635828:112636427:112636511:112640990:112641293	112636427:112636511	ENSG00000150593.11	ENST00000393104.2,ENST00000483670.1
exon_skip_45056	10	112642760:112642855:112645010:112645124:112647422:112647519	112645010:112645124	ENSG00000150593.11	ENST00000280154.7,ENST00000393104.2,ENST00000467574.1,ENST00000444997.1,ENST00000492932.1
exon_skip_45062	10	112645010:112645124:112647422:112647644:112649290:112649388	112647422:112647644	ENSG00000150593.11	ENST00000280154.7,ENST00000393104.2,ENST00000481353.1
exon_skip_45063	10	112650395:112650428:112653848:112653956:112654169:112654280	112653848:112653956	ENSG00000150593.11	ENST00000280154.7,ENST00000393104.2,ENST00000462577.1
exon_skip_45065	10	112653848:112653956:112654169:112654280:112655705:112655801	112654169:112654280	ENSG00000150593.11	ENST00000280154.7,ENST00000393104.2,ENST00000462577.1
exon_skip_45066	10	112654169:112654280:112655705:112655845:112657785:112657880	112655705:112655845	ENSG00000150593.11	ENST00000280154.7,ENST00000393104.2,ENST00000462577.1,ENST00000498367.1

PSI values of skipped exons in GTEx.

* Skipped exon sequences.

Top

Open reading frame (ORF) annotation in the exon skipping event for PDCD4

Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000280154	112655705	112655845	Frame-shift
ENST00000280154	112645010	112645124	In-frame
ENST00000280154	112647422	112647644	In-frame
ENST00000280154	112653848	112653956	In-frame
ENST00000280154	112654169	112654280	In-frame

Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000280154	112655705	112655845	Frame-shift
ENST00000280154	112645010	112645124	In-frame
ENST00000280154	112647422	112647644	In-frame
ENST00000280154	112653848	112653956	In-frame
ENST00000280154	112654169	112654280	In-frame

Top

Infer the effects of exon skipping event on protein functional features for PDCD4

Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.

Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000280154	3619	469	112645010	112645124	716	829	147	185
ENST00000280154	3619	469	112647422	112647644	830	1051	185	259
ENST00000280154	3619	469	112653848	112653956	1265	1372	330	366
ENST00000280154	3619	469	112654169	112654280	1373	1483	366	403

Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000280154	3619	469	112645010	112645124	716	829	147	185
ENST00000280154	3619	469	112647422	112647644	830	1051	185	259
ENST00000280154	3619	469	112653848	112653956	1265	1372	330	366
ENST00000280154	3619	469	112654169	112654280	1373	1483	366	403

Lost protein functional features of individual exon skipping events in TCGA.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q53EL6	147	185	1	469	Chain	ID=PRO_0000256519;Note=Programmed cell death protein 4
Q53EL6	147	185	163	284	Domain	Note=MI 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00698
Q53EL6	147	185	161	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2RG8
Q53EL6	147	185	181	191	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2RG8
Q53EL6	147	185	152	152	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:15592455;Dbxref=PMID:15592455
Q53EL6	147	185	174	174	Mutagenesis	Note=Reduced inhibition of EIF4A1 helicase activity. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19153607;Dbxref=PMID:19153607
Q53EL6	185	259	1	469	Chain	ID=PRO_0000256519;Note=Programmed cell death protein 4
Q53EL6	185	259	163	284	Domain	Note=MI 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00698
Q53EL6	185	259	181	191	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2RG8
Q53EL6	185	259	195	198	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2RG8
Q53EL6	185	259	199	209	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2RG8
Q53EL6	185	259	213	226	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2RG8
Q53EL6	185	259	233	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2RG8
Q53EL6	185	259	257	270	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2RG8
Q53EL6	185	259	241	250	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q53EL6	185	259	210	210	Mutagenesis	Note=Reduced inhibition of EIF4A1 helicase activity. Strongly reduced inhibition of translation. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19153607;Dbxref=PMID:19153607
Q53EL6	185	259	249	249	Mutagenesis	Note=Reduced interaction with EIF4A1. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19153607;Dbxref=PMID:19153607
Q53EL6	185	259	252	252	Mutagenesis	Note=Strongly reduced interaction with EIF4A1. Reduced inhibition of EIF4A1 helicase activity. Strongly reduced inhibition of translation. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19153607;Dbxref=PMID:19153607
Q53EL6	185	259	253	253	Mutagenesis	Note=Strongly reduced interaction with EIF4A1. Strongly reduced inhibition of translation. Reduced inhibition of EIF4A1 helicase activity. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:19153607,ECO:0000269\|PubMed:19204291;Dbxref=P
Q53EL6	185	259	255	255	Mutagenesis	Note=Reduced inhibition of EIF4A1 helicase activity. Strongly reduced inhibition of translation. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19153607;Dbxref=PMID:19153607
Q53EL6	185	259	220	220	Sequence conflict	Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q53EL6	185	259	222	222	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q53EL6	185	259	227	229	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2RG8
Q53EL6	330	366	1	469	Chain	ID=PRO_0000256519;Note=Programmed cell death protein 4
Q53EL6	330	366	326	449	Domain	Note=MI 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00698
Q53EL6	330	366	324	341	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2ZU6
Q53EL6	330	366	344	354	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2ZU6
Q53EL6	330	366	357	359	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2ZU6
Q53EL6	330	366	360	372	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2ZU6
Q53EL6	330	366	333	333	Mutagenesis	Note=No effect on inhibition of EIF4A1 and on inhibition of translation%3B when associated with A-340. M->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19204291;Dbxref=PMID:19204291
Q53EL6	330	366	337	337	Mutagenesis	Note=No effect on inhibition of EIF4A1 and on inhibition of translation. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19204291;Dbxref=PMID:19204291
Q53EL6	330	366	340	340	Mutagenesis	Note=No effect on inhibition of EIF4A1 and on inhibition of translation%3B when associated with A-333. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19204291;Dbxref=PMID:19204291
Q53EL6	330	366	358	358	Mutagenesis	Note=Strongly reduced interaction with EIF4A1. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19153607;Dbxref=PMID:19153607
Q53EL6	330	366	359	359	Mutagenesis	Note=Strongly reduced inhibition of EIF4A1. Strongly reduced inhibition of translation. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19204291;Dbxref=PMID:19204291
Q53EL6	330	366	361	361	Mutagenesis	Note=Strongly reduced inhibition of EIF4A1. Strongly reduced inhibition of translation. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19204291;Dbxref=PMID:19204291
Q53EL6	366	403	1	469	Chain	ID=PRO_0000256519;Note=Programmed cell death protein 4
Q53EL6	366	403	326	449	Domain	Note=MI 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00698
Q53EL6	366	403	360	372	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2ZU6
Q53EL6	366	403	378	393	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2ZU6
Q53EL6	366	403	398	418	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2ZU6

Lost protein functional features of individual exon skipping events in GTEx.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q53EL6	147	185	1	469	Chain	ID=PRO_0000256519;Note=Programmed cell death protein 4
Q53EL6	147	185	163	284	Domain	Note=MI 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00698
Q53EL6	147	185	161	178	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2RG8
Q53EL6	147	185	181	191	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2RG8
Q53EL6	147	185	152	152	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:15592455;Dbxref=PMID:15592455
Q53EL6	147	185	174	174	Mutagenesis	Note=Reduced inhibition of EIF4A1 helicase activity. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19153607;Dbxref=PMID:19153607
Q53EL6	185	259	1	469	Chain	ID=PRO_0000256519;Note=Programmed cell death protein 4
Q53EL6	185	259	163	284	Domain	Note=MI 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00698
Q53EL6	185	259	181	191	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2RG8
Q53EL6	185	259	195	198	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2RG8
Q53EL6	185	259	199	209	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2RG8
Q53EL6	185	259	213	226	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2RG8
Q53EL6	185	259	233	253	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2RG8
Q53EL6	185	259	257	270	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2RG8
Q53EL6	185	259	241	250	Motif	Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q53EL6	185	259	210	210	Mutagenesis	Note=Reduced inhibition of EIF4A1 helicase activity. Strongly reduced inhibition of translation. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19153607;Dbxref=PMID:19153607
Q53EL6	185	259	249	249	Mutagenesis	Note=Reduced interaction with EIF4A1. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19153607;Dbxref=PMID:19153607
Q53EL6	185	259	252	252	Mutagenesis	Note=Strongly reduced interaction with EIF4A1. Reduced inhibition of EIF4A1 helicase activity. Strongly reduced inhibition of translation. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19153607;Dbxref=PMID:19153607
Q53EL6	185	259	253	253	Mutagenesis	Note=Strongly reduced interaction with EIF4A1. Strongly reduced inhibition of translation. Reduced inhibition of EIF4A1 helicase activity. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:19153607,ECO:0000269\|PubMed:19204291;Dbxref=P
Q53EL6	185	259	255	255	Mutagenesis	Note=Reduced inhibition of EIF4A1 helicase activity. Strongly reduced inhibition of translation. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19153607;Dbxref=PMID:19153607
Q53EL6	185	259	220	220	Sequence conflict	Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q53EL6	185	259	222	222	Sequence conflict	Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q53EL6	185	259	227	229	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2RG8
Q53EL6	330	366	1	469	Chain	ID=PRO_0000256519;Note=Programmed cell death protein 4
Q53EL6	330	366	326	449	Domain	Note=MI 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00698
Q53EL6	330	366	324	341	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2ZU6
Q53EL6	330	366	344	354	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2ZU6
Q53EL6	330	366	357	359	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2ZU6
Q53EL6	330	366	360	372	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2ZU6
Q53EL6	330	366	333	333	Mutagenesis	Note=No effect on inhibition of EIF4A1 and on inhibition of translation%3B when associated with A-340. M->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19204291;Dbxref=PMID:19204291
Q53EL6	330	366	337	337	Mutagenesis	Note=No effect on inhibition of EIF4A1 and on inhibition of translation. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19204291;Dbxref=PMID:19204291
Q53EL6	330	366	340	340	Mutagenesis	Note=No effect on inhibition of EIF4A1 and on inhibition of translation%3B when associated with A-333. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19204291;Dbxref=PMID:19204291
Q53EL6	330	366	358	358	Mutagenesis	Note=Strongly reduced interaction with EIF4A1. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19153607;Dbxref=PMID:19153607
Q53EL6	330	366	359	359	Mutagenesis	Note=Strongly reduced inhibition of EIF4A1. Strongly reduced inhibition of translation. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19204291;Dbxref=PMID:19204291
Q53EL6	330	366	361	361	Mutagenesis	Note=Strongly reduced inhibition of EIF4A1. Strongly reduced inhibition of translation. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19204291;Dbxref=PMID:19204291
Q53EL6	366	403	1	469	Chain	ID=PRO_0000256519;Note=Programmed cell death protein 4
Q53EL6	366	403	326	449	Domain	Note=MI 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00698
Q53EL6	366	403	360	372	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2ZU6
Q53EL6	366	403	378	393	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2ZU6
Q53EL6	366	403	398	418	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2ZU6

Top

SNVs in the skipped exons for PDCD4

- Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.

- Differential PSIs between mutated versus non-mutated samples.

- Non-synonymous mutations located in the skipped exons in TCGA.

Cancer type	Sample	ESID	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
LIHC	TCGA-G3-A3CJ-01	exon_skip_45066	112655706	112655845	112655795	112655795	Frame_Shift_Del	T	-	p.C422fs
UCEC	TCGA-AP-A059-01	exon_skip_45063	112653849	112653956	112653867	112653867	Nonsense_Mutation	G	T	p.E337*
SARC	TCGA-DX-A8BH-01	exon_skip_45063	112653849	112653956	112653894	112653894	Nonsense_Mutation	G	T	p.E335*

- Depth of coverage in the three exons composing exon skipping event

Depth of coverage in three exons

Mutation description

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
HSC4_UPPER_AERODIGESTIVE_TRACT	112635724	112635828	112635790	112635790	Missense_Mutation	A	T	p.D2V
CW2_LARGE_INTESTINE	112645011	112645124	112645060	112645060	Missense_Mutation	T	G	p.F164C
SNU1040_LARGE_INTESTINE	112645011	112645124	112645105	112645105	Missense_Mutation	G	A	p.G179E
SCMCRM2_SOFT_TISSUE	112645011	112645124	112645113	112645113	Missense_Mutation	A	C	p.N182H
CMLT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	112647423	112647644	112647478	112647478	Missense_Mutation	C	T	p.A204V
LNZTA3WT4_CENTRAL_NERVOUS_SYSTEM	112653849	112653956	112653880	112653880	Missense_Mutation	C	T	p.S341F
LNZ308_CENTRAL_NERVOUS_SYSTEM	112653849	112653956	112653880	112653880	Missense_Mutation	C	T	p.S341F
LOVO_LARGE_INTESTINE	112653849	112653956	112653889	112653889	Missense_Mutation	T	C	p.I344T
EW24_BONE	112653849	112653956	112653905	112653905	Missense_Mutation	T	G	p.H349Q
HEC108_ENDOMETRIUM	112653849	112653956	112653925	112653925	Missense_Mutation	T	C	p.V356A
KMOE2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	112653849	112653956	112653939	112653939	Missense_Mutation	C	T	p.H361Y
BICR18_UPPER_AERODIGESTIVE_TRACT	112654170	112654280	112654176	112654176	Missense_Mutation	A	G	p.I369V
HT3_CERVIX	112654170	112654280	112654252	112654252	Missense_Mutation	C	G	p.S394C
NCIH64_LUNG	112654170	112654280	112654266	112654266	Missense_Mutation	G	C	p.D399H
JHUEM7_ENDOMETRIUM	112655706	112655845	112655716	112655716	Missense_Mutation	G	T	p.R407I
ABC1_LUNG	112655706	112655845	112655734	112655734	Missense_Mutation	C	T	p.P413L
MOLT16_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	112655706	112655845	112655779	112655779	Missense_Mutation	G	A	p.R428Q
JVM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	112655706	112655845	112655799	112655799	Nonsense_Mutation	C	T	p.Q435*
HCC2998_LARGE_INTESTINE	112647423	112647644	112647424	112647424	Splice_Site	A	G	p.E186G
2313287_STOMACH	112654170	112654280	112654280	112654283	Splice_Site	AGTA	-	p.R403fs

Top

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PDCD4

sQTL information located at the skipped exons.

Exon skip ID

Chromosome

Three exons

Skippped exon

ENST

Cancer type

SNP id

Location

DNA change (ref/var)

P-value

Top

Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PDCD4

Top

Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PDCD4

Top

RelatedDrugs for PDCD4

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for PDCD4

Diseases associated with this gene.
(DisGeNet 4.0)

Gene	Disease ID	Disease name	# pubmeds	Source
PDCD4	C0027626	Neoplasm Invasiveness	1	CTD_human

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in TCGA
	Exon skipping events with PSIs in GTEx
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	SNVs in the skipped exons with depth of coverage
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Splicing Quantitative Trait Methylation (sQTM) in the skipped exon
	Related drugs with this gene
	Related diseases with this gene

Home

Download

Statistics

Landscape

Help

Contact