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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for MORC1 |
 Gene summary |
| Gene information | Gene symbol | MORC1 | Gene ID | 27136 |
| Gene name | MORC family CW-type zinc finger 1 | |
| Synonyms | CT33|MORC|ZCW6 | |
| Cytomap | 3q13.13 | |
| Type of gene | protein-coding | |
| Description | MORC family CW-type zinc finger protein 1cancer/testis antigen 33microrchidia, mouse, homolog of | |
| Modification date | 20180523 | |
| UniProtAcc | Q86VD1 | |
| Context | PubMed: MORC1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for MORC1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for MORC1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for MORC1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_386450 | 3 | 108677691:108677967:108682260:108682455:108688515:108688569 | 108682260:108682455 | ENSG00000114487.5 | ENST00000232603.5,ENST00000483760.1 |
| exon_skip_386451 | 3 | 108723916:108724162:108725875:108725938:108746597:108746736 | 108725875:108725938 | ENSG00000114487.5 | ENST00000232603.5 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for MORC1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_386450 | 3 | 108677691:108677967:108682260:108682455:108688515:108688569 | 108682260:108682455 | ENSG00000114487.5 | ENST00000232603.5,ENST00000483760.1 |
| exon_skip_386451 | 3 | 108723916:108724162:108725875:108725938:108746597:108746736 | 108725875:108725938 | ENSG00000114487.5 | ENST00000232603.5 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for MORC1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000232603 | 108682260 | 108682455 | In-frame |
| ENST00000232603 | 108725875 | 108725938 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000232603 | 108682260 | 108682455 | In-frame |
| ENST00000232603 | 108725875 | 108725938 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MORC1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000232603 | 3781 | 984 | 108725875 | 108725938 | 1788 | 1850 | 568 | 589 |
| ENST00000232603 | 3781 | 984 | 108682260 | 108682455 | 2688 | 2882 | 868 | 933 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000232603 | 3781 | 984 | 108725875 | 108725938 | 1788 | 1850 | 568 | 589 |
| ENST00000232603 | 3781 | 984 | 108682260 | 108682455 | 2688 | 2882 | 868 | 933 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q86VD1 | 568 | 589 | 569 | 589 | Alternative sequence | ID=VSP_055495;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q86VD1 | 568 | 589 | 1 | 984 | Chain | ID=PRO_0000248241;Note=MORC family CW-type zinc finger protein 1 |
| Q86VD1 | 868 | 933 | 1 | 984 | Chain | ID=PRO_0000248241;Note=MORC family CW-type zinc finger protein 1 |
| Q86VD1 | 868 | 933 | 900 | 934 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q86VD1 | 568 | 589 | 569 | 589 | Alternative sequence | ID=VSP_055495;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q86VD1 | 568 | 589 | 1 | 984 | Chain | ID=PRO_0000248241;Note=MORC family CW-type zinc finger protein 1 |
| Q86VD1 | 868 | 933 | 1 | 984 | Chain | ID=PRO_0000248241;Note=MORC family CW-type zinc finger protein 1 |
| Q86VD1 | 868 | 933 | 900 | 934 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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SNVs in the skipped exons for MORC1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SKCM | TCGA-EE-A17X-06 | exon_skip_386450 | 108682261 | 108682455 | 108682332 | 108682333 | Frame_Shift_Del | TT | - | p.910_910del |
| SKCM | TCGA-EE-A17X-06 | exon_skip_386450 | 108682261 | 108682455 | 108682332 | 108682333 | Frame_Shift_Del | TT | - | p.KR909fs |
| BLCA | TCGA-DK-A1A3-01 | exon_skip_386450 | 108682261 | 108682455 | 108682419 | 108682419 | Frame_Shift_Del | T | - | p.I881fs |
| GBM | TCGA-76-6656-01 | exon_skip_386450 | 108682261 | 108682455 | 108682419 | 108682419 | Frame_Shift_Del | T | - | p.I881fs |
| STAD | TCGA-BR-4184-01 | exon_skip_386450 | 108682261 | 108682455 | 108682419 | 108682420 | Frame_Shift_Del | TT | - | p.881_881del |
| HNSC | TCGA-IQ-A61O-01 | exon_skip_386450 | 108682261 | 108682455 | 108682418 | 108682419 | Frame_Shift_Ins | - | T | p.K881fs |
| HNSC | TCGA-T2-A6X0-01 | exon_skip_386450 | 108682261 | 108682455 | 108682418 | 108682419 | Frame_Shift_Ins | - | T | p.K881fs |
| LUSC | TCGA-18-4086-01 | exon_skip_386450 | 108682261 | 108682455 | 108682280 | 108682280 | Nonsense_Mutation | A | T | p.L927* |
| UCEC | TCGA-B5-A11N-01 | exon_skip_386450 | 108682261 | 108682455 | 108682456 | 108682456 | Splice_Site | C | A | e27-1 |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 108682261 | 108682455 | 108682294 | 108682294 | Missense_Mutation | T | C | p.I901M |
| SNU175_LARGE_INTESTINE | 108682261 | 108682455 | 108682298 | 108682298 | Missense_Mutation | C | T | p.R900H |
| ISHIKAWAHERAKLIO02ER_ENDOMETRIUM | 108682261 | 108682455 | 108682350 | 108682350 | Missense_Mutation | C | A | p.G883W |
| SW1271_LUNG | 108682261 | 108682455 | 108682377 | 108682377 | Missense_Mutation | T | C | p.R874G |
| OUMS23_LARGE_INTESTINE | 108682261 | 108682455 | 108682400 | 108682400 | Missense_Mutation | G | C | p.S866C |
| CPCN_LUNG | 108682261 | 108682455 | 108682438 | 108682438 | Missense_Mutation | C | T | p.M853I |
| HARA_LUNG | 108725876 | 108725938 | 108725893 | 108725893 | Missense_Mutation | G | T | p.L584I |
| LB647SCLC_LUNG | 108725876 | 108725938 | 108725922 | 108725922 | Missense_Mutation | A | T | p.V574E |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MORC1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MORC1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MORC1 |
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RelatedDrugs for MORC1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MORC1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| MORC1 | C0041696 | Unipolar Depression | 1 | PSYGENET |
| MORC1 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
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