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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for SDCBP2 |
 Gene summary |
| Gene information | Gene symbol | SDCBP2 | Gene ID | 27111 |
| Gene name | syndecan binding protein 2 | |
| Synonyms | SITAC|SITAC18|ST-2|ST2 | |
| Cytomap | 20p13 | |
| Type of gene | protein-coding | |
| Description | syntenin-2syndecan binding protein (syntenin) 2 | |
| Modification date | 20180523 | |
| UniProtAcc | Q9H190 | |
| Context | PubMed: SDCBP2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for SDCBP2 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for SDCBP2 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for SDCBP2 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_354281 | 20 | 1291443:1291535:1292980:1293152:1293230:1293406 | 1292980:1293152 | ENSG00000125775.10 | ENST00000360779.3,ENST00000381812.1,ENST00000381808.3,ENST00000339987.3 |
| exon_skip_354287 | 20 | 1292980:1293152:1293230:1293406:1293983:1294142 | 1293230:1293406 | ENSG00000125775.10 | ENST00000360779.3,ENST00000381812.1,ENST00000381808.3,ENST00000339987.3 |
| exon_skip_354291 | 20 | 1293983:1294142:1298961:1299062:1300233:1300303 | 1298961:1299062 | ENSG00000125775.10 | ENST00000360779.3,ENST00000381812.1,ENST00000339987.3 |
| exon_skip_354293 | 20 | 1298961:1299062:1300233:1300303:1301006:1301079 | 1300233:1300303 | ENSG00000125775.10 | ENST00000360779.3,ENST00000381812.1,ENST00000339987.3 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for SDCBP2 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_354281 | 20 | 1291443:1291535:1292980:1293152:1293230:1293406 | 1292980:1293152 | ENSG00000125775.10 | ENST00000381808.3,ENST00000381812.1,ENST00000339987.3,ENST00000360779.3 |
| exon_skip_354287 | 20 | 1292980:1293152:1293230:1293406:1293983:1294142 | 1293230:1293406 | ENSG00000125775.10 | ENST00000381808.3,ENST00000381812.1,ENST00000339987.3,ENST00000360779.3 |
| exon_skip_354291 | 20 | 1293983:1294142:1298961:1299062:1300233:1300303 | 1298961:1299062 | ENSG00000125775.10 | ENST00000381812.1,ENST00000339987.3,ENST00000360779.3 |
| exon_skip_354293 | 20 | 1298961:1299062:1300233:1300303:1301006:1301079 | 1300233:1300303 | ENSG00000125775.10 | ENST00000381812.1,ENST00000339987.3,ENST00000360779.3 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for SDCBP2 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000339987 | 1292980 | 1293152 | Frame-shift |
| ENST00000360779 | 1292980 | 1293152 | Frame-shift |
| ENST00000381812 | 1292980 | 1293152 | Frame-shift |
| ENST00000339987 | 1293230 | 1293406 | Frame-shift |
| ENST00000360779 | 1293230 | 1293406 | Frame-shift |
| ENST00000381812 | 1293230 | 1293406 | Frame-shift |
| ENST00000339987 | 1298961 | 1299062 | Frame-shift |
| ENST00000360779 | 1298961 | 1299062 | Frame-shift |
| ENST00000381812 | 1298961 | 1299062 | Frame-shift |
| ENST00000339987 | 1300233 | 1300303 | Frame-shift |
| ENST00000360779 | 1300233 | 1300303 | Frame-shift |
| ENST00000381812 | 1300233 | 1300303 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000339987 | 1292980 | 1293152 | Frame-shift |
| ENST00000360779 | 1292980 | 1293152 | Frame-shift |
| ENST00000381812 | 1292980 | 1293152 | Frame-shift |
| ENST00000339987 | 1293230 | 1293406 | Frame-shift |
| ENST00000360779 | 1293230 | 1293406 | Frame-shift |
| ENST00000381812 | 1293230 | 1293406 | Frame-shift |
| ENST00000339987 | 1298961 | 1299062 | Frame-shift |
| ENST00000360779 | 1298961 | 1299062 | Frame-shift |
| ENST00000381812 | 1298961 | 1299062 | Frame-shift |
| ENST00000339987 | 1300233 | 1300303 | Frame-shift |
| ENST00000360779 | 1300233 | 1300303 | Frame-shift |
| ENST00000381812 | 1300233 | 1300303 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for SDCBP2 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for SDCBP2 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_354281 | 1292981 | 1293152 | 1293090 | 1293090 | Frame_Shift_Del | T | - | p.K209fs |
| LIHC | TCGA-DD-A3A1-01 | exon_skip_354287 | 1293231 | 1293406 | 1293241 | 1293241 | Frame_Shift_Del | C | - | p.V184fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_354293 | 1300234 | 1300303 | 1300242 | 1300242 | Frame_Shift_Del | G | - | p.P41fs |
| BLCA | TCGA-XF-A9T0-01 | exon_skip_354287 | 1293231 | 1293406 | 1293283 | 1293283 | Nonsense_Mutation | G | A | p.Q170* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| JMSU1_URINARY_TRACT | 1292981 | 1293152 | 1293004 | 1293004 | Missense_Mutation | C | T | p.G237R |
| HCT15_LARGE_INTESTINE | 1292981 | 1293152 | 1293049 | 1293049 | Missense_Mutation | C | T | p.A222T |
| HCC515_LUNG | 1293231 | 1293406 | 1293319 | 1293319 | Missense_Mutation | G | T | p.R158S |
| UOK101_KIDNEY | 1298962 | 1299062 | 1298992 | 1298992 | Missense_Mutation | C | G | p.E65D |
| LNCAPCLONEFGC_PROSTATE | 1298962 | 1299062 | 1299045 | 1299045 | Missense_Mutation | C | A | p.A48S |
| SNU449_LIVER | 1300234 | 1300303 | 1300277 | 1300277 | Missense_Mutation | C | A | p.M27I |
| LNCAPCLONEFGC_PROSTATE | 1298962 | 1299062 | 1299036 | 1299036 | Nonsense_Mutation | C | A | p.E51* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SDCBP2 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SDCBP2 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SDCBP2 |
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RelatedDrugs for SDCBP2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SDCBP2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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