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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for RPS6KC1

check button Gene summary
Gene informationGene symbol

RPS6KC1

Gene ID

26750

Gene nameribosomal protein S6 kinase C1
SynonymsRPK118|RSKL1|S6K-delta-1|S6PKh1|humS6PKh1
Cytomap

1q32.3

Type of geneprotein-coding
Descriptionribosomal protein S6 kinase delta-152 kDa ribosomal protein S6 kinaseSPHK1-binding proteinribosomal S6 kinase-like protein with two PSK domains 118 kDa proteinribosomal protein S6 kinase, 52kDa, polypeptide 1
Modification date20180519
UniProtAcc

Q96S38

ContextPubMed: RPS6KC1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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Exon skipping events across known transcript of Ensembl for RPS6KC1 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for RPS6KC1

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for RPS6KC1

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_178651213224603:213224851:213244347:213244383:213251037:213251158213244347:213244383ENSG00000136643.7ENST00000366960.3
exon_skip_178671213224603:213224851:213251037:213251158:213277795:213277911213251037:213251158ENSG00000136643.7ENST00000366959.3,ENST00000543354.1
exon_skip_178681213244347:213244383:213246211:213246328:213251037:213251158213246211:213246328ENSG00000136643.7ENST00000543470.1
exon_skip_178691213244347:213244383:213251037:213251158:213277795:213277911213251037:213251158ENSG00000136643.7ENST00000366960.3
exon_skip_178731213251037:213251158:213277795:213277911:213290658:213290752213277795:213277911ENSG00000136643.7ENST00000543470.1,ENST00000366959.3,ENST00000366960.3
exon_skip_178741213251037:213251158:213277795:213277911:213302869:213303232213277795:213277911ENSG00000136643.7ENST00000490299.1
exon_skip_178771213277795:213277911:213290658:213290752:213302869:213303232213290658:213290752ENSG00000136643.7ENST00000543470.1,ENST00000366959.3,ENST00000366960.3
exon_skip_178821213277795:213277911:213302869:213303232:213341200:213341316213302869:213303232ENSG00000136643.7ENST00000490299.1
exon_skip_178861213290658:213290752:213302869:213303232:213341200:213341316213302869:213303232ENSG00000136643.7ENST00000543470.1,ENST00000366959.3,ENST00000366960.3
exon_skip_178891213302869:213303232:213341200:213341316:213403839:213403887213341200:213341316ENSG00000136643.7ENST00000543470.1
exon_skip_178921213341200:213341316:213349742:213349835:213403839:213403887213349742:213349835ENSG00000136643.7ENST00000366959.3,ENST00000543354.1,ENST00000366960.3,ENST00000490299.1
exon_skip_178951213341200:213341316:213403839:213403887:213405465:213405598213403839:213403887ENSG00000136643.7ENST00000543470.1
exon_skip_179001213349742:213349835:213403839:213403887:213405465:213405598213403839:213403887ENSG00000136643.7ENST00000366959.3,ENST00000543354.1,ENST00000366960.3,ENST00000490299.1
exon_skip_179061213403839:213403887:213405465:213405598:213414044:213415640213405465:213405598ENSG00000136643.7ENST00000543470.1,ENST00000366959.3,ENST00000543354.1,ENST00000366960.3,ENST00000490299.1
exon_skip_179081213405465:213405598:213414044:213416001:213434900:213434983213414044:213416001ENSG00000136643.7ENST00000543354.1
exon_skip_179091213414044:213415640:213415911:213416001:213434900:213434983213415911:213416001ENSG00000136643.7ENST00000543470.1,ENST00000366959.3,ENST00000366960.3,ENST00000490299.1
exon_skip_179111213434900:213434983:213436063:213436159:213445866:213445887213436063:213436159ENSG00000136643.7ENST00000543470.1,ENST00000366959.3,ENST00000543354.1,ENST00000366960.3,ENST00000490299.1

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for RPS6KC1

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_178651213224603:213224851:213244347:213244383:213251037:213251158213244347:213244383ENSG00000136643.7ENST00000366960.3
exon_skip_178671213224603:213224851:213251037:213251158:213277795:213277911213251037:213251158ENSG00000136643.7ENST00000366959.3,ENST00000543354.1
exon_skip_178681213244347:213244383:213246211:213246328:213251037:213251158213246211:213246328ENSG00000136643.7ENST00000543470.1
exon_skip_178691213244347:213244383:213251037:213251158:213277795:213277911213251037:213251158ENSG00000136643.7ENST00000366960.3
exon_skip_178731213251037:213251158:213277795:213277911:213290658:213290752213277795:213277911ENSG00000136643.7ENST00000543470.1,ENST00000366960.3,ENST00000366959.3
exon_skip_178741213251037:213251158:213277795:213277911:213302869:213303232213277795:213277911ENSG00000136643.7ENST00000490299.1
exon_skip_178771213277795:213277911:213290658:213290752:213302869:213303232213290658:213290752ENSG00000136643.7ENST00000543470.1,ENST00000366960.3,ENST00000366959.3
exon_skip_178821213277795:213277911:213302869:213303232:213341200:213341316213302869:213303232ENSG00000136643.7ENST00000490299.1
exon_skip_178861213290658:213290752:213302869:213303232:213341200:213341316213302869:213303232ENSG00000136643.7ENST00000543470.1,ENST00000366960.3,ENST00000366959.3
exon_skip_178891213302869:213303232:213341200:213341316:213403839:213403887213341200:213341316ENSG00000136643.7ENST00000543470.1
exon_skip_178921213341200:213341316:213349742:213349835:213403839:213403887213349742:213349835ENSG00000136643.7ENST00000366960.3,ENST00000366959.3,ENST00000543354.1,ENST00000490299.1
exon_skip_178951213341200:213341316:213403839:213403887:213405465:213405598213403839:213403887ENSG00000136643.7ENST00000543470.1
exon_skip_179001213349742:213349835:213403839:213403887:213405465:213405598213403839:213403887ENSG00000136643.7ENST00000366960.3,ENST00000366959.3,ENST00000543354.1,ENST00000490299.1
exon_skip_179061213403839:213403887:213405465:213405598:213414044:213415640213405465:213405598ENSG00000136643.7ENST00000543470.1,ENST00000366960.3,ENST00000366959.3,ENST00000543354.1,ENST00000490299.1
exon_skip_179081213405465:213405598:213414044:213416001:213434900:213434983213414044:213416001ENSG00000136643.7ENST00000543354.1
exon_skip_179091213414044:213415640:213415911:213416001:213434900:213434983213415911:213416001ENSG00000136643.7ENST00000543470.1,ENST00000366960.3,ENST00000366959.3,ENST00000490299.1
exon_skip_179111213434900:213434983:213436063:213436159:213445866:213445887213436063:213436159ENSG00000136643.7ENST00000543470.1,ENST00000366960.3,ENST00000366959.3,ENST00000543354.1,ENST00000490299.1

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for RPS6KC1

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST00000366960213251037213251158Frame-shift
ENST00000366960213277795213277911Frame-shift
ENST00000366960213290658213290752Frame-shift
ENST00000366960213405465213405598Frame-shift
ENST00000366960213244347213244383In-frame
ENST00000366960213302869213303232In-frame
ENST00000366960213349742213349835In-frame
ENST00000366960213403839213403887In-frame
ENST00000366960213415911213416001In-frame
ENST00000366960213436063213436159In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST00000366960213251037213251158Frame-shift
ENST00000366960213277795213277911Frame-shift
ENST00000366960213290658213290752Frame-shift
ENST00000366960213405465213405598Frame-shift
ENST00000366960213244347213244383In-frame
ENST00000366960213302869213303232In-frame
ENST00000366960213349742213349835In-frame
ENST00000366960213403839213403887In-frame
ENST00000366960213415911213416001In-frame
ENST00000366960213436063213436159In-frame

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Infer the effects of exon skipping event on protein functional features for RPS6KC1

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST00000366960550710662132443472132443832562913547
ENST0000036696055071066213302869213303232623985157278
ENST000003669605507106621334974221334983511021194317348
ENST000003669605507106621340383921340388711951242348364
ENST000003669605507106621341591121341600129723061940970
ENST0000036696055071066213436063213436159314532409981030

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST00000366960550710662132443472132443832562913547
ENST0000036696055071066213302869213303232623985157278
ENST000003669605507106621334974221334983511021194317348
ENST000003669605507106621340383921340388711951242348364
ENST000003669605507106621341591121341600129723061940970
ENST0000036696055071066213436063213436159314532409981030

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q96S3835473647Alternative sequenceID=VSP_046333;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q96S38354711066ChainID=PRO_0000233127;Note=Ribosomal protein S6 kinase delta-1
Q96S3835478132DomainNote=PX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00147
Q96S3835474242Natural variantID=VAR_040647;Note=P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56087470,PMID:17344846
Q96S3835473535Sequence conflictNote=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q96S3815727811066ChainID=PRO_0000233127;Note=Ribosomal protein S6 kinase delta-1
Q96S38157278277305DomainNote=MIT
Q96S38157278250250Sequence conflictNote=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q96S3831734811066ChainID=PRO_0000233127;Note=Ribosomal protein S6 kinase delta-1
Q96S38317348344445DomainNote=Protein kinase 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q96S38317348319319Natural variantID=VAR_040649;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56369827,PMID:17344846
Q96S3834836411066ChainID=PRO_0000233127;Note=Ribosomal protein S6 kinase delta-1
Q96S38348364344445DomainNote=Protein kinase 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q96S3894097011066ChainID=PRO_0000233127;Note=Ribosomal protein S6 kinase delta-1
Q96S389409707941056DomainNote=Protein kinase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q96S38998103011066ChainID=PRO_0000233127;Note=Ribosomal protein S6 kinase delta-1
Q96S3899810307941056DomainNote=Protein kinase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q96S38998103010031003Natural variantID=VAR_040656;Note=In a lung adenocarcinoma sample%3B somatic mutation. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
Q96S38998103010221022Natural variantID=VAR_040657;Note=In a breast infiltrating ductal carcinoma sample%3B somatic mutation. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q96S3835473647Alternative sequenceID=VSP_046333;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q96S38354711066ChainID=PRO_0000233127;Note=Ribosomal protein S6 kinase delta-1
Q96S3835478132DomainNote=PX;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00147
Q96S3835474242Natural variantID=VAR_040647;Note=P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56087470,PMID:17344846
Q96S3835473535Sequence conflictNote=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q96S3815727811066ChainID=PRO_0000233127;Note=Ribosomal protein S6 kinase delta-1
Q96S38157278277305DomainNote=MIT
Q96S38157278250250Sequence conflictNote=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q96S3831734811066ChainID=PRO_0000233127;Note=Ribosomal protein S6 kinase delta-1
Q96S38317348344445DomainNote=Protein kinase 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q96S38317348319319Natural variantID=VAR_040649;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56369827,PMID:17344846
Q96S3834836411066ChainID=PRO_0000233127;Note=Ribosomal protein S6 kinase delta-1
Q96S38348364344445DomainNote=Protein kinase 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q96S3894097011066ChainID=PRO_0000233127;Note=Ribosomal protein S6 kinase delta-1
Q96S389409707941056DomainNote=Protein kinase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q96S38998103011066ChainID=PRO_0000233127;Note=Ribosomal protein S6 kinase delta-1
Q96S3899810307941056DomainNote=Protein kinase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
Q96S38998103010031003Natural variantID=VAR_040656;Note=In a lung adenocarcinoma sample%3B somatic mutation. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846
Q96S38998103010221022Natural variantID=VAR_040657;Note=In a breast infiltrating ductal carcinoma sample%3B somatic mutation. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846


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SNVs in the skipped exons for RPS6KC1

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
STADTCGA-BR-4362-01exon_skip_17873
exon_skip_17874
213277796213277911213277903213277903Frame_Shift_DelT-p.D123fs
KIRPTCGA-2Z-A9J3-01exon_skip_17882
exon_skip_17886
213302870213303232213302993213302993Frame_Shift_DelC-p.S199fs
LIHCTCGA-G3-A3CJ-01exon_skip_17908
213414045213416001213414119213414119Frame_Shift_DelA-p.K435fs
LIHCTCGA-G3-A3CJ-01exon_skip_17908
213414045213416001213414668213414668Frame_Shift_DelT-p.F617fs
LIHCTCGA-DD-A39Y-01exon_skip_17908
213414045213416001213415378213415378Frame_Shift_DelG-p.L853fs
LIHCTCGA-DD-A3A0-01exon_skip_17908
213414045213416001213415431213415431Frame_Shift_DelA-p.E871fs
LUSCTCGA-37-4135-01exon_skip_17869
exon_skip_17867
213251038213251158213251154213251155Frame_Shift_Ins-Tp.V86fs
UCECTCGA-BS-A0UJ-01exon_skip_17908
213414045213416001213415093213415094Frame_Shift_Ins-Ap.S759fs
LGGTCGA-DU-6392-01exon_skip_17873
exon_skip_17874
213277796213277911213277798213277798Nonsense_MutationCTp.R89*
LUADTCGA-99-8028-01exon_skip_17882
exon_skip_17886
213302870213303232213303052213303052Nonsense_MutationGTp.E219*
UCECTCGA-AP-A056-01exon_skip_17889
213341201213341316213341224213341224Nonsense_MutationGTp.E287*
UCSTCGA-ND-A4WC-01exon_skip_17908
213414045213416001213414614213414614Nonsense_MutationGTp.E599*
UCSTCGA-ND-A4WC-01exon_skip_17908
213414045213416001213414614213414614Nonsense_MutationGTp.E599X
READTCGA-AF-6136-01exon_skip_17908
213414045213416001213414659213414659Nonsense_MutationGTp.G614X
HNSCTCGA-CR-6484-01exon_skip_17908
213414045213416001213414696213414696Nonsense_MutationCAp.S626*
LUADTCGA-17-Z000-01exon_skip_17908
213414045213416001213414788213414788Nonsense_MutationCTp.Q657*
UCECTCGA-BS-A0UF-01exon_skip_17908
213414045213416001213414983213414983Nonsense_MutationGTp.E722*
HNSCTCGA-BA-7269-01exon_skip_17911
213436064213436159213436154213436154Nonsense_MutationCTp.Q1029*
KIRPTCGA-A4-7732-01exon_skip_17865
213244348213244383213244385213244385Splice_SiteTC.

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
EB2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE213436064213436159213436140213436141Frame_Shift_DelCT-p.A1024fs
KE37_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE213414045213416001213415489213415490Frame_Shift_Ins-Ap.K891fs
SNU1197_LARGE_INTESTINE213244348213244383213244367213244367Missense_MutationCTp.P42L
LS411N_LARGE_INTESTINE213277796213277911213277847213277847Missense_MutationTCp.L105P
SKMEL2_SKIN213290659213290752213290731213290731Missense_MutationTCp.F151L
NCIH2029_LUNG213302870213303232213302902213302902Missense_MutationACp.T169P
HT3_CERVIX213302870213303232213302918213302918Missense_MutationCTp.S174F
RKO_LARGE_INTESTINE213302870213303232213303065213303065Missense_MutationGAp.R223H
SNU81_LARGE_INTESTINE213302870213303232213303107213303107Missense_MutationGTp.R237I
639V_URINARY_TRACT213302870213303232213303226213303226Missense_MutationGAp.V277I
VMRCRCZ_KIDNEY213341201213341316213341264213341264Missense_MutationCAp.A300E
BICR18_UPPER_AERODIGESTIVE_TRACT213349743213349835213349771213349771Missense_MutationTCp.L327P
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE213349743213349835213349771213349771Missense_MutationTCp.L327P
BICR18_UPPER_AERODIGESTIVE_TRACT213349743213349835213349777213349777Missense_MutationAGp.N329S
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE213349743213349835213349777213349777Missense_MutationAGp.N329S
HCC202_BREAST213349743213349835213349778213349778Missense_MutationCGp.N329K
JHUEM7_ENDOMETRIUM213349743213349835213349830213349830Missense_MutationGTp.D347Y
MCCAR_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE213403840213403887213403856213403856Missense_MutationAGp.D354G
NO10_CENTRAL_NERVOUS_SYSTEM213403840213403887213403870213403870Missense_MutationCGp.Q359E
UACC812_BREAST213403840213403887213403874213403874Missense_MutationCTp.T360I
ISHIKAWAHERAKLIO02ER_ENDOMETRIUM213405466213405598213405533213405533Missense_MutationTCp.M387T
HEC108_ENDOMETRIUM213405466213405598213405551213405551Missense_MutationAGp.Y393C
GP2D_LARGE_INTESTINE213405466213405598213405572213405572Missense_MutationTCp.V400A
GP5D_LARGE_INTESTINE213405466213405598213405572213405572Missense_MutationTCp.V400A
EFO27_OVARY213414045213416001213414090213414090Missense_MutationCAp.P424H
NCIH2110_LUNG213414045213416001213414260213414260Missense_MutationCGp.Q481E
JHH7_LIVER213414045213416001213414336213414336Missense_MutationACp.E506A
NCIH1755_LUNG213414045213416001213414342213414342Missense_MutationGTp.C508F
KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE213414045213416001213414363213414363Missense_MutationTCp.L515S
JMSU1_URINARY_TRACT213414045213416001213414411213414411Missense_MutationACp.E531A
NCIH1770_LUNG213414045213416001213414479213414479Missense_MutationCAp.L554I
NCIH2106_LUNG213414045213416001213414479213414479Missense_MutationCAp.L554I
SNU1040_LARGE_INTESTINE213414045213416001213414608213414608Missense_MutationCTp.P597S
SNU81_LARGE_INTESTINE213414045213416001213414619213414619Missense_MutationCAp.F600L
DBTRG05MG_CENTRAL_NERVOUS_SYSTEM213414045213416001213414750213414750Missense_MutationGAp.S644N
ZR7530_BREAST213414045213416001213414834213414834Missense_MutationCTp.S672L
GIMEN_AUTONOMIC_GANGLIA213414045213416001213414842213414842Missense_MutationGTp.D675Y
HLFA_FIBROBLAST213414045213416001213414861213414861Missense_MutationTCp.V681A
TOV21G_OVARY213414045213416001213414979213414979Missense_MutationAGp.I720M
HEC251_ENDOMETRIUM213414045213416001213415011213415011Missense_MutationTCp.V731A
HCT15_LARGE_INTESTINE213414045213416001213415019213415019Missense_MutationCAp.L734I
HRT18_LARGE_INTESTINE213414045213416001213415019213415019Missense_MutationCAp.L734I
NCIH1155_LUNG213414045213416001213415046213415046Missense_MutationGAp.A743T
HEC151_ENDOMETRIUM213414045213416001213415059213415059Missense_MutationAGp.K747R
SKM1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE213414045213416001213415059213415059Missense_MutationAGp.K747R
JHH4_LIVER213414045213416001213415059213415059Missense_MutationAGp.K747R
IGROV1_OVARY213414045213416001213415066213415066Missense_MutationAGp.I749M
VAL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE213414045213416001213415182213415182Missense_MutationAGp.D788G
G401_SOFT_TISSUE213414045213416001213415211213415211Missense_MutationACp.K798Q
MEWO_SKIN213414045213416001213415292213415292Missense_MutationCTp.L825F
HUNS1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE213414045213416001213415366213415366Missense_MutationGTp.Q849H
LNCAPCLONEFGC_PROSTATE213414045213416001213415509213415509Missense_MutationCAp.S897Y
HEC1A_ENDOMETRIUM213414045213416001213415544213415544Missense_MutationTCp.W909R
HEC1_ENDOMETRIUM213414045213416001213415544213415544Missense_MutationTCp.W909R
HEC1B_ENDOMETRIUM213414045213416001213415544213415544Missense_MutationTCp.W909R
NCIH841_LUNG213414045213416001213415612213415612Missense_MutationCGp.N931K
BICR18_UPPER_AERODIGESTIVE_TRACT213414045213416001213415637213415637Missense_MutationAGp.R940G
BICR18_UPPER_AERODIGESTIVE_TRACT213415912213416001213415977213415977Missense_MutationAGp.I963V
BICR18_UPPER_AERODIGESTIVE_TRACT213414045213416001213415977213415977Missense_MutationAGp.I963V
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE213415912213416001213415977213415977Missense_MutationAGp.I963V
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE213414045213416001213415977213415977Missense_MutationAGp.I963V
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE213415912213416001213415981213415981Missense_MutationACp.E964A
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE213414045213416001213415981213415981Missense_MutationACp.E964A
BICR18_UPPER_AERODIGESTIVE_TRACT213415912213416001213415981213415981Missense_MutationACp.E964A
BICR18_UPPER_AERODIGESTIVE_TRACT213414045213416001213415981213415981Missense_MutationACp.E964A
HCC2450_LUNG213436064213436159213436082213436082Missense_MutationCTp.P1005S
HCC2218_BREAST213436064213436159213436133213436133Missense_MutationGAp.E1022K
YKG1_CENTRAL_NERVOUS_SYSTEM213436064213436159213436140213436140Missense_MutationCAp.A1024D
HT115_LARGE_INTESTINE213251038213251158213251049213251049Nonsense_MutationGAp.W51*
MHHNB11_AUTONOMIC_GANGLIA213290659213290752213290711213290711Nonsense_MutationCAp.S144*
NCIH3255_LUNG213414045213416001213414260213414260Nonsense_MutationCTp.Q481*
SW156_KIDNEY213414045213416001213414878213414878Nonsense_MutationGTp.G687*
SNU81_LARGE_INTESTINE213414045213416001213414983213414983Nonsense_MutationGTp.E722*
U87MG_CENTRAL_NERVOUS_SYSTEM213414045213416001213415037213415037Nonsense_MutationCTp.Q740*
NCIH211_LUNG213244348213244383213244348213244348Splice_SiteGTp.V36F

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for RPS6KC1

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RPS6KC1


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RPS6KC1


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RelatedDrugs for RPS6KC1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RPS6KC1

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource