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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for CKAP2 |
 Gene summary |
| Gene information | Gene symbol | CKAP2 | Gene ID | 26586 |
| Gene name | cytoskeleton associated protein 2 | |
| Synonyms | LB1|TMAP|se20-10 | |
| Cytomap | 13q14.3 | |
| Type of gene | protein-coding | |
| Description | cytoskeleton-associated protein 2CTCL tumor antigen se20-10tumor- and microtubule-associated proteintumor-associated microtubule-associated protein | |
| Modification date | 20180519 | |
| UniProtAcc | Q8WWK9 | |
| Context | PubMed: CKAP2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for CKAP2 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for CKAP2 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for CKAP2 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_100608 | 13 | 53030657:53030742:53035030:53035109:53035192:53035393 | 53035030:53035109 | ENSG00000136108.10 | ENST00000378037.5,ENST00000480747.1 |
| exon_skip_100609 | 13 | 53030657:53030742:53035033:53035109:53035192:53035393 | 53035033:53035109 | ENSG00000136108.10 | ENST00000378034.3,ENST00000490903.1,ENST00000258607.5 |
| exon_skip_100612 | 13 | 53039429:53039600:53042412:53042482:53047963:53048219 | 53042412:53042482 | ENSG00000136108.10 | ENST00000490903.1,ENST00000378037.5,ENST00000258607.5 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for CKAP2 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_100608 | 13 | 53030657:53030742:53035030:53035109:53035192:53035393 | 53035030:53035109 | ENSG00000136108.10 | ENST00000378037.5,ENST00000480747.1 |
| exon_skip_100609 | 13 | 53030657:53030742:53035033:53035109:53035192:53035393 | 53035033:53035109 | ENSG00000136108.10 | ENST00000378034.3,ENST00000258607.5,ENST00000490903.1 |
| exon_skip_100612 | 13 | 53039429:53039600:53042412:53042482:53047963:53048219 | 53042412:53042482 | ENSG00000136108.10 | ENST00000258607.5,ENST00000378037.5,ENST00000490903.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for CKAP2 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000378037 | 53035030 | 53035109 | Frame-shift |
| ENST00000378037 | 53042412 | 53042482 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000378037 | 53035030 | 53035109 | Frame-shift |
| ENST00000378037 | 53042412 | 53042482 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for CKAP2 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for CKAP2 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| KICH | TCGA-KO-8407-01 | exon_skip_100608 exon_skip_100609 | 53035031 | 53035109 | 53035065 | 53035065 | Nonsense_Mutation | C | T | p.Q64X |
| KICH | TCGA-KO-8407-01 | exon_skip_100608 exon_skip_100609 | 53035034 | 53035109 | 53035065 | 53035065 | Nonsense_Mutation | C | T | p.Q64X |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| IGR1_SKIN | 53035031 | 53035109 | 53035096 | 53035096 | Missense_Mutation | T | G | p.L74R |
| IGR1_SKIN | 53035034 | 53035109 | 53035096 | 53035096 | Missense_Mutation | T | G | p.L74R |
| CTV1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 53042413 | 53042482 | 53042473 | 53042473 | Missense_Mutation | G | T | p.A514S |
| HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 53042413 | 53042482 | 53042479 | 53042479 | Missense_Mutation | T | G | p.L516V |
| SNU1040_LARGE_INTESTINE | 53042413 | 53042482 | 53042428 | 53042428 | Nonsense_Mutation | C | T | p.R499* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CKAP2 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CKAP2 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CKAP2 |
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RelatedDrugs for CKAP2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CKAP2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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