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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for UBXN7 |
 Gene summary |
| Gene information | Gene symbol | UBXN7 | Gene ID | 26043 |
| Gene name | UBX domain protein 7 | |
| Synonyms | UBXD7 | |
| Cytomap | 3q29 | |
| Type of gene | protein-coding | |
| Description | UBX domain-containing protein 7UBX domain containing 7 | |
| Modification date | 20180519 | |
| UniProtAcc | O94888 | |
| Context | PubMed: UBXN7 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for UBXN7 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for UBXN7 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for UBXN7 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_420656 | 3 | 196083507:196083717:196088714:196088794:196089164:196089415 | 196088714:196088794 | ENSG00000163960.7 | ENST00000535858.1,ENST00000429160.1,ENST00000296328.4,ENST00000428095.1 |
| exon_skip_420657 | 3 | 196089164:196089558:196094898:196095026:196096291:196096382 | 196094898:196095026 | ENSG00000163960.7 | ENST00000535858.1,ENST00000429160.1,ENST00000296328.4,ENST00000428095.1 |
| exon_skip_420660 | 3 | 196094898:196095026:196096291:196096382:196098766:196098913 | 196096291:196096382 | ENSG00000163960.7 | ENST00000535858.1,ENST00000429160.1,ENST00000296328.4,ENST00000428095.1 |
| exon_skip_420661 | 3 | 196096291:196096382:196098766:196098913:196118683:196118796 | 196098766:196098913 | ENSG00000163960.7 | ENST00000535858.1,ENST00000429160.1,ENST00000296328.4 |
| exon_skip_420663 | 3 | 196118708:196118796:196120424:196120490:196129822:196129890 | 196120424:196120490 | ENSG00000163960.7 | ENST00000535858.1,ENST00000429160.1,ENST00000296328.4 |
| exon_skip_420666 | 3 | 196120451:196120490:196129822:196129890:196134116:196134264 | 196129822:196129890 | ENSG00000163960.7 | ENST00000413584.1,ENST00000296328.4 |
| exon_skip_420667 | 3 | 196120451:196120490:196129822:196129890:196159197:196159268 | 196129822:196129890 | ENSG00000163960.7 | ENST00000535858.1,ENST00000429160.1 |
| exon_skip_420669 | 3 | 196129822:196129890:196134116:196134264:196159197:196159268 | 196134116:196134264 | ENSG00000163960.7 | ENST00000381887.3,ENST00000493566.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for UBXN7 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_420656 | 3 | 196083507:196083717:196088714:196088794:196089164:196089415 | 196088714:196088794 | ENSG00000163960.7 | ENST00000296328.4,ENST00000429160.1,ENST00000428095.1,ENST00000535858.1 |
| exon_skip_420657 | 3 | 196089164:196089558:196094898:196095026:196096291:196096382 | 196094898:196095026 | ENSG00000163960.7 | ENST00000296328.4,ENST00000429160.1,ENST00000428095.1,ENST00000535858.1 |
| exon_skip_420660 | 3 | 196094898:196095026:196096291:196096382:196098766:196098913 | 196096291:196096382 | ENSG00000163960.7 | ENST00000296328.4,ENST00000429160.1,ENST00000428095.1,ENST00000535858.1 |
| exon_skip_420663 | 3 | 196118708:196118796:196120424:196120490:196129822:196129890 | 196120424:196120490 | ENSG00000163960.7 | ENST00000296328.4,ENST00000429160.1,ENST00000535858.1 |
| exon_skip_420666 | 3 | 196120451:196120490:196129822:196129890:196134116:196134264 | 196129822:196129890 | ENSG00000163960.7 | ENST00000296328.4,ENST00000413584.1 |
| exon_skip_420667 | 3 | 196120451:196120490:196129822:196129890:196159197:196159268 | 196129822:196129890 | ENSG00000163960.7 | ENST00000429160.1,ENST00000535858.1 |
| exon_skip_420669 | 3 | 196129822:196129890:196134116:196134264:196159197:196159268 | 196134116:196134264 | ENSG00000163960.7 | ENST00000381887.3,ENST00000493566.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for UBXN7 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000296328 | 196088714 | 196088794 | Frame-shift |
| ENST00000296328 | 196094898 | 196095026 | Frame-shift |
| ENST00000296328 | 196096291 | 196096382 | Frame-shift |
| ENST00000296328 | 196129822 | 196129890 | Frame-shift |
| ENST00000296328 | 196098766 | 196098913 | In-frame |
| ENST00000296328 | 196120424 | 196120490 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000296328 | 196088714 | 196088794 | Frame-shift |
| ENST00000296328 | 196094898 | 196095026 | Frame-shift |
| ENST00000296328 | 196096291 | 196096382 | Frame-shift |
| ENST00000296328 | 196129822 | 196129890 | Frame-shift |
| ENST00000296328 | 196120424 | 196120490 | In-frame |
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Infer the effects of exon skipping event on protein functional features for UBXN7 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000296328 | 10585 | 489 | 196120424 | 196120490 | 365 | 430 | 96 | 118 |
| ENST00000296328 | 10585 | 489 | 196098766 | 196098913 | 544 | 690 | 156 | 205 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000296328 | 10585 | 489 | 196120424 | 196120490 | 365 | 430 | 96 | 118 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O94888 | 96 | 118 | 2 | 489 | Chain | ID=PRO_0000211035;Note=UBX domain-containing protein 7 |
| O94888 | 96 | 118 | 99 | 99 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) |
| O94888 | 156 | 205 | 167 | 173 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DLX |
| O94888 | 156 | 205 | 201 | 210 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DLX |
| O94888 | 156 | 205 | 2 | 489 | Chain | ID=PRO_0000211035;Note=UBX domain-containing protein 7 |
| O94888 | 156 | 205 | 154 | 164 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DLX |
| O94888 | 156 | 205 | 180 | 186 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DLX |
| O94888 | 156 | 205 | 191 | 199 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DLX |
| O94888 | 156 | 205 | 177 | 179 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DLX |
| O94888 | 156 | 205 | 187 | 189 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2DLX |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O94888 | 96 | 118 | 2 | 489 | Chain | ID=PRO_0000211035;Note=UBX domain-containing protein 7 |
| O94888 | 96 | 118 | 99 | 99 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) |
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SNVs in the skipped exons for UBXN7 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HNSC | TCGA-F7-A624-01 | exon_skip_420656 | 196088715 | 196088794 | 196088753 | 196088753 | Frame_Shift_Del | T | - | p.R424fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_420656 | 196088715 | 196088794 | 196088753 | 196088753 | Frame_Shift_Del | T | - | p.R424fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_420656 | 196088715 | 196088794 | 196088753 | 196088753 | Frame_Shift_Del | T | - | p.R424fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_420656 | 196088715 | 196088794 | 196088753 | 196088753 | Frame_Shift_Del | T | - | p.R424fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_420657 | 196094899 | 196095026 | 196094917 | 196094917 | Frame_Shift_Del | G | - | p.P272fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_420657 | 196094899 | 196095026 | 196094917 | 196094917 | Frame_Shift_Del | G | - | p.P272fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_420657 | 196094899 | 196095026 | 196094917 | 196094917 | Frame_Shift_Del | G | - | p.P272fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_420657 | 196094899 | 196095026 | 196094917 | 196094917 | Frame_Shift_Del | G | - | p.P272fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_420657 | 196094899 | 196095026 | 196094984 | 196094984 | Frame_Shift_Del | A | - | p.F250fs |
| STAD | TCGA-BR-4370-01 | exon_skip_420660 | 196096292 | 196096382 | 196096324 | 196096324 | Frame_Shift_Del | A | - | p.F225fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_420661 | 196098767 | 196098913 | 196098861 | 196098861 | Frame_Shift_Del | T | - | p.N174fs |
| STAD | TCGA-BR-4187-01 | exon_skip_420663 | 196120425 | 196120490 | 196120448 | 196120448 | Frame_Shift_Del | A | - | p.F111fs |
| LIHC | TCGA-CC-5264-01 | exon_skip_420669 | 196134117 | 196134264 | 196134222 | 196134222 | Frame_Shift_Del | T | - | p.N39fs |
| LIHC | TCGA-CC-5264-01 | exon_skip_420669 | 196134117 | 196134264 | 196134222 | 196134222 | Frame_Shift_Del | T | - | p.N41fs |
| COAD | TCGA-AD-6889-01 | exon_skip_420657 | 196094899 | 196095026 | 196094916 | 196094917 | Frame_Shift_Ins | - | G | p.K273fs |
| STAD | TCGA-BR-8284-01 | exon_skip_420661 | 196098767 | 196098913 | 196098766 | 196098766 | Splice_Site | C | T | p.Q205_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| CL34_LARGE_INTESTINE | 196094899 | 196095026 | 196094911 | 196094911 | Frame_Shift_Del | T | - | p.K274fs |
| LIM1215_LARGE_INTESTINE | 196094899 | 196095026 | 196094911 | 196094911 | Frame_Shift_Del | T | - | p.K274fs |
| EN_ENDOMETRIUM | 196094899 | 196095026 | 196094910 | 196094911 | Frame_Shift_Ins | - | T | p.C275fs |
| SNGM_ENDOMETRIUM | 196088715 | 196088794 | 196088770 | 196088770 | Missense_Mutation | C | T | p.R418Q |
| IHH4_THYROID | 196094899 | 196095026 | 196094930 | 196094930 | Missense_Mutation | G | C | p.S268C |
| NO10_CENTRAL_NERVOUS_SYSTEM | 196094899 | 196095026 | 196094930 | 196094930 | Missense_Mutation | G | C | p.S268C |
| CCK81_LARGE_INTESTINE | 196096292 | 196096382 | 196096352 | 196096352 | Missense_Mutation | A | G | p.Y216H |
| CMLT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 196098767 | 196098913 | 196098807 | 196098807 | Missense_Mutation | G | A | p.A192V |
| HEC59_ENDOMETRIUM | 196098767 | 196098913 | 196098811 | 196098811 | Missense_Mutation | C | T | p.E191K |
| PECAPJ15_UPPER_AERODIGESTIVE_TRACT | 196098767 | 196098913 | 196098867 | 196098867 | Missense_Mutation | A | T | p.I172N |
| TK10_KIDNEY | 196098767 | 196098913 | 196098867 | 196098867 | Missense_Mutation | A | C | p.I172S |
| CROAP2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 196120425 | 196120490 | 196120463 | 196120463 | Missense_Mutation | G | A | p.S106L |
| SNU1040_LARGE_INTESTINE | 196134117 | 196134264 | 196134120 | 196134120 | Missense_Mutation | G | A | p.T73I |
| PANC0813_PANCREAS | 196134117 | 196134264 | 196134148 | 196134148 | Missense_Mutation | C | G | p.A64P |
| EBC1_LUNG | 196134117 | 196134264 | 196134172 | 196134172 | Missense_Mutation | C | T | p.A56T |
| LS411N_LARGE_INTESTINE | 196134117 | 196134264 | 196134180 | 196134180 | Missense_Mutation | C | T | p.G53E |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for UBXN7 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for UBXN7 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for UBXN7 |
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RelatedDrugs for UBXN7 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UBXN7 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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