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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for CNOT10

check button Gene summary
Gene informationGene symbol

CNOT10

Gene ID

25904

Gene nameCCR4-NOT transcription complex subunit 10
Synonyms-
Cytomap

3p22.3

Type of geneprotein-coding
DescriptionCCR4-NOT transcription complex subunit 10
Modification date20180523
UniProtAcc

Q9H9A5

ContextPubMed: CNOT10 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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Exon skipping events across known transcript of Ensembl for CNOT10 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for CNOT10

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for CNOT10

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_372443332726855:32726974:32745359:32745454:32750161:3275026732745359:32745454ENSG00000182973.14ENST00000435630.1
exon_skip_372446332745359:32745454:32746302:32746464:32750161:3275026732746302:32746464ENSG00000182973.14ENST00000463006.1,ENST00000538368.1,ENST00000485136.1,ENST00000454516.2,ENST00000331889.6,ENST00000328834.5
exon_skip_372448332750188:32750312:32754718:32754861:32757716:3275780332754718:32754861ENSG00000182973.14ENST00000494439.1,ENST00000556853.1,ENST00000454516.2,ENST00000331889.6,ENST00000328834.5,ENST00000435630.1,ENST00000416457.1
exon_skip_372450332754718:32754861:32757716:32757803:32758645:3275872932757716:32757803ENSG00000182973.14ENST00000454516.2,ENST00000331889.6,ENST00000328834.5,ENST00000435630.1,ENST00000416457.1
exon_skip_372453332757716:32757803:32758645:32758729:32761605:3276172332758645:32758729ENSG00000182973.14ENST00000538368.1,ENST00000463697.1,ENST00000454516.2,ENST00000331889.6,ENST00000328834.5,ENST00000435630.1,ENST00000455381.1
exon_skip_372454332758645:32758729:32761605:32761723:32766941:3276709132761605:32761723ENSG00000182973.14ENST00000538368.1,ENST00000463697.1,ENST00000454516.2,ENST00000331889.6,ENST00000328834.5,ENST00000435630.1,ENST00000455381.1
exon_skip_372455332761605:32761723:32766941:32767091:32769159:3276930032766941:32767091ENSG00000182973.14ENST00000538368.1,ENST00000463697.1,ENST00000454516.2,ENST00000331889.6,ENST00000328834.5,ENST00000435630.1,ENST00000455381.1
exon_skip_372456332766941:32767091:32769159:32769362:32774914:3277503632769159:32769362ENSG00000182973.14ENST00000538368.1,ENST00000454516.2,ENST00000331889.6,ENST00000328834.5,ENST00000435630.1,ENST00000416457.1
exon_skip_372462332774914:32775036:32776291:32776468:32778901:3277898232776291:32776468ENSG00000182973.14ENST00000538368.1,ENST00000454516.2,ENST00000328834.5,ENST00000416457.1
exon_skip_372464332774914:32775036:32776291:32776468:32800949:3280106332776291:32776468ENSG00000182973.14ENST00000331889.6,ENST00000435630.1
exon_skip_372467332776313:32776468:32778901:32778982:32800949:3280106332778901:32778982ENSG00000182973.14ENST00000430408.1,ENST00000538368.1,ENST00000454516.2,ENST00000328834.5,ENST00000416457.1
exon_skip_372471332776313:32776468:32800949:32801063:32804224:3280435532800949:32801063ENSG00000182973.14ENST00000331889.6,ENST00000435630.1
exon_skip_372472332778904:32778982:32800949:32801063:32804224:3280435532800949:32801063ENSG00000182973.14ENST00000430408.1,ENST00000538368.1,ENST00000454516.2,ENST00000328834.5,ENST00000416457.1
exon_skip_372473332800949:32801063:32804224:32804355:32805946:3280598232804224:32804355ENSG00000182973.14ENST00000471003.2,ENST00000454516.2,ENST00000331889.6,ENST00000328834.5,ENST00000435630.1,ENST00000416457.1
exon_skip_372474332800949:32801063:32804224:32804355:32806173:3280630132804224:32804355ENSG00000182973.14ENST00000430408.1
exon_skip_372479332804328:32804355:32805946:32805982:32806173:3280630132805946:32805982ENSG00000182973.14ENST00000471003.2,ENST00000454516.2,ENST00000331889.6,ENST00000328834.5,ENST00000435630.1,ENST00000416457.1
exon_skip_372482332806173:32806301:32806541:32806669:32814948:3281510832806541:32806669ENSG00000182973.14ENST00000435630.1
exon_skip_372487332806173:32806301:32811378:32811454:32814948:3281500432811378:32811454ENSG00000182973.14ENST00000454516.2,ENST00000331889.6,ENST00000328834.5,ENST00000416457.1

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for CNOT10

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_372443332726855:32726974:32745359:32745454:32750161:3275026732745359:32745454ENSG00000182973.14ENST00000435630.1
exon_skip_372446332745359:32745454:32746302:32746464:32750161:3275026732746302:32746464ENSG00000182973.14ENST00000331889.6,ENST00000328834.5,ENST00000538368.1,ENST00000463006.1,ENST00000454516.2,ENST00000485136.1
exon_skip_372448332750188:32750312:32754718:32754861:32757716:3275780332754718:32754861ENSG00000182973.14ENST00000331889.6,ENST00000328834.5,ENST00000435630.1,ENST00000556853.1,ENST00000494439.1,ENST00000454516.2,ENST00000416457.1
exon_skip_372450332754718:32754861:32757716:32757803:32758645:3275872932757716:32757803ENSG00000182973.14ENST00000331889.6,ENST00000328834.5,ENST00000435630.1,ENST00000454516.2,ENST00000416457.1
exon_skip_372453332757716:32757803:32758645:32758729:32761605:3276172332758645:32758729ENSG00000182973.14ENST00000331889.6,ENST00000328834.5,ENST00000435630.1,ENST00000538368.1,ENST00000454516.2,ENST00000455381.1,ENST00000463697.1
exon_skip_372454332758645:32758729:32761605:32761723:32766941:3276709132761605:32761723ENSG00000182973.14ENST00000331889.6,ENST00000328834.5,ENST00000435630.1,ENST00000538368.1,ENST00000454516.2,ENST00000455381.1,ENST00000463697.1
exon_skip_372455332761605:32761723:32766941:32767091:32769159:3276930032766941:32767091ENSG00000182973.14ENST00000331889.6,ENST00000328834.5,ENST00000435630.1,ENST00000538368.1,ENST00000454516.2,ENST00000455381.1,ENST00000463697.1
exon_skip_372456332766941:32767091:32769159:32769362:32774914:3277503632769159:32769362ENSG00000182973.14ENST00000331889.6,ENST00000328834.5,ENST00000435630.1,ENST00000538368.1,ENST00000454516.2,ENST00000416457.1
exon_skip_372462332774914:32775036:32776291:32776468:32778901:3277898232776291:32776468ENSG00000182973.14ENST00000328834.5,ENST00000538368.1,ENST00000454516.2,ENST00000416457.1
exon_skip_372464332774914:32775036:32776291:32776468:32800949:3280106332776291:32776468ENSG00000182973.14ENST00000331889.6,ENST00000435630.1
exon_skip_372467332776313:32776468:32778901:32778982:32800949:3280106332778901:32778982ENSG00000182973.14ENST00000328834.5,ENST00000538368.1,ENST00000454516.2,ENST00000416457.1,ENST00000430408.1
exon_skip_372471332776313:32776468:32800949:32801063:32804224:3280435532800949:32801063ENSG00000182973.14ENST00000331889.6,ENST00000435630.1
exon_skip_372472332778904:32778982:32800949:32801063:32804224:3280435532800949:32801063ENSG00000182973.14ENST00000328834.5,ENST00000538368.1,ENST00000454516.2,ENST00000416457.1,ENST00000430408.1
exon_skip_372473332800949:32801063:32804224:32804355:32805946:3280598232804224:32804355ENSG00000182973.14ENST00000331889.6,ENST00000328834.5,ENST00000435630.1,ENST00000454516.2,ENST00000416457.1,ENST00000471003.2
exon_skip_372474332800949:32801063:32804224:32804355:32806173:3280630132804224:32804355ENSG00000182973.14ENST00000430408.1
exon_skip_372479332804328:32804355:32805946:32805982:32806173:3280630132805946:32805982ENSG00000182973.14ENST00000331889.6,ENST00000328834.5,ENST00000435630.1,ENST00000454516.2,ENST00000416457.1,ENST00000471003.2
exon_skip_372482332806173:32806301:32806541:32806669:32814948:3281510832806541:32806669ENSG00000182973.14ENST00000435630.1
exon_skip_372487332806173:32806301:32811378:32811454:32814948:3281500432811378:32811454ENSG00000182973.14ENST00000331889.6,ENST00000328834.5,ENST00000454516.2,ENST00000416457.1

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for CNOT10

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003288343275471832754861Frame-shift
ENST000003288343276160532761723Frame-shift
ENST000003288343276915932769362Frame-shift
ENST000003288343280422432804355Frame-shift
ENST000003288343281137832811454Frame-shift
ENST000003288343274630232746464In-frame
ENST000003288343275771632757803In-frame
ENST000003288343275864532758729In-frame
ENST000003288343276694132767091In-frame
ENST000003288343277629132776468In-frame
ENST000003288343277890132778982In-frame
ENST000003288343280094932801063In-frame
ENST000003288343280594632805982In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003288343275471832754861Frame-shift
ENST000003288343276160532761723Frame-shift
ENST000003288343276915932769362Frame-shift
ENST000003288343280422432804355Frame-shift
ENST000003288343281137832811454Frame-shift
ENST000003288343274630232746464In-frame
ENST000003288343275771632757803In-frame
ENST000003288343275864532758729In-frame
ENST000003288343276694132767091In-frame
ENST000003288343277629132776468In-frame
ENST000003288343277890132778982In-frame
ENST000003288343280094932801063In-frame
ENST000003288343280594632805982In-frame

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Infer the effects of exon skipping event on protein functional features for CNOT10

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST00000328834283274432746302327464644345953993
ENST0000032883428327443275771632757803890976191220
ENST00000328834283274432758645327587299771060220248
ENST000003288342832744327669413276709111791328287337
ENST000003288342832744327762913277646816541830446504
ENST000003288342832744327789013277898218311911505531
ENST000003288342832744328009493280106319122025532569
ENST000003288342832744328059463280598221572192613625

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST00000328834283274432746302327464644345953993
ENST0000032883428327443275771632757803890976191220
ENST00000328834283274432758645327587299771060220248
ENST000003288342832744327669413276709111791328287337
ENST000003288342832744327762913277646816541830446504
ENST000003288342832744327789013277898218311911505531
ENST000003288342832744328009493280106319122025532569
ENST000003288342832744328059463280598221572192613625

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature


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SNVs in the skipped exons for CNOT10

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LIHCTCGA-DD-A39Y-01exon_skip_372446
32746303327464643274639932746399Frame_Shift_DelT-p.F73fs
LIHCTCGA-DD-A3A0-01exon_skip_372446
32746303327464643274640532746405Frame_Shift_DelA-p.K74fs
LIHCTCGA-DD-A39Y-01exon_skip_372446
32746303327464643274643932746439Frame_Shift_DelA-p.Q85fs
LIHCTCGA-DD-A1EG-01exon_skip_372454
32761606327617233276162732761627Frame_Shift_DelA-p.K256fs
LIHCTCGA-G3-A3CJ-01exon_skip_372454
32761606327617233276162732761627Frame_Shift_DelA-p.K256fs
LIHCTCGA-DD-A39Y-01exon_skip_372456
32769160327693623276918032769180Frame_Shift_DelC-p.P345fs
LIHCTCGA-G3-A3CJ-01exon_skip_372467
32778902327789823277895932778959Frame_Shift_DelA-p.R524fs
COADTCGA-F4-6856-01exon_skip_372487
32811379328114543281140932811409Frame_Shift_DelC-p.V651fs
UCECTCGA-A5-A0GH-01exon_skip_372487
32811379328114543281140932811409Frame_Shift_DelC-p.P739fs
LGGTCGA-DU-6392-01exon_skip_372448
32754719327548613275474332754744Frame_Shift_Ins-Tp.F152fs
STADTCGA-B7-5816-01exon_skip_372448
32754719327548613275474332754744Frame_Shift_Ins-Tp.C212fs
HNSCTCGA-DQ-5625-01exon_skip_372453
32758646327587293275866432758665Frame_Shift_Ins-Tp.I227fs
HNSCTCGA-DQ-5625-01exon_skip_372453
32758646327587293275866432758665Frame_Shift_Ins-Tp.P227fs
SKCMTCGA-ER-A19M-06exon_skip_372450
32757717327578033275780132757801Nonsense_MutationCTp.Q220*
STADTCGA-BR-6452-01exon_skip_372474
exon_skip_372473
32804225328043553280434632804346Nonsense_MutationCTp.Q611*

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
WM88_SKIN32754719327548613275474332754744Frame_Shift_Ins-Tp.CF152fs
HEC251_ENDOMETRIUM32746303327464643274636032746360Missense_MutationGTp.D59Y
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE32746303327464643274640932746409Missense_MutationGAp.S75N
MZ7MEL_SKIN32754719327548613275479932754799Missense_MutationCTp.L171F
GP5D_LARGE_INTESTINE32754719327548613275483632754836Missense_MutationAGp.N183S
SNU81_LARGE_INTESTINE32754719327548613275484632754846Missense_MutationATp.K186N
SNU1214_UPPER_AERODIGESTIVE_TRACT32757717327578033275776332757763Missense_MutationGTp.S207I
MDAMB330_BREAST32757717327578033275779632757796Missense_MutationTCp.I218T
HCC2998_LARGE_INTESTINE32758646327587293275867232758672Missense_MutationGTp.M229I
HUH28_BILIARY_TRACT32758646327587293275868032758680Missense_MutationTAp.L232Q
HEC59_ENDOMETRIUM32761606327617233276166632761666Missense_MutationGAp.A269T
NCIH2172_LUNG32766942327670913276695432766954Missense_MutationGTp.R292I
JL1_PLEURA32766942327670913276697732766977Missense_MutationGAp.G300S
HEC1A_ENDOMETRIUM32766942327670913276705932767059Missense_MutationGAp.C327Y
HEC1_ENDOMETRIUM32766942327670913276705932767059Missense_MutationGAp.C327Y
HEC1B_ENDOMETRIUM32766942327670913276705932767059Missense_MutationGAp.C327Y
HCC70_BREAST32766942327670913276707132767071Missense_MutationGCp.S331T
MRKNU1_BREAST32769160327693623276934032769340Missense_MutationGCp.C398S
MZ7MEL_SKIN32800950328010633280097032800970Missense_MutationGAp.S539N
NCIH2106_LUNG32800950328010633280105332801053Missense_MutationGAp.G567R
EKVX_LUNG32804225328043553280423132804231Missense_MutationGCp.L572F
MM383_SKIN32811379328114543281143032811430Missense_MutationGTp.A686S
SNU1040_LARGE_INTESTINE32745360327454543274541632745416Nonsense_MutationGTp.E27*
CW2_LARGE_INTESTINE32769160327693623276932332769323Nonsense_MutationGAp.W392*
EKVX_LUNG32804225328043553280423132804232Nonsense_MutationGGCTp.572_573LG>F*
EKVX_LUNG32804225328043553280423232804232Nonsense_MutationGTp.G573*
A101D_SKIN32811379328114543281145432811454Splice_SiteGAp.G694S

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CNOT10

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CNOT10


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CNOT10


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RelatedDrugs for CNOT10

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CNOT10

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource