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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for RAB26 |
 Gene summary |
| Gene information | Gene symbol | RAB26 | Gene ID | 25837 |
| Gene name | RAB26, member RAS oncogene family | |
| Synonyms | V46133 | |
| Cytomap | 16p13.3 | |
| Type of gene | protein-coding | |
| Description | ras-related protein Rab-26Ras-related oncogene protein | |
| Modification date | 20180523 | |
| UniProtAcc | Q9ULW5 | |
| Context | PubMed: RAB26 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for RAB26 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for RAB26 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for RAB26 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_132482 | 16 | 2198792:2198979:2199941:2200052:2201569:2201611 | 2199941:2200052 | ENSG00000167964.8 | ENST00000541451.1,ENST00000210187.6,ENST00000562735.1 |
| exon_skip_132484 | 16 | 2199982:2200052:2201130:2201316:2201569:2201611 | 2201130:2201316 | ENSG00000167964.8 | ENST00000565592.1,ENST00000564426.1 |
| exon_skip_132486 | 16 | 2201576:2201611:2201695:2201762:2201856:2201909 | 2201695:2201762 | ENSG00000167964.8 | ENST00000565592.1,ENST00000541451.1,ENST00000561600.1,ENST00000567145.2,ENST00000210187.6,ENST00000562735.1,ENST00000564426.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for RAB26 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_132482 | 16 | 2198792:2198979:2199941:2200052:2201569:2201611 | 2199941:2200052 | ENSG00000167964.8 | ENST00000541451.1,ENST00000562735.1,ENST00000210187.6 |
| exon_skip_132484 | 16 | 2199982:2200052:2201130:2201316:2201569:2201611 | 2201130:2201316 | ENSG00000167964.8 | ENST00000565592.1,ENST00000564426.1 |
| exon_skip_132486 | 16 | 2201576:2201611:2201695:2201762:2201856:2201909 | 2201695:2201762 | ENSG00000167964.8 | ENST00000565592.1,ENST00000541451.1,ENST00000564426.1,ENST00000562735.1,ENST00000210187.6,ENST00000561600.1,ENST00000567145.2 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for RAB26 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000210187 | 2201695 | 2201762 | Frame-shift |
| ENST00000210187 | 2199941 | 2200052 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000210187 | 2201695 | 2201762 | Frame-shift |
| ENST00000210187 | 2199941 | 2200052 | In-frame |
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Infer the effects of exon skipping event on protein functional features for RAB26 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000210187 | 1692 | 256 | 2199941 | 2200052 | 356 | 466 | 65 | 102 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000210187 | 1692 | 256 | 2199941 | 2200052 | 356 | 466 | 65 | 102 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9ULW5 | 65 | 102 | 1 | 66 | Alternative sequence | ID=VSP_056879;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9ULW5 | 65 | 102 | 61 | 69 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G6B |
| Q9ULW5 | 65 | 102 | 100 | 108 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G6B |
| Q9ULW5 | 65 | 102 | 1 | 256 | Chain | ID=PRO_0000121218;Note=Ras-related protein Rab-26 |
| Q9ULW5 | 65 | 102 | 76 | 85 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G6B |
| Q9ULW5 | 65 | 102 | 93 | 101 | Motif | Note=Effector region;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q9ULW5 | 65 | 102 | 77 | 77 | Mutagenesis | Note=Inactive%2C constitutively GDP-bound. Abolishes location at Golgi membranes. Impairs transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. T->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20038531,ECO:0000269|PubMe |
| Q9ULW5 | 65 | 102 | 70 | 78 | Nucleotide binding | Note=GTP;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.10 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9ULW5 | 65 | 102 | 1 | 66 | Alternative sequence | ID=VSP_056879;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9ULW5 | 65 | 102 | 61 | 69 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G6B |
| Q9ULW5 | 65 | 102 | 100 | 108 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G6B |
| Q9ULW5 | 65 | 102 | 1 | 256 | Chain | ID=PRO_0000121218;Note=Ras-related protein Rab-26 |
| Q9ULW5 | 65 | 102 | 76 | 85 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2G6B |
| Q9ULW5 | 65 | 102 | 93 | 101 | Motif | Note=Effector region;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q9ULW5 | 65 | 102 | 77 | 77 | Mutagenesis | Note=Inactive%2C constitutively GDP-bound. Abolishes location at Golgi membranes. Impairs transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. T->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:20038531,ECO:0000269|PubMe |
| Q9ULW5 | 65 | 102 | 70 | 78 | Nucleotide binding | Note=GTP;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.10 |
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SNVs in the skipped exons for RAB26 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_132482 | 2199942 | 2200052 | 2199953 | 2199953 | Frame_Shift_Del | G | - | p.V69fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_132482 | 2199942 | 2200052 | 2199962 | 2199962 | Frame_Shift_Del | G | - | p.S72fs |
| HNSC | TCGA-CV-7568-01 | exon_skip_132486 | 2201696 | 2201762 | 2201701 | 2201701 | Nonsense_Mutation | G | A | p.W118* |
| HNSC | TCGA-CV-6948-01 | exon_skip_132486 | 2201696 | 2201762 | 2201695 | 2201695 | Splice_Site | G | T | p.M117_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| CALU3_LUNG | 2199942 | 2200052 | 2200033 | 2200033 | Missense_Mutation | C | G | p.T96S |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for RAB26 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RAB26 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RAB26 |
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RelatedDrugs for RAB26 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RAB26 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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