|
||||||
|
 | |
| |
| |
| |
| Open reading frame (ORF) annotation in the exon skipping event |
| |
| |
| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
| |
|
Gene summary for TAC4 |
 Gene summary |
| Gene information | Gene symbol | TAC4 | Gene ID | 255061 |
| Gene name | tachykinin 4 | |
| Synonyms | EK|HK-1|HK1|PPT-C | |
| Cytomap | 17q21.33 | |
| Type of gene | protein-coding | |
| Description | tachykinin-4endokininpreprotachykinin-Ctachykinin 4 (hemokinin) | |
| Modification date | 20180523 | |
| UniProtAcc | Q86UU9 | |
| Context | PubMed: TAC4 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TAC4 | GO:1902093 | positive regulation of flagellated sperm motility | 17437961 |
Top |
Exon skipping events across known transcript of Ensembl for TAC4 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
Top |
Gene isoform structures and expression levels for TAC4 |
| Expression levels of gene isoforms across TCGA. |
 |
| Expression levels of gene isoforms across GTEx. |
 |
Top |
Exon skipping events with PSIs in TCGA for TAC4 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_291263 | 17 | 47915670:47916035:47917211:47917271:47918913:47918942 | 47917211:47917271 | ENSG00000176358.11 | ENST00000334568.4,ENST00000436235.1 |
| exon_skip_291264 | 17 | 47915670:47916035:47917211:47917271:47921425:47921519 | 47917211:47917271 | ENSG00000176358.11 | ENST00000398154.1 |
| exon_skip_291267 | 17 | 47915670:47916035:47918913:47918946:47921425:47921519 | 47918913:47918946 | ENSG00000176358.11 | ENST00000326219.5 |
| exon_skip_291269 | 17 | 47917211:47917271:47918913:47918946:47921425:47921519 | 47918913:47918946 | ENSG00000176358.11 | ENST00000334568.4,ENST00000436235.1 |
| PSI values of skipped exons in TCGA. |
 |
Top |
Exon skipping events with PSIs in GTEx for TAC4 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_291263 | 17 | 47915670:47916035:47917211:47917271:47918913:47918942 | 47917211:47917271 | ENSG00000176358.11 | ENST00000334568.4,ENST00000436235.1 |
| exon_skip_291264 | 17 | 47915670:47916035:47917211:47917271:47921425:47921519 | 47917211:47917271 | ENSG00000176358.11 | ENST00000398154.1 |
| exon_skip_291267 | 17 | 47915670:47916035:47918913:47918946:47921425:47921519 | 47918913:47918946 | ENSG00000176358.11 | ENST00000326219.5 |
| exon_skip_291269 | 17 | 47917211:47917271:47918913:47918946:47921425:47921519 | 47918913:47918946 | ENSG00000176358.11 | ENST00000334568.4,ENST00000436235.1 |
| PSI values of skipped exons in GTEx. |
 |
| * Skipped exon sequences. |
Top |
Open reading frame (ORF) annotation in the exon skipping event for TAC4 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000334568 | 47917211 | 47917271 | In-frame |
| ENST00000334568 | 47918913 | 47918946 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000334568 | 47917211 | 47917271 | In-frame |
| ENST00000334568 | 47918913 | 47918946 | In-frame |
Top |
Infer the effects of exon skipping event on protein functional features for TAC4 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
 |
| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000334568 | 692 | 113 | 47917211 | 47917271 | 251 | 310 | 83 | 103 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000334568 | 692 | 113 | 47917211 | 47917271 | 251 | 310 | 83 | 103 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q86UU9 | 83 | 103 | 73 | 83 | Alternative sequence | ID=VSP_052677;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12716968;Dbxref=PMID:12716968 |
| Q86UU9 | 83 | 103 | 75 | 105 | Alternative sequence | ID=VSP_052680;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12716968;Dbxref=PMID:12716968 |
| Q86UU9 | 83 | 103 | 84 | 103 | Alternative sequence | ID=VSP_052681;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12716968;Dbxref=PMID:12716968 |
| Q86UU9 | 83 | 103 | 95 | 95 | Modified residue | Note=Leucine amide;Ontology_term=ECO:0000255,ECO:0000303;evidence=ECO:0000255,ECO:0000303|PubMed:12716968;Dbxref=PMID:12716968 |
| Q86UU9 | 83 | 103 | 82 | 95 | Peptide | ID=PRO_5000063347;Note=Endokinin-C |
| Q86UU9 | 83 | 103 | 98 | 113 | Propeptide | ID=PRO_0000320013;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q86UU9 | 83 | 103 | 73 | 83 | Alternative sequence | ID=VSP_052677;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12716968;Dbxref=PMID:12716968 |
| Q86UU9 | 83 | 103 | 75 | 105 | Alternative sequence | ID=VSP_052680;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12716968;Dbxref=PMID:12716968 |
| Q86UU9 | 83 | 103 | 84 | 103 | Alternative sequence | ID=VSP_052681;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12716968;Dbxref=PMID:12716968 |
| Q86UU9 | 83 | 103 | 95 | 95 | Modified residue | Note=Leucine amide;Ontology_term=ECO:0000255,ECO:0000303;evidence=ECO:0000255,ECO:0000303|PubMed:12716968;Dbxref=PMID:12716968 |
| Q86UU9 | 83 | 103 | 82 | 95 | Peptide | ID=PRO_5000063347;Note=Endokinin-C |
| Q86UU9 | 83 | 103 | 98 | 113 | Propeptide | ID=PRO_0000320013;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
Top |
SNVs in the skipped exons for TAC4 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_291263 exon_skip_291264 | 47917212 | 47917271 | 47917232 | 47917232 | Frame_Shift_Del | T | - | p.K97fs |
| COAD | TCGA-AZ-6598-01 | exon_skip_291269 exon_skip_291267 | 47918914 | 47918946 | 47918915 | 47918915 | Frame_Shift_Del | T | - | p.A78fs |
| ESCA | TCGA-L5-A4OI-01 | exon_skip_291269 exon_skip_291267 | 47918914 | 47918946 | 47918915 | 47918915 | Frame_Shift_Del | T | - | p.A84fs |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 47917212 | 47917271 | 47917253 | 47917253 | Missense_Mutation | G | A | p.T90M |
| TM31_CENTRAL_NERVOUS_SYSTEM | 47918914 | 47918946 | 47918933 | 47918933 | Missense_Mutation | G | C | p.I77M |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 47918914 | 47918946 | 47918914 | 47918915 | Splice_Site | - | T | p.A84fs |
| HEC59_ENDOMETRIUM | 47918914 | 47918946 | 47918915 | 47918915 | Splice_Site | T | - | p.K83fs |
| SNUC4_LARGE_INTESTINE | 47918914 | 47918946 | 47918915 | 47918915 | Splice_Site | T | - | p.K83fs |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TAC4 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
Top |
Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TAC4 |
Top |
Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TAC4 |
Top |
RelatedDrugs for TAC4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for TAC4 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|