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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for CLDN15 |
 Gene summary |
| Gene information | Gene symbol | CLDN15 | Gene ID | 24146 |
| Gene name | claudin 15 | |
| Synonyms | - | |
| Cytomap | 7q22.1 | |
| Type of gene | protein-coding | |
| Description | claudin-15 | |
| Modification date | 20180519 | |
| UniProtAcc | P56746 | |
| Context | PubMed: CLDN15 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for CLDN15 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for CLDN15 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for CLDN15 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_478466 | 7 | 100875768:100875796:100875884:100876001:100876113:100876195 | 100875884:100876001 | ENSG00000106404.9 | ENST00000308344.5,ENST00000401528.1,ENST00000414035.1,ENST00000433833.1 |
| exon_skip_478483 | 7 | 100875884:100876001:100876113:100876195:100877558:100877654 | 100876113:100876195 | ENSG00000106404.9 | ENST00000308344.5,ENST00000401528.1,ENST00000412417.1 |
| exon_skip_478484 | 7 | 100875884:100876001:100876113:100876195:100880645:100880758 | 100876113:100876195 | ENSG00000106404.9 | ENST00000414035.1 |
| exon_skip_478497 | 7 | 100876113:100876195:100877153:100877397:100877558:100877654 | 100877153:100877397 | ENSG00000106404.9 | ENST00000433833.1 |
| exon_skip_478501 | 7 | 100876113:100876195:100877558:100877654:100880645:100880758 | 100877558:100877654 | ENSG00000106404.9 | ENST00000412417.1 |
| exon_skip_478502 | 7 | 100876113:100876195:100877558:100877723:100880645:100880758 | 100877558:100877723 | ENSG00000106404.9 | ENST00000401528.1 |
| exon_skip_478512 | 7 | 100877618:100877723:100880027:100880167:100880645:100880758 | 100880027:100880167 | ENSG00000106404.9 | ENST00000433422.1,ENST00000463331.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for CLDN15 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_478466 | 7 | 100875768:100875796:100875884:100876001:100876113:100876195 | 100875884:100876001 | ENSG00000106404.9 | ENST00000308344.5,ENST00000401528.1,ENST00000433833.1,ENST00000414035.1 |
| exon_skip_478483 | 7 | 100875884:100876001:100876113:100876195:100877558:100877654 | 100876113:100876195 | ENSG00000106404.9 | ENST00000308344.5,ENST00000401528.1,ENST00000412417.1 |
| exon_skip_478484 | 7 | 100875884:100876001:100876113:100876195:100880645:100880758 | 100876113:100876195 | ENSG00000106404.9 | ENST00000414035.1 |
| exon_skip_478497 | 7 | 100876113:100876195:100877153:100877397:100877558:100877654 | 100877153:100877397 | ENSG00000106404.9 | ENST00000433833.1 |
| exon_skip_478501 | 7 | 100876113:100876195:100877558:100877654:100880645:100880758 | 100877558:100877654 | ENSG00000106404.9 | ENST00000412417.1 |
| exon_skip_478502 | 7 | 100876113:100876195:100877558:100877723:100880645:100880758 | 100877558:100877723 | ENSG00000106404.9 | ENST00000401528.1 |
| exon_skip_478512 | 7 | 100877618:100877723:100880027:100880167:100880645:100880758 | 100880027:100880167 | ENSG00000106404.9 | ENST00000463331.1,ENST00000433422.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for CLDN15 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000308344 | 100876113 | 100876195 | Frame-shift |
| ENST00000401528 | 100876113 | 100876195 | Frame-shift |
| ENST00000308344 | 100875884 | 100876001 | In-frame |
| ENST00000401528 | 100875884 | 100876001 | In-frame |
| ENST00000401528 | 100877558 | 100877723 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000308344 | 100876113 | 100876195 | Frame-shift |
| ENST00000401528 | 100876113 | 100876195 | Frame-shift |
| ENST00000308344 | 100875884 | 100876001 | In-frame |
| ENST00000401528 | 100875884 | 100876001 | In-frame |
| ENST00000401528 | 100877558 | 100877723 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CLDN15 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000401528 | 2148 | 228 | 100877558 | 100877723 | 1344 | 1508 | 72 | 127 |
| ENST00000308344 | 1387 | 228 | 100875884 | 100876001 | 830 | 946 | 155 | 193 |
| ENST00000401528 | 2148 | 228 | 100875884 | 100876001 | 1591 | 1707 | 155 | 193 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000401528 | 2148 | 228 | 100877558 | 100877723 | 1344 | 1508 | 72 | 127 |
| ENST00000308344 | 1387 | 228 | 100875884 | 100876001 | 830 | 946 | 155 | 193 |
| ENST00000401528 | 2148 | 228 | 100875884 | 100876001 | 1591 | 1707 | 155 | 193 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P56746 | 72 | 127 | 1 | 228 | Chain | ID=PRO_0000144771;Note=Claudin-15 |
| P56746 | 72 | 127 | 111 | 111 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332 |
| P56746 | 72 | 127 | 25 | 74 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P56746 | 72 | 127 | 100 | 115 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P56746 | 72 | 127 | 75 | 99 | Transmembrane | Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P56746 | 72 | 127 | 116 | 140 | Transmembrane | Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P56746 | 155 | 193 | 1 | 228 | Chain | ID=PRO_0000144771;Note=Claudin-15 |
| P56746 | 155 | 193 | 1 | 228 | Chain | ID=PRO_0000144771;Note=Claudin-15 |
| P56746 | 155 | 193 | 141 | 159 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P56746 | 155 | 193 | 141 | 159 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P56746 | 155 | 193 | 183 | 228 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P56746 | 155 | 193 | 183 | 228 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P56746 | 155 | 193 | 160 | 182 | Transmembrane | Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P56746 | 155 | 193 | 160 | 182 | Transmembrane | Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P56746 | 72 | 127 | 1 | 228 | Chain | ID=PRO_0000144771;Note=Claudin-15 |
| P56746 | 72 | 127 | 111 | 111 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19690332;Dbxref=PMID:19690332 |
| P56746 | 72 | 127 | 25 | 74 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P56746 | 72 | 127 | 100 | 115 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P56746 | 72 | 127 | 75 | 99 | Transmembrane | Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P56746 | 72 | 127 | 116 | 140 | Transmembrane | Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P56746 | 155 | 193 | 1 | 228 | Chain | ID=PRO_0000144771;Note=Claudin-15 |
| P56746 | 155 | 193 | 1 | 228 | Chain | ID=PRO_0000144771;Note=Claudin-15 |
| P56746 | 155 | 193 | 141 | 159 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P56746 | 155 | 193 | 141 | 159 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P56746 | 155 | 193 | 183 | 228 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P56746 | 155 | 193 | 183 | 228 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P56746 | 155 | 193 | 160 | 182 | Transmembrane | Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P56746 | 155 | 193 | 160 | 182 | Transmembrane | Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
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SNVs in the skipped exons for CLDN15 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_478466 | 100875885 | 100876001 | 100875968 | 100875968 | Frame_Shift_Del | C | - | p.W166fs |
| HNSC | TCGA-CN-5367-01 | exon_skip_478483 exon_skip_478484 | 100876114 | 100876195 | 100876196 | 100876196 | Splice_Site | C | A | p.G128_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| CW2_LARGE_INTESTINE | 100877559 | 100877723 | 100877621 | 100877621 | Frame_Shift_Del | C | - | p.G107fs |
| CW2_LARGE_INTESTINE | 100877559 | 100877654 | 100877621 | 100877621 | Frame_Shift_Del | C | - | p.G107fs |
| JHUEM1_ENDOMETRIUM | 100875885 | 100876001 | 100875976 | 100875976 | Missense_Mutation | G | T | p.L164M |
| UACC257_SKIN | 100876114 | 100876195 | 100876182 | 100876182 | Missense_Mutation | C | T | p.M132I |
| DG75_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 100876114 | 100876195 | 100876187 | 100876187 | Missense_Mutation | C | T | p.G131R |
| BHY_UPPER_AERODIGESTIVE_TRACT | 100876114 | 100876195 | 100876187 | 100876187 | Missense_Mutation | C | A | p.G131W |
| NCIH513_PLEURA | 100876114 | 100876195 | 100876191 | 100876191 | Missense_Mutation | G | C | p.I129M |
| MRKNU1_BREAST | 100877559 | 100877723 | 100877583 | 100877583 | Missense_Mutation | C | T | p.A120T |
| MRKNU1_BREAST | 100877559 | 100877654 | 100877583 | 100877583 | Missense_Mutation | C | T | p.A120T |
| C33A_CERVIX | 100877559 | 100877723 | 100877672 | 100877672 | Missense_Mutation | A | G | p.F90S |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CLDN15 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CLDN15 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CLDN15 |
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RelatedDrugs for CLDN15 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CLDN15 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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