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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ZKSCAN5 |
 Gene summary |
| Gene information | Gene symbol | ZKSCAN5 | Gene ID | 23660 |
| Gene name | zinc finger with KRAB and SCAN domains 5 | |
| Synonyms | ZFP-95|ZFP95|ZNF914|ZSCAN37 | |
| Cytomap | 7q22.1 | |
| Type of gene | protein-coding | |
| Description | zinc finger protein with KRAB and SCAN domains 5zinc finger protein 95 homologzinc finger protein homologous to Zfp95 in mouse | |
| Modification date | 20180522 | |
| UniProtAcc | Q9Y2L8 | |
| Context | PubMed: ZKSCAN5 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for ZKSCAN5 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ZKSCAN5 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ZKSCAN5 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_468723 | 7 | 99110075:99110214:99117449:99117532:99123435:99123878 | 99117449:99117532 | ENSG00000196652.7 | ENST00000454175.1 |
| exon_skip_468724 | 7 | 99117449:99117532:99117791:99117927:99123435:99123878 | 99117791:99117927 | ENSG00000196652.7 | ENST00000326775.5,ENST00000394170.2,ENST00000451158.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ZKSCAN5 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_468723 | 7 | 99110075:99110214:99117449:99117532:99123435:99123878 | 99117449:99117532 | ENSG00000196652.7 | ENST00000454175.1 |
| exon_skip_468724 | 7 | 99117449:99117532:99117791:99117927:99123435:99123878 | 99117791:99117927 | ENSG00000196652.7 | ENST00000326775.5,ENST00000451158.1,ENST00000394170.2 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ZKSCAN5 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000326775 | 99117791 | 99117927 | Frame-shift |
| ENST00000394170 | 99117791 | 99117927 | Frame-shift |
| ENST00000451158 | 99117791 | 99117927 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000326775 | 99117791 | 99117927 | Frame-shift |
| ENST00000394170 | 99117791 | 99117927 | Frame-shift |
| ENST00000451158 | 99117791 | 99117927 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for ZKSCAN5 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for ZKSCAN5 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HNSC | TCGA-CR-7382-01 | exon_skip_468723 | 99117450 | 99117532 | 99117510 | 99117510 | Nonsense_Mutation | C | A | p.S205* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SW403_LARGE_INTESTINE | 99117450 | 99117532 | 99117482 | 99117482 | Missense_Mutation | C | A | p.L196M |
| MKN45_STOMACH | 99117450 | 99117532 | 99117501 | 99117501 | Missense_Mutation | T | G | p.L202R |
| KM12_LARGE_INTESTINE | 99117450 | 99117532 | 99117522 | 99117522 | Missense_Mutation | C | T | p.T209I |
| A4FUK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 99117792 | 99117927 | 99117883 | 99117883 | Missense_Mutation | A | T | p.Y243F |
| COLO668_LUNG | 99117792 | 99117927 | 99117904 | 99117904 | Missense_Mutation | A | T | p.N250I |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZKSCAN5 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZKSCAN5 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZKSCAN5 |
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RelatedDrugs for ZKSCAN5 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZKSCAN5 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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