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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for VSIG2 |
 Gene summary |
| Gene information | Gene symbol | VSIG2 | Gene ID | 23584 |
| Gene name | V-set and immunoglobulin domain containing 2 | |
| Synonyms | 2210413P10Rik|CTH|CTXL | |
| Cytomap | 11q24.2 | |
| Type of gene | protein-coding | |
| Description | V-set and immunoglobulin domain-containing protein 2CT-like proteincortical thymocyte receptor (X. laevis CTX) likecortical thymocyte-like protein | |
| Modification date | 20180519 | |
| UniProtAcc | Q96IQ7 | |
| Context | PubMed: VSIG2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for VSIG2 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for VSIG2 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for VSIG2 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_78217 | 11 | 124617367:124617563:124618285:124618430:124618539:124618659 | 124618285:124618430 | ENSG00000019102.7 | ENST00000326621.5 |
| exon_skip_78244 | 11 | 124619603:124619762:124620609:124620817:124621318:124621476 | 124620609:124620817 | ENSG00000019102.7 | ENST00000326621.5,ENST00000403470.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for VSIG2 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_78217 | 11 | 124617367:124617563:124618285:124618430:124618539:124618659 | 124618285:124618430 | ENSG00000019102.7 | ENST00000326621.5 |
| exon_skip_78244 | 11 | 124619603:124619762:124620609:124620817:124621318:124621476 | 124620609:124620817 | ENSG00000019102.7 | ENST00000326621.5,ENST00000403470.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for VSIG2 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000326621 | 124618285 | 124618430 | Frame-shift |
| ENST00000326621 | 124620609 | 124620817 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000326621 | 124618285 | 124618430 | Frame-shift |
| ENST00000326621 | 124620609 | 124620817 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for VSIG2 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for VSIG2 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_78217 | 124618286 | 124618430 | 124618298 | 124618298 | Frame_Shift_Del | C | - | p.G280fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_78217 | 124618286 | 124618430 | 124618298 | 124618298 | Frame_Shift_Del | C | - | p.G280fs |
| OV | TCGA-24-1435-01 | exon_skip_78244 | 124620610 | 124620817 | 124620707 | 124620710 | Frame_Shift_Del | GTCA | - | p.D110fs |
| COAD | TCGA-AD-6964-01 | exon_skip_78244 | 124620610 | 124620817 | 124620740 | 124620740 | Frame_Shift_Del | G | - | p.T100fs |
| BLCA | TCGA-ZF-A9R0-01 | exon_skip_78244 | 124620610 | 124620817 | 124620739 | 124620740 | Frame_Shift_Ins | - | G | p.T100fs |
| KIRC | TCGA-A3-3378-01 | exon_skip_78244 | 124620610 | 124620817 | 124620739 | 124620740 | Frame_Shift_Ins | - | G | p.S100fs |
| KIRC | TCGA-AK-3465-01 | exon_skip_78244 | 124620610 | 124620817 | 124620739 | 124620740 | Frame_Shift_Ins | - | G | p.S100fs |
| KIRC | TCGA-AS-3778-01 | exon_skip_78244 | 124620610 | 124620817 | 124620739 | 124620740 | Frame_Shift_Ins | - | G | p.S100fs |
| READ | TCGA-AG-A002-01 | exon_skip_78244 | 124620610 | 124620817 | 124620809 | 124620809 | Nonsense_Mutation | G | T | p.Y76X |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| MFE319_ENDOMETRIUM | 124618286 | 124618430 | 124618358 | 124618358 | Missense_Mutation | G | A | p.A260V |
| KCL22_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 124618286 | 124618430 | 124618361 | 124618361 | Missense_Mutation | G | A | p.A259V |
| SW1783_CENTRAL_NERVOUS_SYSTEM | 124618286 | 124618430 | 124618407 | 124618407 | Missense_Mutation | C | T | p.G244R |
| MEWO_SKIN | 124620610 | 124620817 | 124620640 | 124620640 | Missense_Mutation | C | T | p.G133R |
| JHUEM7_ENDOMETRIUM | 124620610 | 124620817 | 124620777 | 124620777 | Missense_Mutation | G | T | p.S87Y |
| SNU81_LARGE_INTESTINE | 124618286 | 124618430 | 124618367 | 124618367 | Nonsense_Mutation | G | T | p.S257* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for VSIG2 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for VSIG2 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for VSIG2 |
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RelatedDrugs for VSIG2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for VSIG2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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